First Author & Reference | Year of Publication | Number of Patients | Population | Questionnaire | Tests | Results | Comments |
---|---|---|---|---|---|---|---|
McLennan [21] | 2016 | 257 | H/B | Maslach | HCC | Nl | |
Schmidt [69] (part 1) | 2016 | 265 | Breast Cancer | FAQ | DAC, CAR, SCR, NSC | ↑NSC, ↑AUC, Nl CAR, Nl DAC, ↓SCR | Pts. mostly on chemotherapy (ChTx); schemes not specified. No controls, only correlation between fatigue levels and tests. ChTx related to worse fatigue. Initial tests performed during, w/ or w/o ChTx. |
Schmidt [69] (part 2) | 2016 | 265 | Breast Cancer | FAQ | DAC, CAR, SCR, NSC | ↑AUC, ↑CAR, ↑NSC, ↑SCR, Nl DAC | Second test of the study, performed after 14 weeks of procedures. |
Sjors [25] | 2015 | 220 | H/B | SMBQ | DAC, CAR | ↓CAR, ↑DAC | Results normalized after adjustment of anti-depressive use; SCR results not provided |
Oosterholt [28] | 2015 | 91 | H/B | Maslach | DAC, CAR, SCR, AUC, CAR 60 min | Nl SCR, ↓CAR, Nl AUC, Nl CAR 60 min, ↓DAC | Control of variations did not change results |
De Vente [22] | 2015 | 95 | H/B | Acute Psychosocial Stressor diagnosis | MSC, MST | Nl MSC, Nl MST | MST: Nl (women), reduced (men); MSC: Nl (men), reduced (women). Mental arithmetic and public speech stressors also performed |
Lennartsson [24] | 2015 | 56 | H/B | DCSRD; exclusion w/ SEQ | DHEA-S; ACTH; ACTH and DHEA-S post-TSST (TSST stress test performed) | ↓DHEA-S, ↓post-TSST DHEA-S, Nl ACTH, Nl post-TSST ACTH | |
Tao [23] | 2015 | 171 | H/B | Maslach | MSC, ACTH | ↑ACTH, ↑MSC | |
Jonsson [29] | 2015 | 51 | H/B | SMBQ | MSC, MST | Nl MSC, ↓MST | |
Lennartsson [27] | 2015 | 56 | H/B | DCSRD and SMBQ | MSC, MST, ACTH, ACTH post-TSST (TSST stress test performed) | Nl MSC, Nl MST, Nl ACTH, Nl post-TSST ACTH | Severe BO: lower ACTH, cortisol response to TSST vs controls, whereas low BO: higher ACTH, cortisol responses vs controls |
Schmaling [26] | 2015 | 62 | Healthy | ADAS | AUC, SCR | ↓AUC, ↓SCR | 31 couples studied, one of which had chronic fatigue (but not CFS) |
Sveinsdottir [68] | 2015 | 1150 | Chronic Lombalgia | CFQ | DAC, CAR, SCR, NSC | Nl DAC, Nl CAR, Nl NSC, Nl SCR | **Colocar como SAUDÁVEL – porque é só lombalgia (increased CAR in Low back pain) |
Powell [67] | 2015 | 76 | Multiple Sclerosis | CFQ | DAC, CAR, SCR | ↓DAC, ↑CAR, Nl SCR | Sleep disorders excluded; adjusted for depressive symptoms; NSC not published. Multiple sclerosis had increased awakening cortisol and decreased CAR |
Cruz [70] | 2015 | 43 | Breast cancer | BFI and CFQ | MSC, DHEA-S | Nl MSC, Nl DHEA-S | Pts undergoing ChTx included anthracyclines |
Marchand [31] | 2014 | 1043 | H/B | Maslach | DAC, CAR, SCR, NSC | ↑DAC, ↓CAR, ↑SCR, ↓NSC | Only BO; Groups of severe distress or depression not included |
Aggarwal [30] | 2014 | 227 | Healthy | CFQ | MSC, NSC, 0.25 mg DST, DHEA-S | Nl MSC, Nl NSC, Nl 0.25 mg DST, ↓DHEA-S | Evaluation of chronic, widespread pain, chronic orofacial pain, chronic fatigue (but not CFS), irritable bowel syndrome |
Tell D [71] | 2014 | 130 | Breast cancer | MFI | DAC, CAR, SCR, NSC | ↓CAR, ↓SCR, ↑DAC, ↑NSC | Post-surgery breast cancer, regardless of ChTx. Not adjusted to sleeping patterns |
