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  1. To investigate potential associations of serum prolactin concentration (PRL) with metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM), previously observed in small and selected study samples, in a la...

    Authors: Lisa Balbach, Henri Wallaschofski, Henry Völzke, Matthias Nauck, Marcus Dörr and Robin Haring

    Citation: BMC Endocrine Disorders 2013 13:12

    Content type: Research article

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  2. Osteocalcin (OC) is a bone-specific protein produced primarily by osteoblasts during bone formation. Besides its role in bone formation, osteocalcin may play a role in the regulation of energy metabolism and m...

    Authors: Anke Hannemann, Nele Friedrich, Christin Spielhagen, Rainer Rettig, Till Ittermann, Matthias Nauck and Henri Wallaschofski

    Citation: BMC Endocrine Disorders 2013 13:11

    Content type: Research article

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  3. The editors of BMC Endocrine Disorders would like to thank all our reviewers who have contributed to the journal in Volume 12 (2012).

    Authors: Tim Shipley

    Citation: BMC Endocrine Disorders 2013 13:6

    Content type: Reviewer acknowledgement

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  4. Diabetic patients with positive glutamic acid decarboxylase antibody (GAD-Ab) could be classified as autoimmune diabetes, which is discriminated into acute-onset classical type 1 diabetes (T1DM) and latent aut...

    Authors: Xia Li, Gan Huang, Jian Lin, Lin Yang and Zhiguang Zhou

    Citation: BMC Endocrine Disorders 2013 13:10

    Content type: Research article

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  5. The glycated haemoglobin A1c (HbA1c) level may be used for screening for type 2 diabetes and prediabetes instead of a more burdensome oral glucose tolerance test (OGTT). However, among the high-risk South Asia...

    Authors: Everlina MA Vlaar, Wanda M Admiraal, Wim B Busschers, Frits Holleman, Vera Nierkens, Barend JC Middelkoop, Karien Stronks and Irene GM van Valkengoed

    Citation: BMC Endocrine Disorders 2013 13:8

    Content type: Research article

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  6. Obesity is a major risk factor for type 2 diabetes mellitus (T2DM). A proper anthropometric characterisation of T2DM risk is essential for disease prevention and clinical risk assessement.

    Authors: José María Huerta, María-José Tormo, María-Dolores Chirlaque, Diana Gavrila, Pilar Amiano, Larraitz Arriola, Eva Ardanaz, Laudina Rodríguez, María-José Sánchez, Michelle Mendez, Diego Salmerón, Aurelio Barricarte, Rosana Burgui, Miren Dorronsoro, Nerea Larrañaga, Esther Molina-Montes…

    Citation: BMC Endocrine Disorders 2013 13:7

    Content type: Research article

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  7. Insulin resistance is frequent in human immunodeficiency virus (HIV) infection and may be related to antiretroviral therapy. Cytokines secreted by adipose tissue (adipokines) are linked to insulin sensitivity....

    Authors: Victoria Arama, Catalin Tiliscan, Adrian Streinu-Cercel, Daniela Ion, Raluca Mihailescu, Daniela Munteanu, Adriana Hristea and Stefan Sorin Arama

    Citation: BMC Endocrine Disorders 2013 13:4

    Content type: Research article

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  8. Adrenal insufficiency is a rare and potentially lethal disease if untreated. Several clinical signs and biological markers are associated with glucocorticoid failure but the importance of these factors for dia...

    Authors: Jean-Baptiste Oboni, Pedro Marques-Vidal, François Pralong and Gérard Waeber

    Citation: BMC Endocrine Disorders 2013 13:3

    Content type: Research article

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  9. The mechanism behind parathyroid hormone (PTH) activation of bone remodeling is intimately dependent on the time of exposure of bone cells to hormone levels. Sustained high PTH levels trigger catabolism, while...

    Authors: Maira L Mendonça, Francisco A Pereira, Marcello H Nogueira-Barbosa, Lucas M Monsignore, Sara R Teixeira, Plauto CA Watanabe, Lea MZ Maciel and Francisco JA de Paula

    Citation: BMC Endocrine Disorders 2013 13:1

    Content type: Research article

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  10. Severe hypoglycaemia (SH) is one of the most feared complications of type 1 diabetes (T1DM) with a reported prevalence of nearly 40%. In randomized trials of Multiple Daily Injections (MDI) and Continuous Subc...

    Authors: Stuart Little, Thomas Chadwick, Pratik Choudhary, Cath Brennand, Julia Stickland, Shalleen Barendse, Tolulope Olateju, Lalantha Leelarathna, Emma Walkinshaw, Horng K Tan, Sally M Marshall, Reena M Thomas, Simon Heller, Mark Evans, David Kerr, Daniel Flanagan…

    Citation: BMC Endocrine Disorders 2012 12:33

    Content type: Study protocol

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  11. The use of chromium supplements is widespread for the prevention and treatment of diabetes mellitus but there are conflicting reports on efficacy, possibly reflecting discrepant effects across different popula...

    Authors: Umesh Masharani, Christine Gjerde, Shelley McCoy, Betty A Maddux, Danielle Hessler, Ira D Goldfine and Jack F Youngren

    Citation: BMC Endocrine Disorders 2012 12:31

    Content type: Research article

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  12. Gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) is the most common type of neuroendocrine tumors accounting for 65–75% of neuroendocrine neoplasms (NENs). Given the fact that there are few studies on ...

    Authors: Yu-hong Wang, Yuan Lin, Ling Xue, Jin-hui Wang, Min-hu Chen and Jie Chen

    Citation: BMC Endocrine Disorders 2012 12:30

    Content type: Research article

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  13. Thyroid hemiagenesis is a rare anomaly, more commonly seen on the left side (ratio 4:1) and in females (ratio 3:1). The first to describe this anomaly was Handfield Jones in 1852.

    Authors: Merima Oruci, Yasuhiro Ito, Marko Buta, Ziv Radisavljevic, Gordana Pupic, Igor Djurisic and Radan Dzodic

    Citation: BMC Endocrine Disorders 2012 12:29

    Content type: Case report

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  14. Structured education programmes are now established as an essential component to assist effective self-management of diabetes. In the case of Type 1 diabetes, the Dose Adjustment For Normal Eating (DAFNE) prog...

    Authors: Jackie Elliott, Julia Lawton, David Rankin, Celia Emery, Mike Campbell, Simon Dixon and Simon Heller

    Citation: BMC Endocrine Disorders 2012 12:28

    Content type: Study protocol

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  15. Vitamin D deficiency is associated with multiple adverse health outcomes including increased morbidity and mortality in the general population and in critically ill patients. However, no randomized controlled ...

    Authors: Karin Amrein, Christian Schnedl, Andrea Berghold, Thomas R Pieber and Harald Dobnig

    Citation: BMC Endocrine Disorders 2012 12:27

    Content type: Study protocol

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  16. In addition to stimulating linear growth in children, growth hormone (GH) influences metabolism and body composition. These effects should be considered when individualizing GH treatment as dose-dependent chan...

    Authors: Ralph Decker, Anders Nygren, Berit Kriström, Andreas FM Nierop, Jan Gustafsson, Kerstin Albertsson-Wikland and Jovanna Dahlgren

    Citation: BMC Endocrine Disorders 2012 12:26

    Content type: Research article

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  17. The Metabolic syndrome (MS) which is a constellation of cardiometabolic risk factors including dyslipidaemia, hypertension, hyperglycaemia, central obesity, and endothelial dysfunction was hitherto relatively ...

    Authors: Mawuli Gyakobo, Albert GB Amoah, De-Anne Martey-Marbell and Rachel C Snow

    Citation: BMC Endocrine Disorders 2012 12:25

    Content type: Research article

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  18. Oxidative stress has been implicated in the development of type 2 diabetes mellitus. Bilirubin is a potent endogenous antioxidant, and coffee is a major source of exogenous antioxidants. Serum gamma-glutamyltr...

