Table 6 Genes with changed expression in diaphragm of type II and type I (12) diabetic rats that were assigned to specific statistically over-represented gene ontology (GO) terms
From: Gene expression of sternohyoid and diaphragm muscles in type 2 diabetic rats
TYPE II DIAPHRAGM | Â | Â |
|---|---|---|
| Â | Gene | Fold |
Oxidoreductase activity | Symbol | Change |
2,4-dienoyl CoA reductase 1, mitochondrial | Decr1 | 2 |
IMP (inosine monophosphate) dehydrogenase 2 | Impdh2 | 1.6 |
Potassium large conductance calcium-activated channel subfamily M, alpha member 1 | Kcnma1 | 1.5 |
Solute carrier family 30 (zinc transporter), member 4 | Slc30a4 | 1.5 |
Coenzyme Q7 homolog, ubiquinone (yeast) | Coq7 | −1.6 |
Glycerol-3-phosphate dehydrogenase 2, mitochondrial | Gpd2 | −1.7 |
S100 calcium binding protein A3 | S100a3 | −1.7 |
Dicarbonyl L-xylulose reductase | Dcxr | −2 |
Phytanoyl-CoA dioxygenase domain containing 1 | Phyhd1 | −2.1 |
Transmembrane 7 superfamily member 2 | Tm7sf2 | −2.5 |
Carbohydrate metabolism | ||
protein kinase, AMP-activated, alpha 1 catalytic subunit | Prkaa1 | 2.2 |
UDP-glucose pyrophosphorylase 2 | Ugp2 | −1.5 |
Solute carrier family 2 (facilitated glucose transporter), member 4 | Slc2a4 | −1.5 |
Coenzyme Q7 homolog, ubiquinone (yeast) | Coq7 | −1.6 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | Pfkfb1 | −1.7 |
Glycerol-3-phosphate dehydrogenase 2, mitochondrial | Gpd2 | −1.7 |
Dicarbonyl L-xylulose reductase | Dcxr | −2 |
Collagen | ||
Collagen, type I, alpha 2 | Col1a2 | −1.6 |
Collagen, type III, alpha 1 | Col3a1 | −1.7 |
Collagen, type I, alpha 1 | Col1a1 | −2 |
Ficolin (collagen/fibrinogen domain containing) 1 | Fcn1 | −2.1 |
TYPE I DIAPHRAGM | Â | Â |
Oxidoreductase activity | ||
Cytochrome P450, family 2, subfamily e, polypeptide 1 | Cyp2e1 | 6 |
Flavin containing monooxygenase 3 | Fmo3 | 2.9 |
Crystallin, lamda 1 | Cryl1 | 2.4 |
Lysyl oxidase | Lox | 2.3 |
Ceruloplasmin | Cp | 2.2 |
2,4-dienoyl CoA reductase 1, mitochondrial | Decr1 | 2.2 |
Aldehyde oxidase 1 | Aox1 | 2.1 |
P450 (cytochrome) oxidoreductase | Por | 2.1 |
Carbohydrate metabolism | ||
Neuraminidase 2 | Neu2 | −8.5 |
Phosphofructokinase, liver, B-type | Pfkl | −3.7 |
Solute carrier family 37 (glycerol-6-phosphate transporter), member 4 | Slc37a4 | −2.5 |
Glycerol-3-phosphate dehydrogenase 2 | Gpd2 | −2.3 |
Amylase 1, salivary | Amy1 | −2.3 |
Phosphoglycerate mutase 2 | Pgam2 | −2.1 |
Lactate dehydrogenase A | Ldha | −2 |
Phosphoglucomutase 1 | Pgm1 | −2 |
Dihydrolipoamide S-acetyltransferase | Dlat | −2 |
Collagen | ||
Collagen, type III, alpha 1 | Col3a1 | −3.7 |
Collagen, type 1, alpha 1 | Col1a1 | −3.5 |
Procollagen, type I, alpha 2 | Col1a2 | −3.2 |
Fibrillin 1 | Fbn1 | −2.8 |
Secreted acidic cysteine rich glycoprotein | Sparc | −2.7 |
Collagen, type V, alpha 1 | Col5a1 | −2.4 |
Collagen, type V, alpha 3 | Col5a3 | −2.2 |