From: Lipid profile in girls with precocious puberty: a systematic review and meta-analysis
No. | Study | Region | Study design | Sample size (n) | Chronological Age(y) | Bone Age | Tanner stage | BMI(kg/m2) | Drug used | Measuring method | Primary conclusion | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cases | Control | Cases | Control | Cases | Control | Cases | Control | Cases | Control | |||||||
1. | Ibáñez (1998) [43] | Spain (Barcelona) | cross-sectional study | PP 21 | 14 | 7.5 ± 0.2 | 8.5 ± 0.3 | 8.6 ± 0.2 | 7.8 ± 0.3 | I | I | 18.8 ± 0.6 | 17.0 ± 0.4 | No | CHOD-PAP and GPO-PAP based methods in a Hitachi 917 autoanalyser (Boehringer Mannheim, Mannheim, Germany) | TG increased in PP; TC, HDL, LDL remained unchanged in PP |
2. | Ibáñez (2004) [22] | Spain (Barcelona) | cross-sectional study | PP 33 | 37 | 8.0 ± 0.57 | 8.3 ± 1.83 | 9.1 ± 0.57 | NA | I | I | 18.5 ± 0.3 | 17.7 ± 0.4 | No | NA | TG and LDL increased in PP; HDL decreased in PP |
3. | Teixeira (2004) [25] | Brazil (Rio de Janeiro) | cross-sectional study | PP 25 | 14 | 7.3 ± 1.5 | 6.4 ± 1.3 | NA | NA | NA | NA | 19.7 ± 4.4 | 19.3 ± 4.6 | NA | TC, HDL and TG were measured by an automated enzymatic colorimetric method; LDL was calculated using the Friedewald formula | TG, TC, HDL and LDL remained unchanged in PP |
4. | Guven (2005) [44] | Turkey (Ankara) | cross-sectional study | PA 24 | 13 | 7.6 ± 0.1 | 6.9 ± 0.3 | 7.6 ± 0.2 | 6.4 ± 0.4 | II | II | 17.1 ± 0.33 | 15.9 ± 0.4 | No | TC, TG and HDL were measured by the Abbott-Aeroset system through enzyme assay; LDL was estimated by indirect calculation | TC and LDL increased in PA; TG and HDL remained unchanged in PA |
5. | Larqué (2010) [26] | Spain (Granada) | cross-sectional study | PP 22 | 20 | 8.34 ± 0.29 | 9.12 ± 0.37 | NA | NA | I | I | 19.33 ± 0.71 | 17.30 ± 0.60 | No | Automatic analyzer (Roche-Hitachi Modular PyD Autoanalyzer, Roche Laboratory Systems) | TG, TC, HDL and LDL remained unchanged in PP |
6. | Sorensen (2010) [45] | Denmark (Copenhagen) | cross-sectional study | CPP 15 | 24 | 8.67 ± 1.96 | 9.26 ± 3.15 | NA | NA | II, III | I | 18.9 ± 3.4 | 16.21 ± 4.18 | 13 girls with CPP were initiated on long-acting GnRHa treatment with sc injections every 28th day | Enzymatic colorimetric analyses (CFAS TC/LDL/HDL plus, TG GPO-PAP; Roche) | TG increased in CPP; TC, HDL and LDL remained unchanged in CPP |
7. | Sopher (2011) [27] | USA (New York) | cross-sectional study | PA 24 | 25 | 7.7 ± 1.4 | 7.2 ± 1.5 | NA | NA | I | I | 1.2 ± 1.1 (z-score) | 1.8 ± 1.0 (z-score) | No | TC, HDL, and TG by Hitachi analyzer; LDL was calculated | TG, TC, HDL and LDL remained unchanged in PA |
8. | Su (2012) [28] | Taiwan (Taichung) | cross-sectional study | CPP 249 | 219 | 8.5 ± 1.4 | 8.3 ± 1.4 | 10.4 ± 1.5 | 8.9 ± 2.1 | 134 II, 115 III | 90 I, 129 II | 18.7 ± 2.9 | 17.6 ± 3.5 | No | Enzymatic color test and Olympus analyzers (AU600, Clare, Ireland) | TG and TC remained unchanged in CPP |
9. | Ucar (2013) [23] | Turkey (Kayseri) | cross-sectional study | PA 69 | 45 | 7.1 ± 1.0 | 7.5 ± 1.9 | NA | NA | NA | NA | 0.5 ± 1.2 (SDS) | 0.2 ± 1.1 (SDS) | NA | Integra-800 autoanalyzer (Roche) | TG and LDL decreased in PA; HDL increased in PA; TC remained unchanged in PA |
10. | Hur (2017) [29] | Korea (Seoul) | cross-sectional study | CPP 164 | 67 | 8.3 ± 0.6 | 7.9 ± 0.6 | 9.7 ± 0.9 | 8.2 ± 0.9 | II | I | 0.3 ± 1.1 (SDS) | 0.4 ± 0.9 (SDS) | NA | NA | TG, TC, HDL and LDL remained unchanged in CPP |
11. | Zurita-Cruz (2018) [30] | México (Mexico City) | cross-sectional study | CPP 31 | 22 | 6.5 ± 2.5 | 6.0 ± 2.0 | NA | NA | II, III | I | 1.7 ± 0.4 (z-score) | 1.8 ± 0.4 (z-score) | No | Colorimetric enzymatic method (Bayer Diagnostics, Puteaux, France) | TG, HDL and LDL remained unchanged in CPP |
12. | Xu (2019) [24] | China (Jinan) | cross-sectional study | PT 263 | 222 | 5.3 ± 0.7 | 5.5 ± 0.8 | 6.1 ± 1.1 | 5.9 ± 1.2 | II, III | I | 15.1 ± 2.6 | 15.8 ± 2.1 | No | AU5800 Chemistry Analyzer (Olympus, Japan) | TC, TG and LDL increased in PT; HDL remained unchanged in PT |
13. | Aydin (2022) [31] | Sweden (Uppsala) | cross-sectional study | PA 48 | 49 | 7.71 ± 1.0 | 7.54 ± 0.9 | 8.2 ± 1.0 | 7.45 ± 1.4 | NA | NA | 1.2 ± 1.5 (SDS) | 0.94 ± 1.6 (SDS) | No | Absorbance photometry (Roche Diagnostics, Cobas Integra 800 Device) | TC, TG, HDL and LDL remained unchanged in PA |
14. | Bezen (2022) [32] | Turkey (İstanbul) | cross-sectional study | PP 35 | 35 | 8.3 ± 1.1 | 8.1 ± 1.0 | NA | NA | NA | NA | 0.34 ± 0.83 (SDS) | -0.04 ± 0.78 (SDS) | No | Spectrophotometer method in Advia 1800 device | TC, TG, HDL and LDL remained unchanged in PP |