Clinical application of combination [11C]C-methionine and [13N]N-ammonia PET/CT in recurrent functional pituitary adenomas with negative MRI or [18F]F-FDG PET/CT

Table 2 Radiographic results of [¹¹C]C-MET with [¹³N]N-NH3 PET/CT and patients’ outcomes

Patient No	secretion	Adenoma position	Pituitary position	Therapeutic decision	Follow-up Period (month)	hypopituitarism		Hormonal testing
Patient No	secretion	Adenoma position	Pituitary position	Therapeutic decision	Follow-up Period (month)	Pre-	Post-	Pre-	Post-
1	ACTH	L	R	surgery	1	N	N	23.61(a)	1.22
2	ACTH	L	M	surgery	1	N	N	17.96(a)	< 0.8
3	ACTH	L	R	surgery	1	N	N	30.37(a)	< 0.8
4	GH	R&M	L	surgery	1	N	N	8.66(b)	0.93
5	GH	R^a	L	GKRS	6	Y	Y	9.87(b)	10.32
6	PRL	L^a	R&M	GKRS	6	N	N	267.95(c)	236.51
7	PRL	R^a	L&M	medicine	-	Y	-	338.68(c)	-
8	PRL	R^a	L	medicine	-	N	-	179.34(c)	15.3
9	PRL	L	R&M	observation	6	N	N	135.79(c)	127.62

(a) = serum of cortisol, (b) = serum of growth hormone, (c) = serum of prolactin,—= lost to follow-up; Reference value:(a): 2.90–19.40ug/dl, (b): 0.00 – 2.5ug/L, (c): 1.39—29.93 ng/mL
Pre- before treatment, Post- after treatment, R right part of sella turcica, M median part of sella turcica, L left part of sella turcica, GKRS gamma-knife radiosurgery, N no, Y yes
^alocalize or invaded into cavernous sinus

ISSN: 1472-6823