| Insulin detemir | Insulin glargine | p value |
---|---|---|---|
N | 2395 | 491 | Â |
Percentage completing the 24-week study (%) | 76.2% | 68.4% | Â |
Age (years) | 56.8 ± 10.2 | 56.6 ± 10.3 | 0.7979 |
Female (%) | 57.2% | 59.5% | 0.3468 |
Duration of Diabetes (years) | 8.1 ± 5.6 | 8.6 ± 5.4 | 0.0279 |
Weight (kg) | 79.8 ± 13.9 | 78.5 ± 13.0 | 0.0606 |
BMI (kg/m2) | 29.6 ± 4.8 | 29.6 ± 4.8 | 0.9541 |
Previous medical history (%) | Â | Â | Â |
Microvascular disease | 30.0% | 31.6% | 0.4663 |
Macrovascular disease | 21.3% | 19.8% | 0.4347 |
Hypoglycaemia | 3.8% | 3.9% | 0.8940 |
HbA1c (%) | 9.72 ± 1.74 | 9.24 ± 1.71 | 0.0033 |
HbA1c (mmol/mol) | 83 ± 19 | 77 ± 19 |  |
FBG (mg/dl) | 233 ± 75 | 221 ± 68 | 0.0989 |
FBG (mmol/l) | 12.9 ± 4.2 | 12.3 ± 3.7 |  |
Rate of minor Hypoglycaemia (events ppy) | 0.37 | 0.59 | 0.0554 |
OAD Treatment at time of Insulin Initiation (%) | Â | Â | Â |
Number of OADs | Â | Â | 0.0214 |
1 OAD | 29.6% | 26.3% | Â |
2 OADs | 45.0% | 51.8% | Â |
>2 OADs | 25.4% | 21.8% | Â |
Class of OAD | Â | Â | Â |
Metformin | 81.9% | 86.7% | 0.0100 |
Sulphonylureas | 55.5% | 52.0% | 0.1611 |
Glinides | 21.6% | 26.1% | 0.0279 |
Thiazolidinediones | 20.2% | 18.8% | 0.4745 |
α-glucosidase inhibitors | 18.0% | 10.8% | 0.0001 |
DPP-IV inhibitors | 1.8% | 2.7% | 0.2441 |