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Cancer and Endocrine Tumors

This section concerns all aspects of endocrine tumours and cancer including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Cushing’s disease (CD) is defined as hypercortisolemia caused by adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas (corticotroph PA) that afflicts humans and dogs. In order to map common aberrant...

    Authors: Andrew Wang, Stewart G. Neill, Scott Newman, Marianna A. Tryfonidou, Adriana Ioachimescu, Michael R. Rossi, Björn P. Meij and Nelson M. Oyesiku

    Citation: BMC Endocrine Disorders 2021 21:185

    Content type: Research article

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  2. In contrast to all prior AJCC/TNM classifications for differentiated thyroid cancer (DTC) the 8th edition does not take minimal extrathyroidal extension (M-ETE) into consideration for local tumor staging. We t...

    Authors: Manuel Weber, Ina Binse, Karin Oebbecke, Tim Brandenburg, Ken Herrmann, Sarah Theurer, Frank Weber, Ann-Kathrin Ehrlich, Kurt Werner Schmid, Dagmar Führer-Sakel, Irfan Vardarli, Wolfgang P. Fendler, Elena Gilman and Rainer Görges

    Citation: BMC Endocrine Disorders 2021 21:161

    Content type: Research article

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  3. Hypertension and overweight are independent risk factors for cardiovascular disease, and overweight increase the risk of developing high blood pressure. ERBB3( also known as HER3) plays a considerable role in ...

    Authors: Lijun Zhu, Zhengmei Fang, Yuelong Jin, Weiwei Chang, Mengyun Huang, Yan Chen and Yingshui Yao

    Citation: BMC Endocrine Disorders 2021 21:130

    Content type: Research article

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  4. Patients with growth hormone (GH)-secreting adenoma usually develop glucose intolerance. GH increases metabolic rate and, when secreted aberrantly, may result in metabolic syndrome. Herein, we examine the asso...

    Authors: JinYu Pan, XiangHong Yang and Wei Zhu

    Citation: BMC Endocrine Disorders 2021 21:109

    Content type: Case report

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  5. Manifestations of hypokalaemia in ectopic adrenocorticotropic hormonesyndrome(EAS) vary from mild muscle weakness to life-threatening arrhythmia. Herein, we present a rare case of EAS with concomitant rhabdomy...

    Authors: Wei Qiang, Sucai Song, Tianjun Chen, Zhe Wang, Jun Feng, Jiaojiao Zhang and Hui Guo

    Citation: BMC Endocrine Disorders 2021 21:98

    Content type: Case report

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  6. Papillary thyroid cancer (PTC) is the most common type of thyroid cancer and the incidence of PTC has continued to increase over the past decades. Many studies have shown that obesity is an independent risk fa...

    Authors: Maoguang Ma, Mingdian Wang, Zhanqiang Zhang, Bo Lin, Zicheng Sun, Haoyan Guan, Weiming Lv and Jie Li

    Citation: BMC Endocrine Disorders 2021 21:69

    Content type: Research article

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  7. Multiple endocrine neoplasia type 1 (MEN1) is a rare inherited syndrome that concurrently involves various endocrine glands. We report a rare case of MEN1 in a 43-year-old man whose first manifestation was an ...

    Authors: Ji Eun Jun, You-Cheol Hwang, Kyu Jeong Ahn, Ho Yeon Chung and In-Kyung Jeong

    Citation: BMC Endocrine Disorders 2021 21:31

    Content type: Case report

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  8. Functional gonadotroph adenomas (FGAs) are rare adenomas that most commonly secrete FSH. However, solitary LH-secreting pituitary adenomas are unusual.

    Authors: Yi Zhang, Cheng Chen, Min Lin, Kan Deng, Huijuan Zhu, Wenbin Ma, Hui Pan, Renzhi Wang and Yong Yao

    Citation: BMC Endocrine Disorders 2021 21:15

    Content type: Case report

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  9. Neuroendocrine tumor (NET) with adrenocorticotropic hormone (ACTH) secretion are very rare. To our knowledge, no follow-up study is published for ACTH-secreting NET, regardless of the primary site, to show sec...

