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Diabetes and Metabolism

This section concerns all aspects of diabetes and metabolic syndrome including but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Besides the classical role of vitamin D on calcium and bone homeostasis, vitamin D deficiency has recently been identified as a contributing factor in the onset of insulin resistance in type 2 diabetes mellitu...

    Authors: Yvonne HM Krul-Poel, Hans van Wijland, Frank Stam, Edwin ten Boekel, Paul Lips and Suat Simsek

    Citation: BMC Endocrine Disorders 2014 14:59

    Content type: Study protocol

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  2. Despite the consistent relationship between serum γ-glutamyltransferase (GGT) and type 2 diabetes (T2D), one unsolved issue is the role of serum GGT in the well-known association between obesity and T2D. This ...

    Authors: Nam Soo Hong, Jeong-Gook Kim, Yu-Mi Lee, Hyun-Woo Kim, Sin Kam, Keon-Yeop Kim, Ki-Su Kim and Duk-Hee Lee

    Citation: BMC Endocrine Disorders 2014 14:57

    Content type: Research article

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  3. Advanced glycation endproducts (AGEs) contribute to the development of vascular complications of diabetes and have been recently implicated in the pathogenesis of diabetes. Since AGEs are generated within food...

    Authors: Nicole J Kellow, Melinda T Coughlan, Gayle S Savige and Christopher M Reid

    Citation: BMC Endocrine Disorders 2014 14:55

    Content type: Study protocol

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  4. Oral medication for patients with type 2 diabetes mellitus plays an important role in diabetes care and is associated with a high level self-care behavior and self-management. However, poor adherence to diabet...

    Authors: Sunya-Lee Antoine, Dawid Pieper, Tim Mathes and Michaela Eikermann

    Citation: BMC Endocrine Disorders 2014 14:53

    Content type: Research article

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  5. Obesity and gestational diabetes (GDM) in pregnancy are recognized risk factors for adverse outcomes, including cesarean section (CS), macrosomia and preeclampsia. The aim of this study was to investigate the ...

    Authors: Hayfaa A Wahabi, Amel A Fayed, Rasmieh A Alzeidan and Ahmed A Mandil

    Citation: BMC Endocrine Disorders 2014 14:47

    Content type: Research article

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  6. 11 patients were referred to our Molecular Genetics Department at the Royal Devon and Exeter Hospital between 2000-2012 with a physician’s diagnosis of remitting diabetes. Our aim was to identify patients with...

    Authors: Tarig Babiker, Ali J Chakera, Maggie Shepherd and Andrew T Hattersley

    Citation: BMC Endocrine Disorders 2014 14:45

    Content type: Research article

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  7. Previously considered as a disease of the affluent, west or urban people and not of public health importance, diabetes mellitus is increasingly becoming a significant cause of morbidity and mortality in sub-Sahar...

    Authors: Kelias Phiri Msyamboza, Chimwemwe J Mvula and Damson Kathyola

    Citation: BMC Endocrine Disorders 2014 14:41

    Content type: Research article

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  8. Few studies have examined young adults with type 1 diabetes use of health services and the development of vascular complications. As part of the Youth Outreach for Diabetes (YOuR-Diabetes) project, this study ...

    Authors: Steven James, Lin Perry, Robyn Gallagher, Julia Lowe, Janet Dunbabin, Patrick McElduff, Shamasunder Acharya and Katharine Steinbeck

    Citation: BMC Endocrine Disorders 2014 14:39

    Content type: Research article

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  9. Canagliflozin is a sodium glucose co-transporter 2 inhibitor developed for the treatment of patients with type 2 diabetes mellitus (T2DM). The efficacy and safety of canagliflozin were evaluated in patients wi...

    Authors: Alan Sinclair, Bruce Bode, Stewart Harris, Ujjwala Vijapurkar, Cristiana Mayer, Albert Fung, Wayne Shaw, Keith Usiskin, Mehul Desai and Gary Meininger

    Citation: BMC Endocrine Disorders 2014 14:37

    Content type: Research article

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  10. Insulin aspart (IAsp) and its biphasic preparations BIAsp50 and BIAsp70 (containing 50% and 70% IAsp, respectively) have distinct glucose-lowering properties as compared to human insulin (HI). We investigated ...

