Skip to main content

Advertisement

Basic and Clinical Endocrinology

Section edited by Amar Agha

This section concerns disorders of the pituitary axis and related organs and tissues; incuding specific disorders of the thyroid, adrenals, gonads etc. Articles concerning prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology are considered within this section.

Page 1 of 3

  1. Primary aldosteronism (PA) plus subclinical Cushing’s syndrome (SCS), PASCS, has occasionally been reported. We aimed to clinically characterize patients with PASCS who are poorly profiled.

    Authors: Shigemitsu Yasuda, Yusuke Hikima, Yusuke Kabeya, Shinichiro Iida, Yoichi Oikawa, Masashi Isshiki, Ikuo Inoue, Akira Shimada and Mitsuhiko Noda

    Citation: BMC Endocrine Disorders 2020 20:9

    Content type: Research article

    Published on:

  2. Patients with primary hyperparathyroidism (PHPT) may be asymptomatic, and some may present with normocalcemic PHPT (NPHPT). Patients with vitamin D deficiency may also be asymptomatic, with normal calcium and ...

    Authors: Yanhong Guo, Qin Wang, Chunyan Lu, Pianpian Fan, Jing Li, Ximing Luo and Decai Chen

    Citation: BMC Endocrine Disorders 2020 20:5

    Content type: Research article

    Published on:

  3. Mannan-binding lectin (MBL) is a main component of the lectin pathway of the complement system. Lower MBL levels are associated with, among other conditions, hypothyroidism and adverse pregnancy outcomes. In t...

    Authors: Malgorzata Karbownik-Lewinska, Jan Stepniak, Magdalena Marcinkowska, Adrian Krygier and Andrzej Lewinski

    Citation: BMC Endocrine Disorders 2020 20:1

    Content type: Research article

    Published on:

  4. Irisin is a myokine that leads to increased energy expenditure by stimulating the browning of white adipose tissue. We aimed to investigate the association of serum irisin levels with metabolic parameters in m...

    Authors: Lizhi Tang, Yuzhen Tong, Fang Zhang, Guilin Chen, Yun Cong Zhang, John Jobin and Nanwei Tong

    Citation: BMC Endocrine Disorders 2019 19:147

    Content type: Research article

    Published on:

  5. Abscess in the thyroid gland is a rare but severe infectious disease. The condition can have anatomic or iatrogenic underlying causes. If untreated it could be fatal. Pathogens vary considerably. Treatment is ...

    Authors: Henrik Falhammar, Göran Wallin and Jan Calissendorff

    Citation: BMC Endocrine Disorders 2019 19:130

    Content type: Case report

    Published on:

  6. Exercise is known to induce multiple beneficial conditioning processes. Conversely, although exercise may generate several hormonal effects, an intrinsic hormonal conditioning process has not been reported. In...

    Authors: Flavio A. Cadegiani and Claudio E. Kater

    Citation: BMC Endocrine Disorders 2019 19:117

    Content type: Research article

    Published on:

  7. We report a novel mutation within the StAR gene, causing congenital adrenal hyperplasia, with the so far unreported association with heterochromia iridis.

    Authors: Vera Splittstösser, Felix Schreiner, Bettina Gohlke, Maik Welzel, Paul-Martin Holterhus and Joachim Woelfle

    Citation: BMC Endocrine Disorders 2019 19:116

    Content type: Case report

    Published on:

  8. Barakat syndrome is an autosomal dominant rare genetic disease caused by haploinsufficiency of the GATA binding protein 3 (GATA3) gene. It is also known as HDR syndrome, and is characterized by varying degrees of...

    Authors: Anne D. D. Joseph, Nirmala D. Sirisena, Thirunavukarasu Kumanan, Vathualan Sujanitha, Veronika Strelow, Raina Yamamoto, Stefan Wieczorek and Vajira H. W. Dissanayake

    Citation: BMC Endocrine Disorders 2019 19:111

    Content type: Case report

    Published on:

  9. Abnormal levels of liver enzymes, particularly aminotransferases, are prognostic features of non-alcoholic fatty liver disease (NAFLD). Considering the important role of dietary intakes in development of NAFLD...

    Authors: Parvin Mirmiran, Zahra Gaeini, Zahra Bahadoran and Fereidoun Azizi

    Citation: BMC Endocrine Disorders 2019 19:100

    Content type: Research article

    Published on:

  10. Obese women with polycystic ovary syndrome (PCOS) may face additional barriers in achieving weight loss. We aimed to compare the effects of the hypocaloric low glycemic index (LGI) diet on anthropometric varia...

