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Diabetes and Metabolism

Section edited by Abd Tahrani

This section concerns all aspects of diabetes and metabolic syndrome including but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. In contrast to insulin-dependent type 1 diabetes mellitus (T1DM), the indication for Simultaneous pancreas-kidney transplantation (SPK) in patients with type 2 diabetes mellitus (T2DM) is still ambiguous and w...

    Authors: Hans-Michael Hau, Nora Jahn, Maximilian Brunotte, Andri Arnosson Lederer, Elisabeth Sucher, Franz Maximilian Rasche, Daniel Seehofer and Robert Sucher

    Citation: BMC Endocrine Disorders 2020 20:30

    Content type: Research article

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  2. The number of patients with obesity continues to increase in our society. At the same time, digitalization defines our everyday life. Therefore, the question arises whether to use digital media for effective t...

    Authors: Alexandra Ziegeldorf, Petra Wagner and Hagen Wulff

    Citation: BMC Endocrine Disorders 2020 20:28

    Content type: Research article

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  3. There is still a lack of knowledge on long-term effects of surgical and non-surgical weight-lowering treatments. BASUN is a prospective study with 10 years of follow-up that will observe the effects and conseq...

    Authors: Gudrún Höskuldsdóttir, Karin Mossberg, Ville Wallenius, Angelos Al Nimer, Wiveka Björkvall, Sören Lundberg, Carl-Johan Behre, Malin Werling, Björn Eliasson and Lars Fändriks

    Citation: BMC Endocrine Disorders 2020 20:23

    Content type: Research article

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  4. Currently, bariatric surgery is the most effective treatment for severe obesity and its metabolic complications; however, 15–35% of the patients that undergo bariatric surgery do not reach their goal for weigh...

    Authors: Diego Cadena-Obando, Claudia Ramírez-Rentería, Aldo Ferreira-Hermosillo, Alejandra Albarrán-Sanchez, Ernesto Sosa-Eroza, Mario Molina-Ayala and Etual Espinosa-Cárdenas

    Citation: BMC Endocrine Disorders 2020 20:20

    Content type: Research article

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  5. Strict glycaemic control early in the treatment process has been shown to reduce the occurrence of micro- and macro- vascular complications of diabetes in the long-term. Thus, treatment guidelines advise early...

    Authors: Kyriakos Souliotis, Anastasios Koutsovasilis, Georgia Vatheia, Christina Golna, Sofia Nikolaidi, Erifili Hatziagelaki, Kalliopi Kotsa, Theocharis Koufakis, Andreas Melidonis, Athanasia Papazafiropoulou, Nikolaos Tentolouris, Evangelia Siami and Alexios Sotiropoulos

    Citation: BMC Endocrine Disorders 2020 20:16

    Content type: Research article

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  6. Self- management is vital to the control of diabetes. This study aims to assess the diabetes self-care behaviours of patients attending two tertiary hospitals in Gauteng, South Africa. The study also seeks to ...

    Authors: Chipo Mutyambizi, Milena Pavlova, Charles Hongoro and Wim Groot

    Citation: BMC Endocrine Disorders 2020 20:15

    Content type: Research article

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  7. The risk of colon or breast cancer in metabolically healthy obese (MHO) were lower than that in metabolically abnormal obese (MAO). We hypothesized that the risk of incident gastric cancer in MHO is lower than...

    Authors: Yoshitaka Hashimoto, Masahide Hamaguchi, Akihiro Obora, Takao Kojima and Michiaki Fukui

    Citation: BMC Endocrine Disorders 2020 20:11

    Content type: Research article

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  8. Medically-tailored meal programs that provide home-delivered medically-appropriate food are an emerging intervention when type 2 diabetes co-occurs with food insecurity (limited or uncertain access to nutritio...

