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Diabetes and Metabolism

Section edited by Abd Tahrani

This section concerns all aspects of diabetes and metabolic syndrome including but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Content type: Research article

    Hypoxia inducible factor 1 (HIF-1) activates protective pathways to counteract hypoxia and prevent tissue damage in conjunction with renal injury. The aim of this study was to evaluate a role of HIF-1 in diabe...

    Authors: Romana Bohuslavova, Radka Cerychova, Katerina Nepomucka and Gabriela Pavlinkova

    Citation: BMC Endocrine Disorders 2017 17:48

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  2. Content type: Study protocol

    Diabetes risk is extremely high for Latinos from low-income households. Health guidelines recommend that individuals learn strategies to self-manage their diabetes, but getting people to adopt required lifesty...

    Authors: Janet Page-Reeves, Lidia Regino, Cristina Murray-Krezan, Molly Bleecker, Erik Erhardt, Mark Burge, Elaine Bearer and Shiraz Mishra

    Citation: BMC Endocrine Disorders 2017 17:46

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  3. Content type: Research article

    Type 2 diabetes (T2D) is associated with substantial morbidity and mortality. Individuals with a family history of T2D are at an increased risk of developing the disease. The aim of this study was to assess me...

    Authors: Josefin Henninger, Araz Rawshani, Ann Hammarstedt and Björn Eliasson

    Citation: BMC Endocrine Disorders 2017 17:40

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  4. Content type: Research article

    The metabolic syndrome (MetS) is a clustering of interrelated risk factors which doubles the risk of cardio-vascular disease (CVD) in 5–10 years and increases the risk of type 2 diabetes 5 fold. The identifica...

    Authors: Geoffrey Omuse, Daniel Maina, Mariza Hoffman, Jane Mwangi, Caroline Wambua, Elizabeth Kagotho, Angela Amayo, Peter Ojwang, Zulfiqarali Premji, Kiyoshi Ichihara and Rajiv Erasmus

    Citation: BMC Endocrine Disorders 2017 17:37

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    The Erratum to this article has been published in BMC Endocrine Disorders 2017 17:43

  5. Content type: Research article

    Achieving control of glycated hemoglobin (HbA1c), blood pressure (BP), and body weight (BW) remains a challenge for most patients with type 2 diabetes mellitus (T2DM). In clinical trials, canagliflozin (CANA),...

    Authors: Carol H. Wysham, Patrick Lefebvre, Dominic Pilon, Mike Ingham, Marie-Hélène Lafeuille, Bruno Emond, Rhiannon Kamstra, Wing Chow, Michael Pfeifer and Mei Sheng Duh

    Citation: BMC Endocrine Disorders 2017 17:32

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  6. Content type: Research article

    Evidence suggests disparities in quality of care (QoC) indicators based on sex exist in adults diagnosed with diabetes; however, this research is limited. Therefore, the objective of this research study was to...

    Authors: Joni S. Williams, Kinfe G. Bishu, Alessandra St. Germain and Leonard E. Egede

    Citation: BMC Endocrine Disorders 2017 17:31

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  7. Content type: Research article

    Diabetes registry enables practitioners to measure the characteristics and patterns of diabetes across their patient population. They also provide insight into practice patterns which can be very effective in ...

    Authors: Jaweed Akhter, Asma Ahmed, Minaz Mawani, Laila Lakhani, Ayaz Kalsekar, Shehla Tabassum and Najmul Islam

    Citation: BMC Endocrine Disorders 2017 17:30

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  8. Content type: Research article

    Increased carotid-femoral pulse wave velocity (PWV) has been associated with incident cardiovascular disease, independently of traditional risk factors. Cardiac autonomic dysfunction is a common complication o...

    Authors: Stamatina Chorepsima, Ioanna Eleftheriadou, Anastasios Tentolouris, Ioannis Moyssakis, Athanasios Protogerou, Alexandros Kokkinos, Petros P. Sfikakis and Nikolaos Tentolouris

    Citation: BMC Endocrine Disorders 2017 17:27

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  9. Content type: Study protocol

    Cognitive impairment is common in type 2 diabetes mellitus, and there is a strong association between type 2 diabetes and Alzheimer’s disease. However, we do not know which type 2 diabetes patients will dement...

