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Epidemiology of Endocrine Disorders

Section edited by Stavros Liatis

This section concerns all aspects of the epidemiology of endocrine disorders including but not limited to: cohort studies, genetic association studies, and prevalence studies.

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  1. The epidemic rise of diabetes carries major negative public health and economic consequences particularly for low and middle-income countries. The highest predicted percentage growth in diabetes is in the sub-...

    Authors: Andrew Bastawrous, Wanjiku Mathenge, Kevin Wing, Madeleine Bastawrous, Hillary Rono, Helen A. Weiss, David Macleod, Allen Foster, Tunde Peto, Peter Blows, Matthew Burton and Hannah Kuper

    Citation: BMC Endocrine Disorders 2017 17:19

    Content type: Research article

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  2. Associations between lung function and non-alcoholic fatty liver disease (NAFLD) have been reported. However, evidence from large-scale populations about the relationship is scarce. The objective of the study ...

    Authors: Li Qin, Weiwei Zhang, Zhen Yang, Yixin Niu, Xiaoyong Li, Shuai Lu, Yin Xing, Ning Lin, Hongmei Zhang, Guang Ning, Jiangao Fan and Qing Su

    Citation: BMC Endocrine Disorders 2017 17:18

    Content type: Research article

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  3. The prevalence of erectile dysfunction among diabetic men varies between 35–90%. Although erectile dysfunction is widespread among men with diabetes, the condition often remains undiagnosed and demands appropr...

    Authors: Awole Seid, Hadgu Gerensea, Shambel Tarko, Yosef Zenebe and Rahel Mezemir

    Citation: BMC Endocrine Disorders 2017 17:16

    Content type: Research article

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  4. The study aim was to estimate the proportion of acromegaly patients with various comorbidities and to determine if biochemical control was associated with reduced proportion of cardiovascular risk factors.

    Authors: John D. Carmichael, Michael S. Broder, Dasha Cherepanov, Eunice Chang, Adam Mamelak, Qayyim Said, Maureen P. Neary and Vivien Bonert

    Citation: BMC Endocrine Disorders 2017 17:15

    Content type: Research article

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  5. Sleep disorders are common and associated with multiple metabolic and psychological derangements. Obstructive sleep apnoea (OSA) is among the most common sleep disorders and an inter-relationship between OSA, ...

    Authors: Sairabanu Mohammed Rashid Sokwalla, Mark David Joshi, Erastus Olonde Amayo, Kirtida Acharya, Jared Ongechi Mecha and Kenneth Kipyegon Mutai

    Citation: BMC Endocrine Disorders 2017 17:7

    Content type: Research article

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  6. Subclinical hypothyroidism (SCH) is a common condition in elderly people, defined as elevated serum thyroid-stimulating hormone (TSH) with normal circulating free thyroxine (fT4). Evidence is lacking about the...

    Authors: David J. Stott, Jacobijn Gussekloo, Patricia M. Kearney, Nicolas Rodondi, Rudi G. J. Westendorp, Simon Mooijaart, Sharon Kean, Terence J. Quinn, Naveed Sattar, Kirsty Hendry, Robert Du Puy, Wendy P. J. Den Elzen, Rosalinde K. E. Poortvliet, Jan W. A. Smit, J. Wouter Jukema, Olaf M. Dekkers…

    Citation: BMC Endocrine Disorders 2017 17:6

    Content type: Study protocol

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  7. Factual data exploring the relationship between obesity and diabetes mellitus prevalence from rural areas of sub-Saharan Africa remain scattered and are unreliable. To address this scarceness, this work report...

    Authors: Philippe Bianga Katchunga, Justin Cikomola, Christian Tshongo, Arsene Baleke, David Kaishusha, Patrick Mirindi, Théodore Tamburhe, Yves Kluyskens, Antoine Sadiki, Socrate Bwanamudogo, Zacharie Kashongwe and Marc Twagirumukiza

    Citation: BMC Endocrine Disorders 2016 16:60

    Content type: Research article

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  8. Diabetes and hypertension increase arterial stiffness and cardiovascular events in all societies studied so far; sub-Saharan African studies are sparse. We investigated factors affecting arterial function in G...

