Skip to main content


Diabetes and Metabolism

Section edited by Abd Tahrani

This section concerns all aspects of diabetes and metabolic syndrome including but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

Page 1 of 5

  1. Content type: Case report

    Charcot neuropathic osteoarthropathy (CNO) is one of the most devastating complications of neuropathy in patients with diabetes. Establishing diagnosis of CNO is difficult, due to the lack of clear clinical an...

    Authors: C. V. Loupa, E. Meimeti, A. Kokas, E. D. Voyatzoglou and A. Donou

    Citation: BMC Endocrine Disorders 2019 19:96

    Published on:

  2. Content type: Case report

    Hypertriglyceridemia is often observed as the result of lipid abnormality and frequently associated with other lipid and metabolic disorders. Aggravation of hypertriglyceridemia is caused by various conditions...

    Authors: Shintaro Irie, Takatoshi Anno, Fumiko Kawasaki, Ryo Shigemoto, Shuhei Nakanishi, Kohei Kaku and Hideaki Kaneto

    Citation: BMC Endocrine Disorders 2019 19:92

    Published on:

  3. Content type: Research article

    Diabetes-related kidney disease is associated with end-stage renal disease and mortality, but opportunities remain to quantify its association with cardiovascular and non-cardiovascular morbidity outcomes.

    Authors: James B. Wetmore, Suying Li, Thanh G. N. Ton, Yi Peng, Michael K. Hansen, Cheryl Neslusan, Ralph Riley, Jiannong Liu and David T. Gilbertson

    Citation: BMC Endocrine Disorders 2019 19:89

    Published on:

  4. Content type: Research article

    Glycosylated hemoglobin (HbA1c) has a detrimental impact on the myocardium with left ventricular (LV) diastolic dysfunction. Obesity is a risk factor of type 2 diabetes. To understand the relationships between...

    Authors: Xin Zuo, Xueting Liu, Runtian Chen, Huiting Ou, Jiabao Lai, Youming Zhang and Dewen Yan

    Citation: BMC Endocrine Disorders 2019 19:88

    Published on:

  5. Content type: Research article

    Subjects with prediabetes are at increased risk of future T2DM and cardiovascular disease (CVD) compared to NGT individuals. The OGTT (FPG = 100–125 and 2 h-PG = 140–199 mg/dl) and HbA1c 5.7–6.4% have been use...

    Authors: Saadallah Iskandar, Ayman Migahid, Dalia Kamal, Osama Megahed, Ralph A. DeFronzo, Mahmoud Zirie, Amin Jayyousi, Mahmood Al Jaidah and Muhammad Abdul-Ghani

    Citation: BMC Endocrine Disorders 2019 19:87

    Published on:

  6. Content type: Research article

    Older patients with type 2 diabetes mellitus represent a heterogeneous group in terms of metabolic profile. It makes glucose-lowering-therapy (GLT) complex to manage, as it needs to be individualised according...

    Authors: Antoine CHRISTIAENS, Michel P. HERMANS, Benoit BOLAND and Séverine HENRARD

    Citation: BMC Endocrine Disorders 2019 19:85

    Published on:

  7. Content type: Research article

    In patients with diabetes mellitus, the urinary microalbumin-to-urine creatinine ratio (UACR) can not only predict the occurrence of diabetic nephropathy but also can be a risk factor for cardiovascular diseas...

    Authors: Juan Xie, Xiaoqing Wang, Yiyuan Zhang, Hailun Li, Yong Xu and Donghui Zheng

    Citation: BMC Endocrine Disorders 2019 19:84

    Published on:

  8. Content type: Research article

    Elderly patients with type 2 diabetes mellitus (T2DM) experience fractures more frequently than elderly individuals without diabetes. Fractures requiring hospitalization greatly affect quality of life, and alt...

    Authors: Takeshi Horii, Makiko Iwasawa, Yusuke Kabeya, Jyunichi Shimizu and Koichiro Atsuda

    Citation: BMC Endocrine Disorders 2019 19:81

    Published on:

  9. Content type: Study protocol

    Hypoglycaemia, especially nocturnal, remains the main limiting factor of achieving good glycaemic control in type 1 diabetes.