    Authors: Sheila K. Patel, Carolina Restrepo, Emilio Werden, Leonid Churilov, Elif I. Ekinci, Piyush M. Srivastava, Jay Ramchand, Bryan Wai, Brian Chambers, Christopher J. O’Callaghan, David Darby, Vladimir Hachinski, Toby Cumming, Geoff Donnan, Louise M. Burrell and Amy Brodtmann

    Citation: BMC Endocrine Disorders 2017 17:24

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  10. Content type: Research article

    Many studies indicated that mean platelet volume (MPV) and platelet distribution width (PDW) may be valuable in the diagnosis and management of clinical disorders; also, serum butyrylcholinesterase activity (B...

    Authors: Suzan Omar Mousa, Samira Zein Sayed, Mahmoud Mohammed Moussa and Ahmed Hamdy Hassan

    Citation: BMC Endocrine Disorders 2017 17:23

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  11. Content type: Study protocol

    Type 2 diabetes mellitus (T2DM) patients experience many psychosocial problems related to their diabetes. These often lead to emotional disorders such as distress, stress, anxiety and depression, resulting in ...

    Authors: Boon-How Chew, Rimke C. Vos, Sazlina Shariff Ghazali, Nurainul Hana Shamsuddin, Aaron Fernandez, Firdaus Mukhtar, Mastura Ismail, Azainorsuzila Mohd Ahad, Narayanan N. Sundram, Siti Zubaidah Mohd Ali and Guy E. H. M. Rutten

    Citation: BMC Endocrine Disorders 2017 17:22

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  12. Content type: Research article

    Previous research has failed to examine more than one self-care behaviour in type 2 diabetes patients in Ghana. The purpose of this study is to investigate adult Ghanaian type 2 diabetes patients’ adherence to...

    Authors: Victor Mogre, Zakaria Osman Abanga, Flora Tzelepis, Natalie A. Johnson and Christine Paul

    Citation: BMC Endocrine Disorders 2017 17:20

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  13. Content type: Research article

    The liver-derived C-reactive protein (CRP) is a sensitive and systemic biomarker of inflammation, and has been associated with increased risk of developing type 2 diabetes in populations other than Chinese. Th...

    Authors: An Pan, Yeli Wang, Jian-Min Yuan and Woon-Puay Koh

    Citation: BMC Endocrine Disorders 2017 17:8

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  14. Content type: Study protocol

    The benefit of Self-monitoring of Blood Glucose (SMBG) in people with non-insulin treated type 2 diabetes remains unclear with inconsistent evidence from randomised controlled trials fuelling the continued deb...

    Authors: Sharon Parsons, Stephen Luzio, Stephen Bain, John Harvey, Jillian McKenna, Atir Khan, Sam Rice, Alan Watkins and David R. Owens

    Citation: BMC Endocrine Disorders 2017 17:4

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  15. Content type: Research article

    Despite the recognition of the importance of diagnosing dysglycaemia in patients with acute coronary syndrome (ACS) there remains a lack of consensus on the best screening modality. Our primary aims were to de...

    Authors: Muhammad A. Karamat, Umar Y. Raja, Susan E. Manley, Alan Jones, Wasim Hanif and Abd A. Tahrani

    Citation: BMC Endocrine Disorders 2017 17:3

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  16. Content type: Research article

    The link between type 1 diabetes and thyroid autoimmunity is well described. The same cannot be said for type 2 diabetes where results have been mixed so far. We investigated the prevalence and determinants of...

    Authors: Osei Sarfo-Kantanka, Fred Stephen Sarfo, Eunice Oparebea Ansah, Ernest Yorke, Josephine Akpalu, Bernard C. Nkum and Benjamin Eghan

    Citation: BMC Endocrine Disorders 2017 17:2

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  17. Content type: Research article

    Obese, type two diabetics are at an increased risk for fracturing their limb bones in comparison to the general population. Phytoestrogens like as the soy isoflavone genistein have been shown to protect agains...

    Authors: Britton Odle, Nathan Dennison, Layla Al-Nakkash, Tom L. Broderick and Jeffrey H. Plochocki

    Citation: BMC Endocrine Disorders 2017 17:1

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  18. Content type: Research article

    To investigate the ameliorating effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on blood glucose control in patients with type 2 diabetes mellitus who were previously untreated with or who have a po...

    Authors: Hiroshi Sakura, Naotake Hashimoto, Kazuo Sasamoto, Hiroshi Ohashi, Sumiko Hasumi, Noriko Ujihara, Tadasu Kasahara, Osamu Tomonaga, Hideo Nunome, Masashi Honda and Yasuhiko Iwamoto

    Citation: BMC Endocrine Disorders 2016 16:70

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  19. Content type: Research article

    The prevalence of diabetes mellitus and factors associated with it, nowadays, are increasing in alarming rates among different occupational groups. Of these occupational groups are Police officers that, often,...

