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Basic and Clinical Endocrinology

Section edited by Amar Agha

This section concerns disorders of the pituitary axis and related organs and tissues; incuding specific disorders of the thyroid, adrenals, gonads etc. Articles concerning prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology are considered within this section.

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  1. The nonthyroidal illness syndrome (NTIS) is prevalent among patients with enterocutaneous fistula and is associated with poor outcomes. The present study aimed to explore the role of enteral nutrition (EN) the...

    Authors: Ranran Li, Jianan Ren, Qin Wu, Gefei Wang, Xiuwen Wu, Jun Chen, Guanwei Li, Zhiwu Hong, Huajian Ren, Yunzhao Zhao and Jieshou Li

    Citation: BMC Endocrine Disorders 2015 15:69

    Content type: Research article

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  2. Coexisting of Graves’ disease and functioning struma ovarii is a rare condition. Although the histology of struma ovarii predominantly composed of thyrocytes, the majority of the patients did not have thyrotox...

    Authors: Tullaya Sitasuwan, Suchanan Hanamornroongruang, Thavatchai Peerapatdit and Nuntakorn Thongtang

    Citation: BMC Endocrine Disorders 2015 15:68

    Content type: Case report

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  3. Chronic kidney disease (CKD) is becoming a serious health problem; the number of people with impaired renal function is rapidly rising. Progression of CKD is associated with having a number of complications, i...

    Authors: Saroj Khatiwada, Rajendra KC, Sharad Gautam, Madhab Lamsal and Nirmal Baral

    Citation: BMC Endocrine Disorders 2015 15:65

    Content type: Research article

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  4. This is the first case report of focal seizure as a manifestation of Immunoglobulin G4 (IgG4)-related hypophysitis. IgG4-related hypophysitis is a novel category of hypophysitis. The clinical presentations, im...

    Authors: Kanchana Ngaosuwan, Therdkiat Trongwongsa and Shanop Shuangshoti

    Citation: BMC Endocrine Disorders 2015 15:64

    Content type: Case report

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  5. Hypoxia inducible factor-1α (HIF-1α) is the central transcriptional regulator of hypoxic responses during the progression of pituitary adenomas. Although previous immunohistochemical studies revealed that HIF-...

    Authors: Chenran Zhang, Qiang Qiang, Ying Jiang, Liuhua Hu, Xuehua Ding, Yicheng Lu and Guohan Hu

    Citation: BMC Endocrine Disorders 2015 15:24

    Content type: Research article

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  6. Low-dose combined oral contraceptives (COCs) can interfere with bone mass acquisition during adolescence. This study aimed to evaluate bone mineral density (BMD) and bone mineral content (BMC) in female adoles...

    Authors: Talita Poli Biason, Tamara Beres Lederer Goldberg, Cilmery Suemi Kurokawa, Maria Regina Moretto, Altamir Santos Teixeira and Hélio Rubens de Carvalho Nunes

    Citation: BMC Endocrine Disorders 2015 15:15

    Content type: Research article

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  7. Polycystic ovary syndrome (PCOS) is associated with obesity and increased cardiovascular (CV) risk markers. In this study our aim was to assess the effects of six months treatment with liraglutide 1.8 mg od on...

    Authors: Hassan Kahal, Ahmed Aburima, Tamas Ungvari, Alan S Rigby, Anne M Coady, Rebecca V Vince, Ramzi A Ajjan, Eric S Kilpatrick, Khalid M Naseem and Stephen L Atkin

    Citation: BMC Endocrine Disorders 2015 15:14

    Content type: Research article

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  8. The prevailing view that advocates long-term hormonal follow-up of adrenal incidentalomas is currently under debate. The purpose of the present study was to examine all adrenal incidentalomas presented during ...

    Authors: Hannah Yeomans, Jan Calissendorff, Cristina Volpe, Henrik Falhammar and Buster Mannheimer

    Citation: BMC Endocrine Disorders 2015 15:6

    Content type: Research article

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  9. Primary hyperparathyroidism (PHPT) is often found on routine blood tests, at a relatively asymptomatic stage. However many studies suggest different systemic effects related to PHPT, which could be enhanced by...

    Authors: Chiara Sabbadin, Gabriella Donà, Luciana Bordin, Maurizio Iacobone, Valentina Camozzi, Caterina Mian and Decio Armanini

    Citation: BMC Endocrine Disorders 2015 15:4

    Content type: Case report

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  10. Galactorrhoea is a common clinical problem in endocrinology. Visual and auditory cues from the newborn are known to stimulate prolactin secretion in lactating women. However, hyperprolactinaemia and galactorrh...

    Authors: Harsha Dissanayake, Sisil Keerthisena, Chinthana Dematapitiya and Prasad Katulanda

    Citation: BMC Endocrine Disorders 2014 14:98

    Content type: Case report

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  11. Glucocorticoid replacement is essential in patients with primary and secondary adrenal insufficiency, but many patients remain on higher than recommended dose regimens. There is no uniformly accepted method to...

    Authors: Caroline Jung, Santo Greco, Hanh HT Nguyen, Jui T Ho, John G Lewis, David J Torpy and Warrick J Inder

    Citation: BMC Endocrine Disorders 2014 14:91

    Content type: Research article

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  12. A number of studies of adults have shown that pituitary deficiencies can develop in a considerable proportion of subjects during the acute phase of meningitis or years after the infection has disappeared. The ...

    Authors: Claudia Giavoli, Claudia Tagliabue, Eriselda Profka, Laura Senatore, Silvia Bergamaschi, Giulia Rodari, Anna Spada, Paolo Beck-Peccoz and Susanna Esposito

    Citation: BMC Endocrine Disorders 2014 14:80

    Content type: Research article

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  13. Physiological functioning of the testes is important for cardiac health besides for virilisation, physical strength, behavior and reproduction; moreover, hypogonadism has been demonstrated as a significant ris...