    Authors: Seth A. Berkowitz, Naysha N. Shahid, Jean Terranova, Barbara Steiner, Melanie P. Ruazol, Roshni Singh, Linda M. Delahanty and Deborah J. Wexler

    Citation: BMC Endocrine Disorders 2020 20:10

    Content type: Research article

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  9. Although there are numerous studies on the global prevalence of cardiometabolic risk factors (CMRFs) in military personnel, the pooled prevalence of CMRFs in this population remains unclear. We aimed to system...

    Authors: Fereshteh Baygi, Kimmo Herttua, Olaf Chresten Jensen, Shirin Djalalinia, Armita Mahdavi Ghorabi, Hamid Asayesh and Mostafa Qorbani

    Citation: BMC Endocrine Disorders 2020 20:8

    Content type: Research article

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  10. In the United States (U.S.), the prevalence of both diagnosed and undiagnosed type 2 diabetes (T2D) is nearly twice as high among Mexican-origin Hispanic/Latino adults compared to non-Hispanic Whites. Rates of...

    Authors: Jessikah Morales, Namino Glantz, Arianna Larez, Wendy Bevier, Mary Conneely, Ludi Fan, Beverly Reed, Carlos Alatorre, Rosirene Paczkowski, Tamim Ahmed, Andrew Mackenzie, Ian Duncan and David Kerr

    Citation: BMC Endocrine Disorders 2020 20:4

    Content type: Study protocol

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  11. Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, characterized by hyperandrogenism, oligomenorrhea, polycystic ovary morphology, and insulin resistance. Vitamin ...

    Authors: Do Kyeong Song, Hyejin Lee, Young Sun Hong and Yeon-Ah Sung

    Citation: BMC Endocrine Disorders 2019 19:145

    Content type: Research article

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  12. The use of immune checkpoint inhibitor (ICI) therapy is becoming a standard of care for several cancers. Monoclonal antibodies targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed cell death prot...

    Authors: Marco Zezza, Christophe Kosinski, Carine Mekoguem, Laura Marino, Haithem Chtioui, Nelly Pitteloud and Faiza Lamine

    Citation: BMC Endocrine Disorders 2019 19:144

    Content type: Case report

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  13. Diabetes mellitus causes multiple medical, psychological and sexual problems in both men and women. Sexual dysfunction is one of those problems that lead to a strong social and psychological problem which adve...

    Authors: Adane Asefa, Tadesse Nigussie, Andualem Henok and Yitagesu Mamo

    Citation: BMC Endocrine Disorders 2019 19:141

    Content type: Research article

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  14. Diabetes self-management education can be helpful for patients with type 2 diabetes in managing their condition. We aimed to study the effects of the group-based PRoactive Interdisciplinary Self-MAnagement (PR...

    Authors: Esther du Pon, Nanne Kleefstra, Frits Cleveringa, Ad van Dooren, Eibert R. Heerdink and Sandra van Dulmen

    Citation: BMC Endocrine Disorders 2019 19:139

    Content type: Research article

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  15. To evaluate the impact of treatment with recombinant human growth hormone (rhGH; Omnitrope®) on the risk of diabetes mellitus in adults with growth hormone deficiency (GHD), using data from the ongoing PATRO A...

    Authors: Paolo Beck-Peccoz, Charlotte Höybye, Robert D. Murray, Suat Simsek, Markus Zabransky, Hichem Zouater and Günter Stalla

    Citation: BMC Endocrine Disorders 2019 19:138

    Content type: Research article

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  16. Abdominal obesity and presence of the metabolic syndrome (MetS) significantly increase the risk of developing diseases such as Type 2 diabetes mellitus (T2DM) with escalating emergence of MetS and T2DM constit...

    Authors: Doris Pierce, Lea Merone, Chris Lewis, Tony Rahman, John Croese, Alex Loukas, Malcolm McDonald, Paul Giacomin and Robyn McDermott

    Citation: BMC Endocrine Disorders 2019 19:136

    Content type: Study protocol

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  17. The burden of non-communicable diseases is growing rapidly in low- and middle-income countries. Research suggests that health interventions that aim to improve patient self-management and empower patients to c...