    Authors: Farnaz Shishehgar, Parvin Mirmiran, Maryam Rahmati, Maryam Tohidi and Fahimeh Ramezani Tehrani

    Citation: BMC Endocrine Disorders 2019 19:93

    Content type: Research article

    Published on:

  11. In 2015 approximately 5.0 million people were estimated to have died from diabetes. Poor glycemic control is the most determinant of diabetes-related complication and death. The percentage of patients whose bl...

    Authors: Yitagesu Mamo, Fekede Bekele, Tadesse Nigussie and Ameha Zewudie

    Citation: BMC Endocrine Disorders 2019 19:91

    Content type: Research article

    Published on:

  12. The diagnosis of subacute thyroiditis (SAT) is based mainly on the presence of painful thyroid goitre and a significant increase in erythrocyte sedimentation rate (ESR). Proceeding according to these diagnosti...

    Authors: Magdalena Stasiak, Renata Michalak and Andrzej Lewinski

    Citation: BMC Endocrine Disorders 2019 19:86

    Content type: Case report

    Published on:

  13. Myasthenia gravis (MG) is the most common disorder of neuromuscular transmission, and it is typified by fluctuating degrees and variable combinations of weakness in the ocular, bulbar, limb, and respiratory mu...

    Authors: Mi-Chu Lin, Ming-Hsien Tsai, Jyh-Gang Leu and Yu-Wei Fang

    Citation: BMC Endocrine Disorders 2019 19:80

    Content type: Case report

    Published on:

  14. Further knowledge about the pubertal development mode of girls with Turner syndrome (TS) who have undergone hormone replacement therapy (HRT) is beneficial to the proposal of an optimal HRT regimen. This study...

    Authors: Song Guo, Jun Zhang, Yanhong Li, Huamei Ma, Qiuli Chen, Hongshan Chen and Minlian Du

    Citation: BMC Endocrine Disorders 2019 19:72

    Content type: Research article

    Published on:

  15. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in young women and increases risk of cardiovascular and metabolic disease, and infertility. Women with PCOS share many characteristics com...

    Authors: Laura E. McBreairty, Philip D. Chilibeck, Julianne J. Gordon, Donna R. Chizen and Gordon A. Zello

    Citation: BMC Endocrine Disorders 2019 19:70

    Content type: Research article

    Published on:

  16. To assess the association between cardiorespiratory fitness (CRF) and weight changes in treatment seeking patients with severe obesity who underwent a 1-year intensive lifestyle intervention (ILI) program.

    Authors: Jarle Berge, Øyvind Støren, Jens K. Hertel, Espen Gjevestad, Milada Cvancarova Småstuen and Jøran Hjelmesæth

    Citation: BMC Endocrine Disorders 2019 19:69

    Content type: Research article

    Published on:

  17. Endogenous Cushing’s syndrome, a rare endocrine disorder, characterised by chronic cortisol hypersecretion, results in neuropsychiatric disturbances and in cognitive deficits, which are only partially reversib...

    Authors: Malgorzata Monika Brzozowska, Sacha Kepreotis, Fiona Tsang and Sully Xiomara Fuentes- Patarroyo

    Citation: BMC Endocrine Disorders 2019 19:68

    Content type: Case report

    Published on:

  18. This study aimed to examine the associations between gender and the prevalence of metabolic syndrome (MS) components among Korean adults by age and body mass index (BMI) subgroups.

    Authors: Young-Mo Yang, Byung-Cheul Shin, Chihyoung Son and In-Hyuk Ha

    Citation: BMC Endocrine Disorders 2019 19:67

    Content type: Research article

    Published on:

  19. In recent years, the relationship between thyroid stimulating hormone (TSH) and obesity has been widely discussed. However, it is unclear how thyroid hormone concentrations relate to body weight and its impact...

    Authors: Ranran Xu, Fei Huang, Shijie Zhang, Yongman Lv and Qingquan Liu

    Citation: BMC Endocrine Disorders 2019 19:58

    Content type: Research article

    Published on:

  20. Thyrotoxicosis is often caused by destructive thyroiditis (DT) or Graves’ disease (GD), and a prompt and accurate differential diagnosis for thyrotoxicosis is needed as management strategy differs. A meta-anal...

    Authors: Xiaojuan Peng, Shenglan Wu, Caiqun Bie, Huijun Tang, Zhe Xiong and Shaohui Tang

    Citation: BMC Endocrine Disorders 2019 19:56

    Content type: Research article

    Published on:

  21. Hypothyroidism, one of the prevalent endocrine disorders worldwide, has a broad spectrum of clinical manifestations, from an asymptomatic condition to myxedema coma. Although the majority of patients with hypo...

