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Diabetes and Metabolism

This section concerns all aspects of diabetes and metabolic syndrome including but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Diabetic retinopathy is the most common microvascular complication of diabetes and it is a leading cause of visual impairment and blindness among patients with diabetes. This study aimed to investigate the eff...

    Authors: Seyed Shahriar Hosseini, Mohsen Shamsi, Mahboobeh Khorsandi and Rahmatollah Moradzadeh

    Citation: BMC Endocrine Disorders 2021 21:17

    Content type: Research article

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  2. Skin autofluorescence (SAF) is a non-invasive marker of tissue accumulation of advanced glycation endproducts (AGE). Recently, we demonstrated in the general population that elevated SAF levels predict the dev...

    Authors: Henderikus E. Boersma, Robert P. van Waateringe, Melanie M. van der Klauw, Reindert Graaff, Andrew D. Paterson, Andries J. Smit and Bruce H. R. Wolffenbuttel

    Citation: BMC Endocrine Disorders 2021 21:14

    Content type: Research article

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  3. Weight loss therapy is becoming more and more important, and two classes of molecules, namely amylin receptor and GLP-1 receptor agonists, have shown promise in this regard. Interestingly, these molecules have...

    Authors: Anna Thorsø Larsen, Sofie Gydesen, Nina Sonne, Morten Asser Karsdal and Kim Henriksen

    Citation: BMC Endocrine Disorders 2021 21:10

    Content type: Research article

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  4. Studies analyzing the association between parity and normal-weight metabolic syndrome (MetS) in postmenopausal women of normal weight remain limited, this study aimed to explore the association between parity ...

    Authors: Mengte Shi, Xinhe Zhou, Chao Zheng and Youjin Pan

    Citation: BMC Endocrine Disorders 2021 21:8

    Content type: Research article

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  5. Red cell distribution width (RDW) is a predicter of infections, cancer and diabetes. However, the relationship between RDW and β-cell function and insulin resistance remains unclear in patients with type 2 dia...

    Authors: Deyuan Zhang, Siqi Zhang, Lifang Wang, Tianrong Pan and Xing Zhong

    Citation: BMC Endocrine Disorders 2021 21:7

    Content type: Research article

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  6. Serum uric acid (SUA) is associated with the development of diabetic kidney disease (DKD). Thyroid hormones can regulate metabolism and insulin resistance. The relationship between SUA and thyroid function in ...

    Authors: Xiaomeng Feng, Jing Huang, Yan Peng and Yuan Xu

    Citation: BMC Endocrine Disorders 2021 21:1

    Content type: Research article

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  7. Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) are the two most common hyperglycemic emergencies (HEs) associated with diabetes mellitus. Individuals with HEs can present with combined ...

    Authors: Xiao-yan Wu, Dun-min She, Fang Wang, Gang Guo, Ran Li, Ping Fang, Ling Li, Yun Zhou, Ke-qin Zhang and Ying Xue

    Citation: BMC Endocrine Disorders 2020 20:182

    Content type: Research article

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  8. To evaluate the association between diet and disease, the consideration of a whole diet has appeared to be more effective than the examination of single-nutrient intake. This study aimed to examine the relatio...

    Authors: Sahar Golpour-Hamedani, Nahid Rafie, Makan Pourmasoumi, Parvane Saneei and Sayyed Morteza Safavi

    Citation: BMC Endocrine Disorders 2020 20:181

    Content type: Research article

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  9. Existing prevention and treatment strategies target the classic types of diabetes yet this approach might not always be appropriate in some settings where atypical phenotypes exist. This study aims to assess t...

    Authors: Charlotte M. Bavuma, Sanctus Musafiri, Pierre-Claver Rutayisire, Loise M. Ng’ang’a, Ruth McQuillan and Sarah H. Wild

    Citation: BMC Endocrine Disorders 2020 20:180

    Content type: Research article

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  10. Lipid accumulation product (LAP) is a new index based on a combination of waist circumference (WC) and serum triglycerides (TG) reflecting lipid accumulation. In this cross-sectional study, we aimed to explore...

