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Diabetes and Metabolism

Section edited by Abd Tahrani

This section concerns all aspects of diabetes and metabolic syndrome including but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Dysglycemic status defined by prediabetes and diabetes is known to be related with future risk of diabetic complications and cardiovascular diseases. Herein, we aimed to determine the diagnostic accuracy of gl...

    Authors: Yotsapon Thewjitcharoen, Amia Jones Elizabeth, Siriwan Butadej, Soontaree Nakasatien, Phawinpon Chotwanvirat, Ekgaluck Wanothayaroj, Sirinate Krittiyawong, Tinapa Himathongkam and Thep Himathongkam

    Citation: BMC Endocrine Disorders 2019 19:23

    Content type: Research article

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  2. As an insulin-dependent disease, type 1 diabetes requires paying close attention to the glycemic control. Studies have shown that mobile health (mHealth) can improve the management of chronic diseases. However...

    Authors: Xuemei Wang, Wei Shu, Jian Du, Maolin Du, Peiyu Wang, Mingming Xue, Huiqiu Zheng, Yufeng Jiang, Shaohua Yin, Danyan Liang, Ruiqi Wang and Lina Hou

    Citation: BMC Endocrine Disorders 2019 19:21

    Content type: Research article

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  3. Measurement of gylcated hemoglobin A1c (HbA1c) plays a central role in monitoring quality of antidiabetic therapy and in the diagnosis of diabetes. Several studies report increased levels of HbA1c in nondiabet...

    Authors: Annette Masuch, Nele Friedrich, Johannes Roth, Matthias Nauck, Ulrich Alfons Müller and Astrid Petersmann

    Citation: BMC Endocrine Disorders 2019 19:20

    Content type: Research article

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  4. The incretin-based medicines GLP1 analogues (GLP1a) and dipeptidyl peptidase-4 inhibitors (DPP4i) are hypoglycaemic agents licensed for the treatment of type 2 diabetes mellitus (T2DM). Although these drugs po...

    Authors: Giuseppe Roberto, Francesco Barone-Adesi, Francesco Giorgianni, Valeria Pizzimenti, Carmen Ferrajolo, Michele Tari, Claudia Bartolini, Roberto Da Cas, Marina Maggini, Stefania Spila-Alegiani, Paolo Francesconi, Gianluca Trifirò, Elisabetta Poluzzi, Fabio Baccetti and Rosa Gini

    Citation: BMC Endocrine Disorders 2019 19:18

    Content type: Research article

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  5. Hypoglycemia presents a barrier to optimum diabetes management and it is related to a negative impact on health-related quality of life, healthcare resource use, and work productivity. Despite the fact that th...

    Authors: Gashayeneh Genetu Tiruneh, Nurilign Abebe and Getenet Dessie

    Citation: BMC Endocrine Disorders 2019 19:17

    Content type: Research article

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  6. A comparative study of 11 β HSD 1 activity in type 2 diabetes mellitus subjects with respect to fasting blood glucose and other metabolic parameters was conducted.

    Authors: Ravindra Shukla, Asish Kumar Basu, Biplab Mandal, Pradip Mukhopadhyay, Animesh Maity, Satyam Chakraborty and Praveen Kumar Devrabhai

    Citation: BMC Endocrine Disorders 2019 19:15

    Content type: Research article

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  7. Fasting plasma glucose (FPG) is the most commonly used screening tool for diabetes in Sri Lanka. Cut-off values from American Diabetes Association recommendations are adopted in the absence of local data. We a...

    Authors: G. W. Katulanda, P. Katulanda, C. Dematapitiya, H. A. Dissanayake, S. Wijeratne, M. H. R. Sheriff and D. R. Matthews

    Citation: BMC Endocrine Disorders 2019 19:11

    Content type: Research article

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  8. The role of technology in the self-management of type 1 diabetes mellitus (T1DM) among children and young people is not well understood. Interventions should aim to improve key diabetes self-management behavio...

    Authors: Emily C. L. Knox, Helen Quirk, Cris Glazebrook, Tabitha Randell and Holly Blake

    Citation: BMC Endocrine Disorders 2019 19:7

    Content type: Research article

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  9. Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that increases the cardiovascular risk. Regular physical exercise can promote benefits, but the MetS individuals are demotivated to perform it....