    Authors: Chung Gyo Seo, Kyoung Jin Kim, Euyhyun Park, Nam Hoon Kim, Joo Hyung Kim, Hee Young Kim, Sin Gon Kim and Kyeong Jin Kim

    Citation: BMC Endocrine Disorders 2019 19:52

    Content type: Case report

    Published on:

  22. Ovarian reserve, vital for reproductive function, can be adversely affected by thyroid diseases. Despite alternations of thyroid hormones with ageing, data on interactions between the overtime trend of thyroid...

    Authors: Sara Bahri, Fahimeh Ramezani Tehrani, Atieh Amouzgar, Maryam Rahmati, Maryam Tohidi, Maryam Vasheghani and Fereidoun Azizi

    Citation: BMC Endocrine Disorders 2019 19:47

    Content type: Research article

    Published on:

  23. Some microRNAs are involved in diabetes pathology and some are known to have role in stroke. MiR-503 causes endothelial dysfunction in diabetic patients, predisposing to ischemia. There has been no study evalu...

    Authors: Saba Sheikhbahaei, Danesh Manizheh, Saadatnia Mohammad, Tajaddini Mohamad Hasan, Nazemian Saman, Rafiee Laleh, Motieian Mahsa, Amoushahi Khouzani Sanaz and Haghjooy Javanmard Shaghayegh

    Citation: BMC Endocrine Disorders 2019 19:42

    Content type: Research article

    Published on:

  24. Early diagnosis and relapse prediction in Graves’ disease influences treatment. We assessed the abilities of four TSH-receptor antibody tests [TRAb] and one cyclic adenosine monophosphate bioassay to predict r...

    Authors: Tristan Struja, Rebecca Jutzi, Noemi Imahorn, Marina Kaeslin, Fabienne Boesiger, Alexander Kutz, Esther Mundwiler, Andreas Huber, Marius Kraenzlin, Beat Mueller, Christian Meier, Luca Bernasconi and Philipp Schuetz

    Citation: BMC Endocrine Disorders 2019 19:38

    Content type: Research article

    Published on:

  25. In the treatment for hypothyroidism, a historically symptom-orientated approach has given way to reliance on a single biochemical parameter, thyroid stimulating hormone (TSH).

    Authors: John E. M. Midgley, Anthony D. Toft, Rolf Larisch, Johannes W. Dietrich and Rudolf Hoermann

    Citation: BMC Endocrine Disorders 2019 19:37

    Content type: Debate

    Published on:

  26. As a member of peroxiredoxin (PRX) family, PRX3 is predominantly located in mitochondria and plays an important role of free radical scavenging. Since a body of evidence demonstrated the involvement of PRX3 in...

    Authors: Hou-Li Liu, Tian-Tian Li, Ai-Qun Yu, Jingmin Li, Xiaoyan Li, Lianqin Li and Tomonori Kaifu

    Citation: BMC Endocrine Disorders 2019 19:32

    Content type: Research article

    Published on:

  27. Irregular menstruation is clinically associated with an increased risk for ovarian cancer and disease-related mortality. This relationship remains poorly understood, and a mechanism explaining it has yet to be...

    Authors: Jiao Jiao, Matthew Sagnelli, Bei Shi, Yuanyuan Fang, Ziqi Shen, Tianyu Tang, Bingying Dong, Da Li and Xiuxia Wang

    Citation: BMC Endocrine Disorders 2019 19:30

    Content type: Research article

    Published on:

  28. Sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3) proteins have an important role in counteracting oxidative stress. Although diabetes and hypothyroidism (HT) are both characterized by oxidative stress, the mechanisms a...

    Authors: Abdullah Al-Khaldi and Samar Sultan

    Citation: BMC Endocrine Disorders 2019 19:19

    Content type: Research article

    Published on:

  29. Renal hyperparathyroidism is a common complication of chronic kidney disease (CKD) or end-stage renal disease (ESRD) characterized by elevated parathyroid hormone levels secondary to derangements in the homeos...

    Authors: Tsai-Sung Tai, Yueh-Han Hsu, Jia Ming Chang and Chien-Chin Chen

    Citation: BMC Endocrine Disorders 2019 19:16

    Content type: Case report

    Published on:

  30. Increased urinary free cortisol in response to the oral administration of dexamethasone is a paradoxical reaction mainly reported in patients with primary pigmented nodular adrenocortical disease. Here, we des...

    Authors: Chihiro Sakaguchi, Kenji Ashida, Kenichi Kohashi, Kenji Ohe, Yoichi Fujii, Seiichi Yano, Yayoi Matsuda, Shohei Sakamoto, Ryuichi Sakamoto, Yoshinao Oda, Masatoshi Nomura and Yoshihiro Ogawa

    Citation: BMC Endocrine Disorders 2019 19:13

    Content type: Case report

    Published on:

  31. Zinc-α2-glycoprotein (ZAG) is a recently novel lipolytic adipokine implicated in regulation of glucose and lipid metabolism in many metabolic disorders. In vitro and animal studies suggest that thyroid hormone...