    Authors: Tariku Tesfaye, Bilal Shikur, Tariku Shimels and Naod Firdu

    Citation: BMC Endocrine Disorders 2016 16:68

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  20. Content type: Research article

    We aimed to describe the safety and efficacy of insulin glargine in Chinese paediatric patients with type 1 diabetes mellitus (T1DM). Neutral protamine Hagedorn (NPH) insulin was the reference therapy.

    Authors: Min Liu, Zhiguang Zhou, Jinhua Yan, Pin Li, Wenhui Song, Junfen Fu, Xiaobo Chen, Weigang Zhao, Li Xi, Xiaoping Luo, Liang Sha, Xueyuan Deng and Chunxiu Gong

    Citation: BMC Endocrine Disorders 2016 16:67

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  21. Content type: Research article

    Guidelines for frequency of Type 2 diabetes mellitus (DM) screening remain unclear, with proposed screening intervals typically based on expert opinion. This study aims to demonstrate that HbA1c screening inte...

    Authors: Sachiko Ohde, Emily McFadden, Gautam A. Deshpande, Hiroshi Yokomichi, Osamu Takahashi, Tsuguya Fukui, Rafael Perera and Zentaro Yamagata

    Citation: BMC Endocrine Disorders 2016 16:65

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  22. Content type: Research article

    Identifying patients with diabetes at increased risk of chronic kidney disease (CKD) is essential to prevent/slow the progression to end-stage renal disease (ESRD). CKD and diabetic peripheral neuropathy (DPN)...

    Authors: Quratul A. Altaf, Hamed Sadiqi, Milan K. Piya and Abd A. Tahrani

    Citation: BMC Endocrine Disorders 2016 16:64

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  23. Content type: Research article

    Cases of severe hypoglycaemia were reported in HIV/AIDS patients receiving high dose of the sulfonylurea co-trimoxazole for opportunistic infections. Whether co-trimoxazole at prophylactic dose would induce si...

    Authors: Bernold Kenteu, Jean Jacques N. Noubiap, Martine Claude Etoa, Marcel Azabji-Kenfack, Mesmin Dehayem and Eugene Sobngwi

    Citation: BMC Endocrine Disorders 2016 16:62

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  24. Content type: Research article

    Initial classification of diabetes of young may require revision to improve diagnostic accuracy of different forms of diabetes.

    Authors: Rasa Verkauskiene, Evalda Danyte, Rimante Dobrovolskiene, Ingrida Stankute, Diana Simoniene, Dovile Razanskaite-Virbickiene, Audrone Seibokaite, Brone Urbonaite, Nijole Jurgeviciene, Astra Vitkauskiene, Valerie Schwitzgebel and Dalia Marciulionyte

    Citation: BMC Endocrine Disorders 2016 16:61

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  25. Content type: Research article

    Roux-en-Y gastric bypass surgery is widely applied to ameliorate morbid obesity, including diabetes in people with type 2 diabetes. The latter vanish a few days after surgery for many, but not in all patients ...

    Authors: Mogens Fenger, Dorte Lindqvist Hansen, Dorte Worm, Lisbeth Hvolris, Viggo B. Kristiansen, Elin Rebecka Carlsson and Sten Madsbad

    Citation: BMC Endocrine Disorders 2016 16:59

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  26. Content type: Research article

    The aim of this study was to investigate the effect of a lifestyle intervention in obesity on the soluble form of the activated leukocyte cell adhesion molecule (sALCAM) and its association with metabolic para...

    Authors: Alba Sulaj, Johanna Zemva, Ulrike Zech, Annika Woehning, Maik Brune, Gottfried Rudofsky, Peter P. Nawroth, Thomas Fleming and Rüdiger von Bauer

    Citation: BMC Endocrine Disorders 2016 16:56

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  27. Content type: Research article

    Acarbose slows down the intestinal absorption of carbohydrates, but its effects on the secretion of incretins are still poorly known. This study aimed to examine the effects of single-dose acarbose on the secr...

    Authors: Zhong Chen, Xiaoying Fu, Jian Kuang, Ju Chen, Hongmei Chen, Jianhao Pei and Huazhang Yang

    Citation: BMC Endocrine Disorders 2016 16:55

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  28. Content type: Research article

    To evaluate the neonatal and obstetric outcomes of pregnancies complicated by gestational diabetes mellitus (GDM). Screening and treatment – diet-only versus additional insulin therapy – were based on the 2010...