    Authors: Danúbia Sá-Caputo, Laisa Liane Paineiras-Domingos, Arlete Francisca-Santos, Elzi Martins dos Anjos, Aline Silva Reis, Mario Fritsch Toros Neves, Wille Oigman, Ricardo Oliveira, Andrea Brandão, Christiano Bittencourt Machado, Xavier Chiementin, Redha Taiar, Alessandro Sartório and Mario Bernardo-Filho

    Citation: BMC Endocrine Disorders 2019 19:6

    Content type: Research article

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  10. Insulin injection, especially with insulin analogs, occasionally induces the production of insulin antibodies with high binding capacity and low affinity, similar to the insulin autoantibodies characteristic o...

    Authors: Keizo Kaneko, Chihiro Satake, Tomohito Izumi, Mamiko Tanaka, Junpei Yamamoto, Yoichiro Asai, Shojiro Sawada, Junta Imai, Tetsuya Yamada and Hideki Katagiri

    Citation: BMC Endocrine Disorders 2019 19:5

    Content type: Case report

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  11. Several clinical trials have studied the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on glycometabolism and cardiovascular risk factors since they were identified. Because of their cardiova...

    Authors: Xu Zhao, Kun Huang, Meijie Zheng and Junting Duan

    Citation: BMC Endocrine Disorders 2019 19:4

    Content type: Research article

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  12. Dipeptidyl peptidase-4 (DPP-4) inhibitors could effectively reduce HbA1C and postprandial hyperglycemia and could incur only minimal danger of hypoglycemia. Patients with uncontrolled diabetes might be treated by...

    Authors: Fu-Shun Yen, Jen-Huai Chiang, Chii-Min Hwu, Yu-Hsin Yen, Boniface J. Lin, James Cheng-Chung Wei and Chih-Cheng Hsu

    Citation: BMC Endocrine Disorders 2019 19:3

    Content type: Research article

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  13. Chronic diabetic complications may afflict all organ tissues, including those of the respiratory system. The six-minute walk test (6MWT) is an alternative and widely used method of assessing functional capacity a...

    Authors: Krzysztof Kuziemski, Wojciech Słomiński and Ewa Jassem

    Citation: BMC Endocrine Disorders 2019 19:2

    Content type: Research article

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  14. Diabetic foot ulcers (DFU) are a common problem in longstanding diabetes. However, mortality outcomes in Australian patients with DFU are still unclear.

    Authors: Kanakamani Jeyaraman, Thomas Berhane, Mark Hamilton, Abhilash P. Chandra and Henrik Falhammar

    Citation: BMC Endocrine Disorders 2019 19:1

    Content type: Research article

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  15. Sub-Saharan Africa continues to face the highest rate of mortality from diabetes in the world due to limited access to quality diabetes care. We assessed the quality of diabetes care in a rural diabetes clinic...

    Authors: Sonak D. Pastakia, Bernardo Nuche-Berenguer, Chelsea Regina Pekny, Benson Njuguna, Elizabeth Guinevere O’Hara, Stephanie Y. Cheng, Jeremiah Laktabai, Victor Buckwalter, Nicholas Kirui and Patrick Chege

    Citation: BMC Endocrine Disorders 2018 18:97

    Content type: Research article

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  16. Diabetes is a risk factor for cognitive impairment, but whether there is also a link between pre-diabetes and cognitive dysfunction is not yet fully established. The aim of this observational study was to inve...

    Authors: Elin Dybjer, Peter M. Nilsson, Gunnar Engström, Catherine Helmer and Katarina Nägga

    Citation: BMC Endocrine Disorders 2018 18:91

    Content type: Research article

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  17. Bariatric surgery is effective in remission of obesity comorbidities. This study was aimed at comparing CVD risk between morbidly obese patients with type 2 diabetes and pre-diabetes before and after bariatric...

    Authors: Matilde Rubio-Almanza, Rosa Cámara-Gómez, David Hervás-Marín, José Luis Ponce-Marco and Juan Francisco Merino-Torres

    Citation: BMC Endocrine Disorders 2018 18:90

    Content type: Research article

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  18. Alström syndrome (ALMS) is a very rare autosomal recessive monogenic disorder caused by a mutation in the ALMS1 gene and characterised by childhood onset obesity, dyslipidaemia, advanced non-alcoholic fatty liver...

    Authors: Shanat Baig, Vishy Veeranna, Shaun Bolton, Nicola Edwards, Jeremy W. Tomlinson, Konstantinos Manolopoulos, John Moran, Richard P. Steeds and Tarekegn Geberhiwot

    Citation: BMC Endocrine Disorders 2018 18:88

    Content type: Study protocol

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  19. Soluble receptor for advanced glycation end-products (sRAGE) and advanced glycation end-products (AGE) have been associated with risks of cardiovascular disease. Because sRAGE is regarded as a scavenger to AGE...