    Authors: Lianqin Dong, Mingzhu Lin, Wengui Wang, Danyan Ma, Yun Chen, Weijuan Su, Zheng Chen, Shunhua Wang, Xuejun Li, Zhibin Li and Changqin Liu

    Citation: BMC Endocrine Disorders 2020 20:179

    Content type: Research article

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  11. Circulating angiopoietin-like 2 (ANGPTL2) protein levels are known to be significantly increased in numerous chronic inflammatory diseases and are associated with the diagnosis and/or prognosis of cardiovascular ...

    Authors: Yan Wang, Zhaohui Zheng, Yuxian Yang, Jianan Lang, Ning Zhang, Longyan Yang and Dong Zhao

    Citation: BMC Endocrine Disorders 2020 20:178

    Content type: Research article

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  12. Individuals with normal weight obesity (NWO) are predisposed to having cardiometabolic disorders. This study aims to investigate the circulating levels of vaspin, leptin and their association with glycemic and...

    Authors: Ehsaneh Taheri, Saeed Hosseini, Mostafa Qorbani and Parvin Mirmiran

    Citation: BMC Endocrine Disorders 2020 20:171

    Content type: Research article

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  13. Metabolic syndrome (MetS) is a major public health concern due to its high prevalence and association with heart disease and diabetes. Artificial neural networks (ANN) are emerging as a reliable means of model...

    Authors: Meysam Eyvazlou, Mahdi Hosseinpouri, Hamidreza Mokarami, Vahid Gharibi, Mehdi Jahangiri, Rosanna Cousins, Hossein-Ali Nikbakht and Abdullah Barkhordari

    Citation: BMC Endocrine Disorders 2020 20:169

    Content type: Research article

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  14. While obesity and overweight status are firmly established risk factors for Type 2 diabetes mellitus (T2DM), a substantial proportion of diabetic individuals, especially in Africa and Asia, are often underweig...

    Authors: Anuradha Rajamanickam, Saravanan Munisankar, Chandra Kumar Dolla, Kannan Thiruvengadam and Subash Babu

    Citation: BMC Endocrine Disorders 2020 20:168

    Content type: Research article

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  15. Despite the current debate about the effects of high intensity interval training (HIIT), HIIT elicits big morpho-physiological benefit on Metabolic Syndrome (MetS) treatment. However, no review or meta-analysi...

    Authors: I. Serrablo-Torrejon, A. Lopez-Valenciano, M. Ayuso, E. Horton, X. Mayo, G. Medina-Gomez, G. Liguori and A. Jimenez

    Citation: BMC Endocrine Disorders 2020 20:167

    Content type: Research article

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  16. Vitamin D deficiency is diagnosed by total serum 25-hydroxyvitamin D (25(OH)D) concentration and is associated with poor health and increased mortality; however, some populations have low 25(OH) D concentratio...

    Authors: Lina H. M. Ahmed, Alexandra E. Butler, Soha R. Dargham, Aishah Latif, Omar M. Chidiac, Stephen L. Atkin and Charbel Abi Khalil

    Citation: BMC Endocrine Disorders 2020 20:161

    Content type: Research article

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  17. Dietary fatty acids are important dietary determinants of metabolic disorders in human. However, it is important to develop an index that considers not only the amount of dietary fatty acids but also the struc...

    Authors: Nika Soltani, Mahdieh Abbasalizad Farhangi, Leila Nikniaz and Mahsa Mahmoudinezhad

    Citation: BMC Endocrine Disorders 2020 20:159

    Content type: Research article

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  18. A growing body of evidence supports neutrophils as having an active role in the development of diabetic kidney disease (DKD). However, the clinical relevance of neutrophils and DKD in autoimmune diabetes remai...

    Authors: Yao Yu, Qiuqiu Lin, Dewei Ye, Yanfei Wang, Binbin He, Yanhua Li, Gan Huang, Zhiguang Zhou and Yang Xiao

    Citation: BMC Endocrine Disorders 2020 20:158

    Content type: Research article

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  19. Follow-up care provided via telemedicine (TM) is intended to be a more integrated care pathway to manage diabetes-related foot ulcers (DFU) than traditionally-delivered healthcare. However, knowledge of the ef...