    Authors: Fatemeh Rahmani, Maryam Tohidi, Maryam Dehghani, Behrooz Broumand and Farzad Hadaegh

    Citation: BMC Endocrine Disorders 2021 21:9

    Content type: Case report

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  10. Neuroendocrine tumors (NETs) are rare tumors harboring overexpression of somatostatin receptors (SSTRs) on their cell membrane. Because some organs, such as the spleen, adrenal glands and liver, physiologicall...

    Authors: Emre Gezer, Berrin Çetinarslan, Dilek Karakaya, Zeynep Cantürk, Alev Selek, Mehmet Sözen and Serkan İşgören

    Citation: BMC Endocrine Disorders 2021 21:6

    Content type: Case report

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  11. Hypercalcemia of malignancy is relatively common in several cancers. However, in colorectal cancer, paraneoplastic phenomena that cause hypercalcemia is uncommon. In the few cases that are reported, secretion ...

    Authors: Vegard Heimly Brun, Erik Knutsen, Helge Stenvold and Hanne Halvorsen

    Citation: BMC Endocrine Disorders 2021 21:4

    Content type: Case report

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  12. Approximately 60% of adrenocortical carcinomas (ACC) are functional, and Cushing’s syndrome is the most frequent diagnosis that has been revealed to have a particularly poor prognosis. Since 30% of ACC present...

    Authors: Sawako Suzuki, Tomoki Minamidate, Akina Shiga, Yutarou Ruike, Kazuki Ishiwata, Kumiko Naito, Akiko Ishida, Hanna Deguchi, Masanori Fujimoto, Hisashi Koide, Ichiro Tatsuno, Jun-ichiro Ikeda, Yuto Yamazaki, Hironobu Sasano and Koutaro Yokote

    Citation: BMC Endocrine Disorders 2020 20:173

    Content type: Research article

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  13. Recent study showed that individuals with type 2 diabetes have a high risk of developing colorectal cancer (CRC), in which Receptor for Advanced Glycation End Products (RAGE) plays a pivotal role. We conducted...

    Authors: Xiaohai Zhou, Ning Lin, Mingjie Zhang, Xiaoling Wang, Ye An, Qing Su, Peng Du, Bo Li and Hanbei Chen

    Citation: BMC Endocrine Disorders 2020 20:170

    Content type: Research article

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  14. Primary nasopharyngeal lymphoma (NPL) is a very rare tumor of Waldeyer ring (WR) lymphoid tissue. It is challenging to differentiate lymphoma infiltration of pituitary from a pituitary adenoma, meningioma infi...

    Authors: Maryam Zahedi, Reyhane Hizomi Arani, Maryam Tohidi, Shirin Haghighi, Masoud Mehrpour and Farzad Hadaegh

    Citation: BMC Endocrine Disorders 2020 20:163

    Content type: Case report

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  15. A high-molecular-weight form of insulin-like growth factor-2 (IGF-2), known as “big” IGF-2, is occasionally produced by various tumor types, leading to hypoglycemia. Although solitary fibrous tumor (SFT) is a ...

    Authors: Keizo Kaneko, Shojiro Sawada, Chihiro Satake, Keiichi Kondo, Tomohito Izumi, Mamiko Tanaka, Junta Imai, Tetsuya Yamada, Hiroki Katsushima, Fumiyoshi Fujishima and Hideki Katagiri

    Citation: BMC Endocrine Disorders 2020 20:148

    Content type: Case report

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  16. Studies have shown that the response of bone mineral density (BMD) to parathyroidectomy for symptomatic primary hyperparathyroidism (PHPT) is heterogeneous and difficult to predict. However, the independent fa...

