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Diabetes and Metabolism

Section edited by Abd Tahrani

This section concerns all aspects of diabetes and metabolic syndrome including but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Diabetic ketoacidosis (DKA) is an acute, major, life-threatening complication of diabetes that requires immediate treatment. Allergic reaction to insulin is rare, especially when using recombinant human insuli...

    Authors: Anh Dat Nguyen, Chinh Quoc Luong, Hieu Chi Chu, Van Khoa Dieu Nguyen, Chi Van Nguyen, Tuan Anh Nguyen, Quan Huu Nguyen, Ton Duy Mai, Dinh Van Nguyen, Bay Quang Nguyen, Thong Huu Tran, Phuong Viet Dao, Dat Tuan Nguyen, Nguyet Nhu Nguyen and Son Ngoc Do

    Citation: BMC Endocrine Disorders 2019 19:121

    Content type: Case report

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  2. Agenesis of the dorsal pancreas (ADP) is clinically rare, and it is usually accompanied by abdominal pain. Various disorders of glucose metabolism associating with ADP have been reported, but there are only tw...

    Authors: Tian Yang, Xudan Yang, Luping Wang and Jun Mo

    Citation: BMC Endocrine Disorders 2019 19:120

    Content type: Case report

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  3. The shape of the glucose response curve during an oral glucose tolerance test (OGTT) can predict β-cell function and insulin resistance. However, there have been few studies conducted on Chinese people. Thus, ...

    Authors: Xinqi Cheng, Na Yang, Yuxiu Li, Qi Sun, Ling Qiu, Lingling Xu, Fan Ping, Wei Li and Huabing Zhang

    Citation: BMC Endocrine Disorders 2019 19:119

    Content type: Research article

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  4. Diabetes is 7th largest cause of death worldwide, and prevalence is increasing rapidly in low-and middle-income countries. There is an urgent need to develop and test interventions to prevent and control diabe...

    Authors: Joanna Morrison, Kohenour Akter, Hannah Maria Jennings, Tasmin Nahar, Abdul Kuddus, Sanjit Kumer Shaha, Naveed Ahmed, Carina King, Hassan Haghparast-Bidgoli, Anthony Costello, A. K. Azad Khan, Kishwar Azad and Edward Fottrell

    Citation: BMC Endocrine Disorders 2019 19:118

    Content type: Research article

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  5. The prevalence of obesity and its comorbidities, including type 2 diabetes mellitus (T2DM), is dramatically increasing throughout the world; however, the underlying aetiology is incompletely understood. Genome...

    Authors: Naomi L. Cook, Milos Pjanic, Andrew G. Emmerich, Abhiram S. Rao, Susanne Hetty, Joshua W. Knowles, Thomas Quertermous, Casimiro Castillejo-López and Erik Ingelsson

    Citation: BMC Endocrine Disorders 2019 19:115

    Content type: Research article

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  6. Colorectal cancer (CRC) is the fourth most commonly diagnosed gastrointestinal (GI) malignancy and the third leading cause of cancer-related death worldwide. In the current case-control study, an association b...

    Authors: Ghodratollah Soltani, Arash Poursheikhani, Maryam Yassi, Abdorasool Hayatbakhsh, Matin Kerachian and Mohammad Amin Kerachian

    Citation: BMC Endocrine Disorders 2019 19:113

    Content type: Research article

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  7. Severe hypoglycaemia carries a significant risk of morbidity and mortality for people with type 1 diabetes. Economic costs are also high, estimated at approximately £13 million annually in England, UK. Continu...

    Authors: Parizad Avari, Rozana Ramli, Monika Reddy, Nick Oliver and Rachael Fothergill

    Citation: BMC Endocrine Disorders 2019 19:110

    Content type: Study protocol

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  8. The adipokine adipsin contributes to insulin resistance (IR), inflammation, and obesity, which are all regarded as high-risk factors for mild cognitive impairment (MCI) in patients with type 2 diabetes mellitu...

