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Table 2 Type of interventions and inclusion criteria

From: Comparing the effectiveness of metformin with lifestyle modification for the primary prevention of type II diabetes: a systematic review and meta-analysis

The study, Author (publish year)

Follow up

(year)

Intervention

Control

Diagnostic

criteria

Subject type

Evaluated outcome

DPP,

Knowler, W. C [10]

(2002)

2.8

The lifestyle modification program contained 16 individual counselling sessions on diet, exercise, and behaviour modification over 24 weeks. Goals were 7% weight loss and ≥ 150 min physical activity per week. Maintenance: subsequent individual sessions (usually monthly) and group sessions (the Diabetes Prevention Program)

The Metformin group received 850 mg twice daily

ADA 1997

Perdiabetes with IGT and IFG

Diabetes incidence, weight, BMI, FPG

IDPP1,

Ramachandran, A [11]. (2006)

3

The lifestyle modification group encouraged to exercise 30 min/per day and improve their diet during monthly phone calls and in person every six months

The Metformin group received 250 mg of Metformin twice daily

WHO 1999

Prediabetes with IGT

Diabetes incidence

D-CLIP,

Weber, M. B [13]

(2016)

2.54

Weekly classes included 16 core intervention classes on active lifestyle changes in months 0–4, followed by 8 maintenance classes in months 5–6. participants had two study goals: 7% weight loss and 150 min weekly of moderate-intensity exercise Plus metformin at a dose of 500 mg twice daily

A single day with one-on-one visits with a physician, a dietitian, and a fitness trainer and one group class on diabetes prevention

ADA 2003

overweight or obese prediabetes with iIGT or iIFG or IGT & IFG

Diabetes incidence

Lu, Y. H. et al. [12]

(2011)

2

Intervention participants received lifestyle coaching in person every 3 months and by phone monthly and those with IFG received metformin 250 mg 3 times daily

Received basic education and usual care

ADA 2003

Prediabetes with IGT or IFG

Diabetes incidence

PREVENT-DM, O'Brien, M. J [14]. (2016)

1

Intensive lifestyle interventions (ILI) were adapted from the Diabetes Prevention Program’s ILI and delivered by community health workers (promotoras) over 24 sessions

The Metformin group received metformin 850 mg twice daily

impaired fasting glucose (fasting plasma glucose of 100–125 mg/dl), elevated haemoglobin A1c (HbA1c) of 5.7%–6.4%

Latinas prediabetes

Diabetes incidence, weight, BMI, FPG, HbA1c

  1. ADA American Diabetes Association Statements, IGT Impaired Glucose Tolerance, IFG Impaired Fasting Glucose, iIGT Isolated impaired glucose tolerance, iIFG Isolated impaired fasting glucose, D-CLIP The Diabetes Community Lifestyle Improvement Program, IDDP Indian diabetes prevention program, PREVENT-DM The Promotora Effectiveness Versus Metformin Trial