    Authors: Xin-Hua Xiao, Xiao-Yan Qi, Jiao-Yang Li, Yi-Bing Wang, Ya-Di Wang, Zhe-Zhen Liao, Jing Yang, Li Ran, Ge-Bo Wen and Jiang-Hua Liu

    Citation: BMC Endocrine Disorders 2019 19:12

    Content type: Research article

    Published on:

  32. The most frequently used methods of assessing Graves’ orbithopathy (GO) include: Clinical Activity Score (CAS), ultrasonography (USG), computed tomography (CT), and magnetic resonance imaging (MRI). There exis...

    Authors: Piotr Szumowski, Saeid Abdelrazek, Łukasz Żukowski, Małgorzata Mojsak, Monika Sykała, Katarzyna Siewko, Katarzyna Maliszewska, Anna Popławska-Kita and Janusz Myśliwiec

    Citation: BMC Endocrine Disorders 2019 19:10

    Content type: Research article

    Published on:

  33. Vitamin-D2 (D2) treatment has been associated with a decrease in 25-hydroxy (25(OH)) vitamin-D3 (D3) level, suggesting that D3 treatment would be preferred to raise total 25(OH) vitamin-D (D) level. We postula...

    Authors: Muhammad M. Hammami, Kafa Abuhdeeb, Safa Hammami and Ahmed Yusuf

    Citation: BMC Endocrine Disorders 2019 19:8

    Content type: Research article

    Published on:

  34. Growth hormone (GH) is a heterogeneous protein composed of several molecular isoforms, the most abundant ones being the 22 kDa- and 20 kDa-GH. Exercise-induced secretion of GH isoforms has been extensively inv...

    Authors: A. E. Rigamonti, M. Haenelt, M. Bidlingmaier, A. De Col, S. Tamini, G. Tringali, R. De Micheli, L. Abbruzzese, C. R. Goncalves da Cruz, M. Bernardo-Filho, S. G. Cella and A. Sartorio

    Citation: BMC Endocrine Disorders 2018 18:96

    Content type: Research article

    Published on:

  35. Hyponatraemia is the most common electrolyte disturbance amongst hospitalised patients. Both American and European guidelines recommend fluid restriction as first line treatment for SIADH, however differ on se...

    Authors: Kathryn Berkman, Kate Haigh, Ling Li, Jack Lockett, Goce Dimeski, Anthony Russell and Warrick J. Inder

    Citation: BMC Endocrine Disorders 2018 18:93

    Content type: Research article

    Published on:

  36. Cognitive impairment is commonly observed in patients with Hashimoto thyroiditis (HT). Low levels of vitamin D have been correlated with cognitive impairment in non-HT population. We examined the association o...

    Authors: Jun Xu, Xiang-yun Zhu, Hui Sun, Xiao-qin Xu, Song-ao Xu, Yuan Suo, Li-jun Cao, Qiang Zhou, Hui-jie Yu and Wei-zhong Cao

    Citation: BMC Endocrine Disorders 2018 18:87

    Content type: Research article

    Published on:

  37. After hormonal replacement therapy (HRT) including androgen replacement or sequential therapy of estrogen and progesterone, The combination of human chorionic gonadotropin (hCG) and human menopausal gonadotrop...

    Authors: Yinjie Gao, Bingqing Yu, Jiangfeng Mao, Xi Wang, Min Nie and Xueyan Wu

    Citation: BMC Endocrine Disorders 2018 18:85

    Content type: Research article

    Published on:

  38. Mucopolysaccharidosis type I (MPS I) results in significant disease burden and early treatment is important for optimal outcomes. Recognition of short stature and growth failure as symptoms of MPS I among pedi...

    Authors: Ana Maria Martins, Kristin Lindstrom, Sandra Obikawa Kyosen, Maria Veronica Munoz-Rojas, Nathan Thibault and Lynda E. Polgreen

    Citation: BMC Endocrine Disorders 2018 18:83

    Content type: Case report

    Published on:

  39. Gitelman syndrome (GS) is an inherited autosomal recessive renal tubular disorder characterized by low levels of potassium and magnesium in the blood, decreased excretion of calcium in the urine, and elevated ...

    Authors: Haiyang Zhou, Xinhuan Liang, Yingfen Qing, Bihui Meng, Jia Zhou, Song Huang, Shurong Lu, Zhenxing Huang, Haiyan Yang, Yan Ma and Zuojie Luo

    Citation: BMC Endocrine Disorders 2018 18:82

    Content type: Case report

    Published on: