From: Association of SGLT-2 inhibitors with bacterial urinary tract infection in type 2 diabetes
Total (n = 101) | Group A SGLT-2i (+) (n = 51) | Group B SGLT-2i (-) (n = 50) | P | |
---|---|---|---|---|
n (%) or median (min-max) | n (%) or median (min-max) | n (%) or median (min-max) | ||
Sex (female) | 57 (56.4) | 28 (54.9) | 29 (58) | 0.842 c |
Age (year) | 56 (45–67) | 56 (45–66) | 56.5 (45–67) | 0.370 u |
BMI (kg/m2) | 32 (24–41) | 32 (25–41) | 28.5 (24–34) | 0.001u |
Smoking (present) | 40 (39.6) | 15 (29.4) | 25 (50) | 0.043c |
Hypertension (present) | 57 (56.4) | 29 (56.9) | 28 (56) | 0.999 c |
Fever (present) | 27 (26.7) | 18 (35.3) | 9 (18) | 0.071c |
Dysuria (present) | 60 (59.4) | 51 (100) | 9 (18) | < 0.001c |
Pollakiuria (present) | 60 (59.4) | 51 (100) | 9 (18) | < 0.001c |
Urgency (present) | 54 (53.5) | 45 (88.2) | 9 (18) | < 0.001c |
Nausea-Vomiting (present) | 27 (26.7) | 18 (35.3) | 9 (18) | 0.071c |
HbA1c (%) | 6.8 (5.6–11) | 7.8 (6.1–11) | 5.8 (5.6–11) | < 0.001u |
FBG (mg/dL) | 156 (112–234) | 156 (112–234) | 145 (112–234) | 0.160 u |
Leukocyte (/mm3) | 12,540 (2300–23,800) | 15,600 (10,800–23,800) | 7700 (2300–21,000) | < 0.001u |
CRP (mg/dL) | 45 (1-145) | 89 (37–145) | 5 (1-123) | < 0.001u |
Urinalysis | ||||
Nitrite (positive) | 15 (14.9) | 14 (27.5) | 1 (2) | < 0.001c |
Pyuria (positive) | 60 (59.4) | 51 (100) | 9 (18) | < 0.001c |
Hematuria (positive) | 0 (0) | 0 (0) | 0 (0) | |
Bacteriuria (positive) | 58 (57.4) | 49 (96.1) | 9 (18) | < 0.001c |
Glucosuria (positive) | 62 (61.4) | 43 (84.3) | 19 (38) | < 0.001c |
Proteinuria (positive) | 57 (56.4) | 30 (58.8) | 27 (54) | 0.690 c |
Urine culture (positive) | 36 (35.6) | 28 (54.9) | 8 (16) | < 0.001c |
Isolated bacteria | 0.302 f | |||
Escherichia coli | 30 (83.3) | 22 (78.6) | 8 (100) | |
Escherichia coli + Klebsiella pneumoniae | 6 (16.7) | 6 (21.4) | 0 (0) | |
Antibacterial treatment | 0.101 ff | |||
Fluoroquinolone | 33 (55) | 25 (49) | 8 (88.9) | |
Carbapenem | 15 (25) | 14 (27.5) | 1 (11.1) | |
Fosfomycin + Nitrofurantoin | 12 (20) | 12 (23.5) | 0 (0) | |
Antibacterial treatment (yes) | 60 (59.4) | 51 (100.0) | 9 (18.0) | < 0.001c |
Hospitalization (yes) | 19 (18.8) | 18 (35.3) | 1 (2) | < 0.001c |
Duration of hospitalization (day) | 0 (0–7) | 0 (0–7) | 0 (0–3) | < 0.001u |