    Authors: Shuai Lu, Maoqi Gong, Yejun Zha, Aimin Cui, Chen Chen, Weitong Sun, Kehan Hua, Wei Tian and Xieyuan Jiang

    Citation: BMC Endocrine Disorders 2020 20:141

    Content type: Research article

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  17. The specific underlying pathogenesis of prolactinoma has not been clarified yet, to the best of our knowledge. p38 mitogen-activated protein kinase (MAPK) signaling including p38α MAPK (MAPK14), p38β (MAPK11),...

    Authors: Qiao-yan Ding, Yu Zhang, Li Ma, Yong-gang Chen, Jin-hu Wu, Hong-feng Zhang and Xiong Wang

    Citation: BMC Endocrine Disorders 2020 20:138

    Content type: Research article

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  18. Cushing’s syndrome has been described as a complex endocrine disorder characterized with high cortisol concentration. Correct and early diagnosis of Cushing’s syndrome is challenging. According to the latest g...

    Authors: Huiwen Tan, Dawei Chen, Yerong Yu, Kai Yu, Weiming He, Bowen Cai, Su Jiang, Ying Tang, Nanwei Tong and Zhenmei An

    Citation: BMC Endocrine Disorders 2020 20:116

    Content type: Case report

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  19. Colorectal cancer (CRC), which is related with insulin resistance, is a one of the most common cancers. Triglyceride-glucose index (TyG index) was made for a marker of insulin resistance. We conducted the inve...

    Authors: Takuro Okamura, Yoshitaka Hashimoto, Masahide Hamaguchi, Akihiro Obora, Takao Kojima and Michiaki Fukui

    Citation: BMC Endocrine Disorders 2020 20:113

    Content type: Research article

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  20. Marital status proves to be an independent prognostic factor in a variety of cancers. However, its prognostic impact on gastric neuroendocrine neoplasms (G-NEN) has not been investigated.

    Authors: Yu-Jie Zhou, Xiao-Fan Lu, Kenneth I. Zheng, Qi-Wen Wang, Jin-Nan Chen, Qing-Wei Zhang, Fang-Rong Yan and Xiao-Bo Li

    Citation: BMC Endocrine Disorders 2020 20:111

    Content type: Research article

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  21. Takotsubo syndrome is an uncommon, acute, and reversible cardiomyopathy that occurs primarily in postmenopausal females. The clinical presentation of the syndrome resembles acute coronary syndrome, but coronar...

    Authors: Min Chen, Tong Zhao, Guoping Chen and Shenjiang Hu

    Citation: BMC Endocrine Disorders 2020 20:93

    Content type: Case report

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  22. It is clinically emergent to further understand the pathological mechanism to advance therapeutic strategy for endocrine tumors. A high amount of secretory protein with tumorigenic triggers are thought to indu...

    Authors: Shuhei Morita, Ken Takeshima, Hiroyuki Ariyasu, Yasushi Furukawa, Shohei Kishimoto, Tomoya Tsuji, Shinsuke Uraki, Hiroyuki Mishima, Akira Kinoshita, Yuichi Takahashi, Hidefumi Inaba, Hiroshi Iwakura, Hiroto Furuta, Masahiro Nishi, Asako Doi, Shin-ichi Murata…

    Citation: BMC Endocrine Disorders 2020 20:90

    Content type: Case report

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  23. Thyroid hormone has been shown to be involved in carcinogenesis via its effects on cell proliferation pathways. The objective of this study is to determine the association between subclinical hypothyroidism (S...

    Authors: Juan Gómez-Izquierdo, Kristian B. Filion, Jean-Franҫois Boivin, Laurent Azoulay, Michael Pollak and Oriana Hoi Yun Yu

    Citation: BMC Endocrine Disorders 2020 20:83

    Content type: Research article

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  24. Surgical resection of prolactinomas resistant to dopamine agonists is frequently incomplete due to fibrotic changes of the tumour under pharmacological therapy. In order to identify a subgroup of patients who ...