    Authors: Kwame Yeboah, Daniel A. Antwi, Ben Gyan, Virginia Govoni, Charlotte E. Mills, J. Kennedy Cruickshank and Albert G. B. Amoah

    Citation: BMC Endocrine Disorders 2016 16:53

    Content type: Research article

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  9. Twins may be at increased risk of dysglycaemic disorders due to adverse fetal conditions. Data from Africa regarding this association is limited. We studied impaired glucose tolerance (IGT) and other types of ...

    Authors: Ditte Egegaard Hennild, Morten Bjerregaard-Andersen, Luis Carlos Joaquím, Kaare Christensen, Morten Sodemann, Henning Beck-Nielsen and Dorte Møller Jensen

    Citation: BMC Endocrine Disorders 2016 16:46

    Content type: Research article

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  10. There is a scarcity of epidemiological researches examining the relationship between blood pressure (BP) and glucose level among older adults. The objective of the current study was to investigate the associat...

    Authors: Qun Yan, Dongmei Sun, Xu Li, Guoliang Chen, Qinghu Zheng, Lun Li, Chenhong Gu and Bo Feng

    Citation: BMC Endocrine Disorders 2016 16:40

    Content type: Research article

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  11. The provision of health education involving self-care and good adherence to medications has been acknowledged to be a cost effective strategy for improving quality of life of diabetes patients. We assessed lev...

    Authors: Tefera Kassahun, Hailay Gesesew, Lillian Mwanri and Tesfahun Eshetie

    Citation: BMC Endocrine Disorders 2016 16:28

    Content type: Research article

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  12. Associations between metabolic syndrome (MetS) and osteoporotic fracture have been reported. However, the epidemiological studies are not conclusive. The objective of the study was to determine whether metabol...

    Authors: Li Qin, Zhen Yang, Weiwei Zhang, Hongxia Gu, Xiaoyong Li, Lingfei Zhu, Shuai Lu, Yin Xing, Hongmei Zhang, Yixin Niu, Guang Ning and Qing Su

    Citation: BMC Endocrine Disorders 2016 16:27

    Content type: Research article

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  13. Prevalence of diabetes and cardiovascular (CVD) disease amongst UK South Asians is higher than in the general population. Non-adherence to medicines may lead to poor clinical outcomes for South Asian patients ...

    Authors: Kanta Kumar, Sheila Greenfield, Karim Raza, Paramjit Gill and Rebecca Stack

    Citation: BMC Endocrine Disorders 2016 16:24

    Content type: Research article

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  14. Islet cell transplantation is a method to stabilize type 1 diabetes patients with hypoglycemia unawareness and unstable blood glucose levels by reducing insulin dependency and protecting against severe hypogly...

    Authors: Klemens Wallner, A. M. James Shapiro, Peter A. Senior and Christopher McCabe

    Citation: BMC Endocrine Disorders 2016 16:17

    Content type: Research article

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  15. The relationship between alterations in thyroid function and cognitive deficits has been investigated in several previous studies. Hypo-or hyperthyroidism and, to a lesser extent, subclinical thyroid dysfuncti...

    Authors: Yao Hu, Zhi-cheng Wang, Qi-hao Guo, Wei Cheng and Yan-wen Chen

    Citation: BMC Endocrine Disorders 2016 16:11

    Content type: Research article

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  16. Experiments in mice initially suggested a role for the protein angiopoietin-like 8 (ANGPTL8) in glucose homeostasis. However, subsequent experiments in model systems have challenged this proposed role. We soug...

