Figure 1

a.Dose–response relationship of outcome variables – relative changes. Dose–response relationships between metabolic outcome variables fitted with S-shaped piecewise linear regression lines with corresponding 90% confidence intervals. The y-axis is scaled as percent (%) of the maximum range of the fitted piecewise function. The lowest level of the piecewise function is set to 0% and the highest to 100%. The diamonds indicate the percentage change (Δ) in dose-group means (between start and 2 years) of the metabolic variables on the y-axis vs GH dose on the x-axis. LVDd: Left ventricular diameter in diastole, ALP: alkaline phosphatase, LST: lean soft tissue, IGF-I: insulin-like growth factor I. The effective GH dose (ED 50%) required to achieve half of the dose effect is calculated according to the linear regression equation of the middle part of the piecewise linear GH dose effect. b.Dose–response relationship of outcome variables – absolute changes. Dose–response relationship of metabolic outcome variables fitted with S-shaped piecewise linear regression lines with corresponding 90% confidence intervals. The small dots indicate the change (Δ) in response values (between start and 2 years) for 87 children receiving individualized growth hormone (GH) treatment on the y-axis vs GH dose on the x-axis. The diamonds show the dose-group means. LVDd: Left ventricular diameter in diastole, ALP: alkaline phosphatase, LST: lean soft tissue, IGF-I: insulin-like growth factor I. The effective GH dose (ED 50%) required to achieve half of the dose effect is calculated according to the linear regression equation of the middle part of the piecewise linear GH dose effect.