    Authors: Rikke Mette Agesen, Amra Ciric Alibegovic, Henrik Ullits Andersen, Henning Beck-Nielsen, Peter Gustenhoff, Troels Krarup Hansen, Christoffer Hedetoft, Tonny Jensen, Claus Bogh Juhl, Susanne Søgaard Lerche, Kirsten Nørgaard, Hans-Henrik Parving, Lise Tarnow, Birger Thorsteinsson and Ulrik Pedersen-Bjergaard

    Citation: BMC Endocrine Disorders 2019 19:78

    Published on:

  10. Content type: Research article

    Chronic inflammation has been associated with dysglycemia among people living with HIV (PLHIV). There is however, limited data regarding this phenomenon in sub-Sahara Africa (SSA). Therefore we assessed the le...

    Authors: Lilian Nkinda, Kirtika Patel, Benson Njuguna, Jean Pierre Ngangali, Peter Memiah, George M. Bwire, Mtebe V. Majigo, Mucho Mizinduko, Sonak D. Pastakia and Eligius Lyamuya

    Citation: BMC Endocrine Disorders 2019 19:77

    Published on:

  11. Content type: Research article

    Sarcopenic obesity, central obesity combined with decreased skeletal muscle mass, is identified to be associated with metabolic syndrome and cardiovascular diseases; however, its role in the occurrence of non-...

    Authors: Xiaoyou Su, Jing Xu and Chao Zheng

    Citation: BMC Endocrine Disorders 2019 19:76

    Published on:

  12. Content type: Research article

    To investigate any associations between blood glucose (BG) and lipid levels in patients with different glucose tolerance statuses, including type 2 diabetes (T2DM) and impaired glucose regulation (IGR) cases a...

    Authors: Shujin Wang, Guohong Li, Hong Zuo, Hua Yang, Lei Ma, Jia Feng, Yu Niu, Liming Ma, Songfang Liu, Ting Qi and Xufeng Liu

    Citation: BMC Endocrine Disorders 2019 19:75

    Published on:

  13. Content type: Study protocol

    Type 2 Diabetes Mellitus (T2DM) has become an endemic disease. A number of interrelated factors increase the risk of the onset of T2DM, however much of the pathogenesis of the disease is associated with lifest...

    Authors: Linda Cloete, Brett G. Mitchell and Darren Morton

    Citation: BMC Endocrine Disorders 2019 19:74

    Published on:

  14. Content type: Research article

    Several studies have indicated that inflammatory markers were associated with the risk of mild cognitive impairment (MCI) in type 2 diabetes (T2D). Serum folate was related to MCI as well as inflammation. Howe...

    Authors: Miaoyan Zheng, Baocheng Chang, Liqiang Tian, Chunyan Shan, Hui Chen, Yuxia Gao, Guowei Huang and Meilin Zhang

    Citation: BMC Endocrine Disorders 2019 19:73

    Published on:

  15. Content type: Case report

    Metabolic encephalopathy is a rare but potentially devastating complication of diabetic ketoacidosis (DKA). This case highlights the dramatic cognitive decline of a young man due to metabolic encephalopathy co...

    Authors: Maria Tomkins, Richard McCormack, Karen O’Connell, Amar Agha and Áine Merwick

    Citation: BMC Endocrine Disorders 2019 19:71

    Published on:

  16. Content type: Correspondence

    For patients with type 2 diabetes (T2D), cardiovascular disease (CVD) is the single most common cause of mortality. In 2008 and 2012, the Federal Drug Administration (FDA) and the European Medicines Agency (EM...

    Authors: Guntram Schernthaner, Heinz Drexel, Evgeny Moshkovich, Birute Zilaitiene, Emil Martinka, Leszek Czupryniak, Tamás Várkonyi, Andrej Janež, Kristine Ducena, Katarina Lalić, Tsvetalina Tankova, Martin Prázný, Lea Smirčić Duvnjak, Olga Sukhareva and Harald Sourij

    Citation: BMC Endocrine Disorders 2019 19:64

    Published on:

  17. Content type: Research article

    Patients with type 2 diabetes mellitus (T2DM) have accelerated atherosclerosis as a pro thrombotic state that is associated with the platelet activation priming. Platelets, which undergo the continuous mild st...

    Authors: Razie Mahmoodian, Morteza Salimian, Mohsen Hamidpour, Ali Akbar Khadem-Maboudi and Ahmad Gharehbaghian

    Citation: BMC Endocrine Disorders 2019 19:62

    Published on:

  18. Content type: Case report

    Insulin-derived amyloidosis is a skin-related complication of insulin therapy that interferes with insulin therapy. Although toxicities of in vitro-formed insulin amyloid fibrils have been well studied, the to...

    Authors: Keiichi Iwaya, Tamotsu Zako, Junta Fukunaga, Karin Margareta Sörgjerd, Kentaro Ogata, Koichiro Kogure, Hiroshi Kosano, Masayuki Noritake, Mizuo Maeda, Yukio Ando, Yoshiya Katsura and Terumasa Nagase

    Citation: BMC Endocrine Disorders 2019 19:61

    Published on:

  19. Content type: Research article

    Survival from many cancer types is steadily increasing, and as a result, a growing number of cancer patients will live with other chronic diseases, of which diabetes is one of the most prevalent. This study ai...

    Authors: Anne Beiter Arreskov, Maria Å. Olsen, Sandra Sinius Pouplier, Volkert Siersma, Christen L. Andersen, Søren Friis and Niels de Fine Olivarius

    Citation: BMC Endocrine Disorders 2019 19:60

    Published on:

  20. Content type: Research article

    The present study aimed to investigate the inhibitory effects of aminoguanidine (AG) and 2-bromoethylamine (2-BEA) on the semicarbazide-sensitive amine oxidase (SSAO) activity both in vitro and in vivo, and th...

    Authors: Chaosheng Li, Zhenhua Wang, Xiaoli Li and Jun Chen

    Citation: BMC Endocrine Disorders 2019 19:59

    Published on:

  21. Content type: Research article

    Although exercise seems to be beneficial for type 2 diabetes mellitus (T2DM) patients, there is limited research elucidating the optimal accessible indices of adiposity and insulin resistance for identifying e...

    Authors: Hong-Ting Zhu, Min Yu, Hao Hu, Qing-Fang He, Jin Pan and Ru-Ying Hu

    Citation: BMC Endocrine Disorders 2019 19:57

    Published on:

  22. Content type: Research article

    The diet quality of adults living in the United States has improved overtime. We aim to determine whether diet quality among adults with diabetes mellitus has changed over time, and to examine trends in socioe...

    Authors: Colin J. Orr, Thomas C. Keyserling, Alice S. Ammerman and Seth A. Berkowitz

    Citation: BMC Endocrine Disorders 2019 19:54

    Published on:

  23. Content type: Study protocol

    Teenagers and young adults with type 1 diabetes (T1D) experience significant burden managing this serious chronic condition and glycaemic control is at its unhealthiest during this life stage. Flash glucose mo...

    Authors: Sara E. Boucher, Andrew R. Gray, Martin de Bock, Esko J. Wiltshire, Barbara C. Galland, Paul A. Tomlinson, Jenny Rayns, Karen E. MacKenzie and Benjamin J. Wheeler

    Citation: BMC Endocrine Disorders 2019 19:50

    Published on:

  24. Content type: Research article

    On average, patients in Japan with type 2 diabetes mellitus have a clinical consultation every month, although evidence for a favorable follow-up interval is lacking. This study investigated whether the follow...