    Authors: Dan Guo, Yang Yuan, Rong Huang, Sai Tian, Jiaqi Wang, Hongyan Lin, Ke An, Jin Han and Shaohua Wang

    Citation: BMC Endocrine Disorders 2019 19:108

    Content type: Research article

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  9. Hypoglycemia is a common complication of insulin therapy in patients with Type 1 Diabetes Mellitus (DM). Awareness of hypoglycemic symptoms helps patients to recognize hypoglycemia and initiate self-treatment....

    Authors: Mohammad J. Alkhatatbeh, Nedaa A. Abdalqader and Mohammad A. Y. Alqudah

    Citation: BMC Endocrine Disorders 2019 19:107

    Content type: Research article

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  10. Lifestyle modification targeting weight management is the first-line treatment for women with Polycystic Ovary Syndrome (PCOS) regardless of presenting symptoms. Women with PCOS are more likely to gain more we...

    Authors: Siew Lim, Caroline A. Smith, Michael F. Costello, Freya MacMillan, Lisa Moran and Carolyn Ee

    Citation: BMC Endocrine Disorders 2019 19:106

    Content type: Research article

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  11. Glucagon stimulation test (GST) is often employed to assess the insulin reserve of the pancreatic beta cells in diabetic subjects. The clinical significance of the increment of plasma glucose (Δglucose) by exo...

    Authors: Yasutaka Takeda, Yukihiro Fujita, Ryoichi Bessho, Mao Sato, Tomoe Abe, Tsuyoshi Yanagimachi, Hidemitsu Sakagami, Atsuko Abiko, Yumi Takiyama, Tsuguhito Ota and Masakazu Haneda

    Citation: BMC Endocrine Disorders 2019 19:99

    Content type: Research article

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  12. To investigate the prevalence of cardiovascular disease (CVD) risk factors and assess the 10-year risk of CVD in non-menopausal and postmenopausal women with type 2 diabetes mellitus (T2DM).

    Authors: Huanhuan Zhou, Chenghuan Zhang, Jingyu Ni and Xiaoyun Han

    Citation: BMC Endocrine Disorders 2019 19:98

    Content type: Research article

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  13. Charcot neuropathic osteoarthropathy (CNO) is one of the most devastating complications of neuropathy in patients with diabetes. Establishing diagnosis of CNO is difficult, due to the lack of clear clinical an...

    Authors: C. V. Loupa, E. Meimeti, A. Kokas, E. D. Voyatzoglou and A. Donou

    Citation: BMC Endocrine Disorders 2019 19:96

    Content type: Case report

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  14. Hypertriglyceridemia is often observed as the result of lipid abnormality and frequently associated with other lipid and metabolic disorders. Aggravation of hypertriglyceridemia is caused by various conditions...

    Authors: Shintaro Irie, Takatoshi Anno, Fumiko Kawasaki, Ryo Shigemoto, Shuhei Nakanishi, Kohei Kaku and Hideaki Kaneto

    Citation: BMC Endocrine Disorders 2019 19:92

    Content type: Case report

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  15. Diabetes-related kidney disease is associated with end-stage renal disease and mortality, but opportunities remain to quantify its association with cardiovascular and non-cardiovascular morbidity outcomes.

    Authors: James B. Wetmore, Suying Li, Thanh G. N. Ton, Yi Peng, Michael K. Hansen, Cheryl Neslusan, Ralph Riley, Jiannong Liu and David T. Gilbertson

    Citation: BMC Endocrine Disorders 2019 19:89

    Content type: Research article

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  16. Glycosylated hemoglobin (HbA1c) has a detrimental impact on the myocardium with left ventricular (LV) diastolic dysfunction. Obesity is a risk factor of type 2 diabetes. To understand the relationships between...