    Authors: Sarah H. Koning, Klaas Hoogenberg, Kirsten A. Scheuneman, Mick G. Baas, Fleurisca J. Korteweg, Krystyna M. Sollie, Bertine J. Schering, Aren J. van Loon, Bruce H.R. Wolffenbuttel, Paul P. van den Berg and Helen L. Lutgers

    Citation: BMC Endocrine Disorders 2016 16:52

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  29. Content type: Research article

    Current international guidelines advocate achieving at least a 30 % reduction in maximum plantar pressure to reduce the risk of foot ulcers in people with diabetes. However, whether plantar pressures differ in...

    Authors: Malindu E. Fernando, Robert G. Crowther, Peter A. Lazzarini, Kunwarjit S. Sangla, Scott Wearing, Petra Buttner and Jonathan Golledge

    Citation: BMC Endocrine Disorders 2016 16:51

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  30. Content type: Research article

    Early identification of children and adolescents with type 1 diabetes at high risk for development of complications is important, as early intervention may prevent further deterioration. Here we investigate th...

    Authors: Josine C. van der Heyden, Erwin Birnie, Dick Mul, Sarah Bovenberg, Henk J. Veeze and Henk-Jan Aanstoot

    Citation: BMC Endocrine Disorders 2016 16:49

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  31. Content type: Research article

    Evidence on the role of irisin in insulin resistance is limited and controversial, and pathways between them remain unknown. We aimed to examine the independent effects of circulating irisin and different adip...

    Authors: Xiulin Shi, Mingzhu Lin, Changqin Liu, Fangsen Xiao, Yongwen Liu, Peiying Huang, Xin Zeng, Bing Yan, Suhuan Liu, Xiaoying Li, Shuyu Yang, Xuejun Li and Zhibin Li

    Citation: BMC Endocrine Disorders 2016 16:44

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  32. Content type: Research article

    Screening for undiagnosed diabetes is not widely undertaken due to the high costs and invasiveness of blood sampling. Simple non-invasive tools to identify high risk individuals can facilitate screening. The m...

    Authors: P. Katulanda, N. R. Hill, I. Stratton, R. Sheriff, S. D. N. De Silva and D. R. Matthews

    Citation: BMC Endocrine Disorders 2016 16:42

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  33. Content type: Research article

    Patients with type 2 diabetes mellitus (T2DM) who participate in diabetes management programs have been shown to have better glycemic control and slower disease progression, although program participation rema...

    Authors: Janice M. S. Lopez, Bozena J. Katic, Marcy Fitz-Randolph, Richard A. Jackson, Wing Chow and C. Daniel Mullins

    Citation: BMC Endocrine Disorders 2016 16:41

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  34. Content type: Research article

    It is essential to anticipate and limit the social, economic and sanitary cost of type 2 diabetes (T2D), which is in constant progression worldwide.

    Authors: Sylvie Erpeldinger, Michaela B. Rehman, Christophe Berkhout, Christophe Pigache, Yves Zerbib, Francis Regnault, Emilie Guérin, Irène Supper, Catherine Cornu, Behrouz Kassaï, François Gueyffier and Rémy Boussageon

    Citation: BMC Endocrine Disorders 2016 16:39

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  35. Content type: Research article

    Diabetic foot ulceration is receiving more attention because of its high amputation and mortality rate. It is essential to establish the frequency of amputations in people with diabetes after any change to the...

    Authors: Chuan Wang, Lifang Mai, Chuan Yang, Dan Liu, Kan Sun, Weidong Song, Baoming Luo, Yan Li, Mingtong Xu, Shaoling Zhang, Fangping Li, Meng Ren and Li Yan

    Citation: BMC Endocrine Disorders 2016 16:38

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  36. Content type: Research article

    The aim of this study was to compare the efficacy, safety, costs, and cost-effectiveness of biphasic insulin aspart 30 (BIAsp 30) with NPH plus regular human insulin (NPH/Reg) in patients with type 2 diabetes ...

    Authors: Amir Farshchi, Rokhsareh Aghili, Maryam Oskuee, Marjan Rashed, Sina Noshad, Abbas Kebriaeezadeh, Maryam Kia and Alireza Esteghamati

    Citation: BMC Endocrine Disorders 2016 16:35

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  37. Content type: Review

    Oxytocin (OT) emerges as a drug for the treatment of diabetes and obesity. The entire OT system is synthesized in the rat and human heart. The direct myocardial infusion with OT into an ischemic or failing hea...