    Authors: Zhulin Ma, Jens Sandahl Christiansen, Torben Laursen, Chunsen Wu, Torsten Lauritzen, Tina Parkner and Jan Frystyk

    Citation: BMC Endocrine Disorders 2014 14:35

    Content type: Research article

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  11. Diabetes education and self-care remains the cornerstone of diabetes management. There are many structured diabetes modules available in the United Kingdom, Europe and United States of America. Contrastingly, ...

    Authors: Badariah Ahmad, Amutha Ramadas, Quek Kia Fatt and Anuar Zaini Md Zain

    Citation: BMC Endocrine Disorders 2014 14:31

    Content type: Research article

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  12. Continuous intraperitoneal insulin infusion (CIPII) with an implantable pump is a treatment option for patients with type 1 diabetes mellitus (T1DM). Aim of the present study was to describe the long-term cour...

    Authors: Peter R van Dijk, Susan JJ Logtenberg, Klaas H Groenier, Rijk OB Gans, Nanne Kleefstra and Henk JG Bilo

    Citation: BMC Endocrine Disorders 2014 14:30

    Content type: Research article

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  13. The effects of brain natriuretic peptide (BNP) on the risk of cardiovascular disease and atherosclerosis have been studied. However, little information is available regarding peripheral arterial disease (PAD),...

    Authors: Qi-hui Jin, Wan-lan Ye, Huai-hong Chen, Xiao-jun He, Tian-lang Li, Qiang Liu, Liang Zhong, Lei Xu and Chun-mao Han

    Citation: BMC Endocrine Disorders 2014 14:27

    Content type: Research article

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  14. To study hormonal changes associated with severe hyperglycemia in critically ill children and the relationship with prognosis and length of stay in intensive care.

    Authors: Yolanda Ballestero, Jesús López-Herce, Rafael González, Maria José Solana, Jimena del Castillo, Javier Urbano, Marta Botran, Ana García, Nieves López and Jose María Bellón

    Citation: BMC Endocrine Disorders 2014 14:25

    Content type: Research article

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  15. The aim of the present study is to examine the clinical indices related to cardiovascular risk management of Greek patients with type 2 diabetes, before and after the major economic crisis that emerged in the ...

    Authors: Stavros Liatis, Stavroula Papaoikonomou, Asimina Ganotopoulou, Athanasia Papazafiropoulou, Constantinos Dinos, Marios Michail, Apostolos Xilomenos, Andreas Melidonis and Stavros Pappas

    Citation: BMC Endocrine Disorders 2014 14:23

    Content type: Research article

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  16. Due to ongoing rise in need for care for people with chronic diseases and lagging increase in number of care providers, alternative forms of care provision and self-management support are needed. Empowering pa...

    Authors: Yvonne Roelofsen, Steven H Hendriks, Floor Sieverink, Michael van Vugt, Kornelis JJ van Hateren, Frank J Snoek, Maartje de Wit, Rijk OB Gans, Klaas H Groenier, Julia EWC van Gemert-Pijnen, Nanne Kleefstra and Henk JG Bilo

    Citation: BMC Endocrine Disorders 2014 14:22

    Content type: Study protocol

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  17. Many type 2 diabetes mellitus patients face difficulties self-managing their illness, which can lead to high levels of diabetes-related distress. Diabetes distress may be decreased by peer support, as peers un...

    Authors: Lianne de Vries, Amber AWA van der Heijden, Esther van 't Riet, Caroline A Baan, Piet J Kostense, Mieke Rijken, Guy EHM Rutten and Giel Nijpels

    Citation: BMC Endocrine Disorders 2014 14:21

    Content type: Study protocol

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  18. Hyperglycemia induces chromatin remodeling with consequences on differential gene expression in mouse hepatocytes, similar to what occurs during aging. The liver is the central organ for the regulation of gluc...

    Authors: Flávia G Ghiraldini, André B Silveira, Dirk A Kleinjan, Nick Gilbert and Maria Luiza S Mello

    Citation: BMC Endocrine Disorders 2014 14:19

    Content type: Research article

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  19. To compare the safety and efficacy of saxagliptin 2.5 mg twice daily (BID) versus placebo add-on therapy to metformin immediate release (IR) in patients with type 2 diabetes and inadequate glycemic control wit...