    Authors: Kuang-Hsing Chiang, Jaw-Wen Chen, Shao-Sung Huang, Hsin-Bang Leu, Shing-Jong Lin and Po-Hsun Huang

    Citation: BMC Endocrine Disorders 2018 18:84

    Content type: Research article

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  20. Poor understanding of diabetes management targets is associated with worse disease outcomes. Patients may use different information than providers to assess their diabetes control. In this study, we identify t...

    Authors: Anjali Gopalan, Katherine Kellom, Kevin McDonough and Marilyn M. Schapira

    Citation: BMC Endocrine Disorders 2018 18:79

    Content type: Research article

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  21. Type 2 diabetes mellitus has become one of the most important public health concerns worldwide. Due to its high prevalence and morbidity, there is an avid necessity to find new therapies that slow the progress...

    Authors: Miguel Ángel Gómez-Sámano, Jorge Enrique Baquerizo-Burgos, Melissa Fabiola Coronel Coronel, Buileng Daniela Wong-Campoverde, Fernando Villanueva-Martinez, Diego Molina-Botello, Jose Alonso Avila-Rojo, Lucía Palacios-Báez, Daniel Cuevas-Ramos, Francisco Javier Gomez-Perez, Alejandro Zentella-Dehesa, Álvaro Aguayo-González and Alfonso Gulias-Herrero

    Citation: BMC Endocrine Disorders 2018 18:77

    Content type: Research article

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  22. Improved glycemic control is the desired outcome after the discharge of patients with diabetes. We aimed to determine the efficacy of a basal-bolus insulin protocol in hospitalized patients with diabetes treat...

    Authors: Elena Chertok Shacham, Hila Kfir, Naama Schwartz and Avraham Ishay

    Citation: BMC Endocrine Disorders 2018 18:75

    Content type: Research article

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  23. Health care providers aim to stimulate self-management in type 2 diabetes (T2DM) patients. However, they have a limited number of patient contacts to do this. With the growing number of T2DM patients, innovati...

    Authors: Anne Meike Boels, Guy Rutten, Nicolaas Zuithoff, Ardine de Wit and Rimke Vos

    Citation: BMC Endocrine Disorders 2018 18:74

    Content type: Study protocol

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  24. Little evidence exists on the impact of diabetes risk scores, e.g. on physicians and patient’s behavior, perceived risk of persons, shared-decision making and particularly on patient’s health. The aim of this ...

    Authors: Esther Jacobs, Miguel Tamayo, Joachim Rosenbauer, Matthias B. Schulze, Oliver Kuss and Wolfgang Rathmann

    Citation: BMC Endocrine Disorders 2018 18:72

    Content type: Study protocol

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  25. When children with type 1 diabetes approach adolescence, they are encouraged to become more involved in diabetes self-management. This study explored the challenges pre-adolescent children encounter when self-...

    Authors: David Rankin, Jeni Harden, Katharine Barnard, Louise Bath, Kathryn Noyes, John Stephen and Julia Lawton

    Citation: BMC Endocrine Disorders 2018 18:71

    Content type: Research article

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  26. This study aimed to examine the switch from glargine+once daily insulin aspart (1 + 1 regimen) to glargine+insulin aspart 30 before breakfast combined with exercise and in patients with type 2 diabetes mellitu...

    Authors: Jing Li, Liming Wang, Fen Chen, Dongxia Xia and Lingling Miao

    Citation: BMC Endocrine Disorders 2018 18:69

    Content type: Research article

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  27. Metabolic syndrome (MetS) includes obesity, diabetes, dyslipidemia and hypertension. Its incidence is rapidly increasing worldwide, particularly in postmenopausal women. Estrogens regulate glucose homeostasis ...

    Authors: Lingxia Zhao, Xuemei Fan, Lin Zuo, Qiang Guo, Xiaole Su, Guangxia Xi, Ziyan Zhang, Jianlin Zhang and Guoping Zheng

    Citation: BMC Endocrine Disorders 2018 18:65

    Content type: Research article

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  28. Type 2 diabetes is a serious clinical problem in both India and the UK. Adoption of a healthy lifestyle through dietary and physical activity modification can help prevent type 2 diabetes. However, implementin...

    Authors: Hazel Thomson, Nick Oliver, Ian F. Godsland, Ara Darzi, Weerachai Srivanichakorn, Azeem Majeed, Desmond G. Johnston, Arun Nanditha, Chamukuttan Snehalatha, Arun Raghavan, Priscilla Susairaj, Mary Simon, Krishnamoorthy Satheesh, Ambady Ramachandran, Stephen Sharp, Kate Westgate…

    Citation: BMC Endocrine Disorders 2018 18:63

    Content type: Study protocol

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  29. The aim of this study was to assess inadequate glycaemic control and its associated factors among people with type 2 diabetes in Saudi Arabia.

    Authors: Mohammed J. Alramadan, Dianna J. Magliano, Turky H. Almigbal, Mohammed Ali Batais, Afsana Afroz, Hesham J. Alramadhan, Waad Faozi Mahfoud, Adel Mehmas Alragas and Baki Billah

    Citation: BMC Endocrine Disorders 2018 18:62

    Content type: Research article

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  30. The aim of the present study is to evaluate the association between BMD and type 2 DM status in middle-aged and elderly men. To investigate a possible correlation, the present study used the BMD dataset of the...

    Authors: Miso Jang, Hyunkyung Kim, Shorry Lea, Sohee Oh, Jong Seung Kim and Bumjo Oh

    Citation: BMC Endocrine Disorders 2018 18:61

    Content type: Research article

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  31. Galactomannan(s) are plant-derived fiber shown to reduce post-prandial blood glucose by delaying intestinal absorption of carbohydrates and slowing down gastric emptying. We examined glucose-lowering effects o...

    Authors: Andrea O. Y. Luk, Benny C. Y. Zee, Marc Chong, Risa Ozaki, Carl W. Rausch, Michael H. M. Chan, Ronald C. W. Ma, Alice P. S. Kong, Francis C. C. Chow and Juliana C. N. Chan

    Citation: BMC Endocrine Disorders 2018 18:59

    Content type: Research article

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  32. Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases in children. Studies on costs related to T1DM are scarce and focused primarily on the costs directly related to diabetes. We aimed to ...

    Authors: E. A. J. M. Spaans, P. R. van Dijk, K. H. Groenier, P. L. P. Brand, N. Kleefstra and H. J. G. Bilo

    Citation: BMC Endocrine Disorders 2018 18:57

    Content type: Research article

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  33. The shapes of the plasma glucose concentration curve during the oral glucose tolerance test are related to different metabolic risk profiles and future risk of type 2 DM. We sought to further analyze the relat...

    Authors: Leonardo de Andrade Mesquita, Luciana Pavan Antoniolli, Giordano Fabricio Cittolin-Santos and Fernando Gerchman

    Citation: BMC Endocrine Disorders 2018 18:56

    Content type: Research article

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  34. To compare the accuracy of different obesity indexes, including waist circumference (WC), weight-to-height ratio (WHtR), body mass index (BMI), and lipid accumulation product (LAP), in predicting metabolic syn...

    Authors: Leilei Liu, Yu Liu, Xizhuo Sun, Zhaoxia Yin, Honghui Li, Kunpeng Deng, Xu Chen, Cheng Cheng, Xinping Luo, Ming Zhang, Linlin Li, Lu Zhang, Bingyuan Wang, Yongcheng Ren, Yang Zhao, Dechen Liu…

    Citation: BMC Endocrine Disorders 2018 18:54

    Content type: Research article

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  35. Diabetic foot ulceration is a serious limb-threatening complication of diabetes. It is the common cause of hospital admissions and amputations.

    Authors: Bilal Bin Younis, Adeela Shahid, Rozina Arshad, Saima Khurshid, Muhammad Ahmad and Haroon Yousaf

    Citation: BMC Endocrine Disorders 2018 18:53

    Content type: Research article

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  36. Type 2 Diabetes Mellitus is a serious metabolic disease that is often associated with vascular complications. There are 1.9 million people living with Diabetes in Ethiopia; diabetes mellitus is found to be the...

    Authors: Haileab Fekadu Wolde, Asrat Atsedeweyen, Addisu Jember, Tadesse Awoke, Malede Mequanent, Adino Tesfahun Tsegaye and Shitaye Alemu

    Citation: BMC Endocrine Disorders 2018 18:52

    Content type: Research article

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  37. Diabetes in the United States has reached epidemic proportions and the people of Appalachia have been disproportionately affected by this disease. Strategies that complement standard diabetes care are critical...

    Authors: Elizabeth A. Beverly, Jane Hamel-Lambert, Laura L. Jensen, Sue Meeks and Anne Rubin

    Citation: BMC Endocrine Disorders 2018 18:50

    Content type: Research article

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  38. Glycaemic control is one of the most effective strategies for the treatment of diabetes-related erectile dysfunction (DMED). Compared to conventional anti-diabetic drugs and insulin, islet transplantation is m...

