The peroxisome proliferator-activated receptor (PPAR) alpha agonist fenofibrate maintains bone mass, while the PPAR gamma agonist pioglitazone exaggerates bone loss, in ovariectomized rats

Table 3 Mechanical properties of the femoral neck and shaft in mean values ± SD after 4 months of treatment

	SHAM (sham-operated controls) (N = 10)	OVX (ovariectomized controls) (N = 10)	WY OVX (ovariectomized, given Wyeth 14643) (N = 9)	FENO OVX (ovariectomized, given fenofibrate) (N = 10)	PIO OVX (ovariectomized, given pioglitazone) (N = 9)
ULTIMATE BENDING MOMENT (Nm) Femoral neck Femoral shaft	63.0 ± 8.9 81.7 ± 6.3	52.1 ± 8.9 ^a 76.8 ± 7.6	62.0 ± 12 79.4 ± 3.7	56.5 ± 9.8 75.0 ± 4.9	47.6 ± 8.2 ^a,c,dd 65.4 ± 7.2 ^aaa,bb,c,ddd
ENERGY ABSORPTION (J × 10^-2) Femoral neck Femoral shaft	13.5 ± 2.7 15.3 ± 2.3	9.94 ± 2.6 ^a 13.3 ± 2.8	13.8 ± 3.7 ^b 13.9 ± 1.4	12.0 ± 3.7 14.3 ± 2.0	8.60 ± 2.2 ^aaa,c,dd 10.0 ± 3.2 ^{aa,b, cc,d}
ULTIMATE BENDING STIFFNESS (Nm/° × 10^-2) Femoral neck Femoral shaft	370 ± 58 574 ± 61	317 ± 53 582 ± 58	359 ± 81 586 ± 66	344 ± 49 550 ± 35	339 ± 83 540 ± 81

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