    Authors: Katharine R. Clapham, Audrey Y. Chu, Jennifer Wessel, Pradeep Natarajan, Jason Flannick, Manuel A. Rivas, Samantha Sartori, Roxana Mehran, Usman Baber, Valentin Fuster, Robert A. Scott, Daniel J. Rader, Michael Boehnke, Mark I. McCarthy, David M. Altshuler, Sekar Kathiresan…

    Citation: BMC Endocrine Disorders 2016 16:7

    Content type: Research article

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  17. Primary hyperparathyroidism (PHPT) and metabolic syndrome (MS) have been independently related to cardiovascular morbidities, however this association is still controversial. Mexican population has a high prev...

    Authors: Victoria Mendoza-Zubieta, Gloria A Gonzalez-Villaseñor, Guadalupe Vargas-Ortega, Baldomero Gonzalez, Claudia Ramirez-Renteria, Moises Mercado, Mario A Molina-Ayala and Aldo Ferreira-Hermosillo

    Citation: BMC Endocrine Disorders 2015 15:16

    Content type: Research article

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  18. Children whose mothers had low thyroid hormone levels during pregnancy have been reported to have decreased cognitive function. The reported research is part of the follow-on study of the Controlled Antenatal ...

    Authors: Charlotte Hales, Sue Channon, Peter N Taylor, Mohd S Draman, Ilaria Muller, John Lazarus, Ruth Paradice, Aled Rees, Dionne Shillabeer, John W Gregory, Colin M Dayan and Marian Ludgate

    Citation: BMC Endocrine Disorders 2014 14:95

    Content type: Study protocol

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  19. Diabetic peripheral neuropathy (PN) and peripheral vasculopathy (PV) are major causes of foot ulcers in patients with diabetes. The early detection of PN/PV with appropriate health counseling is the best strat...

    Authors: Chia-Mou Lee, Chang-Cheng Chang, Mei-Yu Pan, Chyong-Fang Chang and Mei-Yen Chen

    Citation: BMC Endocrine Disorders 2014 14:89

    Content type: Research article

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  20. Unspecific symptoms often proceed a serious chronic disease condition long before the onset of the disease. The role of an unspecific premonitory symptom (UPMS) pattern as premonitory signs of subsequent type ...

    Authors: Jens Baumert, Christa Meisinger, Karoline Lukaschek, Rebecca Thwing Emeny, Ina-Maria Rückert, Johannes Kruse and Karl-Heinz Ladwig

    Citation: BMC Endocrine Disorders 2014 14:87

    Content type: Research article

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  21. Polycystic Ovary Syndrome (PCOS) is an endocrine-metabolic disorder that affects approximately 6-10% of women of child-bearing age. Although preliminary studies suggest that certain pollutants may act as endoc...

    Authors: Sara J Vagi, Eduardo Azziz-Baumgartner, Andreas Sjödin, Antonia M Calafat, Daniel Dumesic, Leonardo Gonzalez, Kayoko Kato, Manori J Silva, Xiaoyun Ye and Ricardo Azziz

    Citation: BMC Endocrine Disorders 2014 14:86

    Content type: Research article

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  22. The aim of this study was to empirically validate a conceptual framework and elucidate the pathways linking social determinants of health to outcomes in individuals with type 2 diabetes.

    Authors: Rebekah J Walker, Mulugeta Gebregziabher, Bonnie Martin-Harris and Leonard E Egede

    Citation: BMC Endocrine Disorders 2014 14:82

    Content type: Research article

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  23. Familial Hyperparathyroidism (HPT) and Familial benign Hypocalciuric Hypercalcemia (FHH) are the most common causes of hereditary hypercalcemia. FHH has been demonstrated to be caused by inactivating mutations...

    Authors: Eugenio Mastromatteo, Olga Lamacchia, Michela Rosaria Campo, Antonella Conserva, Filomena Baorda, Luigia Cinque, Vito Guarnieri, Alfredo Scillitani and Mauro Cignarelli

    Citation: BMC Endocrine Disorders 2014 14:81

    Content type: Case report

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  24. Polycystic ovary syndrome (PCOS) is a common condition estimated to affect 5.61% of Chinese women of reproductive age, but little is known about the prevalence and predictors in Chinese PCOS patients. This stu...

