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Basic and Clinical Endocrinology

Section edited by Amar Agha

This section concerns disorders of the pituitary axis and related organs and tissues; incuding specific disorders of the thyroid, adrenals, gonads etc. Articles concerning prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology are considered within this section.

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  1. Testosterone signals through the androgen receptor (AR) and AR knockout mice develop obesity, suggesting a functional association between AR and leptin signaling. Furthermore, physiological blood concentration...

    Authors: Koichi Yabiku, Keiko Nakamoto and Akihiro Tokushige

    Citation: BMC Endocrine Disorders 2018 18:38

    Content type: Research article

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  2. Nivolumab, an anti-programmed cell death-1 monoclonal antibody, has improved the survival of patients with malignant melanoma. Despite its efficacy, nivolumab inconsistently induces thyroid dysfunction as an i...

    Authors: Seiichi Yano, Kenji Ashida, Hiromi Nagata, Kenji Ohe, Naoko Wada, Yukina Takeichi, Yuki Hanada, Yuta Ibayashi, Lixiang Wang, Shohei Sakamoto, Ryuichi Sakamoto, Hiroshi Uchi, Motoaki Shiratsuchi, Masutaka Furue, Masatoshi Nomura and Yoshihiro Ogawa

    Citation: BMC Endocrine Disorders 2018 18:36

    Content type: Research article

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  3. This study aimed to detect changes in hormone levels in the hypothalamic–pituitary–ovarian axis in Sprague-Dawley (SD) rats with hypothyroidism, and identify differences in the pregnancy and abortion rates of ...

    Authors: Jianran Sun, Cancan Hui, Tongjia Xia, Min Xu, Datong Deng, Faming Pan and Youmin Wang

    Citation: BMC Endocrine Disorders 2018 18:30

    Content type: Research article

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  4. Cushing’s syndrome in humans shares many similarities with its counterpart in dogs in terms of etiology (pituitary versus adrenal causes), clinical signs, and pathophysiologic sequelae. In both species, treatm...

    Authors: Daniel K. Langlois, Michele C. Fritz, William D. Schall, N. Bari Olivier, Rebecca C. Smedley, Paul G. Pearson, Marc B. Bailie and Stephen W. Hunt III

    Citation: BMC Endocrine Disorders 2018 18:24

    Content type: Research article

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  5. 11β-Hydroxylase deficiency (11OHD) is a common form of congenital adrenal hyperplasia that has been shown to result from inactivating CYP11B1 mutations, and pathogenic CYP11B2/CYP11B1 chimeras contribute to a min...

    Authors: Lian Duan, Rufei Shen, Lingyu Song, Yong Liao and Hongting Zheng

    Citation: BMC Endocrine Disorders 2018 18:23

    Content type: Case report

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  6. To our knowledge, no reports are available indicating the effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome (PC...

    Authors: Khadijeh Nasri, Mehri Jamilian, Elham Rahmani, Fereshteh Bahmani, Maryam Tajabadi-Ebrahimi and Zatollah Asemi

    Citation: BMC Endocrine Disorders 2018 18:21

    Content type: Research article

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  7. Growth hormone deficiency (GHD) is a potential consequence of traumatic brain injury (TBI), including sport-related concussion (SRC). GH stimulation testing is required for definitive diagnosis; however, this ...

    Authors: Kirstie Lithgow, Alex Chin, Chantel T. Debert and Gregory A. Kline

    Citation: BMC Endocrine Disorders 2018 18:20

    Content type: Research article

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  8. Thyroid nodules are highly prevalent, but a robust, feasible method for malignancy differentiation has not yet been well documented. This study aimed to establish a practical model for thyroid nodule discrimin...

    Authors: Jia Liu, Dongmei Zheng, Qiang Li, Xulei Tang, Zuojie Luo, Zhongshang Yuan, Ling Gao and Jiajun Zhao

    Citation: BMC Endocrine Disorders 2018 18:17

    Content type: Research article

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  9. Intravenous glucocorticoids (ivGC) have been recommended as a first-line treatment of moderate-to-severe and active thyroid-associated ophthalmopathy (TAO). However, not all patients are responsive to ivGC. Th...

