Table 1 Clinical and glycaemic parameters
From: Continuous intraperitoneal insulin infusion in type 1 diabetes: a 6-year post-trial follow-up
Start 2006 study (A) | End SC phase (B) | End CIPII phase (C) | 2012 study (D) | D vs. A | D vs. B | D vs. C | |
|---|---|---|---|---|---|---|---|
Clinical parameters | |||||||
SBP (mmHg) | 141 (133, 150) | 135 (126, 143) | 139 (130, 147) | 140 (131, 149) | -1. -1.1 (-17.6, 15.5) | 5.5 (-11.0, 22.0) | 1.3 (-15.2, 17.9) |
BMI (kg/m2) | 26 (24, 29) | 27 (24, 29) | 28 (25, 30) | 26 (24, 29) | -0.4 (-4.9, 4.1) | -0.2 (-5.3, 4.9) | -1.2 (-6.1, 3.7) |
Total cholesterol | 4.8 (4.5, 5.2) | 4.7 (4.3, 5.1) | 4.5 (4.1, 4.9) | 4.8 (4.4, 5.2) | -0.1 (-0.9, 0.7) | 0.0 (-0.7, 0.8) | -0.2 (-0.5, 1.0) |
HDL cholesterol | 1.8 (1.6, 2.0) | 1.8 (1.5, 2.0) | 1.6 (1.3, 1.8) | 1.7 (1.4, 1.9) | -0.1 (-0.6, 0.3) | -0.1 (-0.6, 0.4) | 0.1 (-0.3, 0.6) |
LDL cholesterol | 2.6 (2.3, 3.0) | 2.5 (2.2, 2.8) | 2.4 (2.1, 2.7) | 2.8 (2.5, 3.1) | 0.2 (-0.4, 0.8) | 0.3 (-0.3, 0.9) | 0.4 (-0.2, 1.1) |
Triglycerides | 0.9 (0.7, 1.2) | 1.1 (0.8, 1.3) | 1.3 (1.0, 1.5) | 1.0 (0.7, 1.3) | -0.1 (-0.5, 0.6) | -0.1 (-0.6, 0.5) | -0.3 (-0.8, 0.3) |
Total insulin dose (IU/day) | 19 (13, 24) | 25 (20, 31) | 20 (15, 25) | 20 (15, 26) | 8.2 (-18.3, 34.7) | 8.2 (-17.6, 33.9) | 6.1 (-19.7, 31.8) |
Basal insulin dose (IU/day) | 35 (24, 45) | 32 (22, 43) | 35 (25, 46) | 44 (34, 55) | 9.6 (-10.6, 29.8) | 12.0 (-8.1, 32.2) | 8.5 (-11.7, 28.7) |
Bolus insulin dose (IU/day) | 54 (40, 67) | 58 (44, 71) | 56 (42, 69) | 65 (51, 78) | 1.4 (-8.9, 11.7) | -5.1 (-15.3, 5.2) | 0.4 (-9.9, 10.7) |
Glycaemic parameters | |||||||
HbA1c (mmol/mol) | 70 (64, 75) | 65 (60, 71) | 58 (53, 64) | 65 (60, 71) | -4.5 (-14.9, 5.9) | -0.1 (-10.5,10.3) | 7.1 (-3.3, 17.5) |
Hypoglycaemia grade 1 † | 4 (3, 6) | 4 (3, 6) | 4 (2, 5) | 3 (1, 4) | -1.8 (-4.2, 0.7) | -1.7 (-4.2, 0.8) | -1.1 (-3.6, 1.4) |
Hypoglycaemia grade 2 ‡ | 3 (2, 4) | 3 (2, 4) | 2 (2, 3) | 1 (0, 2) | -1.8 (-3.4,-0.4)* | -1.9 (-3.5, -0.4)* | -1.4 (-3.0, 0.1) |
Time spent in hypoglycaemia (%) | 8 (5, 11) | 8 (5, 11) | 6 (3, 9) | 5 (2, 7) | -3.7 (-9.3, 1.9) | -3.6 (-9.2, 2.0) | -1.1 (-6.7, 4.5) |
Time spent in hyperglycaemia (%) | 45 (36, 54) | 47 (38, 56) | 39 (30, 48) | 59 (50, 68) | 13.7 (-3.1, 30.5) | 12.0 (-4.8, 28.8) | 19.8 (3.0, 36.6)* |
Time spent in euglycaemia (%) | 47 (39, 54) | 45 (38, 53) | 55 (48, 63) | 37 (29, 44) | -10.0 (-24.6, 4.6) | -8.4 (-23.0, 6.2) | -18.7 (-33.3, -4.1)* |