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Table 2 Mean systemic arterial blood pressure (MAP), heart rate (HR) and basal left ventricular echocardiographic parameters

From: Partial deficiency of HIF-1α stimulates pathological cardiac changes in streptozotocin-induced diabetic mice

Genotype

Wt

Wt

Hif1a +/-

Hif1a +/-

Parameter

Non-diabetic

Diabetic

Non-diabetic

Diabetic

Males (n)

6

8

10

8

MAP (mmHg)

83.0 ± 2.1

87.5 ± 1.5

84.1 ± 1.4

88.2 ± 1.6

HR (beats/min)

496 ± 23

471 ± 13

449 ± 40

440 ± 36

LVDD (mm)

3.60 ± 0.09

3.59 ± 0.04

3.47 ± 0.10

3.65 ± 0.06

LVDS (mm)

2.22 ± 0.07

2.27 ± 0.05

2.16 ± 0.08

2.42 ± 0.07

AWTD (mm)

0.84 ± 0.02

0.76 ± 0.01

0.89 ± 0.02

0.74 ± 0.03*

PWTD (mm)

0.84 ± 0.03

0.76 ± 0.01

0.92 ± 0.04

0.69 ± 0.03*

AWTS (mm)

1.30 ± 0.03

1.20 ± 0.04

1.27 ± 0.03

1.10 ± 0.05*

PWTS (mm)

1.21 ± 0.03

1.09 ± 0.03

1.20 ± 0.04

1.00 ± 0.04*

Females (n)

7

12

10

8

MAP (mmHg)

84.6 ± 2.1

88.5 ± 2.2

84.8 ± 0.04

88.1 ± 1.3

HR (beats/min)

504 ± 7

478 ± 15

484 ± 16

449 ± 17

LVDD (mm)

3.52 ± 0.08

3.52 ± 0.06

3.45 ± 0.04

3.46 ± 0.04

LVDS (mm)

2.33 ± 0.07

2.37 ± 0.06

2.30 ± 0.05

2.43 ± 0.06

AWTD (mm)

0.75 ± 0.02

0.75 ± 0.01

0.72 ± 0.02

0.72 ± 0.02

PWTD (mm)

0.79 ± 0.02

0.74 ± 0.02

0.78 ± 0.03

0.74 ± 0.02

AWTS (mm)

1.12 ± 0.04

1.05 ± 0.02

1.06 ± 0.01

0.98 ± 0.02*

PWTS (mm)

1.10 ± 0.02

1.05 ± 0.02

1.09 ± 0.02

0.99 ± 0.02*

  1. Values are mean ± SEM. LVDD - diastolic cavity diameter, LVDS - systolic cavity diameter, AWTD - diastolic anterior wall thickness, PWTD - diastolic posterior wall thickness, AWTS - systolic anterior wall thickness, PWTS - systolic posterior wall thickness. Statistical significance was assessed by 2-way ANOVA with Tukey’s multiple-comparison test, *P < 0.05 vs. non-diabetic Wt, P < 0.05 vs. non-diabetic Hif1a +/-.