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Table 2 Comparison of microangiopathy in patients with early-onset diabetes

From: Clinical characteristics of patients with early-onset diabetes mellitus: a single-center retrospective study

Variables

Microangiopathy group

Nonmicrovascular group

|t/X2|

P

Sex (%)

  

0.960

0.378

Male

female

44 (6.7)

21 (3.2)

433 (66.1)

157 (24.0)

  

onset age (year)

31.02 ± 0.76

29.59 ± 0.25

1.808

0.77

Types of diabetes (%)

  

4.217

0.031

T1DM

T2DM

LADA

Special types

5 (0.8)

57 (8.7)

2 (0.3)

1 (0.2)

127 (19.4)

434 (66.3)

22 (3.4)

7 (1.1)

  

Age of first treatment (year)

31.45 ± 0.77

29.85 ± 0.25

1.993

0.047

Time from onset to first hospitalization (month)

7.07 ± 0.95

6.59 ± 0.27

2.153

0.032

BMI (kg/m2)

26.92 ± 0.82

26.31 ± 0.24

0.791

0.429

Weight (kg)

77.01 ± 2.80

77.33 ± 0.79

0.127

0.899

Height (cm)

168.48 ± 1.20

170.84 ± 0.33

2.210

0.027

Initial ketosis (%)

  

6.246

0.013

yes

no

22 (3.4)

43 (16.9)

296 (45.2)

294 (44.9)

  

Weight loss (%)

  

0.355

0.585

yes

no

40 (6.1)

25 (3.8)

385 (58.8)

205 (31.3)

  

Smoking status (%)

  

0.001

1.000

yes

no

27 (4.1)

38 (5.8)

245 (37.4)

345 (52.7)

  

Alcohol (%)

  

0.148

0.776

yes

no

21 (3.2)

44 (6.7)

177 (27.0)

413 (63.1)

  

DM family history (%)

  

1.178

0.298

yes

no

37 (5.6)

28 (4.3)

294 (44.9)

296 (45.2)

  

FBG (mmol/L)

8.39 (6.84,13.45)

9.15 (6.5,13.79)

0.069

0.945

HbA1c (%)

9.90 ± 0.36

10.28 ± 0.12

0.983

0.326

Fatty liver (%)

  

1.218

0.638

yes

no

39 (6.0)

26 (4.0)

328 (50.1)

261 (39.8)

  

Hypertension (%)

  

1.605

0.265

yes

no

18 (2.7)

47 (7.2)

123 (18.8)

466 (71.2)

 

Marriage (%)

  

4.182

0.042

yes

no

49 (7.5)

16 (2.4)

369 (56.3)

221 (33.7)

  

Macrovascular diseases (%)

  

10.847

0.002

yes

no

21 (3.2)

44 (6.7)

94 (14.4)

496 (75.7)

  

DPN (%)

yes

no

11 (1.7)

54 (8.2)

22 (3.4)

568 (86.7)

18.636

0.001

Initiation of insulin therapy (%)

  

0.072

0.889

yes

no

43 (16.9)

22 (3.4)

400 (61.1)

190 (29.0)

  

UACR (mg/g)

58.0(15.5,141.0)

8.00(5.00,13.00)

8.459

0.0001

SCr (umol/L)

68.72 ± 3.54

66.59 ± 1.50

0.455

0.649

TG (mmol/L)

2.03 (1.20,2.81)

1.57 (1.00,2.63)

1.776

0.076

TC (mmol/L)

4.54 (3.78,5.52)

4.41 (3.78,5.23)

0.714

0.475

HDL-C (mmol/L)

0.95 (0.79,1.08)

0.94 (0.79,1.15)

0.175

0.861

LDL-C (mmol/L)

2.77 (2.38,3.37)

2.80 (2.22,3.33)

0.720

0.472

ALT (U/L)

26.10 (17.00,17.90)

26.00 (13.60,44.70)

1.079

0.280

AST (U/L)

16.20 (12.60,25.00)

17.90 (13.20,23.80)

1.036

0.300

GGT (U/L)

28.20 (16.30,55.20)

25.3 5(14.40,47.20)

1.066

0.286

UA (umol/L)

355.5 (302.4,413.4)

324.25 (248.7,410.6)

2.517

0.012

  1. T1DM: Type-1 diabetes mellitus, T2DM: Type-2 diabetes mellitus, LADA: Latent autoimmune diabetes in adults, BMI: body mass index, HbA1c: Glycosylated Hemoglobin, DPN: Diabetic Peripheral Neuropathy, SCr: Serum creatinine, TG: Triglyceride, TC: total cholesterol, HDL-C: high-density lipoprotein cholesterol, LDL-C: low-density Lipoprotein cholesterol, UA: Uric Acid, GGT: gamma-glutamyl transpeptidase, AST: aspartic transaminase, ALT: alanine aminotransferase, FBG: Fasting Blood-glucose, 2hBG: 2 h blood glucose, UACR: Urinary albumin-to-creatinine ratio
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