Table 1 Statistically significant over-represented Gene Ontology (GO) terms to which genes with changed expression in diaphragm and sternohyoid of diabetic animals were assigned

Transport

27

0.000089

Establishment of localization

27

0.00020

Monocarboxylic acid metabolic process

8

0.00035

Localization

29

0.00050

Monosaccharide biosynthetic process

4

0.00067

Alcohol biosynthetic process

4

0.00071

Ion transport

12

0.0015

Alcohol metabolic process

8

0.0018

Hexose metabolic process

6

0.0036

Monosaccharide metabolic process

6

0.0037

Carboxylic acid metabolic process

9

0.0069

Inorganic anion transport

5

0.0072

Organic acid metabolic process

9

0.0073

Regulation of ion transport

3

0.014

Striated muscle contraction

3

0.014

Anion transport

5

0.015

Carbohydrate biosynthetic process

4

0.016

Blood circulation

5

0.016

Circulatory system process

5

0.017

Regulation of biological process

28

0.018

Lipid metabolic process

9

0.019

Heart development

4

0.022

Cardiac muscle development

2

0.027

Cellular carbohydrate metabolic process

6

0.034

Peptide transport

3

0.036

Carbohydrate metabolic process

7

0.040

Circadian rhythm

3

0.040

Multicellular organismal development

18

0.042

Regulation of multicellular organismal process

6

0.044

Developmental process

23

0.045

Regulation of transport

4

0.046

Regulation of the force of heart contraction

2

0.047

Long-chain fatty acid transport

2

0.048

Cellular constituent

Cytoplasm

42

0.0000080

Cytoplasmic part

30

0.0014

Fibrillar collagen

3

0.0015

Sarcoplasmic reticulum

3

0.0047

Intracellular part

50

0.0048

Sarcoplasm

3

0.0065

Sarcomere

4

0.0066

Endosome

5

0.0066

Plasma membrane

20

0.0072

Endoplasmic reticulum

10

0.0097

Myofibril

4

0.010

Contractile fiber part

4

0.010

Intracellular

52

0.011

Collagen type I

2

0.013

Contractile fiber

4

0.014

Collagen

3

0.018

Smooth endoplasmic reticulum

2

0.032

Cell part

71

0.039

Cell

71

0.039

Molecular function

Protein binding

39

0.0034

Substrate specific channel activity

6

0.018

Calcium ion binding

9

0.024

Structural constituent of bone

2

0.026

Passive transmembrane transporter activity

6

0.030

Transporter activity

13

0.031

Channel activity

6

0.031

Auxiliary transport protein activity

3

0.032

Substrate-specific transporter activity

11

0.033

Oxidoreductase activity

10

0.035

Binding

58

0.039

Transmembrane transporter activity

10

0.044

STERNOHYOID

GO classification

GO group

# genes

P value

Biological process

Regulation of multicellular organismal process

12

0.0000012

Humoral immune response

6

0.0000075

Complement activation

5

0.000014

Activation of plasma proteins during acute inflammatory response

5

0.000016

Acute inflammatory response

6

0.000027

Regulation of immune response

6

0.000027

Regulation of immune system process

6

0.000036

Activation of immune response

5

0.000070

Immune effector process

6

0.000076

Response to stress

17

0.000096

Monocarboxylic acid metabolic process

9

0.00010

Positive regulation of immune response

5

0.00013

Positive regulation of immune system process

5

0.00016

Carboxylic acid metabolic process

12

0.00021

Innate immune response

5

0.00025

Organic acid metabolic process

12

0.00078

Positive regulation of multicellular organismal process

5

0.00091

Long-chain fatty acid transport

3

0.0012

Muscle contraction

6

0.0015

Muscle system process

6

0.0017

Fatty acid transport

3

0.0021

Regulation of muscle contraction

4

0.0022

Response to hormone stimulus

6

0.0028

Fatty acid metabolic process

6

0.0030

B cell mediated immunity

4

0.0032

Immune response

9

0.0033

Anion transport

6

0.0037

Lymphocyte mediated immunity

4

0.0048

Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

4

0.0057

Adaptive immune response

4

0.0062

Humoral immune response mediated by circulating immunoglobulin

3

0.0064

Complement activation-classical pathway

3

0.0064

Defense response

8

0.0067

Leukocyte mediated immunity

4

0.0071

Response to biotic stimulus

6

0.0074

Lipid transport

4

0.0077

Inflammatory response

6

0.0082

Positive regulation of biological process

13

0.0082

Response to external stimulus

10

0.0084

Ion transport

11

0.0089

Inorganic anion transport

5

0.010

Cellular lipid metabolic process

9

0.010

Response to unfolded protein

4

0.011

Response to protein stimulus

4

0.011

Lipid metabolic process

10

0.012

Immune system process

10

0.013

Metabolic process

53

0.015

Response to steroid hormone stimulus

4

0.022

Response to wounding

7

0.023

Response to endogenous stimulus

7

0.028

Response to corticosteroid stimulus

3

0.029

Regulation of Wnt receptor signaling pathway

3

0.030

Response to peptide hormone stimulus

3

0.037

Regulation of biological process

28

0.038

Cellular metabolic process

45

0.049

Cellular constituent

Cytoplasm

45

9.2E-07

Extracellular region part

25

0.000068

Proteinaceous extracellular matrix

9

0.000087

Extracellular matrix

9

0.00010

Extracellular region

25

0.00017

Extracellular space

23

0.00030

Collagen

4

0.0013

Cytoplasmic part

31

0.00140

Fibrillar collagen

3

0.0016

Extracellular matrix part

5

0.00230

Intracellular part

52

0.0040

Endoplasmic reticulum

10

0.0080

Intracellular

54

0.011

Complement component C1 complex

2

0.012

Collagen type I

2

0.012

Glycerol-3-phosphate dehydrogenase complex

2

0.018

Organelle outer membrane

3

0.033

Envelope

7

0.034

Organelle envelope

7

0.036

Molecular function

Glutathione transferase activity

4

0.00076

Catalytic activity

43

0.00090

Calcium ion binding

12

0.0033

Transferase activity- transferring alkyl or aryl (other than methyl) groups

4

0.0042

Glycerol-3-phosphate dehydrogenase activity

2

0.012

Transferase activity

17

0.024

Structural constituent of bone

2

0.029

Magnesium ion binding

5

0.037