    Authors: Nina Abrahams, Lucy Gilson, Naomi S. Levitt and Joel A. Dave

    Citation: BMC Endocrine Disorders 2019 19:133

    Content type: Research article

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  18. This analysis evaluates the cost-effectiveness of insulin degludec (degludec) versus biosimilar insulin glargine U100 (glargine U100) in patients with type 1 (T1DM) and type 2 diabetes mellitus (T2DM) in Bulga...

    Authors: Monika Russel-Szymczyk, Vasil Valov, Alexandra Savova and Manoela Manova

    Citation: BMC Endocrine Disorders 2019 19:132

    Content type: Research article

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  19. Finding the relationship between the major dietary patterns and cardiometabolic phenotypes could be used for planning prevention programs based on the cultural and dietary habits to prevent transient from a me...

    Authors: Leila Nikniaz, Mahdieh Abbasalizad Farhangi, Jafar Sadegh Tabrizi and Zeinab Nikniaz

    Citation: BMC Endocrine Disorders 2019 19:131

    Content type: Research article

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  20. We measured the concentrations of the adipocytokines vaspin and visfatin in obese Chinese children. Furthermore, we studied the correlation of these adipocytokines with early-onset metabolic and vascular seque...

    Authors: Chunyan Yin, Wei Hu, Ming Wang and Yanfeng Xiao

    Citation: BMC Endocrine Disorders 2019 19:127

    Content type: Research article

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  21. Compositional abnormalities in lipoproteins and cardiovascular risk factors play an important role in the progression of diabetic peripheral neuropathy (DPN). This systematic review aimed to estimate the predi...

    Authors: Syed Shah Zaman Haider Naqvi, Saber Imani, Hossein Hosseinifard, Qing-Lian Wen, M. Naveed Shahzad, Iqra Ijaz, Youcai Deng, Man Guo and Yong Xu

    Citation: BMC Endocrine Disorders 2019 19:125

    Content type: Research article

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  22. Diabetic ketoacidosis (DKA) is an acute, major, life-threatening complication of diabetes that requires immediate treatment. Allergic reaction to insulin is rare, especially when using recombinant human insuli...

    Authors: Anh Dat Nguyen, Chinh Quoc Luong, Hieu Chi Chu, Van Khoa Dieu Nguyen, Chi Van Nguyen, Tuan Anh Nguyen, Quan Huu Nguyen, Ton Duy Mai, Dinh Van Nguyen, Bay Quang Nguyen, Thong Huu Tran, Phuong Viet Dao, Dat Tuan Nguyen, Nguyet Nhu Nguyen and Son Ngoc Do

    Citation: BMC Endocrine Disorders 2019 19:121

    Content type: Case report

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  23. Agenesis of the dorsal pancreas (ADP) is clinically rare, and it is usually accompanied by abdominal pain. Various disorders of glucose metabolism associating with ADP have been reported, but there are only tw...

    Authors: Tian Yang, Xudan Yang, Luping Wang and Jun Mo

    Citation: BMC Endocrine Disorders 2019 19:120

    Content type: Case report

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  24. The shape of the glucose response curve during an oral glucose tolerance test (OGTT) can predict β-cell function and insulin resistance. However, there have been few studies conducted on Chinese people. Thus, ...

    Authors: Xinqi Cheng, Na Yang, Yuxiu Li, Qi Sun, Ling Qiu, Lingling Xu, Fan Ping, Wei Li and Huabing Zhang

    Citation: BMC Endocrine Disorders 2019 19:119

    Content type: Research article

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  25. Diabetes is 7th largest cause of death worldwide, and prevalence is increasing rapidly in low-and middle-income countries. There is an urgent need to develop and test interventions to prevent and control diabe...