Wolfram [32] | 2013 | 53 | H/B | Maslach | MSC, 1 mcg CST, DST/CRH test (1.5 mg DST + 100 mcg CRH) | Nl MSC, ↓post-1 mcg ACTH, Nl ACTH and cortisol DST-CRH | High over-commitment present blunted serum and salivary cortisol and ACTH responses to DST-CRH test |
Klaassen [33] | 2013 | 27 | Healthy | MP (Beck & Luine, 2010) and Stress Tasks (Wang, 2006) | MSC, post-stress | Nl MSC, Nl post-stress | A complex test sequence was performed but not reproduced |
Eek [34] | 2012 | 581 | Healthy | SOFI-20 | DAC, CAR, NSC, SCR, MSC | Nl DAC, Nl CAR, Nl NSC, Nl SCR, Nl MSC | Women: reduced awakening, increased CAR, increased SCR; Men: increased awakening and reduced CAR – when fatigued |
Sjors [35] | 2012 | 247 | H/B | DCSRD and SMBQ | DAC, 15 min CAR | Nl DAC, Nl 15 min CAR | |
Rahman [54] | 2011 | 30 | CFS | Previous Dx – No questionnaire | MSC, SCR, NSC | Nl MSC, Nl SCR, Nl NSC | |
Moya-Albiol [37] | 2010 | 64 | H/B | Maslach | DAC, CAR | Nl DAC, Nl CAR | |
Kumari [38] | 2009 | 4,299 | Healthy | SF-36 | DAC, CAR, NSC, SCR | ↓DAC, ↓CAR, ↑NSC, ↓SCR | Adjusted for WC, BMI, sleep duration, CVD medication, depressive symptoms, smoking, alcohol intake provides Nl awakening but lower SCR |
Osterberg [39] | 2009 | 304 | H/B | Maslach | DAC, CAR, NSC, SCR | Nl DAC, Nl CAR, ↓NSC, ↑SCR | 0.5 mg DST was not compared to controls |
Wingenfeld [41] | 2009 | 279 | H/B | Maslach and Maastricht | AUC, SCR | Nl AUC, Nl SCR | DAC and CAR not done; conclusions different from results. For AUC, Low BO: Nl, moderate: increased, severe: decreased |
Rydstedt [40] | 2009 | 76 | Healthy | NRWS | DAC, NSC | Nl DAC, Nl NSC | |
Papadopoulos [55] | 2009 | 38 | CFS | CFQ and SF-36 | MSC, AUC, morning AUC, 0,5 mg DST | ↑MSC, ↑AUC, ↑MAUC, Nl 0.5 mg DST | Data on absolute cortisol levels at each point not published. DST reduction evaluated by percent reduction. |
Bay [72] | 2009 | 75 | Post traumatic brain injury | POMS | AUC | Nl AUC | Correlation between brain injury-related fatigue level and cortisol AUC. Basal and NSC results not reported; SCR not evaluated. |
Sudhaus [73] | 2009 | 43 | Chronic Lombalgia | MFI | DAC, CAR, MAUC | ↓CAR, Nl DAC, Nl MAUC (correlation between fatigue levels among low back pain subjects) | |
Lindeberg [36] | 2008 | 78 | Healthy | SF-36 | DAC, CAR, NSC, SCR | Nl DAC, ↓CAR, Nl NSC, ↓SCR | |
Sertoz [42] | 2008 | 72 | H/B | Maslach | Basal and post 1.0 mcg DST cortisol | Nl basal cortisol and 1.0 mg DST | |
Bellingrath [43] | 2008 | 101 | H/B | Maslach and Maastricht | DAC, CAR, NSC, SCR, 0.25 mg DST | Nl DAC, Nl CAR, Nl NSC, Nl SCR, ↓0.25 mg DST | |
Nater [57] | 2008 | 185 | CFS | SF-36 and MFI | DAC, CAR, MAUC | Nl DAC, Nl CAR, ↓MAUC | |
Torres-Harding [56] | 2008 | 108 | CFS | FSE | AUC, SCR | Nl AUC, Nl SCR | Multiple psychological tests performed. Data on NSC, basal and CAR not published. |
Sonnenschein [45] | 2007 | 42 | H/B | Maslach | CAR, 0.5 mg DST, DHEA-S | Nl CAR, Nl 0.5 mg DST, Nl DHEA-S | Adjusted for depression, sleep quality. Awakening levels and each level graphics not available |
Harris [44] | 2007 | 44 | Healthy | SF-36 | DAC, CAR, NSC, SCR | Nl DAC, Nl CAR, Nl NSC, Nl SCR | Other aspects also correlated: complains, job stress and demand, QOL and coping. Adjusted for coffee and tobacco. |