    Authors: Elena Passeri, Marco Bonomi, Francesco Dangelo, Luca Persani and Sabrina Corbetta

    Citation: BMC Endocrine Disorders 2014 14:78

    Content type: Case report

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  14. Glucocorticoids are pleiotropic hormones, which are involved in almost every cellular, molecular and physiologic network of the organism, and regulate a broad spectrum of physiologic functions essential for li...

    Authors: Nicolas C Nicolaides, Evangelia Charmandari, George P Chrousos and Tomoshige Kino

    Citation: BMC Endocrine Disorders 2014 14:71

    Content type: Review

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  15. Congenital hypothyroidism is often secondary to thyroid dysgenesis, including thyroid agenesis, hypoplasia, ectopic thyroid tissue or cysts. Loss of function mutations in TSHR, PAX8, NKX2.1, NKX2.5 and FOXE1 g...

    Authors: Monica Vincenzi, Marta Camilot, Eleonora Ferrarini, Francesca Teofoli, Giacomo Venturi, Rossella Gaudino, Paolo Cavarzere, Giuseppina De Marco, Patrizia Agretti, Antonio Dimida, Massimo Tonacchera, Attilio Boner and Franco Antoniazzi

    Citation: BMC Endocrine Disorders 2014 14:69

    Content type: Research article

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  16. Cushing’s syndrome results from exposure to excess glucocorticoids. Ectopic Cushings is endogenous ACTH dependant form of Cushing’s associated with markedly raised ACTH and cortisol levels. This leads to an im...

    Authors: Azra Rizwan, Aqiba Sarfaraz, Abdul Jabbar, Jaweed Akhter and Najmul Islam

    Citation: BMC Endocrine Disorders 2014 14:51

    Content type: Case report

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  17. Central precocious puberty (CPP) and phenylketonuria (PKU) are two rare conditions, the latter being the rarer. To date, only one case featuring both these conditions has been reported, and hyperphenylalaninem...

    Authors: Laura Lucaccioni, Bernd C Schwahn, Malcolm Donaldson and Claudio Giacomozzi

    Citation: BMC Endocrine Disorders 2014 14:38

    Content type: Case report

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  18. Osmotic demyelination syndrome (ODS) may be observed as a result of a rapid change in serum osmolarity, such as that induced by an overly rapid correction of serum sodium levels in hyponatraemic patients.

    Authors: Giovanni Corona, Luigi Simonetti, Corinna Giuliani, Alessandra Sforza and Alessandro Peri

    Citation: BMC Endocrine Disorders 2014 14:34

    Content type: Case report

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  19. Aldosterone synthase (CYP11B2) deficiency is a rare autosomal recessive disorder, usually presenting with severe salt-wasting in infancy or stress-induced hyperkalaemia and postural hypotension in adulthood. Neon...

    Authors: Elaine Hui, Matthew CW Yeung, Pik To Cheung, Elaine Kwan, Louis Low, Kathryn CB Tan, Karen SL Lam and Angel OK Chan

    Citation: BMC Endocrine Disorders 2014 14:29

    Content type: Case report

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  20. Hyperhomocysteinemia is a well-known cardiovascular risk factor and its elevation is established in overt hypothyroidism. Since some authors suggest that chronic autoimmune thyroiditis per se may be considered...

    Authors: Maciej Owecki, Jolanta Dorszewska, Nadia Sawicka-Gutaj, Anna Oczkowska, Michał K Owecki, Michał Michalak, Jakub Fischbach, Wojciech Kozubski and Marek Ruchała

    Citation: BMC Endocrine Disorders 2014 14:18

    Content type: Research article

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  21. Aromatase deficiency is a rare, autosomal recessive disorder of which there are approximately twenty four case reports. The aromatase enzyme is crucial in the biosynthesis of oestrogens from androgens. The phe...

    Authors: Lucia Gagliardi, Hamish S Scott, Jinghua Feng and David J Torpy

    Citation: BMC Endocrine Disorders 2014 14:16

    Content type: Case report

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  22. Trisomy 9p is an uncommon anomaly characterised by mental retardation, head and facial abnormalities, congenital heart defects, kidney abnormalities, and skeletal malformations. Affected children may also show...

    Authors: Stefano Stagi, Elisabetta Lapi, Salvatore Seminara, Silvia Guarducci, Marilena Pantaleo, Sabrina Giglio, Francesco Chiarelli and Maurizio de Martino

    Citation: BMC Endocrine Disorders 2014 14:3

    Content type: Research article

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  23. The complex process of development of the pituitary gland is regulated by a number of signalling molecules and transcription factors. Mutations in these factors have been identified in rare cases of congenital...

    Authors: Jana Breitfeld, Susanne Martens, Jürgen Klammt, Marina Schlicke, Roland Pfäffle, Kerstin Krause, Kerstin Weidle, Dorit Schleinitz, Michael Stumvoll, Dagmar Führer, Peter Kovacs and Anke Tönjes

    Citation: BMC Endocrine Disorders 2013 13:56

    Content type: Research article

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  24. Autoimmune thyroid diseases including Graves’ disease and Hashimoto’s thyroiditis are caused by immune response to self-thyroid antigens. The rare situation of hyperthyroidism with Graves’ disease in twins has...

    Authors: Christoph A Rüst, Beat Knechtle and Thomas Rosemann

    Citation: BMC Endocrine Disorders 2013 13:17

    Content type: Case report

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