    Authors: Rong Li, Geng Yu, Dongzi Yang, Shangwei Li, Shulan Lu, Xiaoke Wu, Zhaolian Wei, Xueru Song, Xiuxia Wang, Shuxin Fu and Jie Qiao

    Citation: BMC Endocrine Disorders 2014 14:76

    Content type: Research article

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  25. We aimed to examine the prevalence of and modifiable factors associated with elevated C-reactive Protein (CRP), a marker of inflammation, in men and women with newly diagnosed Type 2 Diabetes mellitus (DM) in ...

    Authors: Elisabeth Svensson, Anil Mor, Jørgen Rungby, Klara Berencsi, Jens Steen Nielsen, Jacob V Stidsen, Søren Friborg, Ivan Brandslund, Jens Sandahl Christiansen, Henning Beck-Nielsen, Henrik Toft Sørensen and Reimar W Thomsen

    Citation: BMC Endocrine Disorders 2014 14:74

    Content type: Research article

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  26. The initial treatment strategy for patients with type 2 diabetes includes lifestyle change recommendations. When patients are not successful in controlling their blood glucose levels through healthier lifestyl...

    Authors: Andrew Maguire, Beth D Mitchell and Javier Cid Ruzafa

    Citation: BMC Endocrine Disorders 2014 14:73

    Content type: Research article

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  27. It is not clear to what extent educational programs aimed at promoting diabetes self-management in ethnic minority groups are effective. The aim of this work was to systematically review the effectiveness of e...

    Authors: Ignacio Ricci-Cabello, Isabel Ruiz-Pérez, Antonio Rojas-García, Guadalupe Pastor, Miguel Rodríguez-Barranco and Daniela C Gonçalves

    Citation: BMC Endocrine Disorders 2014 14:60

    Content type: Research article

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  28. α-amidation is a final, essential step in the biosynthesis of about half of all peptide hormones and neurotransmitters. Peptidylglycine α-amidating monooxygenase (PAM), with enzymatic domains that utilize Cu a...

    Authors: Eric D Gaier, Alison Kleppinger, Martina Ralle, Jonathan Covault, Richard E Mains, Anne M Kenny and Betty A Eipper

    Citation: BMC Endocrine Disorders 2014 14:58

    Content type: Research article

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  29. Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are rare neuroendocrine tumors, and lack of data in Asian populations especially in China. The aim of this retrospective study was to assess the clini...

    Authors: Xianbin Zhang, Li Ma, Haidong Bao, Jing Zhang, Zhongyu Wang and Peng Gong

    Citation: BMC Endocrine Disorders 2014 14:54

    Content type: Research article

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  30. Obesity and diabetes mellitus are well-defined risk factors for cardiovascular mortality. The impact of antecedent hyperglycemia and body size on mortality in critical ill patients in intensive care units (ICU...

    Authors: Marina Verçoza Viana, Rafael Barberena Moraes, Amanda Rodrigues Fabbrin, Manoella Freitas Santos, Vanessa Bielefeldt Leotti Torman, Silvia Regina Vieira, Jorge Luiz Gross, Luis Henrique Canani and Fernando Gerchman

    Citation: BMC Endocrine Disorders 2014 14:50

    Content type: Research article

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  31. In patients with type 2 diabetes, chronic kidney disease (CKD) is associated with increased risk of hypoglycaemia and death. Yet, it remains uncertain whether hypoglycaemia-associated mortality is modified by ...