    Authors: Tomohiko Ukai, Shuhei Ichikawa, Miho Sekimoto, Satoru Shikata and Yousuke Takemura

    Citation: BMC Endocrine Disorders 2019 19:43

    Published on:

  25. Content type: Research article

    Type 2 diabetes mellitus (T2D) is a leading cause of morbidity and mortality in Mexico. Here, we aimed to report incidence rates (IR) of type 2 diabetes in middle-aged apparently-healthy Mexican adults, identi...

    Authors: Olimpia Arellano-Campos, Donaji V. Gómez-Velasco, Omar Yaxmehen Bello-Chavolla, Ivette Cruz-Bautista, Marco A. Melgarejo-Hernandez, Liliana Muñoz-Hernandez, Luz E. Guillén, Jose de Jesus Garduño-Garcia, Ulices Alvirde, Yukiko Ono-Yoshikawa, Ricardo Choza-Romero, Leobardo Sauque-Reyna, Maria Eugenia Garay-Sevilla, Juan Manuel Malacara-Hernandez, Maria Teresa Tusie-Luna, Luis Miguel Gutierrez-Robledo…

    Citation: BMC Endocrine Disorders 2019 19:41

    Published on:

  26. Content type: Research article

    To analyze data in terms of the glycaemic control and therapeutic regimens used for Type-2 Diabetes Mellitus (T2DM) management in Greece, identify factors that influence clinical decisions and determine the le...

    Authors: Stavros Liatis, Styliani Iraklianou, Kyriakos Kazakos, George Mastorakos, Kostas Milios, Zadalla Mouslech, Marina Noutsou, Emmanouil Pagkalos and Christos Sampanis

    Citation: BMC Endocrine Disorders 2019 19:39

    Published on:

  27. Content type: Research article

    To compare neurocognitive functioning of Type 1 diabetic mellitus (T1DM) and healthy adults, and explore risk factors of cognitive dysfunction of T1DM patients, especially the association between cognitive imp...

    Authors: Xin Ding, Chen Fang, Xiang Li, Yong-Jun Cao, Qi-Lin Zhang, Yun Huang, Jian Pan and Xia Zhang

    Citation: BMC Endocrine Disorders 2019 19:34

    Published on:

  28. Content type: Research article

    type 2 diabetes mellitus (T2DM) is a complicated disease that can affect bone health, but the change in bone biochemical markers caused by T2DM was controversial, so the aim of this study was to investigate wh...

    Authors: Lianzi Wang, Tao Li, Jiaqing Liu, Xian Wu, Huihui Wang, Xuemei Li, Enjun Xu, Qiuli Chen, Chuan Yan, Huimin Li, Yuanhong Xu and Wei Wei

    Citation: BMC Endocrine Disorders 2019 19:31

    Published on:

  29. Content type: Research article

    To determine the relation between daily glycemic fluturation and the intestinal mucosal barrier dysfunction in type 2 diabetes mellitus (T2DM).

    Authors: Lijuan Shen, Li Ao, Haoben Xu, Junfeng Shi, Dali You, Xiuwen Yu, Weixin Xu, Jie Sun and Fei Wang

    Citation: BMC Endocrine Disorders 2019 19:29

    Published on:

  30. Content type: Research article

    Data of studies focusing on the trends of adiposity indices among women with prior gestational diabetes mellitus (GDM), are limited and controversial. The aim of this study was to compare overtime trends of ad...

    Authors: Samira Behboudi-Gandevani, Fahimeh Ramezani Tehrani, Maryam Rahmati, Mina Amiri and Fereidoun Azizi

    Citation: BMC Endocrine Disorders 2019 19:24

    Published on:

  31. Content type: Research article

    Dysglycemic status defined by prediabetes and diabetes is known to be related with future risk of diabetic complications and cardiovascular diseases. Herein, we aimed to determine the diagnostic accuracy of gl...

