Fig. 1

Data collected by the advanced hybrid closed-loop insulin delivery system during the evening of the event described in the illustrative case. Note: Maximal basal insulin delivery between 20:00–01:00 hours, glucose peak of 21 mmol/Ljust prior to 01:00 hours followed by a rapid drop in glucose leading to insulin delivery being suspended around 01:10 hours. Hypoglycaemia began at approximately 02:30 hours and continues until 05:00 hours upon which we see a steady increase