    Authors: Zhenjie Wang, Christopher McMonagle, Shinichiro Yoshimitsu, Sanjeev Budhathoki, Makiko Morita, Kengo Toyomura, Keizo Ohnaka, Ryoichi Takayanagi and Suminori Kono

    Citation: BMC Endocrine Disorders 2012 12:24

    Content type: Research article

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  19. Hypoglycaemia is a serious adverse effect of antidiabetic drug therapy. We aimed to determine incidence rates of hypoglycaemia in type-2 diabetic patients and identify predictors of hypoglycaemia when treatmen...

    Authors: Diethelm Tschöpe, Peter Bramlage, Christiane Binz, Michael Krekler, Evelin Deeg and Anselm K Gitt

    Citation: BMC Endocrine Disorders 2012 12:23

    Content type: Research article

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  20. Obesity is a major worldwide health problem. It is commonly observed in Down syndrome individuals than in the general population. The reason for increased risk of obesity in DS is unclear.

    Authors: Sohier Yahia, Reham M EL-farahaty, Amany K El-Hawary, Mona A El-hussiny, Hanaa Abdel-maseih, Faeza El-Dahtory and Abdel-Hady El-Gilany

    Citation: BMC Endocrine Disorders 2012 12:22

    Content type: Research article

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  21. The uncertainties regarding dose similarities between basal long-acting insulin analogues remain. Recent real-world studies indicate dose similarities between insulin detemir and insulin glargine, but further ...

    Authors: Marie Jakobsen, Mette Dalsgaard, Morten Hørmann and Daniél Vega Møller

    Citation: BMC Endocrine Disorders 2012 12:21

    Content type: Research article

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  22. Although consensus guidelines recommend insulin progression among patients with type 2 diabetes (T2DM) who fail to meet glycemic targets over time, many fewer patients are progressed than may benefit. We descr...

    Authors: Jennifer M Polinski, Bradley H Curtis, John D Seeger, Niteesh K Choudhry, Anthony Zagar and William H Shrank

    Citation: BMC Endocrine Disorders 2012 12:20

    Content type: Study protocol

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  23. Increasing evidence suggests the bidirectional interplay between parathyroid hormone and aldosterone as an important mechanism behind the increased risk of cardiovascular damage and bone disease observed in pr...

    Authors: Andreas Tomaschitz, Astrid Fahrleitner-Pammer, Burkert Pieske, Nicolas Verheyen, Karin Amrein, Eberhard Ritz, Katharina Kienreich, Jörg H Horina, Albrecht Schmidt, Elisabeth Kraigher-Krainer, Caterina Colantonio, Andreas Meinitzer and Stefan Pilz

    Citation: BMC Endocrine Disorders 2012 12:19

    Content type: Study protocol

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  24. Assessment of knowledge among resident trainees and nurses is very important since majority of patients admitted in hospital have underlying diabetes which could lead to adverse clinical outcomes if not manage...

    Authors: Asma Ahmed, Abdul Jabbar, Lubna Zuberi, Muhammad Islam and Khusro Shamim

    Citation: BMC Endocrine Disorders 2012 12:18

    Content type: Research article

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  25. The existence of unilateral adrenal hyperplasia (AH) has been considered a rare cause of primary hyperaldosteronism (PA).

    Authors: Helga Agusta Sigurjonsdottir, Mikael Gronowitz, Ove Andersson, Robert Eggertsen, Hans Herlitz, Augustinas Sakinis, Bo Wangberg and Gudmundur Johannsson

    Citation: BMC Endocrine Disorders 2012 12:17

    Content type: Research article

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  26. The association between serum alanine aminotransferase (ALT) levels and hepatic insulin resistance (IR) has been evaluated with the hyperinsulinemic-euglycemic clamp. However, there is no information about the...