    Authors: Marek Jankowski, Tom L. Broderick and Jolanta Gutkowska

    Citation: BMC Endocrine Disorders 2016 16:34

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  38. Content type: Research article

    Pancreatic β-cell dysfunction resulting from inflammation has been recognized to contribute to type 2 diabetes mellitus (T2DM). Netrin-1 is a new indicator of subclinical inflammation and it has a role in β-ce...

    Authors: Chenxiao Liu, Xianjin Ke, Ying Wang, Xiu Feng, Qi Li, Ying Zhang, Jian Zhu and Qian Li

    Citation: BMC Endocrine Disorders 2016 16:33

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  39. Content type: Research article

    To describe common type 2 diabetes treatment intensification regimens, patients’ characteristics and changes in glycated hemoglobin (HbA1c) and body mass index (BMI).

    Authors: Christianne L. Roumie, Robert A. Greevy, Carlos G. Grijalva, Adriana M. Hung, Xulei Liu and Marie R. Griffin

    Citation: BMC Endocrine Disorders 2016 16:32

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  40. Content type: Research article

    Patients with myocardial infarction (MI) have a high mortality. Therefore, new risk markers and predictors of an adverse outcome for MI are required. The role of hyperglycemia in the development of cardiovascu...

    Authors: Victoria Karetnikova, Olga Gruzdeva, Evgenya Uchasova, Anastasia Osokina and Olga Barbarash

    Citation: BMC Endocrine Disorders 2016 16:31

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  41. Content type: Research article

    Advance in medicine has led to an increase in life expectancy of elderly diabetic patients especially on the growing population called the “oldest old”, those in their mid-80s upwards. The aim of this study is...

    Authors: Thewjitcharoen Yotsapon, Krittiyawong Sirinate, Wanothayaroj Ekgaluck, Vongterapak Somboon, Anuntakulnatee Tawee, Kittipoom Worawit, Nakasatien Soontaree and Himathongkam Thep

    Citation: BMC Endocrine Disorders 2016 16:30

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  42. Content type: Research article

    Type 1 Diabetes Mellitus is a rapidly growing problem in Tanzania. Children and adolescents with type 1 diabetes have previously been found to have poor glycaemic control and high prevalence of complications. ...

    Authors: Mariam Noorani, Kaushik Ramaiya and Karim Manji

    Citation: BMC Endocrine Disorders 2016 16:29

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  43. Content type: Research article

    Effective prevention of type 2 diabetes (T2D) requires early identification of high-risk individuals who might benefit from intervention. We sought to determine whether low serum testosterone, a novel risk fac...

    Authors: Evan Atlantis, Paul Fahey, Sean Martin, Peter O’Loughlin, Anne W. Taylor, Robert J. Adams, Zumin Shi and Gary Wittert

    Citation: BMC Endocrine Disorders 2016 16:26

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  44. Content type: Research article

    Diabetic retinopathy (DRP) is a common microvascular complication seen in patients with type 1 diabetes mellitus (T1DM). The effects of T1DM and concomitant (proliferative) DRP on retinal blood flow are curren...

    Authors: Hoang-Ton Nguyen, Eelco van Duinkerken, Frank D. Verbraak, Bettine C. P. Polak, Peter J. Ringens, Michaela Diamant and Annette C. Moll

    Citation: BMC Endocrine Disorders 2016 16:25

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  45. Content type: Research article

    Safe and effective insulin therapy for diabetes mellitus requires initial dose titration and regular adjustments based on blood glucose (BG) monitoring. Our objective was to explore the use of BG measurement i...

    Authors: Kaisa Miikkulainen, Antonio Caruso, Oliver Mast, Rongrong Zhang and Oleg Borisenko

    Citation: BMC Endocrine Disorders 2016 16:21

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  46. Content type: Case report

    Type B insulin resistance is a rare autoimmune disease characterized by the presence of autoantibodies against the insulin receptor. Helicobacter pylori (H pylori) infection may play a causative role in the au...

    Authors: Guo-Qing Yang, Yi-Jun Li, Jing-Tao Dou, Bao-An Wang, Ju-Ming Lu and Yi-Ming Mu

    Citation: BMC Endocrine Disorders 2016 16:20

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  47. Content type: Research article

    The number and activity of circulating endothelial progenitor cells (EPCs) in prehypertension is preserved in premenopausal women. However, whether this favorable effect still exists in prehypertensive premeno...

    Authors: Haitao Zeng, Yanping Jiang, Hailin Tang, Zi Ren, Gaofeng Zeng and Zhen Yang

    Citation: BMC Endocrine Disorders 2016 16:13

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