    Authors: Yang Wang, Shuo Zhang, Yidan Zhang, Xingtong Liu, Hao Gu, Sisi Zhong, Yazhuo Huang, Sijie Fang, Jing Sun, Huifang Zhou and Xianqun Fan

    Citation: BMC Endocrine Disorders 2018 18:13

    Content type: Research article

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  10. The adverse effects of growth hormone (GH) deficiency (GHD) in adults (AGHD) on metabolism and health-related quality of life (HRQoL) can be improved with GH substitution. This investigation aimed to design a ...

    Authors: Peter H. Kann, Simona Bergmann, Martin Bidlingmaier, Christina Dimopoulou, Birgitte T. Pedersen, Günter K. Stalla, Matthias M. Weber and Stefanie Meckes-Ferber

    Citation: BMC Endocrine Disorders 2018 18:10

    Content type: Research article

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  11. Ultrasensitive assays to measure pre-pubertal gonadotropins levels could help identify patients with Turner syndrome (TS) in mid-childhood, but studies in this field are scarce. The aim of this study was to an...

    Authors: Stela Carpini, Annelise Barreto Carvalho, Sofia Helena Valente de Lemos-Marini, Gil Guerra-Junior and Andréa Trevas Maciel-Guerra

    Citation: BMC Endocrine Disorders 2018 18:8

    Content type: Research article

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  12. Thyroid eye disease (TED) is a debilitating autoimmune orbital disease that is often a result of Graves’ disease. Dysthyroid optic neuropathy (DON) is a rare but sight-threatening manifestation of TED with the...

    Authors: Shuo Zhang, Yang Wang, Sisi Zhong, Xingtong Liu, Yazhuo Huang, Sijie Fang, Ai Zhuang, Yinwei Li, Jing Sun, Huifang Zhou and Xianqun Fan

    Citation: BMC Endocrine Disorders 2018 18:7

    Content type: Case report

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  13. Gestational diabetes insipidus (GDI) is a rare endocrine complication during pregnancy that is associated with vasopressinase overproduction from the placenta. Although increased vasopressinase is associated w...

    Authors: Tatsuya Kondo, Miwa Nakamura, Sayaka Kitano, Junji Kawashima, Takeshi Matsumura, Takashi Ohba, Munekage Yamaguchi, Hidetaka Katabuchi and Eiichi Araki

    Citation: BMC Endocrine Disorders 2018 18:4

    Content type: Case report

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  14. The approach to acromegalic patients with persistent acromegaly after surgery and inadequate response to first-generation somatostatin receptor ligands (SRLs) should be strictly tailored. Current options inclu...

    Authors: A. Ciresi, S. Radellini, V. Guarnotta and C. Giordano

    Citation: BMC Endocrine Disorders 2018 18:2

    Content type: Case report

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  15. Vitamin D (VitD) and parathyroid hormone (PTH) play important roles in calcium metabolism and skeletal homeostasis. Estimates of the VitD status in several European countries show large variations between them...

    Authors: Luís Raposo, Sandra Martins, Daniela Ferreira, João Tiago Guimarães and Ana Cristina Santos

    Citation: BMC Endocrine Disorders 2017 17:71

    Content type: Research article

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  16. Slipped capital femoral epiphysis (SCFE) is a common hip disorder characterized by displacement of the capital femoral epiphysis from the metaphysic through the femoral epiphyseal plate. SCFE usually occurs du...

    Authors: Saori Kadowaki, Tomohiro Hori, Hideki Matsumoto, Kaori Kanda, Michio Ozeki, Yu Shirakami, Norio Kawamoto, Hidenori Ohnishi and Toshiyuki Fukao

    Citation: BMC Endocrine Disorders 2017 17:59

    Content type: Case report

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  17. This study aimed to investigate preoperative somatostatin analogs (SSAs) treatment on the surgical outcome in patients with acromegaly.

    Authors: Lian Duan, Huijuan Zhu, Bing Xing and Feng Gu

    Citation: BMC Endocrine Disorders 2017 17:55

    Content type: Research article

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  18. A functional pituitary adenoma can produce multiple anterior-pituitary hormones, such as growth hormone (GH) -producing adenomas (GHoma) with prolactin or thyrotropin stimulating hormone production in the same...