    Authors: Miguel Ángel Gómez-Sámano, Daniel Cuevas-Ramos, Roopa Mehta, Hasan Brau-Figueroa, Clara Elena Meza-Arana and Alfonso Gulias-Herrero

    Citation: BMC Endocrine Disorders 2012 12:16

    Content type: Research article

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  27. Diabetes is a major public health problem worldwide. This problem is particularly relevant to the elderly. The prevalence of each condition increase with age. The present study aimed to determine the prevalenc...

    Authors: Sonia Hammami, Sounira Mehri, Said Hajem, Nadia Koubaa, Hala Souid and Mohamed Hammami

    Citation: BMC Endocrine Disorders 2012 12:15

    Content type: Research article

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  28. Mutations in the transcription factor hepatocyte nuclear factor-1-alpha (HNF1A) result in the commonest type of maturity onset diabetes of the young (MODY). HNF1A-MODY carriers have reduced pancreatic beta cel...

    Authors: Siobhan Bacon, Ma Peyh Kyithar, Jasmin Schmid, Syed R Rizvi, Caroline Bonner, Rolf Graf, Jochen HM Prehn and Maria M Byrne

    Citation: BMC Endocrine Disorders 2012 12:13

    Content type: Research article

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  29. To evaluate the U.K. Prospective Diabetes Study (UKPDS) and Framingham risk equations for predicting short-term risk of coronary heart disease (CHD) events among adults with long-standing type 2 diabetes, incl...

    Authors: Shou-En Lu, Gloria L Beckles, Jesse C Crosson, Dorian Bilik, Andrew J Karter, Robert B Gerzoff, Yong Lin, Sonja V Ross, Laura N McEwen, Beth E Waitzfelder, David Marrero, Norman Lasser and Arleen F Brown

    Citation: BMC Endocrine Disorders 2012 12:12

    Content type: Research article

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  30. Severe hypoglycaemia still represents a significant problem in insulin-treated diabetes. Most patients do not experience severe hypoglycaemia often. However, 20% of patients with type 1 diabetes experience rec...

    Authors: Peter Lommer Kristensen, Ulrik Pedersen-Bjergaard, Henning Beck-Nielsen, Kirsten Nørgaard, Hans Perrild, Jens Sandahl Christiansen, Tonny Jensen, Hans-Henrik Parving, Birger Thorsteinsson and Lise Tarnow

    Citation: BMC Endocrine Disorders 2012 12:10

    Content type: Study protocol

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  31. We are hereby investigating for the first time the effect of the association ethinylestradiol30μg-drospirenone 3mg (DRP/EE30μg) plus metformin and weight loss on endothelial status and C-reactive protein (hsCRP) ...

    Authors: Ioana Rada Ilie, Ioan Marian, Teodora Mocan, Razvan Ilie, Lucian Mocan, Ileana Duncea and Carmen Emanuela Pepene

    Citation: BMC Endocrine Disorders 2012 12:9

    Content type: Research article

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  32. There is uncertainty as to which intake of vitamin D is needed to suppress PTH and maintain normal bone metabolism throughout winter at northern latitudes. We aimed to investigate whether four weeks’ daily sup...

    Authors: Kristin Holvik, Ahmed A Madar, Haakon E Meyer, Cathrine M Lofthus and Lars C Stene

    Citation: BMC Endocrine Disorders 2012 12:7

    Content type: Research article

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  33. In patients with both Type 1 and Type 2 diabetes endogenous insulin secretion falls with time which changes treatment requirements, however direct measurement of endogenous insulin secretion is rarely performe...

    Authors: Angus G Jones, Rachel EJ Besser, Beverley M Shields, Timothy J McDonald, Suzy V Hope, Bridget A Knight and Andrew T Hattersley

    Citation: BMC Endocrine Disorders 2012 12:6

    Content type: Research article

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  34. Hypoglycemia is a common complication of diabetes treatment. This paper describes symptoms, predecessors, consequences and medications associated with the first episode of severe hypoglycemia among ACCORD part...