    Authors: Joanna Morrison, Kohenour Akter, Hannah Maria Jennings, Tasmin Nahar, Abdul Kuddus, Sanjit Kumer Shaha, Naveed Ahmed, Carina King, Hassan Haghparast-Bidgoli, Anthony Costello, A. K. Azad Khan, Kishwar Azad and Edward Fottrell

    Citation: BMC Endocrine Disorders 2019 19:118

    Content type: Research article

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  26. The prevalence of obesity and its comorbidities, including type 2 diabetes mellitus (T2DM), is dramatically increasing throughout the world; however, the underlying aetiology is incompletely understood. Genome...

    Authors: Naomi L. Cook, Milos Pjanic, Andrew G. Emmerich, Abhiram S. Rao, Susanne Hetty, Joshua W. Knowles, Thomas Quertermous, Casimiro Castillejo-López and Erik Ingelsson

    Citation: BMC Endocrine Disorders 2019 19:115

    Content type: Research article

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  27. Colorectal cancer (CRC) is the fourth most commonly diagnosed gastrointestinal (GI) malignancy and the third leading cause of cancer-related death worldwide. In the current case-control study, an association b...

    Authors: Ghodratollah Soltani, Arash Poursheikhani, Maryam Yassi, Abdorasool Hayatbakhsh, Matin Kerachian and Mohammad Amin Kerachian

    Citation: BMC Endocrine Disorders 2019 19:113

    Content type: Research article

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  28. Severe hypoglycaemia carries a significant risk of morbidity and mortality for people with type 1 diabetes. Economic costs are also high, estimated at approximately £13 million annually in England, UK. Continu...

    Authors: Parizad Avari, Rozana Ramli, Monika Reddy, Nick Oliver and Rachael Fothergill

    Citation: BMC Endocrine Disorders 2019 19:110

    Content type: Study protocol

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  29. The adipokine adipsin contributes to insulin resistance (IR), inflammation, and obesity, which are all regarded as high-risk factors for mild cognitive impairment (MCI) in patients with type 2 diabetes mellitu...

    Authors: Dan Guo, Yang Yuan, Rong Huang, Sai Tian, Jiaqi Wang, Hongyan Lin, Ke An, Jin Han and Shaohua Wang

    Citation: BMC Endocrine Disorders 2019 19:108

    Content type: Research article

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  30. Hypoglycemia is a common complication of insulin therapy in patients with Type 1 Diabetes Mellitus (DM). Awareness of hypoglycemic symptoms helps patients to recognize hypoglycemia and initiate self-treatment....

    Authors: Mohammad J. Alkhatatbeh, Nedaa A. Abdalqader and Mohammad A. Y. Alqudah

    Citation: BMC Endocrine Disorders 2019 19:107

    Content type: Research article

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  31. Lifestyle modification targeting weight management is the first-line treatment for women with Polycystic Ovary Syndrome (PCOS) regardless of presenting symptoms. Women with PCOS are more likely to gain more we...

    Authors: Siew Lim, Caroline A. Smith, Michael F. Costello, Freya MacMillan, Lisa Moran and Carolyn Ee

    Citation: BMC Endocrine Disorders 2019 19:106

    Content type: Research article

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  32. Glucagon stimulation test (GST) is often employed to assess the insulin reserve of the pancreatic beta cells in diabetic subjects. The clinical significance of the increment of plasma glucose (Δglucose) by exo...

    Authors: Yasutaka Takeda, Yukihiro Fujita, Ryoichi Bessho, Mao Sato, Tomoe Abe, Tsuyoshi Yanagimachi, Hidemitsu Sakagami, Atsuko Abiko, Yumi Takiyama, Tsuguhito Ota and Masakazu Haneda

    Citation: BMC Endocrine Disorders 2019 19:99

    Content type: Research article

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  33. To investigate the prevalence of cardiovascular disease (CVD) risk factors and assess the 10-year risk of CVD in non-menopausal and postmenopausal women with type 2 diabetes mellitus (T2DM).

