From: Growth hormone (GH) dose-dependent IGF-I response relates to pubertal height gain
ITT | All | 33 × 1 | 67 × 1 | 33 × 2 | 67 × 1 + 33 × 2 | ||||
---|---|---|---|---|---|---|---|---|---|
IGF-I/IGFBP3 RatioSDS | n | Mean ± SD | N | Mean ± SD | n | Mean ± SD | n | Mean ± SD | Mean ± SD |
At GH start | 71 | −1 ± 1.08 | 32 | −1.1 ± 0.94 | 20 | −0.8 ± 1.24 | 19 | −0.8 ± 1.13 | −0.8 ± 1.17 |
1st year after GH start | 76 | 0.6 ± 1.2 | 28 | 0.5 ± 1.21 | 24 | 0.6 ± 1.31 | 24 | 0.7 ± 1.13 | 0.6 ± 1.21 |
ΔRatioSDS 1st year after GH start | 63 | 1.5 ± 1.24 | 25 | 1.6 ± 1.25 | 19 | 1.2 ± 1.6 | 19 | 1.6 ± 0.74 | 1.4 ± 1.24 |
Prepubertal level | 100 | 0.4 ± 0.95 | 37 | 0.2 ± 0.98 | 30 | 0.5 ± 0.97 | 33 | 0.6 ± 0.89 | 0.6 ± 0.92 |
Last pre-pubertal | 90 | 0.7 ± 1.18 | 35 | 0.5 ± 1.11 | 28 | 0.6 ± 1.24 | 27 | 1 ± 1.17 | 0.8 ± 1.22 |
Study start | 104 | 0.5 ± 0.98 | 38 | 0.6 ± 0.99 | 30 | 0.3 ± 1.06 | 36 | 0.6 ± 0.89 | 0.5 ± 0.97 |
1st year after study start | 100 | 0.9 ± 0.87 | 36 | 0.6 ± 0.87 | 30 | 0.9 ± 0.86 | 34 | 1.2 ± 0.78* | 1.1 ± 0.83** |
ΔRatioSDS 1st year after study start | 100 | 0.4 ± 0.93 | 36 | 0 ± 0.95 | 30 | 0.6 ± 1.03 | 34 | 0.6 ± 0.73**** | 0.6 ± 0.87*** |
Pubertal level | 104 | 0.9 ± 0.78 | 38 | 0.7 ± 0.74 | 30 | 0.9 ± 0.82 | 33 | 1 ± 0.78 | 0.9 ± 0.79 |
ΔRatioSDS Pubertal level from study start | 104 | 0.3 ± 0.89 | 38 | 0.1 ± 0.92 | 30 | 0.6 ± 1.04 | 36 | 0.3 ± 0.66 | 0.5 ± 0.86 |
Before study stop | 104 | 0.5 ± 1.1 | 38 | 0.5 ± 0.88 | 30 | 0.7 ± 1.14 | 36 | 0.3 ± 1.26 | 0.5 ± 1.21 |
After study stop | 64 | −0.7 ± 1.03 | 23 | −0.9 ± 0.73 | 17 | −0.7 ± 1.18 | 24 | −0.5 ± 1.16 | −0.6 ± 1.16 |