    Authors: Elle Vermeulen, Jean D’Haens, Tadeusz Stadnik, David Unuane, Kurt Barbe, Vera Van Velthoven and Sven Gläsker

    Citation: BMC Endocrine Disorders 2020 20:68

    Content type: Research article

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  25. Hereditary medullary thyroid carcinoma (MTC) is mainly caused by germline mutations in the RET proto-oncogene, which accounts for 20–30% of all MTC according to foreign studies. However, no English literatures...

    Authors: Qin Huang, Aihua Hu and Mingsheng Zhang

    Citation: BMC Endocrine Disorders 2020 20:64

    Content type: Case report

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  26. Non-islet cell tumor hypoglycemia (NICTH) is a rare paraneoplastic syndrome that secretes incompletely processed high molecular weight insulin growth factor 2 (big-IGF2), which results in stimulation of the in...

    Authors: Haruka Yamasaki, Ayako Itawaki, Miwa Morita, Hitomi Miyake, Masahiro Yamamoto, Hiroki Sonoyama, Sayuri Tanaka, Masakazu Notsu, Mika Yamauchi, Yusuke Fujii, Noriyoshi Ishikawa, Izumi Fukuda, Shunji Ishihara and Keizo Kanasaki

    Citation: BMC Endocrine Disorders 2020 20:60

    Content type: Case report

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  27. Fine-needle aspiration cytology (FNAC) has become a well-established modality in the diagnosis, staging and follow-up of thyroid nodules. FNAC outcomes are routinely classified using the Bethesda System for Re...

    Authors: Busra Yaprak Bayrak and Ahmet Tugrul Eruyar

    Citation: BMC Endocrine Disorders 2020 20:48

    Content type: Research article

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  28. Neuroendocrine neoplasms (NENs) display variable behaviors based on origin and grade. We assumed that both tumor origin and the location of metastasis may play a role in survival.

    Authors: Nikolaos A. Trikalinos, Benjamin R. Tan, Manik Amin, Jingxia Liu, Ramaswamy Govindan and Daniel Morgensztern

    Citation: BMC Endocrine Disorders 2020 20:44

    Content type: Research article

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  29. An accurate diagnosis for high-suspicion nodules based on the 2015 American Thyroid Association (ATA) guidelines would reduce unnecessary invasive examinations. Elastography is a useful tool for discriminating...

    Authors: Li Hairu, Peng Yulan, Wang Yan, Ai Hong, Zhou Xiaodong, Yang Lichun, Yan Kun, Xiao Ying, Liu Lisha, Luo Baoming, Yong Qiang, Cong Shuzhen, Jiang Shuangquan, Fu Xin, Ma Buyun, Li Yi…

    Citation: BMC Endocrine Disorders 2020 20:43

    Content type: Research article

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  30. Pituitary adenomas as multifactorial intracranial neoplasms impose a massive burden of morbidity on patients and characterizing the molecular mechanism underlying their pathogenesis has received considerable a...

    Authors: Nasrin Akbari, Mohammad Ghorbani, Vahid Salimi, Alimohammad Alimohammadi, Mohammad E. Khamseh, Hamideh Akbari, Mitra Nourbakhsh, Alireza Sheikhi, S. Fahimeh Taghavi and Masoumeh Tavakoli-Yaraki

    Citation: BMC Endocrine Disorders 2020 20:39

    Content type: Research article

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  31. Apart from PRKAR1A mutations in a subset of cyclical Cushing’s syndrome due to primary pigmented nodular adrenocortical disease, the molecular basis of cyclical Cushing’s syndrome has not been investigated. We sp...

    Authors: Sunita M. C. De Sousa, Jim Manavis, Jinghua Feng, Paul Wang, Andreas W. Schreiber, Hamish S. Scott and David J. Torpy

    Citation: BMC Endocrine Disorders 2020 20:18

    Content type: Case report

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  32. Pituitary adenomas (PA) have an increased potential for relapse in one to 5 years after resection. In this study, we investigated the genetic differences in genomic DNA of primary and rapidly recurrent tumours...