    Authors: Huanhuan Zhou, Chenghuan Zhang, Jingyu Ni and Xiaoyun Han

    Citation: BMC Endocrine Disorders 2019 19:98

    Content type: Research article

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  34. Charcot neuropathic osteoarthropathy (CNO) is one of the most devastating complications of neuropathy in patients with diabetes. Establishing diagnosis of CNO is difficult, due to the lack of clear clinical an...

    Authors: C. V. Loupa, E. Meimeti, A. Kokas, E. D. Voyatzoglou and A. Donou

    Citation: BMC Endocrine Disorders 2019 19:96

    Content type: Case report

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  35. Hypertriglyceridemia is often observed as the result of lipid abnormality and frequently associated with other lipid and metabolic disorders. Aggravation of hypertriglyceridemia is caused by various conditions...

    Authors: Shintaro Irie, Takatoshi Anno, Fumiko Kawasaki, Ryo Shigemoto, Shuhei Nakanishi, Kohei Kaku and Hideaki Kaneto

    Citation: BMC Endocrine Disorders 2019 19:92

    Content type: Case report

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  36. Diabetes-related kidney disease is associated with end-stage renal disease and mortality, but opportunities remain to quantify its association with cardiovascular and non-cardiovascular morbidity outcomes.

    Authors: James B. Wetmore, Suying Li, Thanh G. N. Ton, Yi Peng, Michael K. Hansen, Cheryl Neslusan, Ralph Riley, Jiannong Liu and David T. Gilbertson

    Citation: BMC Endocrine Disorders 2019 19:89

    Content type: Research article

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  37. Glycosylated hemoglobin (HbA1c) has a detrimental impact on the myocardium with left ventricular (LV) diastolic dysfunction. Obesity is a risk factor of type 2 diabetes. To understand the relationships between...

    Authors: Xin Zuo, Xueting Liu, Runtian Chen, Huiting Ou, Jiabao Lai, Youming Zhang and Dewen Yan

    Citation: BMC Endocrine Disorders 2019 19:88

    Content type: Research article

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  38. Subjects with prediabetes are at increased risk of future T2DM and cardiovascular disease (CVD) compared to NGT individuals. The OGTT (FPG = 100–125 and 2 h-PG = 140–199 mg/dl) and HbA1c 5.7–6.4% have been use...

    Authors: Saadallah Iskandar, Ayman Migahid, Dalia Kamal, Osama Megahed, Ralph A. DeFronzo, Mahmoud Zirie, Amin Jayyousi, Mahmood Al Jaidah and Muhammad Abdul-Ghani

    Citation: BMC Endocrine Disorders 2019 19:87

    Content type: Research article

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  39. Older patients with type 2 diabetes mellitus represent a heterogeneous group in terms of metabolic profile. It makes glucose-lowering-therapy (GLT) complex to manage, as it needs to be individualised according...

    Authors: Antoine CHRISTIAENS, Michel P. HERMANS, Benoit BOLAND and Séverine HENRARD

    Citation: BMC Endocrine Disorders 2019 19:85

    Content type: Research article

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  40. In patients with diabetes mellitus, the urinary microalbumin-to-urine creatinine ratio (UACR) can not only predict the occurrence of diabetic nephropathy but also can be a risk factor for cardiovascular diseas...

    Authors: Juan Xie, Xiaoqing Wang, Yiyuan Zhang, Hailun Li, Yong Xu and Donghui Zheng

    Citation: BMC Endocrine Disorders 2019 19:84

    Content type: Research article

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  41. Elderly patients with type 2 diabetes mellitus (T2DM) experience fractures more frequently than elderly individuals without diabetes. Fractures requiring hospitalization greatly affect quality of life, and alt...

    Authors: Takeshi Horii, Makiko Iwasawa, Yusuke Kabeya, Jyunichi Shimizu and Koichiro Atsuda

    Citation: BMC Endocrine Disorders 2019 19:81

    Content type: Research article

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  42. Hypoglycaemia, especially nocturnal, remains the main limiting factor of achieving good glycaemic control in type 1 diabetes.