    Authors: Denise E Bonds, Michael E Miller, Jim Dudl, Mark Feinglos, Faramarz Ismail-Beigi, Saul Malozowski, Elizabeth Seaquist, Debra L Simmons and Ajay Sood

    Citation: BMC Endocrine Disorders 2012 12:5

    Content type: Research article

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  35. Pituitary disorders following pregnancy are an important yet under reported clinical entity in the developing world. Conversely, post partum panhypopituitarism has a more devastating impact on women in such se...

    Authors: Faheem G Sheriff, William P Howlett and Kajiru G Kilonzo

    Citation: BMC Endocrine Disorders 2012 12:4

    Content type: Case report

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  36. Animal studies suggest that local adipocyte-mediated activity of the renin-angiotensin-aldosterone system (RAAS) contributes to circulating levels, and may promote the development of obesity-related hypertensi...

    Authors: Conall M O'Seaghdha, Shih-Jen Hwang, Ramachandran S Vasan, Martin G Larson, Udo Hoffmann, Thomas J Wang and Caroline S Fox

    Citation: BMC Endocrine Disorders 2012 12:3

    Content type: Research article

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  37. Hypertriglyceridemia may be associated with important complications. The aim of this study is to estimate the magnitude of association and quality of supporting evidence linking hypertriglyceridemia to cardiov...

    Authors: M Hassan Murad, Ahmad Hazem, Fernando Coto-Yglesias, Svitlana Dzyubak, Shabnum Gupta, Irina Bancos, Melanie A Lane, Patricia J Erwin, Lars Berglund, Tarig Elraiyah and Victor M Montori

    Citation: BMC Endocrine Disorders 2012 12:2

    Content type: Research article

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  38. Sub-Saharan Africa is currently enduring the heaviest global burden of diabetes and diabetes care in such resource poor countries is far below standards. This study aims to describe the gaps in the care of Eth...

    Authors: Esayas K Gudina, Solomon T Amade, Fessahaye A Tesfamichael and Rana Ram

    Citation: BMC Endocrine Disorders 2011 11:19

    Content type: Research article

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  39. Recent evidence suggests that there may be a bidirectional, physiological link between hypogonadism and metabolic syndrome (MetS), and testosterone replacement therapy (TRT) has been shown to improve some symp...

    Authors: Rajib K Bhattacharya, Mohit Khera, Gary Blick, Harvey Kushner, Dat Nguyen and Martin M Miner

    Citation: BMC Endocrine Disorders 2011 11:18

    Content type: Research article

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  40. Older patients with newly diagnosed type 2 diabetes mellitus are less likely to receive antihyperglycaemic therapy compared to their younger counterparts. The purpose of this study was to assess the reasons of...

    Authors: Qiaoyi Zhang, Elizabeth Marrett, Kevin Jameson, Susanne Meiler, Michael J Davies, Larry Radican and Alan J Sinclair

    Citation: BMC Endocrine Disorders 2011 11:17

    Content type: Research article

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  41. We examined the association of biomarkers of inflammation and endothelial dysfunction with diabetes and metabolic syndrome (MetS) in persons from Inner Mongolia.

    Authors: Angela M Thompson, Yonghong Zhang, Weijun Tong, Tan Xu, Jing Chen, Li Zhao, Tanika N Kelly, Chung-Shiuan Chen, Lydia A Bazzano and Jiang He

    Citation: BMC Endocrine Disorders 2011 11:16

    Content type: Research article

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  42. Hyperthyroidism is accompanied by osteoporosis with higher incidence of fracture rates. The present work aimed to study bone status in hyperthyroidism and to elucidate the impact of severity, duration, and eti...

    Authors: El Hadidy M El Hadidy, Mohamed Ghonaim, Soma Sh Abd El Gawad and Mohamed Abou El Atta

    Citation: BMC Endocrine Disorders 2011 11:15

    Content type: Research article

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