Day 1 | Oral HC | IV HC | ||
---|---|---|---|---|
Plasma cortisol | Peak1 | 505 ± 46 | 1135 ± 60 | 2450 ± 361 |
(nmol/L) | (318–905) | (943–1419) | (1372–4205) | |
Peak CV2 | 31% | 15% | 42% | |
Tmax 1 | 1.7 ± 0.2 | 0.5 ± 0 | ||
(h) | (0.5-2 5) | |||
AUC0-5 1 | 1469 ± 195 | 3720 ± 280 | 5775 593 | |
(nmol/L.h) | (963–2433) | (2615–4663) | (3458–8684) | |
AUC0–5 CV2 | 37% | 21% | 29% | |
Plasma free cortisol | Peak1 | 64 ± 12 | 179 ± 20 | 694 ± 112 |
(nmol/L) | ||||
Peak CV2 | 63% | 31% | 50% | |
Tmax 1 | 1.7 ± 0.2 | 0.5 ± 0 | ||
(h) | ||||
AUC0-5 1 | 145 ± 23 | 462 ± 67 | 1236 ± 170 | |
(nmol/L.h) | ||||
AUC0-5CV2 | 54% | 41% | 39% | |
Salivary cortisol | Peak1 (nmol/L) | 19 ± 4 | 100 ± 16 | 348 ± 88 |
(6–48) | (58–164)3 | (106–816) | ||
Peak CV2 | 80% | 40% | 71% | |
Tmax 1 | 1.7 ± 0.2 | 1 ± 0 | ||
(h) | (1–2)3 | |||
AUC0-5 1 | 38 ± 4 | 241 ± 30 | 610 ± 147 | |
(nmol/L.h) | (21–68) | (142–325)3 | (210–1422) | |
AUC0–5 CV2 | 40% | 31%3o | 68% | |
Urinary cortisol: creatinine ratio | Peak1 | 73 ± 18 | 789 ± 164 | 4635 ± 926 |
(nmol: mmol) | (29–244) | (227–1468) | (480–8192) | |
Peak CV2 | 88% | 59% | 57% | |
Tmax 1 | 2.1 ± 0.3 | 1.1 ± 0.1 (1—2) | ||
(h) | (1–3) | |||
AUC0-5 1 | 216 ± 41 | 1732 ± 316 | 7280 ± 1488 | |
(nmol:mmol.h) | (93–558) | (440–2839) | (1058–10715) | |
AUC0–5 CV2 | 65% | 51% | 58% |