    Authors: Rikke Mette Agesen, Amra Ciric Alibegovic, Henrik Ullits Andersen, Henning Beck-Nielsen, Peter Gustenhoff, Troels Krarup Hansen, Christoffer Hedetoft, Tonny Jensen, Claus Bogh Juhl, Susanne Søgaard Lerche, Kirsten Nørgaard, Hans-Henrik Parving, Lise Tarnow, Birger Thorsteinsson and Ulrik Pedersen-Bjergaard

    Citation: BMC Endocrine Disorders 2019 19:78

    Content type: Study protocol

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  43. Chronic inflammation has been associated with dysglycemia among people living with HIV (PLHIV). There is however, limited data regarding this phenomenon in sub-Sahara Africa (SSA). Therefore we assessed the le...

    Authors: Lilian Nkinda, Kirtika Patel, Benson Njuguna, Jean Pierre Ngangali, Peter Memiah, George M. Bwire, Mtebe V. Majigo, Mucho Mizinduko, Sonak D. Pastakia and Eligius Lyamuya

    Citation: BMC Endocrine Disorders 2019 19:77

    Content type: Research article

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  44. Sarcopenic obesity, central obesity combined with decreased skeletal muscle mass, is identified to be associated with metabolic syndrome and cardiovascular diseases; however, its role in the occurrence of non-...

    Authors: Xiaoyou Su, Jing Xu and Chao Zheng

    Citation: BMC Endocrine Disorders 2019 19:76

    Content type: Research article

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  45. To investigate any associations between blood glucose (BG) and lipid levels in patients with different glucose tolerance statuses, including type 2 diabetes (T2DM) and impaired glucose regulation (IGR) cases a...

    Authors: Shujin Wang, Guohong Li, Hong Zuo, Hua Yang, Lei Ma, Jia Feng, Yu Niu, Liming Ma, Songfang Liu, Ting Qi and Xufeng Liu

    Citation: BMC Endocrine Disorders 2019 19:75

    Content type: Research article

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  46. Type 2 Diabetes Mellitus (T2DM) has become an endemic disease. A number of interrelated factors increase the risk of the onset of T2DM, however much of the pathogenesis of the disease is associated with lifest...

    Authors: Linda Cloete, Brett G. Mitchell and Darren Morton

    Citation: BMC Endocrine Disorders 2019 19:74

    Content type: Study protocol

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  47. Several studies have indicated that inflammatory markers were associated with the risk of mild cognitive impairment (MCI) in type 2 diabetes (T2D). Serum folate was related to MCI as well as inflammation. Howe...

    Authors: Miaoyan Zheng, Baocheng Chang, Liqiang Tian, Chunyan Shan, Hui Chen, Yuxia Gao, Guowei Huang and Meilin Zhang

    Citation: BMC Endocrine Disorders 2019 19:73

    Content type: Research article

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  48. Metabolic encephalopathy is a rare but potentially devastating complication of diabetic ketoacidosis (DKA). This case highlights the dramatic cognitive decline of a young man due to metabolic encephalopathy co...

    Authors: Maria Tomkins, Richard McCormack, Karen O’Connell, Amar Agha and Áine Merwick

    Citation: BMC Endocrine Disorders 2019 19:71

    Content type: Case report

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  49. For patients with type 2 diabetes (T2D), cardiovascular disease (CVD) is the single most common cause of mortality. In 2008 and 2012, the Federal Drug Administration (FDA) and the European Medicines Agency (EM...

    Authors: Guntram Schernthaner, Heinz Drexel, Evgeny Moshkovich, Birute Zilaitiene, Emil Martinka, Leszek Czupryniak, Tamás Várkonyi, Andrej Janež, Kristine Ducena, Katarina Lalić, Tsvetalina Tankova, Martin Prázný, Lea Smirčić Duvnjak, Olga Sukhareva and Harald Sourij

    Citation: BMC Endocrine Disorders 2019 19:64

    Content type: Correspondence

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