Condition | Weight | Disutility (Decrement) | SD | RSD | Distribution | Hyperparameters | Sourcea |
---|---|---|---|---|---|---|---|
Type 1 diabetes (T1DM) no complicationsb | 0.81 | 0.01 | |||||
Full graft function no complicationsc | 0.82 | [Base value] | 0.041 | 5 % | Beta | α = 70.56 | T1DM no complications plus “no-injection bonus” minus immunosuppression disutility (assumptions) |
β = 15.48 | |||||||
Partial graft function no complications | 0.81 | 0.01 (0.01) | 0.002 | 20 % | Gamma | α = 25.00 | Same as T1DM but with different uncertainty |
β = 0.0004 | |||||||
Hypoglycemia unawareness (intensive insulin therapy) | 0.71 | 0.11 (0.10) | 0.020 | 20 % | Gamma | α = 25.00 | Assumption based on [44] |
β = 0.004 | |||||||
Diabetes-related complications (additional to hypoglycemia unawareness) | |||||||
Amputation | 0.60 | 0.22 | |||||
Blindness or severe vision loss | 0.63 | 0.19 | |||||
Nephropathy | 0.47 | 0.35 | Assumption based on [47] | ||||
Heart failure | 0.55 | 0.27 | Assumption based on [45] | ||||
Stroke | 0.49 | 0.33 | Assumptions based on [46] | ||||
Myocardial infarction | 0.49 | 0.33 | |||||
Angina pectoris | 0.62 | 0.20 | |||||
Aggregated diabetes-related complications | 0.57 | 0.25 (0.14) | 0.042 | 30 % | Gamma | α = 11.11 | Weighted mean of 7 complications above with frequency data from [33] minus 0.03 to account for multiple complication cases |
β = 0.0126 | |||||||
One-time disutilities (per occurrence) | |||||||
Initial immunosuppressive or other complications | X-0.05 | 0.05 | 0.010 | 20 % | Gamma | α = 25.00 | Assumption based on [2] and expert opinion |
β = 0.002 | |||||||
Subsequent major immunosuppressive complications | X-0.10 | 0.10 | 0.025 | 25 % | Gamma | α = 16.00 | Assumption based on [2] and expert opinion |
β = 0.00625 |