    Authors: Xin Zuo, Xueting Liu, Runtian Chen, Huiting Ou, Jiabao Lai, Youming Zhang and Dewen Yan

    Citation: BMC Endocrine Disorders 2019 19:88

    Content type: Research article

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  17. Subjects with prediabetes are at increased risk of future T2DM and cardiovascular disease (CVD) compared to NGT individuals. The OGTT (FPG = 100–125 and 2 h-PG = 140–199 mg/dl) and HbA1c 5.7–6.4% have been use...

    Authors: Saadallah Iskandar, Ayman Migahid, Dalia Kamal, Osama Megahed, Ralph A. DeFronzo, Mahmoud Zirie, Amin Jayyousi, Mahmood Al Jaidah and Muhammad Abdul-Ghani

    Citation: BMC Endocrine Disorders 2019 19:87

    Content type: Research article

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  18. Older patients with type 2 diabetes mellitus represent a heterogeneous group in terms of metabolic profile. It makes glucose-lowering-therapy (GLT) complex to manage, as it needs to be individualised according...

    Authors: Antoine CHRISTIAENS, Michel P. HERMANS, Benoit BOLAND and Séverine HENRARD

    Citation: BMC Endocrine Disorders 2019 19:85

    Content type: Research article

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  19. In patients with diabetes mellitus, the urinary microalbumin-to-urine creatinine ratio (UACR) can not only predict the occurrence of diabetic nephropathy but also can be a risk factor for cardiovascular diseas...

    Authors: Juan Xie, Xiaoqing Wang, Yiyuan Zhang, Hailun Li, Yong Xu and Donghui Zheng

    Citation: BMC Endocrine Disorders 2019 19:84

    Content type: Research article

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  20. Elderly patients with type 2 diabetes mellitus (T2DM) experience fractures more frequently than elderly individuals without diabetes. Fractures requiring hospitalization greatly affect quality of life, and alt...

    Authors: Takeshi Horii, Makiko Iwasawa, Yusuke Kabeya, Jyunichi Shimizu and Koichiro Atsuda

    Citation: BMC Endocrine Disorders 2019 19:81

    Content type: Research article

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  21. Hypoglycaemia, especially nocturnal, remains the main limiting factor of achieving good glycaemic control in type 1 diabetes.

    Authors: Rikke Mette Agesen, Amra Ciric Alibegovic, Henrik Ullits Andersen, Henning Beck-Nielsen, Peter Gustenhoff, Troels Krarup Hansen, Christoffer Hedetoft, Tonny Jensen, Claus Bogh Juhl, Susanne Søgaard Lerche, Kirsten Nørgaard, Hans-Henrik Parving, Lise Tarnow, Birger Thorsteinsson and Ulrik Pedersen-Bjergaard

    Citation: BMC Endocrine Disorders 2019 19:78

    Content type: Study protocol

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  22. Chronic inflammation has been associated with dysglycemia among people living with HIV (PLHIV). There is however, limited data regarding this phenomenon in sub-Sahara Africa (SSA). Therefore we assessed the le...

    Authors: Lilian Nkinda, Kirtika Patel, Benson Njuguna, Jean Pierre Ngangali, Peter Memiah, George M. Bwire, Mtebe V. Majigo, Mucho Mizinduko, Sonak D. Pastakia and Eligius Lyamuya

    Citation: BMC Endocrine Disorders 2019 19:77

    Content type: Research article

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  23. Sarcopenic obesity, central obesity combined with decreased skeletal muscle mass, is identified to be associated with metabolic syndrome and cardiovascular diseases; however, its role in the occurrence of non-...

    Authors: Xiaoyou Su, Jing Xu and Chao Zheng

    Citation: BMC Endocrine Disorders 2019 19:76

    Content type: Research article

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  24. To investigate any associations between blood glucose (BG) and lipid levels in patients with different glucose tolerance statuses, including type 2 diabetes (T2DM) and impaired glucose regulation (IGR) cases a...

