Table 3 Demographic, clinical and laboratory characteristics of CN group VS CI group
Characteristics | CN group (n = 224) | CI group (n = 280) | F/χ2/Z | P value | |
|---|---|---|---|---|---|
Demographic & Clinical Features | Age(y) | 63 (56, 70) | 67 (61, 74) | 4.735 | 0.000∗ |
Gender, male, n (%) | 156 (69.64%) | 183 (65.36%) | 1.038 | 0.308 | |
Residential area, village, n (%) | 55 (24.55%) | 83 (29.64%) | 1.621 | 0.203 | |
Alcohol comsumption, n (%) | 60 (26.79%) | 59 (21.07%) | 2.253 | 0.133 | |
Smoke, n (%) | 75 (33.48%) | 89 (31.79%) | 0.163 | 0.686 | |
Hypertension, n (%) | 152 (67.86%) | 198 (70.71%) | 0.479 | 0.489 | |
Coronary Heart Disease, n (%) | 34 (15.18%) | 53 (18.93%) | 1.225 | 0.268 | |
Brain Infarction, n (%) | 116 (51.79%) | 194 (69.29%) | 16.097 | 0.000∗ | |
Encephalatrophy, n (%) | 12 (5.36%) | 28 (10.00%) | 3.671 | 0.055 | |
Dementia, n (%) | 3 (1.34%) | 36 (12.86%) | 23.124 | 0.000∗ | |
Anxiety Disorder, n (%) | 59 (26.34%) | 70 (25.00%) | 0.117 | 0.732 | |
Depression, n (%) | 56 (25.00%) | 63 (22.50%) | 0.431 | 0.511 | |
Education level | -2.668 | 0.008∗ | |||
Illiteracy, n (%) | 7 (3.12%) | 18 (6.43%) | |||
Elementary school, n (%) | 29 (12.95%) | 54 (19.29%) | |||
Junior high school above, n (%) | 188 (83.93%) | 208 (74.28%) | |||
Clinical Scale Tests | HAMA score | 10 (7, 13) | 11 (7, 15) | 2.017 | 0.044∗ |
HAMD score | 10 (6, 13) | 11 (7, 16) | 1.215 | 0.224 | |
Severity of dependence (BI) | -5.085 | 0.000∗ | |||
Self-care, n(%) | 105 (46.88%) | 79 (28.22%) | |||
Mild dependence, n(%) | 108 (48.21%) | 157 (56.07%) | |||
Moderate dependence, n(%) | 10 (4.46%) | 31 (11.07%) | |||
Severe dependence, n(%) | 1 (0.45%) | 13 (4.64%) | |||
Inflammation Parameters | WBC (× 10^9/L) | 5.87 (4.88, 7.01) | 6.05 (4.94, 7.38) | 1.058 | 0.290 |
ANC (× 10^9/L) | 3.61 (2.73, 4.24) | 3.66 (2.69, 4.66) | 0.881 | 0.378 | |
PLT (× 10^9/L) | 183 (151, 221) | 187 (152, 217) | 0.096 | 0.923 | |
ESR (mm/hr) | 14 (6, 26) | 14 (8, 23) | 0.359 | 0.719 | |
Liver & Renal Function | ALT (IU/L) | 19 (14, 27) | 20 (13, 27) | -0.764 | 0.445 |
AST (IU/L) | 18 (14, 23) | 18 (15, 23) | -0.164 | 0.870 | |
GGT (IU/L) | 24 (17, 34) | 24 (17, 36) | 0.403 | 0.687 | |
TP (g/L) | 66.0 ± 5.4 | 66.2 ± 5.7 | 0.001 | 0.695 | |
Glb (g/L) | 25.5 (23.0, 28.4) | 26.3 (23.5, 29.4) | 2.116 | 0.034∗ | |