    Authors: Marjolein M. Iversen, Jannicke Igland, Hilde Smith-Strøm, Truls Østbye, Grethe S. Tell, Svein Skeie, John G. Cooper, Mark Peyrot and Marit Graue

    Citation: BMC Endocrine Disorders 2020 20:157

    Content type: Research article

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  20. Previous studies have suggested that patients with diabetes mellitus (DM) have higher prevalence of atherosclerotic cardiovascular disease (ASCVD), and plasma levels of free fatty acids (FFAs) are a useful mar...

    Authors: Ming-Hua Zhang, Ye-Xuan Cao, Li-Guo Wu, Na Guo, Bing-Jie Hou, Li-Jing Sun, Yuan-Lin Guo, Na-Qiong Wu, Qian Dong and Jian-Jun Li

    Citation: BMC Endocrine Disorders 2020 20:156

    Content type: Research article

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  21. Detailed description of hyperglycemia management in diabetic patients infected with SARS-CoV-2 remain limited, although patients with diabetes show higher complication and mortality rate than patients without ...

    Authors: François R. Jornayvaz, Benjamin Assouline, Jérôme Pugin and Karim Gariani

    Citation: BMC Endocrine Disorders 2020 20:155

    Content type: Case report

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  22. The objectives of this study were to estimate the prevalence of microalbuminuria and examine the association of microalbuminuria with metabolic syndrome (MetS) and its component in a Bangladeshi adult cohort.

    Authors: Muntakim Mahmud Saadi, Manindra Nath Roy, Rubena Haque, Farida Akhter Tania, Shakil Mahmood and Nurshad Ali

    Citation: BMC Endocrine Disorders 2020 20:153

    Content type: Research article

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  23. Metabolic inflammation is an essential event in obesity-induced diabetes and insulin resistance. In obesity, an increasing number of macrophages recruited into visceral adipose tissues undergo significant M1-like...

    Authors: Chaolong Liu, Yanting Yuan, Ji Zhou, Ruixin Hu, Lixia Ji and Guohui Jiang

    Citation: BMC Endocrine Disorders 2020 20:152

    Content type: Research article

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  24. Despite the evidence available on the adverse impact of gestational diabetes (GDM) and thyroid disorders on developing type 2 diabetes (T2DM), the concurrent influence of these disorders on the incidence of T2...

    Authors: Maryam Zahedi, Elham Kazemian, Fahimeh Ramezani-Tehrani, Maryam Tohidi, Fereidoun Azizi, Davood Khalili, Maryam Rahmati and Atieh Amouzegar

    Citation: BMC Endocrine Disorders 2020 20:150

    Content type: Research article

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  25. Worldwide, the epidemiological and demographic transitions have resulted in nutrition shift characterized by an increased consumption of high energy fast food products. In just over 3 decades, overweight and o...

    Authors: Pedro Pallangyo, Zabella S. Mkojera, Naairah R. Hemed, Happiness J. Swai, Nsajigwa Misidai, Lucy Mgopa, Smita Bhalia, Jalack Millinga, Theophil L. Mushi, Lucia Kabeya, Aisha Omar, Alice Kaijage, Rydiness Mulashani, Silvia Mosha, Faustina Mwapinga and Mohamed Janabi

    Citation: BMC Endocrine Disorders 2020 20:147

    Content type: Research article

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  26. The risk of surgical site infection has been reported to be higher in patients with poorly controlled diabetes. Since chronic hyperglycemia impairs neutrophil functions, preoperative glycemic control may resto...

    Authors: Daichi Fujimoto, Yuki Nomura, Moritoki Egi, Norihiko Obata and Satoshi Mizobuchi

    Citation: BMC Endocrine Disorders 2020 20:146

    Content type: Research article

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  27. This study tested the association between serum levels of microRNA-486, −146b and -15b and betatrophin in normal and obese children with/without type 2 diabetes mellitus (T2DM).

    Authors: Khalid M. Mohany, Osamah Al rugaie, Osama Al-wutayd, Abdullah Al-Nafeesah and Tahia H. Saleem

    Citation: BMC Endocrine Disorders 2020 20:145

    Content type: Research article

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  28. The infants born to women who are overweight or obese in pregnancy are at an increased risk of being born macrosomic or large for gestational age. Antenatal dietary and lifestyle interventions have been shown ...