    Authors: Yotsapon Thewjitcharoen, Amia Jones Elizabeth, Siriwan Butadej, Soontaree Nakasatien, Phawinpon Chotwanvirat, Ekgaluck Wanothayaroj, Sirinate Krittiyawong, Tinapa Himathongkam and Thep Himathongkam

    Citation: BMC Endocrine Disorders 2019 19:23

    Published on:

  32. Content type: Research article

    As an insulin-dependent disease, type 1 diabetes requires paying close attention to the glycemic control. Studies have shown that mobile health (mHealth) can improve the management of chronic diseases. However...

    Authors: Xuemei Wang, Wei Shu, Jian Du, Maolin Du, Peiyu Wang, Mingming Xue, Huiqiu Zheng, Yufeng Jiang, Shaohua Yin, Danyan Liang, Ruiqi Wang and Lina Hou

    Citation: BMC Endocrine Disorders 2019 19:21

    Published on:

  33. Content type: Research article

    Measurement of gylcated hemoglobin A1c (HbA1c) plays a central role in monitoring quality of antidiabetic therapy and in the diagnosis of diabetes. Several studies report increased levels of HbA1c in nondiabet...

    Authors: Annette Masuch, Nele Friedrich, Johannes Roth, Matthias Nauck, Ulrich Alfons Müller and Astrid Petersmann

    Citation: BMC Endocrine Disorders 2019 19:20

    Published on:

  34. Content type: Research article

    The incretin-based medicines GLP1 analogues (GLP1a) and dipeptidyl peptidase-4 inhibitors (DPP4i) are hypoglycaemic agents licensed for the treatment of type 2 diabetes mellitus (T2DM). Although these drugs po...

    Authors: Giuseppe Roberto, Francesco Barone-Adesi, Francesco Giorgianni, Valeria Pizzimenti, Carmen Ferrajolo, Michele Tari, Claudia Bartolini, Roberto Da Cas, Marina Maggini, Stefania Spila-Alegiani, Paolo Francesconi, Gianluca Trifirò, Elisabetta Poluzzi, Fabio Baccetti and Rosa Gini

    Citation: BMC Endocrine Disorders 2019 19:18

    Published on:

  35. Content type: Research article

    Hypoglycemia presents a barrier to optimum diabetes management and it is related to a negative impact on health-related quality of life, healthcare resource use, and work productivity. Despite the fact that th...

    Authors: Gashayeneh Genetu Tiruneh, Nurilign Abebe and Getenet Dessie

    Citation: BMC Endocrine Disorders 2019 19:17

    Published on:

  36. Content type: Research article

    A comparative study of 11 β HSD 1 activity in type 2 diabetes mellitus subjects with respect to fasting blood glucose and other metabolic parameters was conducted.

    Authors: Ravindra Shukla, Asish Kumar Basu, Biplab Mandal, Pradip Mukhopadhyay, Animesh Maity, Satyam Chakraborty and Praveen Kumar Devrabhai

    Citation: BMC Endocrine Disorders 2019 19:15

    Published on:

  37. Content type: Research article

    Fasting plasma glucose (FPG) is the most commonly used screening tool for diabetes in Sri Lanka. Cut-off values from American Diabetes Association recommendations are adopted in the absence of local data. We a...

    Authors: G. W. Katulanda, P. Katulanda, C. Dematapitiya, H. A. Dissanayake, S. Wijeratne, M. H. R. Sheriff and D. R. Matthews

    Citation: BMC Endocrine Disorders 2019 19:11

    Published on:

  38. Content type: Research article

    The role of technology in the self-management of type 1 diabetes mellitus (T1DM) among children and young people is not well understood. Interventions should aim to improve key diabetes self-management behavio...

    Authors: Emily C. L. Knox, Helen Quirk, Cris Glazebrook, Tabitha Randell and Holly Blake

    Citation: BMC Endocrine Disorders 2019 19:7

    Published on:

  39. Content type: Research article

    Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that increases the cardiovascular risk. Regular physical exercise can promote benefits, but the MetS individuals are demotivated to perform it....