Langelaan [46] | 2006 | 55 | H/B | Maslach | DAC, CAR, 0.5 mg DST, DHEA-S | Nl DAC, Nl CAR, Nl 0.5 mg DST, Nl DHEA-S | Engaged work also compared and had stronger suppression in DST |
Mommersteeg [47] | 2006 | 109 | Healthy | NC-WHO | DAC, CAR, 0.5 mg DST, SCR, AUC, NSC | Nl DAC, Nl CAR, Nl NSC, Nl SCR, Nl 0.5 mg DST, Nl AUC | |
Barroso [74] | 2006 | 40 | HIV | HRFS | MSC, NSC | ↓MSC, ↑NSC | |
Jerjes [58] | 2006 | 80 | CFS | CFQ | UFC, TCM | ↓UFC, Nl TCM | |
Grossi [48] | 2005 | 64 | H/B | SMBQ | DAC, CAR | ↓DAC, ↑CAR | Groups were high x moderate x low BO score; correlation was significant |
Segal [59] | 2005 | 40 | CFS | No questionnaire | MSC, 1 mcg CST | ↓ MSC, ↓1 mcg CST | DHEA-S collected only in CFS. No questionnaires used. |
Jerjes [60] | 2005 | 35 | CFS | CFQ | MSC, SCR, NSC, AUC | ↓MSC, ↓SCR, ↓AUC ↓, Nl NSC | |
Bower [75] | 2005 | 29 | Breast cancer | SF-36 | DAC, AUC, SCR, NSC | ↑AUC, ↓SCR, Nl DAC, ↑NSC | Post-ChTx (regardless of time) complete cancer remission and exclusion of other disorders |
McLean [76] | 2005 | 55 | Fybro-mialgia | SF-36 | DAC, 60 min CAR, SCR, AUC, NSC | Nl DAC, Nl 60 min CAR, Nl SCR, Nl AUC, Nl NSC (correlation between fatigue levels among FMG subjects) | FMG subjects presented Nl DAC and CAR, as controls. |
Roberts [62] | 2004 | 92 | CFS | CFQ and SF-36 | DAC, CAR, MAUC | Nl DAC, ↓CAR, ↓MAUC | |
Crofford [61] | 2004 | 72 | CFS/FMG | POMS | ACTH, MSC, SCR, NSC, AUC | Nl ACTH, Nl SCR, Nl NSC, ↓AUC, Nl MSC | Tests performed in: CFS, FMG and CFS + FMG; FMG w/o fatigue had Nl AUC and increased BMC levels |
Moch [50] | 2003 | 16 | H/B | Maslach | UFC, DHEA-S, ACTH, MSC | ↓UFC, Nl DHEA-S, Nl ACTH, ↓MSC | Only women; longitudinal evaluation – Nl initial cortisol. |
De Vente [49] | 2003 | 45 | H/B | Maslach | DAC, MSC, post-TSST | ↑DAC, ↑MSC, Nl post-TSST | |
Gaab [63] | 2002 | 42 | CFS | MFI | DAC, CAR, SCR, 0.5 mg DST | ↓0.5 mg DST, Nl AUC, Nl CAR, Nl DAC, Nl SCR, Nl NSC | CAR also performed at 15, 45 and 60 min. |
Dekkers [77] | 2000 | 53 | Rheumatoid Arthritis | MFI | DAC, CAR, SCR, AUC | Nl AUC, Nl SCR Nl, ↓DAC, ↑CAR | 5/25 subjects with RA taking prednisone (5–10 mg/d); RS subjects had smaller SCR, increased AM cortisol and decreased CAR. 15 and 45 min CAR also performed. |
Melamed [51] | 1999 | 111 | H/B | SMBQ and Maastricht | MSC and 4 PM cortisol | ↑MSC, Nl 4 PM cortisol | |
Pruessner [52] | 1999 | 66 | Healthy | Maslach | DAC, CAR, 0.5 mg DST | ↓DAC, ↓CAR, ↓0.5 mg DST | 15 min and 60 min CAR also performed |
Strickland [65] | 1998 | 74 | CFS | Not specified/detailed | MSC, NSC | ↓NSC, Nl MSC | Adjusted for depression |
Young [66] | 1998 | 45 | CFS | NC-WHO | UFC, SCR, MSC, AUC | Nl UFC, Nl SCR, Nl MSC, Nl AUC | |
Scott [64] | 1998 | 28 | CFS | Not specified (not detailed) | MSC, ACTH, 100 mcg CRH cortisol stimulation | Nl MSC, Nl ACTH, CRH stim test: ↓cortisol, ↓ACTH | |
Raikkonen [53] | 1996 | 22 | Healthy | Not assessed | 1 mcg CST, DST (non specified), OGTT, MSC, ACTH, cortisol/ACTH ratio | ↑Cortisol/ACTH ratio; ↑CST, Nl DST, Nl OGTT, Nl MSC, Nl ACTH | Full article not assessed – not in PUBMED or other database |