The association between creatinine to body weight ratio and the risk of progression to diabetes from pre-diabetes: a 5-year cohort study in Chinese adults

Table 7 Effect size of the Cre/BW ratio on incident diabetes in prespecified and exploratory subgroups

Characteristic	No of participants	HR (95%CI)	P value	P for interacion
Age(years)				0.0002
20 to < 30	1431	0.036 (0.005, 0.245)	0.0007
30 to < 40	5836	0.192 (0.097, 0.380)	< 0.0001
40 to < 50	5366	0.325 (0.196, 0.539)	< 0.0001
50 to < 60	5702	0.545 (0.376, 0.791)	0.0014
60 to < 70	4198	0.689 (0.462, 1.026)	0.0666
≥ 70	1973	0.786 (0.476, 1.298)	0.3475
Gender				0.3762
Male	16,232	0.467 (0.367, 0.595)	< 0.0001
Female	8264	0.382 (0.259, 0.563)	< 0.0001
BMI(kg/m²)				0.5359
< 18.5	437	0.308 (0.014, 6.724)	0.4542
≥ 18.5, < 24	9544	0.517 (0.345, 0.776)	0.0014
≥ 24, < 28	10,450	0.749 (0.533, 1.051)	0.0944
≥ 28	4075	0.593 (0.367, 0.958)	0.0328
Smoking status				0.2491
Never smoker	17,784	0.462 (0.361, 0.591)	< 0.0001
Ever smoker	1110	0.215 (0.088, 0.526)	0.0008
Current smoker	5612	0.461 (0.314, 0.676)	< 0.0001
Drinking status				0.8016
Never drinker	19,704	0.453 (0.360, 0.570)	< 0.0001
Ever drinker	3846	0.380 (0.222, 0.651)	0.0004
Current drinker	956	0.508 (0.204, 1.266)	0.1459
Family history of diabetes				0.7916
No	23,887	0.448 (0.362, 0.554)	< 0.0001
Yes	619	0.393 (0.150, 1.031)	0.0576
SBP(mmHg)				0.4140
< 140	19,302	0.429 (0.335, 0.550)	< 0.0001
≥ 140	2504	0.506 (0.362, 0.705)	< 0.0001
DBP(mmHg)				0.0358
< 90	20,966	0.404 (0.322, 0.508)	< 0.0001
≥ 90	3540	0.675 (0.437, 1.041)	0.0756
TG(mmol/L)				0.0286
< 1.7	14,958	0.373 (0.281, 0.495)	< 0.0001
≥ 1.7	9548	0.570 (0.430, 0.755)	< 0.0001

Note 1: Above model adjusted for age, gender, height, SBP, DBP, FPG, BUN, TG, HDL-c, LDL-c, ALT, AST, family history of diabetes, smoking and drinking status
Note 2: In each case, the model is not adjusted for the stratification variable

ISSN: 1472-6823