    Authors: Alice PS Kong, Xilin Yang, Andrea Luk, Kitty KT Cheung, Ronald CW Ma, Wing Yee So, Chung Shun Ho, Michael HM Chan, Risa Ozaki, Chun Chung Chow, Nicola Brown and Juliana CN Chan

    Citation: BMC Endocrine Disorders 2014 14:48

    Content type: Research article

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  32. Mexican Americans are at an increased risk of both thyroid dysfunction and metabolic syndrome (MS). Thus it is conceivable that some components of the MS may be associated with the risk of thyroid dysfunction ...

    Authors: Manju Mamtani, Hemant Kulkarni, Thomas D Dyer, Laura Almasy, Michael C Mahaney, Ravindranath Duggirala, Anthony G Comuzzie, Paul B Samollow, John Blangero and Joanne E Curran

    Citation: BMC Endocrine Disorders 2014 14:46

    Content type: Research article

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  33. Quantifying the burden of diabetes mellitus is fundamental for managing patients in health service delivery systems and improves the understanding of the importance of prevention and early intervention of diab...

    Authors: Carola A Huber, Matthias Schwenkglenks, Roland Rapold and Oliver Reich

    Citation: BMC Endocrine Disorders 2014 14:44

    Content type: Research article

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  34. Testicular morphology and immunohistochemical studies have never been reported in genetically documented adult patients with 5 alpha-reductase type 2 deficiency (5α-R2 deficiency).

    Authors: Lavinia Vija, Sophie Ferlicot, Diana Paun, Hélène Bry-Gauillard, Gabriela Berdan, Issam Abd-Alsamad, Marc Lombès and Jacques Young

    Citation: BMC Endocrine Disorders 2014 14:43

    Content type: Case report

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  35. Increased morbidity and mortality associated with conventional glucocorticoid replacement therapy for primary adrenal insufficiency (primary AI; estimated prevalence 93–140/million), secondary AI (estimated pr...

    Authors: Bertil Ekman, David Fitts, Claudio Marelli, Robert D Murray, Marcus Quinkler and Pierre MJ Zelissen

    Citation: BMC Endocrine Disorders 2014 14:40

    Content type: Research article

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  36. Increased risk of osteoporosis and its clinical significance in patients with diabetes is controversial. We analyze osteoporosis prevalence and determinants of bone mineral density (BMD) in patients with type ...

    Authors: Gudrun Leidig-Bruckner, Sonja Grobholz, Thomas Bruckner, Christa Scheidt-Nave, Peter Nawroth and Jochen G Schneider

    Citation: BMC Endocrine Disorders 2014 14:33

    Content type: Research article

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  37. The purpose of this study was to evaluate the association between blood manganese levels and the prevalence of chronic diseases in the Korean population.

    Authors: Eun Sil Koh, Sung Jun Kim, Hye Eun Yoon, Jong Hee Chung, Sungjin Chung, Cheol Whee Park, Yoon Sik Chang and Seok Joon Shin

    Citation: BMC Endocrine Disorders 2014 14:24

    Content type: Research article

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  38. Diabetic retinopathy (DR) is one of the leading causes for complete loss of vision among working-aged adults around the world. The present study aims to evaluate the rate of DR and its risk factors among the a...

    Authors: Prasad Katulanda, Yasindu C Waniganayake, Priyanga Ranasinghe, WM Udai Akalanka Wijetunga, Mahesh Jayaweera, Nishantha P Wijesinghe, Rezvi Sheriff and David R Matthews

    Citation: BMC Endocrine Disorders 2014 14:20

    Content type: Research article

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  39. Emerging epidemiological evidence suggest an association between metabolic syndrome and fractures. However, whether metabolic syndrome is an independent risk or protective factor of fractures remains controver...

    Authors: Kan Sun, Jianmin Liu, Nan Lu, Hanxiao Sun and Guang Ning

    Citation: BMC Endocrine Disorders 2014 14:13

    Content type: Research article

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  40. Thyroid dysfunction is a common complication of chronic hepatitis C (CHC) and its therapy. Takotsubo cardiomyopathy (TCM) is a multifactorial, stress related cardiomyopathy, rarely reported in association with th...