    Authors: Tomoko Takiguchi, Hisashi Koide, Hidekazu Nagano, Akitoshi Nakayama, Masanori Fujimoto, Ai Tamura, Eri Komai, Akina Shiga, Takashi Kono, Seiichiro Higuchi, Ikki Sakuma, Naoko Hashimoto, Sawako Suzuki, Yui Miyabayashi, Norio Ishiwatari, Kentaro Horiguchi…

    Citation: BMC Endocrine Disorders 2017 17:54

    Content type: Case report

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  19. dsd-LIFE is a comprehensive cross-sectional clinical outcome study of individuals with disorders/differences of sex development (DSD). This study focuses on various rare genetic conditions characterized by imp...

    Authors: Robert Röhle, Katharina Gehrmann, Maria Szarras-Czapnik, Hedi Claahsen-van der Grinten, Catherine Pienkowski, Claire Bouvattier, Peggy Cohen-Kettenis, Anna Nordenström, Ute Thyen and Birgit Köhler

    Citation: BMC Endocrine Disorders 2017 17:52

    Content type: Study protocol

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  20. Primary adrenal insufficiency (PAI) is a rare and severe condition requiring lifelong steroid replacement. During acute illness or stressful events, it is important to appropriately adjust glucocorticoid dose;...

    Authors: L. M Shepherd, A. A Tahrani, C Inman, W Arlt and D. M Carrick-Sen

    Citation: BMC Endocrine Disorders 2017 17:47

    Content type: Research article

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  21. Primary hyperparathyroidism (PHPT) is uncommon among children with an incidence of 1:300,000. This diagnosis is often missed in children in contrast to adults where it is detected at a pre symptomatic stage du...

    Authors: Maulee Hiromi Arambewela, Kamani Danushka Liyanarachchi, Noel P. Somasundaram, Aruna S. Pallewatte and Gamini L. Punchihewa

    Citation: BMC Endocrine Disorders 2017 17:45

    Content type: Case report

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  22. Evidence suggests that endocannabinoid system activation through the cannabinoid receptor 1 (CB1) is associated with enhanced liver injury, and CB1 antagonism may be beneficial. The aim of this study was to de...

    Authors: Alison J. Dawson, Eric S. Kilpatrick, Anne-Marie Coady, Abeer M. M. Elshewehy, Youssra Dakroury, Lina Ahmed, Stephen L. Atkin and Thozhukat Sathyapalan

    Citation: BMC Endocrine Disorders 2017 17:41

    Content type: Research article

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  23. Communication is complex in endocrine care, particularly during transition from paediatric to adult services. The aims of this study were to examine the feasibility of interventions to support young people to ...

    Authors: J. Downing, H. Gleeson, P.E. Clayton, J.R.E. Davis, P. Dimitri, J. Wales, B. Young and P. Callery

    Citation: BMC Endocrine Disorders 2017 17:33

    Content type: Research article

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  24. Androsterone glucuronide (ADTG) concentrations have been suggested as a marker of the effects of androgens at the target tissue level. As the mechanism for hyperandrogenemia in obese and nonobese polycystic ov...

    Authors: Li-Wei Cho, Thozhukat Sathyapalan, Eric S Kilpatrick, Brian G Keevil, Adrian G Miller, Anne M Coady, Lina Ahmed and Stephen L Atkin

    Citation: BMC Endocrine Disorders 2017 17:26

    Content type: Research article

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  25. Congenital combined pituitary hormone deficiency (CPHD) is a rare heterogeneous group of conditions. CPHD-type 3 (CPHD3; MIM# 221750) is caused by recessive mutations in LHX3, a LIM-homeodomain transcription fact...

    Authors: Khushnooda Ramzan, Bassam Bin-Abbas, Lolwa Al-Jomaa, Rabab Allam, Mohammed Al-Owain and Faiqa Imtiaz

    Citation: BMC Endocrine Disorders 2017 17:17

    Content type: Case report

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  26. Nonalcoholic fatty liver disease (NAFLD) is considered a critical hepatic manifestation of metabolic syndrome. Berberine (BBR) exerts anti-hyperglycemic and anti-dyslipidemic effects and can also ameliorate NA...

    Authors: Li Zhao, Zhen Cang, Honglin Sun, Xiaomin Nie, Ningjian Wang and Yingli Lu

    Citation: BMC Endocrine Disorders 2017 17:13

    Content type: Research article

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  27. Vitamin D (D) supplements are indispensable for its world-wide deficiency. Controversy continues on ergocalciferol (D2) and cholecalciferol (D3) relative potency as well as on dosing-schedule and sex role in r...