Alb (g/L) | 40.1 ± 3.7 | 39.5 ± 3.5 | 0.291 | 0.046∗ | |
A/G | 1.6 (1.4, 1.8) | 1.5 (1.4, 1.7) | -3.292 | 0.001∗ | |
ALP (IU/L) | 74 (60, 90) | 77 (64, 93) | 1.708 | 0.088 | |
Creatinine (umol/L) | 84 (67, 100) | 85 (68, 101) | 0.351 | 0.726 | |
Uric Acid (umol/L) | 272 (224, 331) | 262 (215, 309) | -1.636 | 0.102 | |
Thyroid Function | TSH (uIU/ml) | 2.27 (1.54, 3.49) | 2.11 (1.34, 3.15) | -1.241 | 0.215 |
T4 (nmol/L) | 95.24 (81.25, 111.08) | 94.93 (80.95, 112.38) | -0.138 | 0.890 | |
fT4 (pmol/L) | 16.20 (14.76, 17.91) | 15.91 (14.06, 18.03) | -0.809 | 0.419 | |
T3 (nmol/L) | 1.54 (1.36, 1.76) | 1.44 (1.27, 1.61) | -3.269 | 0.001∗ | |
fT3 (pmol/L) | 4.38 (3.98, 4.69) | 4.13 (3.71, 4.53) | -4.160 | 0.000∗ | |
TPO-Ab (IU/ml) | 16.24 (10.18, 36.78) | 18.76 (10.11, 34.93) | 0.154 | 0.878 | |
Thyroglobulin antibody (IU/ml) | 15.00 (10.00, 26.10) | 15.00 (10.00, 22.18) | -0.872 | 0.383 | |
Thyroglobulin (ng/ml) | 7.32 (3.39, 13.73) | 7.99 (3.42, 14.44) | 0.115 | 0.909 | |
Coagulation Markers | Prothrombin time (s) | 10.70 (10.30, 11.20) | 10.90 (10.40, 11.50) | 1.528 | 0.127 |
APTT (s) | 24.95 (22.70, 27.98) | 25.20 (23.10, 28.60) | 0.961 | 0.337 | |
Fibrinogen (g/L) | 2.76 (2.31, 3.26) | 2.85 (2.40, 3.42) | 1.534 | 0.125 | |
Thrombin time (s) | 18.40 (17.40, 19.30) | 17.90 (17.30, 19.00) | -2.564 | 0.010∗ | |
D-dimer (mg/L) | 0.27 (0.19, 0.45) | 0.33 (0.20, 0.62) | 3.211 | 0.001∗ | |
FDP (ug/ml) | 1.60 (1.20, 2.08) | 1.73 (1.35, 2.42) | 2.535 | 0.011∗ | |
Prothrombin activity (%) | 97.30 (88.50, 105.80) | 95.20 (86.70, 105.20) | -1.099 | 0.272 | |
International Normalized Ratio | 0.95 (0.91, 0.99) | 0.96 (0.91, 1.01) | 1.285 | 0.199 | |
Myocardial enzyme | LDH (IU/L) | 171 (150,191) | 173 (151, 194) | 0.882 | 0.378 |
LDH-1 (IU/L) | 43 ± 14 | 43 ± 15 | 1.258 | 0.594 | |
CK (IU/L) | 66 (51, 100) | 60 (43, 81) | -2.838 | 0.005∗ | |
CK-MB (IU/L) | 12 (10, 16) | 12 (10, 14) | -0.287 | 0.774 | |
α-HBDH (IU/L) | 139 (123, 157) | 139 (124, 161) | 0.667 | 0.505 | |
Homocysteine (umol/L) | 10.87 (8.98, 14.12) | 11.99 (9.28, 15.00) | 2.030 | 0.042∗ | |
Vitamin B12 (pmol/L) | 368.1 (235.4, 718.0) | 363.6 (226.5, 629.6) | -0.776 | 0.438 | |
Folicacid (nmol/L) | 15.10 (10.44, 22.19) | 14.50 (9.33, 23.18) | -0.912 | 0.362 | |
NSE (ng/ml) | 11.64 ± 2.76 | 11.14 ± 2.69 | 0.009 | 0.297 | |