    Authors: Judith L White, Patricia Buchanan, Jia Li and Robert Frederich

    Citation: BMC Endocrine Disorders 2014 14:17

    Content type: Research article

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  20. The possible association between metabolic syndrome (MS) and bone mineral density (BMD) has been highlighted recently. However, the exact effects of MS on calcaneal quantitative ultrasound (QUS) parameters rem...

    Authors: Min Sun, Mengdie Cao, Qi Fu, Zhenxin Zhu, Chuchen Meng, Jia Mao, Yun Shi, Yu Duan, Wei Tang, Xiaoping Huang, Wei He and Tao Yang

    Citation: BMC Endocrine Disorders 2014 14:14

    Content type: Research article

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  21. Diabetic cardiomyopathy is associated with a number of functional and structural pathological changes such as left ventricular dysfunction, cardiac remodeling, and apoptosis. The primary cause of diabetic card...

    Authors: Romana Bohuslavova, Frantisek Kolar, David Sedmera, Lada Skvorova, Frantisek Papousek, Jan Neckar and Gabriela Pavlinkova

    Citation: BMC Endocrine Disorders 2014 14:11

    Content type: Research article

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  22. Adipose tissue (AT) contributes to metabolic dysfunction through imbalanced production of adipokines, including cytokines. Visceral AT in particular is associated with metabolic disorders, indicating a specifi...

    Authors: Henrik Svensson, Birgitta Odén, Staffan Edén and Malin Lönn

    Citation: BMC Endocrine Disorders 2014 14:7

    Content type: Research article

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  23. Several studies have shown the association of solute carrier family 30 (zinc transporter) member 8 (SLC30A8) rs13266634 with type 2 diabetes (T2D). However, the association of alternative variants and haplotyp...

    Authors: Sameer D Salem, Riyadh Saif-Ali, Ikram S Ismail, Zaid Al-Hamodi and Sekaran Muniandy

    Citation: BMC Endocrine Disorders 2014 14:2

    Content type: Research article

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  24. One possible barrier to effective diabetes self-management is hypoglycaemia associated with diabetes medication. The current study was conducted to characterize hypoglycaemic events among UK patients with type...

    Authors: Beth D Mitchell, Jeffrey Vietri, Anthony Zagar, Bradley Curtis and Matthew Reaney

    Citation: BMC Endocrine Disorders 2013 13:59

    Content type: Research article

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  25. The discovery of sodium-glucose co-transporter 2 (SGLT2) inhibitors, with a novel mechanism independent of insulin secretion or sensitization, bring about a new therapeutic approach to the management of type 2...

    Authors: Asres Berhan and Alex Barker

    Citation: BMC Endocrine Disorders 2013 13:58

    Content type: Research article

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  26. Lifestyle intervention in type 2 diabetes mellitus (T2DM) is effective but needs a special local setting and is costly. Therefore, in a randomized-controlled trial we tested the hypothesis that the autonomous ...

    Authors: Kerstin Kempf and Stephan Martin

    Citation: BMC Endocrine Disorders 2013 13:57

    Content type: Research article

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  27. Allograft inflammatory factor 1 (AIF-1) is a putative obesity gene. Our aim was to examine the expression of AIF-1 in human white adipose tissue (WAT) in relation to obesity and metabolic phenotypes in women.

    Authors: Silvia Lorente-Cebrián, Pauline Decaunes, Elisabeth Dungner, Anne Bouloumié, Peter Arner and Ingrid Dahlman

    Citation: BMC Endocrine Disorders 2013 13:54

    Content type: Research article

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  28. Self-management is recognized as the cornerstone of overall diabetes management. Web-based self-management programs have the potential of supporting type 2 diabetes patients with managing their diabetes and re...

    Authors: Michael van Vugt, Maartje de Wit, Steven H Hendriks, Yvonne Roelofsen, Henk JG Bilo and Frank J Snoek

    Citation: BMC Endocrine Disorders 2013 13:53

    Content type: Study protocol

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  29. Immigrants from South Asia to Western countries have a high prevalence of type 2 diabetes mellitus (T2DM). We explored pathogenic factors that might contribute to the high risk of T2DM in Pakistani immigrants ...

    Authors: Cecilie Wium, Erlend T Aasheim, Thor Ueland, Annika E Michelsen, Per M Thorsby, Ingegerd F Larsen, Peter A Torjesen, Pål Aukrust and Kåre I Birkeland

    Citation: BMC Endocrine Disorders 2013 13:49

    Content type: Research article

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  30. To examine the views and current practice of SMBG among Black Caribbean and South Asian individuals with non-insulin treated Type 2 diabetes mellitus.