    Authors: Raitis Peculis, Inga Balcere, Ilze Radovica-Spalvina, Ilze Konrade, Olivija Caune, Kaspars Megnis, Vita Rovite, Janis Stukens, Jurijs Nazarovs, Austra Breiksa, Aigars Kiecis, Ivars Silamikelis, Valdis Pirags and Janis Klovins

    Citation: BMC Endocrine Disorders 2020 20:17

    Content type: Case report

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  33. Nerves and neurotrophic growth factors are emerging promoters of cancer growth. The precursor for Nerve Growth Factor (proNGF) is overexpressed in thyroid cancer, but its potential role as a clinical biomarker...

    Authors: Christopher W. Rowe, Sam Faulkner, Jonathan W. Paul, Jorge M. Tolosa, Craig Gedye, Cino Bendinelli, Katie Wynne, Shaun McGrath, John Attia, Roger Smith and Hubert Hondermarck

    Citation: BMC Endocrine Disorders 2019 19:128

    Content type: Research article

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  35. The present study aimed to investigate the prognostic significance of preoperative main pancreatic duct dilation and the neutrophil-to-lymphocyte ratio (PD-NLR) in pancreatic neuroendocrine tumors (PNETs) of t...

    Authors: Bo Zhou, Canyang Zhan, Jie Xiang, Yuan Ding and Sheng Yan

    Citation: BMC Endocrine Disorders 2019 19:123

    Content type: Research article

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  36. Benign thyroid nodules (BTN) are frequently diagnosed as papillary thyroid carcinoma (PTC), leading to unnecessary treatment. We found that plasma lncRNA DLG1-AS1 was upregulated in PTC patients but not in BTN...

    Authors: Tao He, Huan Wang, Jiangming Sun, Jie Wu, Fakuo Gong, Shujun Li, Hui Wang and Yufeng Li

    Citation: BMC Endocrine Disorders 2019 19:122

    Content type: Research article

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  37. Pituitary metastasis is a rare condition with a poor prognosis. Very few patients with pituitary metastasis are symptomatic. It is often associated with presence of co-existing metastases to other organs. Isol...

    Authors: Sirinart Sirinvaravong, Peeradon Vibhatavata, Paweena Chunharojrith, Pornsuk Cheunsuchon and Sutin Sriussadaporn

    Citation: BMC Endocrine Disorders 2019 19:114

    Content type: Case report

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  38. Cytologically indeterminate thyroid nodules currently present a challenge for clinical decision-making. The main aim of our study was to determine whether the classifications, American College of Radiology (AC...

    Authors: Thayse Lozovoy Madsen Barbosa, Cleo Otaviano Mesa Junior, Hans Graf, Teresa Cavalvanti, Marcus Adriano Trippia, Ricardo Torres da Silveira Ugino, Gabriel Lucca de Oliveira, Victor Hugo Granella and Gisah Amaral de Carvalho

    Citation: BMC Endocrine Disorders 2019 19:112

    Content type: Research article

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  39. Clinical care of patients with cyclic Cushing’s syndrome (CS) is challenging. Classical pitfalls include incorrect subtyping, unnecessary surgical procedures and delayed definite treatment.

    Authors: Adriana Albani, Christina M. Berr, Felix Beuschlein, Marcus Treitl, Klaus Hallfeldt, Jürgen Honegger, Günter Schnauder and Martin Reincke

    Citation: BMC Endocrine Disorders 2019 19:105

    Content type: Case report

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  40. The relationship between breast cancer (BC) and thyroid disease (TD) is still controversial. The aim of the study was to investigate the possible coexistence of TD in patients with newly diagnosed BC and its c...

    Authors: Chiara Dobrinja, Serena Scomersi, Fabiola Giudici, Giulia Vallon, Alessio Lanzaro, Marina Troian, Deborah Bonazza, Andrea Romano, Fabrizio Zanconati, Nicolò de Manzini and Marina Bortul

    Citation: BMC Endocrine Disorders 2019 19:104

    Content type: Research

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  41. Medullary thyroid carcinoma is a malignant uncommon and aggressive tumour of the parafollicular C cells. In about 75% of cases it is sporadic while, in case of RET mutation, it is associated to multiple endocr...