    Authors: Amanda J. Poprzeczny, Jennie Louise, Andrea R. Deussen and Jodie M. Dodd

    Citation: BMC Endocrine Disorders 2020 20:139

    Content type: Research article

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  29. Diabetes is a serious chronic disease. Medical treatment and good psychosocial support are needed to cope with acute and long-term effects of diabetes. Self-management is a large part of diabetes management, w...

    Authors: Elisabet Nerpin, Eva Toft, Johan Fischier, Anna Lindholm-Olinder and Janeth Leksell

    Citation: BMC Endocrine Disorders 2020 20:137

    Content type: Study protocol

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  30. Previous studies have shown the negative impact of sleep disturbances, specifically insomnia symptoms, on glucose metabolism for people with type 2 diabetes (T2D). People with insomnia symptoms are at risk of ...

    Authors: Mohammed M. Alshehri, Shaima A. Alothman, Aqeel M. Alenazi, Jason L. Rucker, Milind A. Phadnis, John M. Miles, Catherine F. Siengsukon and Patricia M. Kluding

    Citation: BMC Endocrine Disorders 2020 20:136

    Content type: Research article

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  31. Euthyroid sick syndrome (ESS) frequently arises in children admitted with diabetic ketoacidosis/diabetic ketosis (DKA/DK). This study evaluates the interplay of various metabolic factors with occurrence of der...

    Authors: Peng Shao, Shujuan Guo, Guimei Li, Daogang Qin, Sen Li and Ying Luan

    Citation: BMC Endocrine Disorders 2020 20:135

    Content type: Research article

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  32. Diabetic foot ulcers (DFU) are associated with high morbidity and mortality globally. Mortality in patients hospitalized for DFU in Nigeria is unacceptably high. This study was undertaken to determine factors ...

    Authors: Olufunmilayo O. Adeleye, Ejiofor T. Ugwu, Ibrahim D. Gezawa, Innocent Okpe, Ignatius Ezeani and Marcelina Enamino

    Citation: BMC Endocrine Disorders 2020 20:134

    Content type: Research article

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  33. Although important achievements have been done in type 2 diabetes mellitus (T2D) treatment and glycemic control, new strategies may take advantage of non-pharmacological approaches and of other potential deter...

    Authors: Rubén Silva-Tinoco, Teresa Cuatecontzi-Xochitiotzi, Viridiana De la Torre-Saldaña, Enrique León-García, Javier Serna-Alvarado, Arturo Orea-Tejeda, Lilia Castillo-Martínez, Juan G. Gay, David Cantú-de-León and Diddier Prada

    Citation: BMC Endocrine Disorders 2020 20:130

    Content type: Research article

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  34. Diabetic foot is an underestimated and redoubtable diabetes complication. The aims of our study were to assess diabetic foot ulcer risk factors according to International Working Group on the Diabetic Foot (IW...

    Authors: B. Zantour, S. Bouchareb, Z. El Ati, F. Boubaker, W. Alaya, W. Kossomtini and M. H. Sfar

    Citation: BMC Endocrine Disorders 2020 20:128

    Content type: Research article

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  35. Fulminant type 1 diabetes mellitus (FT1D) is a newly established subtype of type 1 diabetes. Its etiology has not been fully elucidated. Several cases with FT1D have exhibited pancreatitis or myocarditis.

    Authors: Fujiko Egashira, Midori Kawashima, Ai Morikawa, Minami Kosuda, Hisamitsu Ishihara and Kentaro Watanabe

    Citation: BMC Endocrine Disorders 2020 20:127

    Content type: Case report

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  36. Diabetes is a leading cause of Medicare spending; predicting which individuals are likely to be costly is essential for targeting interventions. Current approaches generally focus on composite measures, short ...

    Authors: Julie C. Lauffenburger, Mufaddal Mahesri and Niteesh K. Choudhry

    Citation: BMC Endocrine Disorders 2020 20:125

    Content type: Research article

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  37. Modern imaging plays a central role in the care of obese patients, and there is an integral focus on its use and accessibility in individuals who have alterations of various in various organs. The objective in...