    Authors: Shujin Wang, Guohong Li, Hong Zuo, Hua Yang, Lei Ma, Jia Feng, Yu Niu, Liming Ma, Songfang Liu, Ting Qi and Xufeng Liu

    Citation: BMC Endocrine Disorders 2019 19:75

    Content type: Research article

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  25. Type 2 Diabetes Mellitus (T2DM) has become an endemic disease. A number of interrelated factors increase the risk of the onset of T2DM, however much of the pathogenesis of the disease is associated with lifest...

    Authors: Linda Cloete, Brett G. Mitchell and Darren Morton

    Citation: BMC Endocrine Disorders 2019 19:74

    Content type: Study protocol

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  26. Several studies have indicated that inflammatory markers were associated with the risk of mild cognitive impairment (MCI) in type 2 diabetes (T2D). Serum folate was related to MCI as well as inflammation. Howe...

    Authors: Miaoyan Zheng, Baocheng Chang, Liqiang Tian, Chunyan Shan, Hui Chen, Yuxia Gao, Guowei Huang and Meilin Zhang

    Citation: BMC Endocrine Disorders 2019 19:73

    Content type: Research article

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  27. Metabolic encephalopathy is a rare but potentially devastating complication of diabetic ketoacidosis (DKA). This case highlights the dramatic cognitive decline of a young man due to metabolic encephalopathy co...

    Authors: Maria Tomkins, Richard McCormack, Karen O’Connell, Amar Agha and Áine Merwick

    Citation: BMC Endocrine Disorders 2019 19:71

    Content type: Case report

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  28. For patients with type 2 diabetes (T2D), cardiovascular disease (CVD) is the single most common cause of mortality. In 2008 and 2012, the Federal Drug Administration (FDA) and the European Medicines Agency (EM...

    Authors: Guntram Schernthaner, Heinz Drexel, Evgeny Moshkovich, Birute Zilaitiene, Emil Martinka, Leszek Czupryniak, Tamás Várkonyi, Andrej Janež, Kristine Ducena, Katarina Lalić, Tsvetalina Tankova, Martin Prázný, Lea Smirčić Duvnjak, Olga Sukhareva and Harald Sourij

    Citation: BMC Endocrine Disorders 2019 19:64

    Content type: Correspondence

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  29. Patients with type 2 diabetes mellitus (T2DM) have accelerated atherosclerosis as a pro thrombotic state that is associated with the platelet activation priming. Platelets, which undergo the continuous mild st...

    Authors: Razie Mahmoodian, Morteza Salimian, Mohsen Hamidpour, Ali Akbar Khadem-Maboudi and Ahmad Gharehbaghian

    Citation: BMC Endocrine Disorders 2019 19:62

    Content type: Research article

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  30. Insulin-derived amyloidosis is a skin-related complication of insulin therapy that interferes with insulin therapy. Although toxicities of in vitro-formed insulin amyloid fibrils have been well studied, the to...

    Authors: Keiichi Iwaya, Tamotsu Zako, Junta Fukunaga, Karin Margareta Sörgjerd, Kentaro Ogata, Koichiro Kogure, Hiroshi Kosano, Masayuki Noritake, Mizuo Maeda, Yukio Ando, Yoshiya Katsura and Terumasa Nagase

    Citation: BMC Endocrine Disorders 2019 19:61

    Content type: Case report

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  31. Survival from many cancer types is steadily increasing, and as a result, a growing number of cancer patients will live with other chronic diseases, of which diabetes is one of the most prevalent. This study ai...

    Authors: Anne Beiter Arreskov, Maria Å. Olsen, Sandra Sinius Pouplier, Volkert Siersma, Christen L. Andersen, Søren Friis and Niels de Fine Olivarius

    Citation: BMC Endocrine Disorders 2019 19:60

    Content type: Research article

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  32. The present study aimed to investigate the inhibitory effects of aminoguanidine (AG) and 2-bromoethylamine (2-BEA) on the semicarbazide-sensitive amine oxidase (SSAO) activity both in vitro and in vivo, and th...

