Table 2 Comparison of lymphocyte subpopulations in HT and HC
Lymphocyte subpopulation | Healthy control (HC) | Hashimoto’s thyroiditis (HT) | ||
|---|---|---|---|---|
Number | Mean ± standard deviation (median; range) | Number | Mean ± standard deviation (median; range) | |
Lymphocytes absolute per μl | 70 | 2508 ± 763 (2550; 960 – 4200) | 18 | 1917 ± 659 (1794; 665 – 3264)*** |
Lymphocytes (% of white blood cells) | 70 | 33.6 ± 10.9 (33.3; 15.0 – 62.0) | 18 | 33.1 ± 12.5 (34.5; 15.0 – 54.0) |
CD3+ (% of total lymphocytes) | 66 | 68.3 ± 6.9 (68.0; 47.8 – 82.5) | 18 | 68.8 ± 8.5 (69.2; 43.8 – 80.8) |
CD4+ (% of total lymphocytes) | 66 | 39.1 ± 6.9 (39.6; 25.8 – 51.1) | 18 | 38.9 ± 7.1 (40.1; 21.5 – 51.6) |
CD8+ (% of total lymphocytes) | 66 | 27.8 ± 6.4 (26.5; 13.7 – 44.3) | 18 | 24.1 ± 6.2 (23.3; 14.5 – 38.5)*** |
CD19+ (% of total lymphocytes) | 66 | 16.1 ± 4.3 (15.3; 9.2 – 25.9) | 18 | 18.6 ± 8.2 (16.1; 10.0 – 44.4) |
CD3-CD16/56+ (% of total lymphocytes) | 66 | 10.9 ± 5.9 (9.7; 3.8 – 33.7) | 17 | 7.3 ± 3.5 (6.4; 3.3 – 15.0) |
HLA-DR + (% of CD3+) | 66 | 5.9 ± 2.8 (5.2; 1.8 – 12.4) | 18 | 6.1 ± 2.5 (5.4; 2.4 – 11.3) |
CD28- (% of CD4+) | 65 | 1.5 ± 1.3 (1.3; 0.09 – 8.4) | 16 | 1.1 ± 0.9 (0.9; 0.1 – 2.7) |
CD28- (% of CD8+) | 66 | 11.1 ± 13.7 (3.9; 0.15 – 61.7) | 17 | 19.8 ± 13.3 (14.5; 4.8 – 52.3)*** |
CD45RO + (% of CD4+) | 31 | 35.9 ± 12.9 (36.4; 1.4 – 59.4) | 17 | 46.2 ± 12.9 (47.3; 23.2 – 74.7)** |
CD45RO + (% of CD8+) | 31 | 19.7 ± 10.6 (17.8; 0.07 – 48.3) | 17 | 29.1 ± 13.2 (27.7; 11.9 – 57.8)*** |
CD45RA + CD62L + (% of CD4+) | 64 | 61.1 ± 14.4 (60.9; 9.9 – 88.2) | 17 | 54.4 ± 18.5 (53.6; 10.6 – 85.3) |
CD45RA + CD62L + (% of CD8+) | 63 | 61.6 ± 14.9 (64.2; 16.7 – 93.3) | 17 | 51.9 ± 14.9 (55.3; 26.5 – 72.5)** |
CD25 + CD62L + (% of CD4+) | 64 | 22.8 ± 11.8 (20.8; 4.5 – 78.1) | 17 | 23.6 ± 7.3 (21.5; 14.2 – 39.4) |