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Table 3 Changes in FPG, FI, 2 h-OGTT, HbA1c, and HOMA-IR after intervention (at Day 84) in the treatment and control groups, mean ± SD (Significance level ANOVA p value < 10− 5)

From: Efficacy and safety of HIMABERB® Berberine on glycemic control in patients with prediabetes: double-blind, placebo-controlled, and randomized pilot trial

Parameters

Treatment Group

(n = 17)

Treatment Group

(n = 17)

Control Group (n = 17)

Control Group (n = 17)

p value

Treatment vs. Control

Day 0

Day 84

Day 0

Day 84

Day 84

FPG (mmol/L)

6.75 ± 0.23

5.33 ± 0.28*¥

6.31 ± 0.44

6.16 ± 0.44

p<10− 5

FI (µIU/mL)

9.81 ± 0.36

7.88 ± 0.52*

9.85 ± 0.35

9.76 ± 0.37

p < 10− 5

2 h-OGTT (mmol/L)

10.44 ± 0.52

8.12 ± 0.40*

9.71 ± 0.63

9.68 ± 0.51

p < 10− 5

HbA1c (%)

6.40 ± 0.20

5.43 ± 0.21*¥

6.15 ± 0.26

6.10 ± 0.24

p < 10− 5

HOMA-IR (units)

3.61 ± 0.31

2.41 ± 0.14*

3.45 ± 0.26

3.40 ± 0.28

p < 10− 5

  1. FPG: Fasting Plasma Glucose; FI: Fasting Insulin; 2 h-OGTT: 2-hour Oral Glucose Tolerance Test; HBA1c: Hemoglobin A1c; HOMA-IR: homeostatic model assessment-insulin resistance. All values represent means. *ANOVA p-values for differences between day 84 and day 0<10− 5. ¥ below prediabetic threshold