    Authors: Danúbia Sá-Caputo, Laisa Liane Paineiras-Domingos, Arlete Francisca-Santos, Elzi Martins dos Anjos, Aline Silva Reis, Mario Fritsch Toros Neves, Wille Oigman, Ricardo Oliveira, Andrea Brandão, Christiano Bittencourt Machado, Xavier Chiementin, Redha Taiar, Alessandro Sartório and Mario Bernardo-Filho

    Citation: BMC Endocrine Disorders 2019 19:6

    Published on:

  40. Content type: Case report

    Insulin injection, especially with insulin analogs, occasionally induces the production of insulin antibodies with high binding capacity and low affinity, similar to the insulin autoantibodies characteristic o...

    Authors: Keizo Kaneko, Chihiro Satake, Tomohito Izumi, Mamiko Tanaka, Junpei Yamamoto, Yoichiro Asai, Shojiro Sawada, Junta Imai, Tetsuya Yamada and Hideki Katagiri

    Citation: BMC Endocrine Disorders 2019 19:5

    Published on:

  41. Content type: Research article

    Several clinical trials have studied the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on glycometabolism and cardiovascular risk factors since they were identified. Because of their cardiova...

    Authors: Xu Zhao, Kun Huang, Meijie Zheng and Junting Duan

    Citation: BMC Endocrine Disorders 2019 19:4

    Published on:

  42. Content type: Research article

    Dipeptidyl peptidase-4 (DPP-4) inhibitors could effectively reduce HbA1C and postprandial hyperglycemia and could incur only minimal danger of hypoglycemia. Patients with uncontrolled diabetes might be treated by...

    Authors: Fu-Shun Yen, Jen-Huai Chiang, Chii-Min Hwu, Yu-Hsin Yen, Boniface J. Lin, James Cheng-Chung Wei and Chih-Cheng Hsu

    Citation: BMC Endocrine Disorders 2019 19:3

    Published on:

  43. Content type: Research article

    Chronic diabetic complications may afflict all organ tissues, including those of the respiratory system. The six-minute walk test (6MWT) is an alternative and widely used method of assessing functional capacity a...

    Authors: Krzysztof Kuziemski, Wojciech Słomiński and Ewa Jassem

    Citation: BMC Endocrine Disorders 2019 19:2

    Published on:

  44. Content type: Research article

    Diabetic foot ulcers (DFU) are a common problem in longstanding diabetes. However, mortality outcomes in Australian patients with DFU are still unclear.

    Authors: Kanakamani Jeyaraman, Thomas Berhane, Mark Hamilton, Abhilash P. Chandra and Henrik Falhammar

    Citation: BMC Endocrine Disorders 2019 19:1

    Published on:

  45. Content type: Research article

    Sub-Saharan Africa continues to face the highest rate of mortality from diabetes in the world due to limited access to quality diabetes care. We assessed the quality of diabetes care in a rural diabetes clinic...

    Authors: Sonak D. Pastakia, Bernardo Nuche-Berenguer, Chelsea Regina Pekny, Benson Njuguna, Elizabeth Guinevere O’Hara, Stephanie Y. Cheng, Jeremiah Laktabai, Victor Buckwalter, Nicholas Kirui and Patrick Chege

    Citation: BMC Endocrine Disorders 2018 18:97

    Published on:

  46. Content type: Research article

    Diabetes is a risk factor for cognitive impairment, but whether there is also a link between pre-diabetes and cognitive dysfunction is not yet fully established. The aim of this observational study was to inve...

    Authors: Elin Dybjer, Peter M. Nilsson, Gunnar Engström, Catherine Helmer and Katarina Nägga

    Citation: BMC Endocrine Disorders 2018 18:91

    Published on:

  47. Content type: Research article

    Bariatric surgery is effective in remission of obesity comorbidities. This study was aimed at comparing CVD risk between morbidly obese patients with type 2 diabetes and pre-diabetes before and after bariatric...

    Authors: Matilde Rubio-Almanza, Rosa Cámara-Gómez, David Hervás-Marín, José Luis Ponce-Marco and Juan Francisco Merino-Torres

    Citation: BMC Endocrine Disorders 2018 18:90

    Published on: