Skip to main content
Figure 1 | BMC Endocrine Disorders

Figure 1

From: Serum levels of pancreatic stone protein (PSP)/reg1A as an indicator of beta-cell apoptosis suggest an increased apoptosis rate in hepatocyte nuclear factor 1 alpha (HNF1A-MODY) carriers from the third decade of life onward

Figure 1

Serum levels of PSP/reg1A in HNF1A-MODY(Δ), T1DM (○) and GCK-MODY (♦) versus non-diabetic controls (▴). Solid lines/box plot showing median and interquartile range (IQR) and dotted line showing mean. Serum levels of PSP/reg1A in HNF1A-MODY are at a median of 12.50 ng/ml showing an IQR of 10.61 to 17.87 ng/ml in n = 37 patients. The median in n = 27 type 1 diabetes mellitus (T1DM) patients is 13.52 ng/ml with IQR of 10.91 to 19.01 ng/ml and the median in n = 60 control subjects is 10.72 ng/ml and IQR is 8.94-12.54 ng/ml. A Mann–Whitney U-test of the groups resulted in (*) p = 0.0008 for differences between HNF1A-MODY and controls and (*) p = 0.0007 for comparison of T1DM versus controls. The median of GCK-MODY is 12.27 ng/ml with an IQR of 9.79 to 16.47 ng/ml in n = 13 patients, which resulted in (n.s.) p = 0.164 when compared to controls.

Back to article page

BMC Endocrine Disorders

ISSN: 1472-6823

Contact us