    Authors: Carmen Sorina Martin, Luminita Nicoleta Ionescu, Carmen Gabriela Barbu, Anca Elena Sirbu, Ioana Maria Lambrescu, Ioana Smarandita Lacau, Doina Ruxandra Dimulescu and Simona Vasilica Fica

    Citation: BMC Endocrine Disorders 2014 14:10

    Content type: Case report

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  41. Not all obese subjects have an adverse metabolic profile predisposing them to developing type 2 diabetes or cardiovascular disease. The BioSHaRE-EU Healthy Obese Project aims to gain insights into the conseque...

    Authors: Jana V van Vliet-Ostaptchouk, Marja-Liisa Nuotio, Sandra N Slagter, Dany Doiron, Krista Fischer, Luisa Foco, Amadou Gaye, Martin Gögele, Margit Heier, Tero Hiekkalinna, Anni Joensuu, Christopher Newby, Chao Pang, Eemil Partinen, Eva Reischl, Christine Schwienbacher…

    Citation: BMC Endocrine Disorders 2014 14:9

    Content type: Research article

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  42. The rate of bone turnover is closely related to osteoporosis risk. We investigated the correlation between bone turnover markers and BMD at various skeletal sites in healthy native Chinese women, and to study ...

    Authors: Xi-Yu Wu, Hong-Li Li, Hui Xie, Xiang-Hang Luo, Yi-Qun Peng, Ling-Qing Yuan, Zhi-Feng Sheng, Ru-Chun Dai, Xian-Ping Wu and Er-Yuan Liao

    Citation: BMC Endocrine Disorders 2014 14:8

    Content type: Research article

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  43. Existing inconclusive data on the relationship between vitamin D status and human glucose homeostasis suggests that other factors, such as adiposity, might influence this relationship. The present study aimed ...

    Authors: Hataikarn Nimitphong, La-or Chailurkit, Suwannee Chanprasertyothin, Piyamitr Sritara and Boonsong Ongphiphadhanakul

    Citation: BMC Endocrine Disorders 2013 13:60

    Content type: Research article

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  44. Testing for 25-hydroxyvitamin D [25(OH)D] has increased dramatically in recent years. The present report compares overall utilization and results for 25(OH)D orders at two academic medical centers - one in New...

    Authors: Jonathan R Genzen, Jennifer T Gosselin, Thomas C Wilson, Emilian Racila and Matthew D Krasowski

    Citation: BMC Endocrine Disorders 2013 13:52

    Content type: Research article

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  45. Over the last few years, awareness and detection rates of hypopituitarism following traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) has steadily increased. Moreover, recent studies have found th...

    Authors: Steffen Kristian Fleck, Henri Wallaschofski, Christian Rosenstengel, Marc Matthes, Thomas Kohlmann, Matthias Nauck, Henry Werner Siegfried Schroeder and Christin Spielhagen

    Citation: BMC Endocrine Disorders 2013 13:51

    Content type: Research article

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  46. Iodine deficiency affects nearly 1.9 billion people worldwide, but it can be prevented by salt iodization. This cross-sectional survey assessed current iodine status, iodized salt coverage and risk factors for...

    Authors: Barbara Matthys, Mohbegim Davlatmamadova, Gulzira Karimova, Vreni Jean-Richard, Michael B Zimmermann and Kaspar Wyss

    Citation: BMC Endocrine Disorders 2013 13:50

    Content type: Research article

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  47. Insulin resistance has been associated with metabolic and hemodynamic alterations and higher cardio metabolic risk. There is great variability in the threshold homeostasis model assessment of insulin resistanc...

    Authors: Pilar Gayoso-Diz, Alfonso Otero-González, María Xosé Rodriguez-Alvarez, Francisco Gude, Fernando García, Angel De Francisco and Arturo González Quintela

    Citation: BMC Endocrine Disorders 2013 13:47

    Content type: Research article

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