    Authors: Chaosheng Li, Zhenhua Wang, Xiaoli Li and Jun Chen

    Citation: BMC Endocrine Disorders 2019 19:59

    Content type: Research article

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  33. Although exercise seems to be beneficial for type 2 diabetes mellitus (T2DM) patients, there is limited research elucidating the optimal accessible indices of adiposity and insulin resistance for identifying e...

    Authors: Hong-Ting Zhu, Min Yu, Hao Hu, Qing-Fang He, Jin Pan and Ru-Ying Hu

    Citation: BMC Endocrine Disorders 2019 19:57

    Content type: Research article

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  34. The diet quality of adults living in the United States has improved overtime. We aim to determine whether diet quality among adults with diabetes mellitus has changed over time, and to examine trends in socioe...

    Authors: Colin J. Orr, Thomas C. Keyserling, Alice S. Ammerman and Seth A. Berkowitz

    Citation: BMC Endocrine Disorders 2019 19:54

    Content type: Research article

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  35. Teenagers and young adults with type 1 diabetes (T1D) experience significant burden managing this serious chronic condition and glycaemic control is at its unhealthiest during this life stage. Flash glucose mo...

    Authors: Sara E. Boucher, Andrew R. Gray, Martin de Bock, Esko J. Wiltshire, Barbara C. Galland, Paul A. Tomlinson, Jenny Rayns, Karen E. MacKenzie and Benjamin J. Wheeler

    Citation: BMC Endocrine Disorders 2019 19:50

    Content type: Study protocol

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  36. On average, patients in Japan with type 2 diabetes mellitus have a clinical consultation every month, although evidence for a favorable follow-up interval is lacking. This study investigated whether the follow...

    Authors: Tomohiko Ukai, Shuhei Ichikawa, Miho Sekimoto, Satoru Shikata and Yousuke Takemura

    Citation: BMC Endocrine Disorders 2019 19:43

    Content type: Research article

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  37. Type 2 diabetes mellitus (T2D) is a leading cause of morbidity and mortality in Mexico. Here, we aimed to report incidence rates (IR) of type 2 diabetes in middle-aged apparently-healthy Mexican adults, identi...

    Authors: Olimpia Arellano-Campos, Donaji V. Gómez-Velasco, Omar Yaxmehen Bello-Chavolla, Ivette Cruz-Bautista, Marco A. Melgarejo-Hernandez, Liliana Muñoz-Hernandez, Luz E. Guillén, Jose de Jesus Garduño-Garcia, Ulices Alvirde, Yukiko Ono-Yoshikawa, Ricardo Choza-Romero, Leobardo Sauque-Reyna, Maria Eugenia Garay-Sevilla, Juan Manuel Malacara-Hernandez, Maria Teresa Tusie-Luna, Luis Miguel Gutierrez-Robledo…

    Citation: BMC Endocrine Disorders 2019 19:41

    Content type: Research article

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  38. To analyze data in terms of the glycaemic control and therapeutic regimens used for Type-2 Diabetes Mellitus (T2DM) management in Greece, identify factors that influence clinical decisions and determine the le...

    Authors: Stavros Liatis, Styliani Iraklianou, Kyriakos Kazakos, George Mastorakos, Kostas Milios, Zadalla Mouslech, Marina Noutsou, Emmanouil Pagkalos and Christos Sampanis

    Citation: BMC Endocrine Disorders 2019 19:39

    Content type: Research article

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  39. To compare neurocognitive functioning of Type 1 diabetic mellitus (T1DM) and healthy adults, and explore risk factors of cognitive dysfunction of T1DM patients, especially the association between cognitive imp...

    Authors: Xin Ding, Chen Fang, Xiang Li, Yong-Jun Cao, Qi-Lin Zhang, Yun Huang, Jian Pan and Xia Zhang

    Citation: BMC Endocrine Disorders 2019 19:34

    Content type: Research article

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  40. type 2 diabetes mellitus (T2DM) is a complicated disease that can affect bone health, but the change in bone biochemical markers caused by T2DM was controversial, so the aim of this study was to investigate wh...

