Genotype | Wt | Wt | Hif1a +/- | Hif1a +/- |
---|---|---|---|---|
Parameter | Non-diabetic | Diabetic | Non-diabetic | Diabetic |
Males (n) | 6 | 8 | 10 | 8 |
MAP (mmHg) | 83.0 ± 2.1 | 87.5 ± 1.5 | 84.1 ± 1.4 | 88.2 ± 1.6 |
HR (beats/min) | 496 ± 23 | 471 ± 13 | 449 ± 40 | 440 ± 36 |
LVDD (mm) | 3.60 ± 0.09 | 3.59 ± 0.04 | 3.47 ± 0.10 | 3.65 ± 0.06 |
LVDS (mm) | 2.22 ± 0.07 | 2.27 ± 0.05 | 2.16 ± 0.08 | 2.42 ± 0.07 |
AWTD (mm) | 0.84 ± 0.02 | 0.76 ± 0.01 | 0.89 ± 0.02 | 0.74 ± 0.03†* |
PWTD (mm) | 0.84 ± 0.03 | 0.76 ± 0.01 | 0.92 ± 0.04 | 0.69 ± 0.03†* |
AWTS (mm) | 1.30 ± 0.03 | 1.20 ± 0.04 | 1.27 ± 0.03 | 1.10 ± 0.05†* |
PWTS (mm) | 1.21 ± 0.03 | 1.09 ± 0.03 | 1.20 ± 0.04 | 1.00 ± 0.04†* |
Females (n) | 7 | 12 | 10 | 8 |
MAP (mmHg) | 84.6 ± 2.1 | 88.5 ± 2.2 | 84.8 ± 0.04 | 88.1 ± 1.3 |
HR (beats/min) | 504 ± 7 | 478 ± 15 | 484 ± 16 | 449 ± 17 |
LVDD (mm) | 3.52 ± 0.08 | 3.52 ± 0.06 | 3.45 ± 0.04 | 3.46 ± 0.04 |
LVDS (mm) | 2.33 ± 0.07 | 2.37 ± 0.06 | 2.30 ± 0.05 | 2.43 ± 0.06 |
AWTD (mm) | 0.75 ± 0.02 | 0.75 ± 0.01 | 0.72 ± 0.02 | 0.72 ± 0.02 |
PWTD (mm) | 0.79 ± 0.02 | 0.74 ± 0.02 | 0.78 ± 0.03 | 0.74 ± 0.02 |
AWTS (mm) | 1.12 ± 0.04 | 1.05 ± 0.02 | 1.06 ± 0.01 | 0.98 ± 0.02†* |
PWTS (mm) | 1.10 ± 0.02 | 1.05 ± 0.02 | 1.09 ± 0.02 | 0.99 ± 0.02* |