    Authors: Enza Gucciardi, Mariella Fortugno, Andrea Senchuk, Heather Beanlands, Elizabeth McCay and Elizabeth E Peel

    Citation: BMC Endocrine Disorders 2013 13:46

    Content type: Research article

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  31. The detection of microvascular damage in type 1 diabetes is difficult and traditional investigations do not detect changes until they are well established. The purpose of this study was to investigate the comb...

    Authors: Sarah P M Hosking, Rani Bhatia, Patricia A Crock, Ian Wright, Marline L Squance and Glenn Reeves

    Citation: BMC Endocrine Disorders 2013 13:41

    Content type: Research article

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  32. Animal studies have shown that zinc intake has protective effects against type 2 diabetes, but few studies have been conducted to examine this relationship in humans. The aim of this study is to investigate if...

    Authors: Khanrin Phungamla Vashum, Mark McEvoy, Zumin Shi, Abul Hasnat Milton, Md Rafiqul Islam, David Sibbritt, Amanda Patterson, Julie Byles, Deborah Loxton and John Attia

    Citation: BMC Endocrine Disorders 2013 13:40

    Content type: Research article

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  33. Ghrelin and peptide YY (PYY) are appetite regulating hormones secreted from the gastrointestinal tract (gut). Aside from their known effect on energy homeostasis, accumulating data indicates that these gut hor...

    Authors: Peyvand Amini, Farrell Cahill, Danny Wadden, Yunqi Ji, Pardis Pedram, Sangeetha Vidyasankar, Yanqing Yi, Wayne Gulliver, Gary Paterno, Hongwei Zhang, Alecia Rideout and Guang Sun

    Citation: BMC Endocrine Disorders 2013 13:35

    Content type: Research article

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  34. Insufficient vitamin D status and increased renin-angiotensin system (RAS) activity have been associated with renal-vascular disease and nephropathy in diabetes. Accumulating evidence indicates that vitamin D ...

    Authors: Jenifer M Brown, Kristina Secinaro, Jonathan S Williams and Anand Vaidya

    Citation: BMC Endocrine Disorders 2013 13:33

    Content type: Study protocol

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  35. The interaction of advanced glycation end products (AGEs) and its receptor (RAGE) has played an important role in the pathogenesis of diabetes and its complications. A soluble form of RAGE (sRAGE) has been rep...

    Authors: Tarek MK Motawi, Mohamed A Abou-Seif, Ahmed MA Bader and Mohamed O Mahmoud

    Citation: BMC Endocrine Disorders 2013 13:32

    Content type: Research article

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  36. Being an intermediate stage in the development of diabetes, pre-diabetics were estimated as high as 14% to 63% in China and one to three quarters of them will develop into diabetes within 10 years. It is well ...

    Authors: Rui Feng, Kaichun Li, Jing Cheng, Shaoyu Xie, Jing Chai, Pingfu Wei and Debin Wang

    Citation: BMC Endocrine Disorders 2013 13:28

    Content type: Study protocol

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  37. In randomized controlled trials (RCTs), colesevelam HCI, added to other anti-diabetic therapy, reduced hemoglobin A1C by approximately 0.3% to 0.4% over 16- to 26-weeks compared with an increase of approximate...

    Authors: Richard A Hansen, Joel F Farley, Matthew L Maciejewski, Xin Ye, Chunlin Qian and Ben Powers

    Citation: BMC Endocrine Disorders 2013 13:24

    Content type: Research article

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  38. The editors of BMC Endocrine Disorders would like to thank all our reviewers who have contributed to the journal in Volume 12 (2012).

    Authors: Tim Shipley

    Citation: BMC Endocrine Disorders 2013 13:6

    Content type: Reviewer acknowledgement

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  39. Insulin resistance is frequent in human immunodeficiency virus (HIV) infection and may be related to antiretroviral therapy. Cytokines secreted by adipose tissue (adipokines) are linked to insulin sensitivity....

    Authors: Victoria Arama, Catalin Tiliscan, Adrian Streinu-Cercel, Daniela Ion, Raluca Mihailescu, Daniela Munteanu, Adriana Hristea and Stefan Sorin Arama

    Citation: BMC Endocrine Disorders 2013 13:4

    Content type: Research article

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