    Authors: Zhigang Wu, Hongwei Wang, Fubiao Ni, Xuan Jiang, Ziqiang Xu, Chengyang Liu, Yong Cai, Hongxing Fu, Jiao Luo, Wenwei Chen, Bicheng Chen and Zhixian Yu

    Citation: BMC Endocrine Disorders 2018 18:49

    Content type: Research article

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  39. Optimal glycaemia, reflected by glycated haemoglobin (HbA1c) levels, is key in reducing type 2 diabetes (T2D) complications. However, most people with T2D have suboptimal recall and understanding of HbA1c. Con...

    Authors: Mei Lyn Tan, Jo-Anne Manski-Nankervis, Sharmala Thuraisingam, Alicia Jenkins, David O’Neal and John Furler

    Citation: BMC Endocrine Disorders 2018 18:47

    Content type: Research article

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  40. The benefit results of postoperative tight glycemic control (TGC) were controversial and there was a lack of well-powered studies that support current guideline recommendations.

    Authors: Yuan-yuan Wang, Shuang-fei Hu, Hui-min Ying, Long Chen, Hui-li Li, Fang Tian and Zhen-feng Zhou

    Citation: BMC Endocrine Disorders 2018 18:42

    Content type: Research article

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  41. The prevalence of childhood obesity and obesity-related metabolic disorder such as dyslipidemia has sharply increased in the past few decades. Chronic low-grade inflammation is associated with the development ...

    Authors: Yuesheng Liu, Dong Xu, Chunyan Yin, Sisi Wang, Min Wang and Yanfeng Xiao

    Citation: BMC Endocrine Disorders 2018 18:39

    Content type: Research article

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  42. Hypoglycaemia is a feared experience for people with diabetes. We aimed to study the prevalence and causes of hypoglycaemia among Sri Lankans with diabetes.

    Authors: H. A. Dissanayake, G. S. P. Keerthisena, K. K. K. Gamage, J. H. Liyanage, I. R. H. S. Ihalagama, W. M. U. A. Wijetunga, T. A. D. Tillekaratne, G. W. Katulanda and P. Katulanda

    Citation: BMC Endocrine Disorders 2018 18:35

    Content type: Research article

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  43. Diabetes mellitus is one of the most prevalent diseases worldwide. Diabetes is a chronic disease associated with micro- and macro-vascular complications and deterioration in general health status. Therefore, t...

    Authors: Masoud Behzadifar, Rahim Sohrabi, Roghayeh Mohammadibakhsh, Morteza Salemi, Sharare Taheri Moghadam, Masood Taheri Mirghaedm, Meysam Behzadifar, Hamid Reza Baradaran and Nicola Luigi Bragazzi

    Citation: BMC Endocrine Disorders 2018 18:34

    Content type: Research article

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  44. Diabetes mellitus is usually preceded by a pre-diabetic stage before the clinical presentation of the disease, the influence of which on persons’ quality of life is not adequately elucidated. The purpose of th...

    Authors: Konstantinos Makrilakis, Stavros Liatis, Afroditi Tsiakou, Chryssoula Stathi, Eleftheria Papachristoforou, Despoina Perrea, Nicholas Katsilambros, Nikolaos Kontodimopoulos and Dimitrios Niakas

    Citation: BMC Endocrine Disorders 2018 18:32

    Content type: Research article

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  45. There is evidence that disparities exist in diabetes prevalence, access to diabetes care, diabetes-related complications, and the quality of diabetes care. A wide range of interventions has been implemented an...

    Authors: Natalie Terens, Simona Vecchi, Anna Maria Bargagli, Nera Agabiti, Zuzana Mitrova, Laura Amato and Marina Davoli

    Citation: BMC Endocrine Disorders 2018 18:31

    Content type: Research article

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  46. The diagnosis of atypical non-autoimmune forms of diabetes mellitus, such as maturity onset diabetes of the young (MODY) presents several challenges, in view of the extensive clinical and genetic heterogeneity...

    Authors: Nikolai Paul Pace, Johann Craus, Alex Felice and Josanne Vassallo

    Citation: BMC Endocrine Disorders 2018 18:28

    Content type: Case report

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  47. Retinol binding protein 4 (RBP4), a protein secreted by adipocytes and bound in plasma to transthyretin (TTR), has been associated with obesity, the early phase of insulin resistance, metabolic syndrome, and t...

    Authors: Karunee Kwanbunjan, Pornpimol Panprathip, Chanchira Phosat, Noppanath Chumpathat, Naruemon Wechjakwen, Somchai Puduang, Ratchada Auyyuenyong, Ina Henkel and Florian J. Schweigert

    Citation: BMC Endocrine Disorders 2018 18:26

    Content type: Research article

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