1,25-dihydroxyvitamin D and PTHrP mediated malignant hypercalcemia in a seminoma

BMC Endocrine Disorders

Table 2 Reported malignant hypercalcemia in seminomas

Author (*)	Ca+	PTH	PTHrP	25D	1,25D	Tx	Ca + after Tx.	Outcome
King [6]	15.4	NS	NS	NS	NS	Orchiectomy	NL	NED 10 mo.
Metcalfe [7]	15.8	NS	NS	NS	NS	GC + RT	NL	NED 8 mo.
Grote [8]	15.4	10.0	NS	24.0	112	BEP	NL	NED 2 yr.
Da Silva [9]	12.7	NL	NS	NS	NS	NSCT	NL	Adenophaty
Da Silva [9]	18.5	NS	NS	NS	NS	BEP	NL	NED 2 mo.
Da Silva [9]	20.1	NS	NS	NS	NS	NSCT	NL	NED 4 mo.
Da Silva [9]	16.4	0.3	NS	NS	79	BEP	NL	Improved after CT
This report	14.7	≤3.0	35.0	22.0	212	BEP	NL	NED 8 mo.

(*) Reference.
Ca+, Calcium (mg/dl); PTH, parathyroid hormone; PTHrP, parathyroid hormone related protein; 25D, 25, Hydroxyvitamin D; 1,25D, 1,25-Dihydroxyvitamin D; Tx, treatment; NS, not stated; NL, normal; NED, not evidence of disease; BEP, bleomycin, etoposide and cisplatinum; NSCT, not specified chemotherapy; CT, chemotherapy.

ISSN: 1472-6823