Table 2 Mean malues ± SD of bone architecture parameters in the femoral metaphysis, determined by means of μCT scanning analyses in rats after 4 months of treatment

CORTICAL VOLUME

(Ct.V) (μm³)

28.77 ± 1.773

27.13 ± 1.551 ^a

28.14 ± 1.222

28.71 ± 1.795

23.37 ± 1.225 ^{aaa, bbb, ccc, ddd}

CORTICAL THICKNESS

(Ct.Th) (μm)

735.5 ± 22.90

694.4 ± 41.84 ^a

700.6 ± 21.83 ^aa

709.9 ± 28.52 ^a

594.7 ± 39.58 ^{aaa, bb, cc, ddd}

TRABECULAR BONE

VOLUME (BV) (μm³)

6.554 ± 0.8317

5.147 ± 0.5373 ^aa

5.697 ± 0.6074 ^a

5.615 ± 1.410

4.996 ± 1.048 ^aa

TOTAL

VOLUME (TV) (μm³)

21.85 ± 1.640

25.23 ± 1.734 ^a

23.65 ± 1.828

23.76 ± 2.448

28.58 ± 2.513 ^{aaa, b, ccc, ddd}

TRABECULAR

THICKNESS (Tb.Th) (μm)

148.3 ± 5.638

146.7 ± 6.034

144.1 ± 6.402 ^c

154.8 ± 11.59

141.5 ± 6.146 ^{aa, cc}

CONNECTIVITY

DENSITY (CD) (1/mm³)

14.20 ± 5.740

10.91 ± 2.118

17.91 ± 5.004 ^bb,c

12.01 ± 4.295

11.56 ± 2.533 ^dd

STRUCTURE MODEL

INDEX (SMI) (0.0-3.0)

0.6682 ± 0.2296

1.596 ± 0.2397 ^aaa

1.394 ± 0.1283 ^{aaa, b}

1.518 ± 0.2138 ^aaa

1.742 ± 0.2773 ^{aaa, dd}

TRABECULAR BONE

VOLUME FRACTION (BV/TV)

0.2991 ± 0.03208

0.2056 ± 0.02008 ^aaa

0.2389 ± 0.02892 ^{aaa, b}

0.2340 ± 0.04048 ^aaa

0.1744 ± 0.02128 ^{aaa, bb, cc, ddd}