    Authors: Muhammad M. Hammami and Ahmed Yusuf

    Citation: BMC Endocrine Disorders 2017 17:12

    Content type: Research article

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  28. MST-4 and TRAF-6 are involved in the regulation of inflammatory and immune responses. However, whether they participate in the pathogenesis of Graves’ disease (GD) has not yet been reported. Therefore, the pur...

    Authors: Ai Guo, Yan Tan, Chun Liu and Xiaoya Zheng

    Citation: BMC Endocrine Disorders 2017 17:11

    Content type: Research article

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  29. Subclinical hypothyroidism (SH) is associated with adverse obstetric outcomes and neurodevelopment disorders. Both iodine deficiency and excess are associated with SH; however, few data regarding iodine nutrit...

    Authors: Kunling Wang, Jie Zhang, Fengao Li, Wanqi Zhang, Hao Wang, Li Ding, Yaxin Liu, Laixiang Lin, Shuang Zhang and Mei Zhu

    Citation: BMC Endocrine Disorders 2017 17:10

    Content type: Research article

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  30. Liraglutide 3 mg was recently approved as an anti-obesity drug. Metformin is weight neutral, yet it could enhance the therapeutic index of GLP-1 agonist. We compared weight-lowering potential of liraglutide 1....

    Authors: Mojca Jensterle, Nika Aleksandra Kravos, Katja Goričar and Andrej Janez

    Citation: BMC Endocrine Disorders 2017 17:5

    Content type: Research article

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  31. To determine the diagnostic efficacy of ultrasonographic malignancy risk features (UMRFs) in follicular lesions (FL) in a population with low risk of malignancy in FL and to compare it with a similar analysis ...

    Authors: Dorota Słowińska-Klencka, Martyna Wojtaszek-Nowicka, Stanisław Sporny, Ewa Woźniak-Oseła, Bożena Popowicz and Mariusz Klencki

    Citation: BMC Endocrine Disorders 2016 16:69

    Content type: Research article

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  32. Growth hormone deficiency (GHD) is associated with non-alcoholic fatty liver disease (NAFLD). A recent animal study showed that hepatocyte-specific receptor activator of nuclear factor-kappa B (RANK) knockout ...

    Authors: Ayumu Takeno, Masahiro Yamamoto, Masakazu Notsu and Toshitsugu Sugimoto

    Citation: BMC Endocrine Disorders 2016 16:66

    Content type: Case report

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  33. The 46,XY female is characterised by a male karyotype and female phenotype arising due to any interruption in the sexual development pathways in utero. The cause is usually genetic and various genes are implicate...

    Authors: Sunita M. C. De Sousa, Karin S. Kassahn, Liam C. McIntyre, Chan-Eng Chong, Hamish S. Scott and David J. Torpy

    Citation: BMC Endocrine Disorders 2016 16:58

    Content type: Case report

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  34. Subclinical hypothyroidism, commonly caused by Hashimoto thyroiditis (HT), is a risk factor for cardiovascular diseases. This disorder is defined as merely having elevated serum thyroid stimulating hormone (TS...

    Authors: Yu Li, Dong-Ning Chen, Jing Cui, Zhong Xin, Guang-Ran Yang, Ming-Jia Niu and Jin-Kui Yang

    Citation: BMC Endocrine Disorders 2016 16:57

    Content type: Research article

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  35. The term “adrenal fatigue” (“AF”) has been used by some doctors, healthcare providers, and the general media to describe an alleged condition caused by chronic exposure to stressful situations. Despite this, “...

    Authors: Flavio A. Cadegiani and Claudio E. Kater

    Citation: BMC Endocrine Disorders 2016 16:48

    Content type: Research article

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    The Erratum to this article has been published in BMC Endocrine Disorders 2016 16:63

  36. As the field of Primary Aldosteronism (PA) becomes ever expanded, diagnosis of PA is increasingly diagnosed by endocrinologists. With increased PA screening, many of the cases are now found in patients with co...

    Authors: A. Tahir, K. McLaughlin and G. Kline

    Citation: BMC Endocrine Disorders 2016 16:43

    Content type: Case report

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  37. Congenital adrenal hyperplasia (CAH) due to steroid 11β-hydroxylase deficiency (11β-OHD) is a rare form of CAH associated with low renin hypertension, hypokalemia, hyperandrogenemia and ambiguous genitalia in ...