    Authors: Lianzi Wang, Tao Li, Jiaqing Liu, Xian Wu, Huihui Wang, Xuemei Li, Enjun Xu, Qiuli Chen, Chuan Yan, Huimin Li, Yuanhong Xu and Wei Wei

    Citation: BMC Endocrine Disorders 2019 19:31

    Content type: Research article

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  41. To determine the relation between daily glycemic fluturation and the intestinal mucosal barrier dysfunction in type 2 diabetes mellitus (T2DM).

    Authors: Lijuan Shen, Li Ao, Haoben Xu, Junfeng Shi, Dali You, Xiuwen Yu, Weixin Xu, Jie Sun and Fei Wang

    Citation: BMC Endocrine Disorders 2019 19:29

    Content type: Research article

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  42. Data of studies focusing on the trends of adiposity indices among women with prior gestational diabetes mellitus (GDM), are limited and controversial. The aim of this study was to compare overtime trends of ad...

    Authors: Samira Behboudi-Gandevani, Fahimeh Ramezani Tehrani, Maryam Rahmati, Mina Amiri and Fereidoun Azizi

    Citation: BMC Endocrine Disorders 2019 19:24

    Content type: Research article

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  43. Dysglycemic status defined by prediabetes and diabetes is known to be related with future risk of diabetic complications and cardiovascular diseases. Herein, we aimed to determine the diagnostic accuracy of gl...

    Authors: Yotsapon Thewjitcharoen, Amia Jones Elizabeth, Siriwan Butadej, Soontaree Nakasatien, Phawinpon Chotwanvirat, Ekgaluck Wanothayaroj, Sirinate Krittiyawong, Tinapa Himathongkam and Thep Himathongkam

    Citation: BMC Endocrine Disorders 2019 19:23

    Content type: Research article

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  44. As an insulin-dependent disease, type 1 diabetes requires paying close attention to the glycemic control. Studies have shown that mobile health (mHealth) can improve the management of chronic diseases. However...

    Authors: Xuemei Wang, Wei Shu, Jian Du, Maolin Du, Peiyu Wang, Mingming Xue, Huiqiu Zheng, Yufeng Jiang, Shaohua Yin, Danyan Liang, Ruiqi Wang and Lina Hou

    Citation: BMC Endocrine Disorders 2019 19:21

    Content type: Research article

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  45. Measurement of gylcated hemoglobin A1c (HbA1c) plays a central role in monitoring quality of antidiabetic therapy and in the diagnosis of diabetes. Several studies report increased levels of HbA1c in nondiabet...

    Authors: Annette Masuch, Nele Friedrich, Johannes Roth, Matthias Nauck, Ulrich Alfons Müller and Astrid Petersmann

    Citation: BMC Endocrine Disorders 2019 19:20

    Content type: Research article

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  46. The incretin-based medicines GLP1 analogues (GLP1a) and dipeptidyl peptidase-4 inhibitors (DPP4i) are hypoglycaemic agents licensed for the treatment of type 2 diabetes mellitus (T2DM). Although these drugs po...

    Authors: Giuseppe Roberto, Francesco Barone-Adesi, Francesco Giorgianni, Valeria Pizzimenti, Carmen Ferrajolo, Michele Tari, Claudia Bartolini, Roberto Da Cas, Marina Maggini, Stefania Spila-Alegiani, Paolo Francesconi, Gianluca Trifirò, Elisabetta Poluzzi, Fabio Baccetti and Rosa Gini

    Citation: BMC Endocrine Disorders 2019 19:18

    Content type: Research article

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  47. Hypoglycemia presents a barrier to optimum diabetes management and it is related to a negative impact on health-related quality of life, healthcare resource use, and work productivity. Despite the fact that th...

    Authors: Gashayeneh Genetu Tiruneh, Nurilign Abebe and Getenet Dessie

    Citation: BMC Endocrine Disorders 2019 19:17

    Content type: Research article

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