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  1. The metabolic syndrome (MetS) concept is widely used in public health and clinical settings without an agreed pathophysiology. We have re-examined the MetS in terms of body fuels, so as to provide a coherent c...

    Authors: Mark L Wahlqvist, Hsing-Yi Chang, Chu-Chih Chen, Chih-Cheng Hsu, Wan-Chi Chang, Wuan-Szu Wang and Chao A Hsiung

    Citation: BMC Endocrine Disorders 2010 10:11

    Content type: Research article

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  2. Pituitary adenomas are associated with a variety of clinical manifestations resulting from excessive hormone secretion and tumor mass effects, and require a multidisciplinary management approach. This article ...

    Authors: Beverly MK Biller, Annamaria Colao, Stephan Petersenn, Vivien S Bonert and Marco Boscaro

    Citation: BMC Endocrine Disorders 2010 10:10

    Content type: Review

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  3. Transcription factor 7-like 2 (TCF7L2) has emerged as a consistently replicated susceptibility gene for type 2 diabetes, however, whether the TCF7L2 gene also has similar effects on the retinal microvasculature i...

    Authors: Yu Yan, Ronald Klein, Gerardo Heiss, Cynthia J Girman, Ethan M Lange, Barbara E Klein, Kathryn M Rose, Eric Boerwinkle, James S Pankow, Frederick L Brancati, Christie M Ballantyne, Anna Köttgen and Kari E North

    Citation: BMC Endocrine Disorders 2010 10:9

    Content type: Research article

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  4. In recent years, there has been an increasing attention to thyroid function in paediatric obese patients. In the present study we aimed 1) to determine the prevalence of abnormally elevated thyroid-stimulating...

    Authors: Anna Grandone, Nicola Santoro, Filomena Coppola, Paolo Calabrò, Laura Perrone and Emanuele Miraglia del Giudice

    Citation: BMC Endocrine Disorders 2010 10:8

    Content type: Research article

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  5. In a previous pooled analysis of 12 double-blind clinical studies that included data on 6,139 patients with type 2 diabetes, treatment with sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, was shown to...

    Authors: Debora Williams-Herman, Samuel S Engel, Elizabeth Round, Jeremy Johnson, Gregory T Golm, Hua Guo, Bret J Musser, Michael J Davies, Keith D Kaufman and Barry J Goldstein

    Citation: BMC Endocrine Disorders 2010 10:7

    Content type: Research article

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  6. Low skeletal muscle mass is associated with insulin resistance and metabolic syndrome. Serum creatinine may serve as a surrogate marker of muscle mass, and a possible relationship between low serum creatinine ...

    Authors: Jøran Hjelmesæth, Jo Røislien, Njord Nordstrand, Dag Hofsø, Helle Hager and Anders Hartmann

    Citation: BMC Endocrine Disorders 2010 10:6

    Content type: Research article

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  7. Endothelial progenitor cells (EPCs) play an important role in vascular repair and a decrease in the number of EPCs is observed in type 2 diabetes. However, there is no report on the change of EPCs after glycem...

    Authors: Worachat Churdchomjan, Pakpoom Kheolamai, Sirikul Manochantr, Pirath Tapanadechopone, Chairat Tantrawatpan, Yaowalak U-pratya and Surapol Issaragrisil

    Citation: BMC Endocrine Disorders 2010 10:5

    Content type: Research article

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  8. Type 2 diabetes mellitus (T2DM) and several types of neurodegeneration, including Alzheimer's, are linked to insulin-resistance, and chronic high dietary fat intake causes T2DM with mild neurodegeneration. Int...

    Authors: Ming Tong, Lisa Longato and Suzanne M de la Monte

    Citation: BMC Endocrine Disorders 2010 10:4

    Content type: Research article

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  9. Obesity, type 2 diabetes mellitus (T2D) and unhealthy blood lipid profile are strongly associated with the risk of developing cardiovascular disease (CVD). We examined whether blood lipid changes with short te...

    Authors: Peter Weeke, Charlotte Andersson, Emil L Fosbøl, Bente Brendorp, Lars Køber, Arya M Sharma, Nick Finer, Philip T James, Ian D Caterson, Richard A Rode and Christian Torp-Pedersen

    Citation: BMC Endocrine Disorders 2010 10:3

    Content type: Research article

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  10. Iodine deficiency is a global problem representing the most common preventable cause of mental retardation. Recently, the impact of subtle deficiencies in iodine intake on children and pregnant women has been ...

    Authors: Marcus M Cranston, Margaret AK Ryan, Tyler C Smith, Carter J Sevick and Stephanie K Brodine

    Citation: BMC Endocrine Disorders 2010 10:2

    Content type: Research article

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  11. Mice lacking Receptor-interacting protein 140 (RIP140) have reduced body fat which at least partly is mediated through increased lipid and glucose metabolism in adipose tissue. In humans, RIP140 is lower expresse...

    Authors: Niklas Mejhert, Jurga Laurencikiene, Amanda T Pettersson, Maria Kaaman, Britta M Stenson, Mikael Rydén and Ingrid Dahlman

    Citation: BMC Endocrine Disorders 2010 10:1

    Content type: Research article

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  12. A significant body of literature indicates that melatonin, a hormone primarily produced nocturnally by the pineal gland, is an important scavenger of hydroxyl radicals and other reactive oxygen species. Melato...

    Authors: Zoreh Davanipour, Henrik E Poulsen, Allan Weimann and Eugene Sobel

    Citation: BMC Endocrine Disorders 2009 9:22

    Content type: Research article

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  13. Numerous studies have reported that age-induced increased parathyroid hormone plasma levels are associated with cognitive decline and dementia. Little is known about the correlation that may exist between neur...

    Authors: Eric R Braverman, Thomas JH Chen, Amanda LC Chen, Vanessa Arcuri, Mallory M Kerner, Anish Bajaj, Javier Carbajal, Dasha Braverman, B William Downs and Kenneth Blum

    Citation: BMC Endocrine Disorders 2009 9:21

    Content type: Research article

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  14. Acromegaly, an orphan disease usually caused by a benign pituitary tumour, is characterised by hyper-secretion of growth hormone (GH) and insulin-like growth factor I (IGF-1). It is associated with reduced lif...

    Authors: David J Moore, Yaser Adi, Martin J Connock and Sue Bayliss

    Citation: BMC Endocrine Disorders 2009 9:20

    Content type: Research article

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  15. Recent data have shown that type 2 diabetes patients in the UK delay initiating insulin on average for over 11 years after first being prescribed an oral medication. Using a published computer simulation model...

    Authors: Gordon Goodall, Eric M Sarpong, Clarice Hayes and William J Valentine

    Citation: BMC Endocrine Disorders 2009 9:19

    Content type: Research article

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  16. While the adverse impact of a history of a foot ulcer on physical health among persons with diabetes is well known, little is known about the association between foot ulcer, perceived health and psychological ...

    Authors: Marjolein M Iversen, Kristian Midthjell, Grethe S Tell, Torbjørn Moum, Truls Østbye, Monica W Nortvedt, Sverre Uhlving and Berit R Hanestad

    Citation: BMC Endocrine Disorders 2009 9:18

    Content type: Research article

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  17. Impaired glucose tolerance (IGT) is a prediabetic state. If IGT can be prevented from progressing to overt diabetes, hyperglycemia-related complications can be avoided. The purpose of the present study was to ...

    Authors: Ralph A DeFronzo, MaryAnn Banerji, George A Bray, Thomas A Buchanan, Stephen Clement, Robert R Henry, Abbas E Kitabchi, Sunder Mudaliar, Nicolas Musi, Robert Ratner, Peter D Reaven, Dawn Schwenke, Frankie B Stentz and Devjit Tripathy

    Citation: BMC Endocrine Disorders 2009 9:17

    Content type: Study protocol

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  18. Most studies on cortisol have focused on smaller, selected samples. We therefore aimed to sex-specifically study the diurnal cortisol pattern and explore its association with abdominal obesity in a large unsel...

    Authors: Charlotte A Larsson, Bo Gullberg, Lennart Råstam and Ulf Lindblad

    Citation: BMC Endocrine Disorders 2009 9:16

    Content type: Research article

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  19. While there are compelling observational data confirming that individuals who exercise are healthier, the efficacy of aerobic exercise interventions to reduce metabolic risk and improve insulin sensitivity in ...

    Authors: Francis M Finucane, Jessica Horton, Lisa R Purslow, David B Savage, Soren Brage, Hervé Besson, Kenneth Horton, Ema De Lucia Rolfe, Alison Sleigh, Stephen J Sharp, Helen J Martin, Avan Aihie Sayer, Cyrus Cooper, Ulf Ekelund, Simon J Griffin and Nicholas J Wareham

    Citation: BMC Endocrine Disorders 2009 9:15

    Content type: Study protocol

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  20. The rising prevalence of type 2 diabetes underlines the importance of secondary strategies for the prevention of target organ damage. While access to diabetes education centers and diabetes intensification man...

    Authors: Sheldon W Tobe, Joan Wentworth, Laurie Ironstand, Susan Hartman, Jackie Hoppe, Judi Whiting, Janice Kennedy, Colin McAllister, Alex Kiss, Nancy Perkins, Lloyd Vincent, George Pylypchuk and Richard Z Lewanczuk

    Citation: BMC Endocrine Disorders 2009 9:13

    Content type: Study protocol

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  21. A lot of studies have showed an excess maternal transmission of type 2 diabetes (T2D). The aim, therefore, of the present study was to estimate the prevalence of familial history of T2D in Greek patients, and ...

    Authors: Athanasia Papazafiropoulou, Alexios Sotiropoulos, Eystathios Skliros, Marina Kardara, Anthi Kokolaki, Ourania Apostolou and Stavros Pappas

    Citation: BMC Endocrine Disorders 2009 9:12

    Content type: Research article

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  22. Primary aldosteronism (PA) affects approximately 5 to 10% of all patients with arterial hypertension and is associated with an excess rate of cardiovascular complications that can be significantly reduced by a...

    Authors: Stefan Pilz, Andreas Tomaschitz, Vinzenz Stepan, Barbara Obermayer-Pietsch, Astrid Fahrleitner-Pammer, Natascha Schweighofer, Horst R Portugaller, Harald Sourij, Harald Dobnig, Andreas Meinitzer and Thomas R Pieber

    Citation: BMC Endocrine Disorders 2009 9:11

    Content type: Study protocol

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  23. All the peroxisome proliferator activated receptors (PPARs) are found to be expressed in bone cells. The PPARγ agonist rosiglitazone has been shown to decrease bone mass in mice and thiazolidinediones (TZDs) h...

    Authors: Unni Syversen, Astrid K Stunes, Björn I Gustafsson, Karl J Obrant, Lars Nordsletten, Rolf Berge, Liv Thommesen and Janne E Reseland

    Citation: BMC Endocrine Disorders 2009 9:10

    Content type: Research article

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  24. Hyperglycaemic emergencies are common acute complications of diabetes mellitus (DM) but unfortunately, there is a dearth of published data on this entity from Nigeria. This study attempts to describe the clini...

    Authors: Anthonia O Ogbera, Jacob Awobusuyi, Chioma Unachukwu and Olufemi Fasanmade

    Citation: BMC Endocrine Disorders 2009 9:9

    Content type: Research article

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  25. Rosiglitazone not only improves insulin-sensitivity, but also exerts anti-inflammatory effects. We have now examined in type 2 diabetic patients if these effects are reflected by changes in mRNA expression in ...

    Authors: Marjolijn CE Bragt, Jogchum Plat, Marco Mensink, Patrick Schrauwen and Ronald P Mensink

    Citation: BMC Endocrine Disorders 2009 9:8

    Content type: Research article

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  26. β-cells are extremely rich in zinc and zinc homeostasis is regulated by zinc transporter proteins. β-cells are sensitive to cytokines, interleukin-1β (IL-1β) has been associated with β-cell dysfunction and -de...

    Authors: Lærke Egefjord, Jens Ledet Jensen, Claus Heiner Bang-Berthelsen, Andreas Brønden Petersen, Kamille Smidt, Ole Schmitz, Allan Ertman Karlsen, Flemming Pociot, Fabrice Chimienti, Jørgen Rungby and Nils E Magnusson

    Citation: BMC Endocrine Disorders 2009 9:7

    Content type: Research article

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  27. The management of diabetes self-care is largely the responsibility of the patient. With more emphasis on the prevention of complications, adherence to diabetes self-care regimens can be difficult. Diabetes sel...

    Authors: Margaret M Collins, Colin P Bradley, Tony O'Sullivan and Ivan J Perry

    Citation: BMC Endocrine Disorders 2009 9:6

    Content type: Research article

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  28. The objective was to examine how the indigenous naming, indigenous self-diagnosis and management of diabetes evolved with awareness in order to develop a socially oriented theoretical model for its care.

    Authors: Paschal K Awah, Nigel C Unwin and Peter R Phillimore

    Citation: BMC Endocrine Disorders 2009 9:5

    Content type: Research article

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  29. Vitamin D deficiency is associated with heightened risk of cardiovascular disease. Potential mechanisms include involvement of vitamin D in regulation of renin-angiotensin system and manufacture and secretion ...

    Authors: Hussein F Saadi, M Gary Nicholls, Christopher M Frampton, Sheela Benedict and Javed Yasin

    Citation: BMC Endocrine Disorders 2009 9:4

    Content type: Research article

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  30. Traditional high volume aerobic exercise training reduces cardiovascular and metabolic disease risk but involves a substantial time commitment. Extremely low volume high-intensity interval training (HIT) has r...

    Authors: John A Babraj, Niels BJ Vollaard, Cameron Keast, Fergus M Guppy, Greg Cottrell and James A Timmons

    Citation: BMC Endocrine Disorders 2009 9:3

    Content type: Research article

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  31. Diabetes has become the single most common cause for end-stage renal disease in the United States. It has been established that mitochondrial damage occurs during diabetes; however, little is known about what ...

    Authors: Shankar Munusamy, Hamida Saba, Tanecia Mitchell, Judit K Megyesi, Robert W Brock and Lee Ann MacMillan-Crow

    Citation: BMC Endocrine Disorders 2009 9:2

    Content type: Research article

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  32. Visceral obesity is positively related to insulin resistance. The nature of the relationship between waist circumference and insulin resistance has not been known in Japanese populations. This study examined t...

    Authors: Shinji Tabata, Shinichiro Yoshimitsu, Tadamichi Hamachi, Hiroshi Abe, Keizo Ohnaka and Suminori Kono

    Citation: BMC Endocrine Disorders 2009 9:1

    Content type: Research article

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  33. Diabetes mellitus is becoming increasingly common in sub-Saharan Africa. Autonomic dysfunction contributes to morbidity and mortality in diabetic patients. Data on autonomic dysfunction in the African populati...

    Authors: Malvin Torsvik, Amanda Häggblom, Geir Egil Eide, Erich Schmutzhard, Kaare Vetvik and Andrea Sylvia Winkler

    Citation: BMC Endocrine Disorders 2008 8:19

    Content type: Research article

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  34. Risk factors underlying the development and progression of some of the less well-recognised complications of type 2 diabetes, including cognitive impairment and non-alcoholic fatty liver disease, are poorly un...

    Authors: Jackie F Price, Rebecca M Reynolds, Rory J Mitchell, Rachel M Williamson, F Gerald R Fowkes, Ian J Deary, Amanda J Lee, Brian M Frier, Peter C Hayes and Mark WJ Strachan

    Citation: BMC Endocrine Disorders 2008 8:18

    Content type: Study protocol

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  35. Angiotensin converting enzyme inhibitors (ACE inhibitors) reduce peripheral vascular resistance via blockage of angiotensin converting enzyme (ACE). ACE inhibitors are commonly used to treat congestive heart f...

    Authors: Maria E Ramos-Nino, Charles D MacLean and Benjamin Littenberg

    Citation: BMC Endocrine Disorders 2008 8:17

    Content type: Research article

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  36. Various structural and functional factors of foot function have been associated with high local plantar pressures. The therapist focuses on these features which are thought to be responsible for plantar ulcera...

    Authors: Nick A Guldemond, Pieter Leffers, Geert HIM Walenkamp, Nicolaas C Schaper, Antal P Sanders, Fred HM Nieman and Lodewijk W van Rhijn

    Citation: BMC Endocrine Disorders 2008 8:16

    Content type: Research article

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  37. Age- and sex-specific reference intervals are an important prerequisite for interpreting thyroid hormone measurements in children. However, only few studies have reported age- and sex-specific pediatric refere...

    Authors: Klaus Kapelari, Christine Kirchlechner, Wolfgang Högler, Katharina Schweitzer, Irene Virgolini and Roy Moncayo

    Citation: BMC Endocrine Disorders 2008 8:15

    Content type: Research article

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  38. Sitagliptin, a highly selective dipeptidyl peptidase-4 inhibitor, is the first in a new class of oral antihyperglycemic agents (AHAs) for the treatment of patients with type 2 diabetes. Type 2 diabetes is a li...

    Authors: Debora Williams-Herman, Elizabeth Round, Arlene S Swern, Bret Musser, Michael J Davies, Peter P Stein, Keith D Kaufman and John M Amatruda

    Citation: BMC Endocrine Disorders 2008 8:14

    Content type: Research article

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  39. Non-thyroidal illness syndrome (NTIS) is a characteristic functional constellation of thyrotropic feedback control that frequently occurs in critically ill patients. Although this condition is associated with ...

    Authors: Johannes W Dietrich, Axel Stachon, Biljana Antic, Harald H Klein and Steffen Hering

    Citation: BMC Endocrine Disorders 2008 8:13

    Content type: Study protocol

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  40. Telomeres are DNA repeat sequences necessary for DNA replication which shorten at cell division at a rate directly related to levels of oxidative stress. Critical telomere shortening predisposes to cell senesc...

    Authors: Deepak Kejariwal, Karolina M Stepien, Tracy Smith, Hugh Kennedy, David A Hughes and Mike J Sampson

    Citation: BMC Endocrine Disorders 2008 8:12

    Content type: Research article

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  41. Ninety percent of cases of diabetes are of the slowly evolving non-insulin-dependent type, or Type 2 diabetes. Lack of exercise is regarded as one of the main causes of this disorder. In this study we analyzed...

    Authors: Clécia Soares de Alencar Mota, Carla Ribeiro, Gustavo Gomes de Araújo, Michel Barbosa de Araújo, Fúlvia de Barros Manchado-Gobatto, Fabrício Azevedo Voltarelli, Camila Aparecida Machado de Oliveira, Eliete Luciano and Maria Alice Rostom de Mello

    Citation: BMC Endocrine Disorders 2008 8:11

    Content type: Research article

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  42. The role of estrogens in male physiology has become evident. However, clinically useful normative data for estradiol secretion in boys has not previously been established due to the insensitivity of current me...

    Authors: Carina Ankarberg-Lindgren and Ensio Norjavaara

    Citation: BMC Endocrine Disorders 2008 8:10

    Content type: Research article

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  43. To estimate the proportion of diabetic patients (DPts) with peripheral vascular disease treated at a primary health care site after an endocrinologist-based intervention, who meet ATP III and Steno targets of ...

    Authors: Alejandra Duran, Isabelle Runkle, Pilar Matía, Maria P de Miguel, Sofia Garrido, Emilio Cervera, Maria D Fernandez, Pilar Torres, Tomas Lillo, Patricia Martin, Lucio Cabrerizo, Nuria Garcia de la Torre, Jose R Calle, Jose Ibarra, Aniceto L Charro and Alfonso L Calle-Pascual

    Citation: BMC Endocrine Disorders 2008 8:9

    Content type: Research article

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  44. Latent autoimmune diabetes in adults [LADA] is a type 1 diabetes that is slowly developing. This means many people are treated as having type 2 diabetes at diagnosis as they are adults who are not immediately ...

    Authors: Sinead Brophy, Helen Davies, Stephen Bain, Jeffrey W Stephens, Wei-yee Cheung, Kez Richards, Kathie Wareham, Charles Beaverstock, Janet Lloyd, Don Page, Meurig Williams, Ian Russell and Rhys Williams

    Citation: BMC Endocrine Disorders 2008 8:8

    Content type: Study protocol

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  45. In Andalusia there were no studies including a representative sample of children and adolescent population assessing growth and weight increase. Our objectives were to develop reference standards for weight, h...

    Authors: Juan Pedro López-Siguero, Juan Manuel Fernández García, Juan de Dios Luna Castillo, Jose Antonio Moreno Molina, Carlos Ruiz Cosano and Antonio Jurado Ortiz

    Citation: BMC Endocrine Disorders 2008 8(Suppl 1):S1

    Content type: Research

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    This article is part of a Supplement: Volume 8 Supplement 1

  46. The number of people with cardiovascular disease (CVD) and diabetes mellitus type 2 (T2DM) is growing rapidly. To a large extend, this increase is due to lifestyle-dependent risk factors, such as overweight, r...

    Authors: Jeroen Lakerveld, Sandra DM Bot, Marijke J Chinapaw, Maurits W van Tulder, Patricia van Oppen, Jacqueline M Dekker and Giel Nijpels

    Citation: BMC Endocrine Disorders 2008 8:6

    Content type: Study protocol

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  47. Accurate identification of hypoglycemia cases by International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes will help to describe epidemiology, monitor trends, and propose in...

    Authors: Adit A Ginde, Phillip G Blanc, Rebecca M Lieberman and Carlos A Camargo Jr

    Citation: BMC Endocrine Disorders 2008 8:4

    Content type: Research article

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