    Authors: Pattaranatcha Charnwichai, Patra Yeetong, Kanya Suphapeetiporn, Vichit Supornsilchai, Taninee Sahakitrungruang and Vorasuk Shotelersuk

    Citation: BMC Endocrine Disorders 2016 16:37

    Content type: Case report

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  38. In order to accurately interpret neonatal thyroid function tests (TFTs), it is necessary to have population specific reference intervals (RIs) as there is significant variation across different populations pos...

    Authors: Geoffrey Omuse, Ali Kassim, Francis Kiigu, Syeda Ra’ana Hussain and Mary Limbe

    Citation: BMC Endocrine Disorders 2016 16:23

    Content type: Research article

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    The Erratum to this article has been published in BMC Endocrine Disorders 2017 17:21

  39. Tolvaptan is the only vasopressin V2 receptor antagonist licensed by the European Medicines Agency for the treatment of hyponatraemia (HN) secondary to the syndrome of inappropriate antidiuretic hormone secretion...

    Authors: Clare Jamookeeah, Paul Robinson, Karl O’Reilly, Johan Lundberg, Martin Gisby, Michael Ländin, Jakob Skov and David Trueman

    Citation: BMC Endocrine Disorders 2016 16:22

    Content type: Research article

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  40. The ubiquitin conjugating enzyme E2L3 (UBE2L3) gene is associated with susceptibility to many autoimmune diseases. The aim of this study was to investigate the association between UBE2L3 gene and autoimmune th...

    Authors: Yu Wang, Yuan-feng Zhu, Qiong Wang, Jing Xu, Ni Yan, Jian Xu, Liang-feng Shi, Shuang-tao He and Jin-an Zhang

    Citation: BMC Endocrine Disorders 2016 16:18

    Content type: Research article

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  41. Many patients with acromegaly do not achieve biochemical control with first-generation somatostatin analogues. A large, multicenter, randomized, Phase III core study demonstrated that pasireotide LAR had signi...

    Authors: Marcello D. Bronstein, Maria Fleseriu, Sebastian Neggers, Annamaria Colao, Michael Sheppard, Feng Gu, Chiung-Chyi Shen, Mônica Gadelha, Andrew J. Farrall, Karina Hermosillo Reséndiz, Matthieu Ruffin, YinMiao Chen and Pamela Freda

    Citation: BMC Endocrine Disorders 2016 16:16

    Content type: Research article

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  42. Women with type 2 diabetes mellitus (T2DM) have a higher risk of fractures despite increased bone mineral density (BMD). In experimental studies a potential role of plasminogen activator inhibitor-1 (PAI-1) in...

    Authors: Silvija Canecki-Varžić, Ivana Prpić-Križevac and Ines Bilić-Ćurčić

    Citation: BMC Endocrine Disorders 2016 16:14

    Content type: Research article

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  43. Neurofibromatosis type 1 (NF1) is a common autosomal dominant genetic disorder with an extremely variable phenotype. In childhood NF1 can be associated with optic glioma and central precocious puberty; the lat...

    Authors: Mirjana Kocova, Elena Kochova and Elena Sukarova-Angelovska

    Citation: BMC Endocrine Disorders 2015 15:82

    Content type: Case report

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  44. Recombinant Growth hormone (rGH) therapy is approved in many countries for treatment of short stature in a number of childhood diagnoses. Despite the increasing body of international literature on rGH use, the...

    Authors: Dalia Al-Abdulrazzaq, Abdullah Al-Taiar, Kholoud Hassan and Iman Al-Basari

    Citation: BMC Endocrine Disorders 2015 15:76

    Content type: Research article

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  45. Ectopic thyroid is a rare disease. In the present study at the 9th People’s Hospital in Shanghai, China, 42 patients’ ectopic thyroid glands between the neck and maxillofacial region were subjected to a retros...

    Authors: Ting Gu, Boren Jiang, Ningjian Wang, Fangzhen Xia, Lizhen Wang, Aichun Gu, Feng Xu, Yongshun Han, Qin Li and Yingli Lu

    Citation: BMC Endocrine Disorders 2015 15:70

    Content type: Research article

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