    Authors: Alejandra Martínez Coria, Norma Angélica Estrada-Cruz, María Inés Pérez Ordoñez, Daniel H. Montes-Cortes and Leticia Manuel-Apolinar

    Citation: BMC Endocrine Disorders 2020 20:124

    Content type: Research article

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  38. Type 1 Diabetes (T1D) is a T cell-mediated autoimmune disorder caused by the destruction of insulin-secreting cells. B7-H3 (CD276) plays a vital role in T cell response. However, B7-H3 expression and its clini...

    Authors: Sisi Ding, Yimei Shan, Lili Sun, Sicheng Li, Rong Jiang, Xin Chang, Ziyi Huang, Jing Sun, Cuiping Liu, Chen Fang and Xueguang Zhang

    Citation: BMC Endocrine Disorders 2020 20:123

    Content type: Research article

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  39. The prevalence of type 2 diabetes mellitus (T2DM) is expected to increase from 7.7% in 2017 to 8.4% in 2045 worldwide. Diabetes complications contribute to morbidity and mortality. To evaluate whether the diab...

    Authors: Hyunju Yoo, Eunjung Choo and Sukhyang Lee

    Citation: BMC Endocrine Disorders 2020 20:122

    Content type: Research article

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  40. The association between the polymorphisms in the vitamin D receptor (VDR) gene and the risk of type 1 diabetes mellitus (T1DM) has been evaluated in several studies. However, the findings were inconclusive. Thus,...

    Authors: Na Zhai, Ramtin Bidares, Masoud Hassanzadeh Makoui, Saeed Aslani, Payam Mohammadi, Bahman Razi, Danyal Imani, Mohammad Yazdchi and Haleh Mikaeili

    Citation: BMC Endocrine Disorders 2020 20:121

    Content type: Research article

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  41. Albuminuria is the early manifestation of the pathogenesis of diabetic nephropathy (DN). The current study was to investigate the relationship of pulmonary function with albuminuria in type 2 diabetic patients...

    Authors: Yun-Yun He, Zhe Chen, Xiang-Yang Fang, Jing Chang, Yong Lu and Xiao-Juan Wang

    Citation: BMC Endocrine Disorders 2020 20:112

    Content type: Research article

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  42. Type 2 diabetes mellitus (T2D) is the most frequent type of diabetes. It has a multifactorial etiology, affecting millions of people worldwide. Ghrelin gene (GHRL) encodes the ghrelin peptide, which promotes food...

    Authors: Edgar Alfonso Rivera-León, Mara Anaís Llamas-Covarrubias, Sergio Sánchez-Enríquez, Erika Martínez-López, Mercedes González-Hita and Iris Monserrat Llamas-Covarrubias

    Citation: BMC Endocrine Disorders 2020 20:109

    Content type: Research article

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  43. Zonulin is a biomarker of impaired intestinal permeability, which has been associated with various disorders. The primary aim was to study serum zonulin (s-zonulin) in individuals with morbid obesity before an...

    Authors: Martin Aasbrenn, Stian Lydersen and Per G Farup

    Citation: BMC Endocrine Disorders 2020 20:108

    Content type: Research article

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  44. Some previous studies have reported inconsistent results on the association between alcohol intake and diabetic retinopathy (DR) risk. This study aimed to evaluate the potential effects of alcohol intake on su...

    Authors: Chen Chen, Zhaojun Sun, Weigang Xu, Jun Tan, Dan Li, Yiting Wu, Ting Zheng and Derong Peng

    Citation: BMC Endocrine Disorders 2020 20:106

    Content type: Research article

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  45. To evaluate the association between high-sensitivity C-reactive protein (hsCRP) and erythrocyte sedimentation rate (ESR), and diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM).

    Authors: Shizhe Guo, Meng Wang, Yifei Yu, Yeping Yang, Fangfang Zeng, Fei Sun, Qin Li, Min He, Yiming Li, Jie Wen, Wei Gong and Zhaoyun Zhang

    Citation: BMC Endocrine Disorders 2020 20:103

    Content type: Research article

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  46. The associations between sociodemographic factors and HbA1c variability in type 2 diabetes are not yet established. Examining group differences in HbA1c variability may help identify patient characteristics re...

    Authors: Emelia Mellergård, Per Johnsson and Frida Eek

    Citation: BMC Endocrine Disorders 2020 20:102

    Content type: Research article

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