    Authors: Claudio Gambardella, Chiara Offi, Guglielmo Clarizia, Roberto Maria Romano, Immacolata Cozzolino, Marco Montella, Rosa Maria Di Crescenzo, Massimo Mascolo, Angelo Cangiano, Sergio Di Martino, Giancarlo Candela and Giovanni Docimo

    Citation: BMC Endocrine Disorders 2019 19:103

    Content type: Case report

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  42. Acromegaly is highly associated with thyroid disorders. However, the clinical characteristics of thyroid nodules in individuals with acromegaly who present with thyroid diseases have not been completely elucid...

    Authors: Dianshuang Xu, Bolin Wu, Xiaoju Li, Yunjiu Cheng, Dubo Chen, Yuefeng Fang, Qiu Du, Zhiyong Chen and Xiaodong Wang

    Citation: BMC Endocrine Disorders 2019 19:94

    Content type: Research article

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  43. Endothelial cell-specific molecule-1 (ESM-1) is a biomarker associated with tumor progression in pituitary adenoma. We specifically focused on one type of pituitary adenoma, namely null cell adenoma (NCA) and ...

    Authors: Shousen Wang, Zhifeng Wu, Liangfeng Wei and Jianhe Zhang

    Citation: BMC Endocrine Disorders 2019 19:90

    Content type: Research article

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  44. Primary hyperparathyroidism (PHPT), which is mostly caused by a parathyroid adenoma, is fairly common in postmenopausal women but is relatively rare in pregnant women. PHPT-induced pancreatitis during pregnanc...

    Authors: Jun Yang, Meng-jie Dong and Feng Chen

    Citation: BMC Endocrine Disorders 2019 19:82

    Content type: Case report

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  45. Co-existing Cushing’s syndrome and primary aldosteronism caused by bilateral adrenocortical adenomas, secreting cortisol and aldosterone, respectively, have rarely been reported. Precise diagnosis and manageme...

    Authors: Kaiyun Ren, Jia Wei, Qilin Liu, Yuchun Zhu, Nianwei Wu, Ying Tang, Qianrui Li, Qianying Zhang, Yerong Yu, Zhenmei An, Jing Chen and Jianwei Li

    Citation: BMC Endocrine Disorders 2019 19:63

    Content type: Case report

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  47. Insulinoma is a rare tumour representing 1–2% of all pancreatic neoplasms and it is malignant in only 10% of cases. Locoregional invasion or metastases define malignancy, whereas the dimension (> 2 cm), CK19 s...

    Authors: Mariasmeralda Caliri, Valentina Verdiani, Edoardo Mannucci, Vittorio Briganti, Luca Landoni, Alessandro Esposito, Giulia Burato, Carlo Maria Rotella, Massimo Mannelli and Alessandro Peri

    Citation: BMC Endocrine Disorders 2018 18:98

    Content type: Case report

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  48. Malignant insulinoma is extremely rare and accounts for only 10% of total insulinoma cases. The goal of this study is to retrospectively analyze clinical data from 15 patients with malignant insulinoma treated...

    Authors: Jie Yu, Fan Ping, Huabing Zhang, Wei Li, Tao Yuan, Yong Fu, Kai Feng, Weibo Xia, Lingling Xu and Yuxiu Li

    Citation: BMC Endocrine Disorders 2018 18:92

    Content type: Research article

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  49. Thyroid lymphomas are an exceptional finding in patients with thyroid nodules. Burkitt’s lymphoma is one of the rarest and most aggressive forms of thyroid lymphomas, and its prognosis depends on the earliness...

    Authors: Stella Bernardi, Andrea Michelli, Deborah Bonazza, Veronica Calabrò, Fabrizio Zanconati, Gabriele Pozzato and Bruno Fabris

    Citation: BMC Endocrine Disorders 2018 18:86

    Content type: Case report

    Published on:

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