Basic and Clinical Endocrinology

Section edited by Amar Agha

This section concerns disorders of the pituitary axis and related organs and tissues; incuding specific disorders of the thyroid, adrenals, gonads etc. Articles concerning prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology are considered within this section.

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  1. Study protocol

    Participation of adults with disorders/differences of sex development (DSD) in the clinical study dsd-LIFE: design, methodology, recruitment, data quality and study population

    dsd-LIFE is a comprehensive cross-sectional clinical outcome study of individuals with disorders/differences of sex development (DSD). This study focuses on various rare genetic conditions characterized by imp...

    Robert Röhle, Katharina Gehrmann, Maria Szarras-Czapnik, Hedi Claahsen-van der Grinten, Catherine Pienkowski, Claire Bouvattier, Peggy Cohen-Kettenis, Anna Nordenström, Ute Thyen and Birgit Köhler

    BMC Endocrine Disorders 2017 17:52

    Published on: 18 August 2017

  2. Case report

    Case report: rare skeletal manifestations in a child with primary hyperparathyroidism

    Primary hyperparathyroidism (PHPT) is uncommon among children with an incidence of 1:300,000. This diagnosis is often missed in children in contrast to adults where it is detected at a pre symptomatic stage du...

    Maulee Hiromi Arambewela, Kamani Danushka Liyanarachchi, Noel P. Somasundaram, Aruna S. Pallewatte and Gamini L. Punchihewa

    BMC Endocrine Disorders 2017 17:45

    Published on: 21 July 2017

  3. Research article

    Endocannabinoid receptor blockade reduces alanine aminotransferase in polycystic ovary syndrome independent of weight loss

    Evidence suggests that endocannabinoid system activation through the cannabinoid receptor 1 (CB1) is associated with enhanced liver injury, and CB1 antagonism may be beneficial. The aim of this study was to de...

    Alison J. Dawson, Eric S. Kilpatrick, Anne-Marie Coady, Abeer M. M. Elshewehy, Youssra Dakroury, Lina Ahmed, Stephen L. Atkin and Thozhukat Sathyapalan

    BMC Endocrine Disorders 2017 17:41

    Published on: 14 July 2017

  4. Research article

    Communication with young people in paediatric and adult endocrine consultations: an intervention development and feasibility study

    Communication is complex in endocrine care, particularly during transition from paediatric to adult services. The aims of this study were to examine the feasibility of interventions to support young people to ...

    J. Downing, H. Gleeson, P.E. Clayton, J.R.E. Davis, P. Dimitri, J. Wales, B. Young and P. Callery

    BMC Endocrine Disorders 2017 17:33

    Published on: 15 June 2017

  5. Research article

    Androsterone glucuronide to dehydroepiandrosterone sulphate ratio is discriminatory for obese Caucasian women with polycystic ovary syndrome

    Androsterone glucuronide (ADTG) concentrations have been suggested as a marker of the effects of androgens at the target tissue level. As the mechanism for hyperandrogenemia in obese and nonobese polycystic ov...

    Li-Wei Cho, Thozhukat Sathyapalan, Eric S Kilpatrick, Brian G Keevil, Adrian G Miller, Anne M Coady, Lina Ahmed and Stephen L Atkin

    BMC Endocrine Disorders 2017 17:26

    Published on: 19 May 2017

  6. Case report

    Two novel LHX3 mutations in patients with combined pituitary hormone deficiency including cervical rigidity and sensorineural hearing loss

    Congenital combined pituitary hormone deficiency (CPHD) is a rare heterogeneous group of conditions. CPHD-type 3 (CPHD3; MIM# 221750) is caused by recessive mutations in LHX3, a LIM-homeodomain transcription fact...

    Khushnooda Ramzan, Bassam Bin-Abbas, Lolwa Al-Jomaa, Rabab Allam, Mohammed Al-Owain and Faiqa Imtiaz

    BMC Endocrine Disorders 2017 17:17

    Published on: 16 March 2017

  7. Research article

    Urinary iodine in early pregnancy is associated with subclinical hypothyroidism in Tianjin, China: an observational study

    Subclinical hypothyroidism (SH) is associated with adverse obstetric outcomes and neurodevelopment disorders. Both iodine deficiency and excess are associated with SH; however, few data regarding iodine nutrit...

    Kunling Wang, Jie Zhang, Fengao Li, Wanqi Zhang, Hao Wang, Li Ding, Yaxin Liu, Laixiang Lin, Shuang Zhang and Mei Zhu

    BMC Endocrine Disorders 2017 17:10

    Published on: 17 February 2017

  8. Research article

    Short-term effectiveness of low dose liraglutide in combination with metformin versus high dose liraglutide alone in treatment of obese PCOS: randomized trial

    Liraglutide 3 mg was recently approved as an anti-obesity drug. Metformin is weight neutral, yet it could enhance the therapeutic index of GLP-1 agonist. We compared weight-lowering potential of liraglutide 1....

    Mojca Jensterle, Nika Aleksandra Kravos, Katja Goričar and Andrej Janez

    BMC Endocrine Disorders 2017 17:5

    Published on: 31 January 2017

  9. Research article

    The predictive value of sonographic images of follicular lesions – a comparison with nodules unequivocal in FNA – single centre prospective study

    To determine the diagnostic efficacy of ultrasonographic malignancy risk features (UMRFs) in follicular lesions (FL) in a population with low risk of malignancy in FL and to compare it with a similar analysis ...

    Dorota Słowińska-Klencka, Martyna Wojtaszek-Nowicka, Stanisław Sporny, Ewa Woźniak-Oseła, Bożena Popowicz and Mariusz Klencki

    BMC Endocrine Disorders 2016 16:69

    Published on: 1 December 2016

  10. Case report

    Administration of anti-receptor activator of nuclear factor-kappa B ligand (RANKL) antibody for the treatment of osteoporosis was associated with amelioration of hepatitis in a female patient with growth hormone deficiency: a case report

    Growth hormone deficiency (GHD) is associated with non-alcoholic fatty liver disease (NAFLD). A recent animal study showed that hepatocyte-specific receptor activator of nuclear factor-kappa B (RANK) knockout ...

    Ayumu Takeno, Masahiro Yamamoto, Masakazu Notsu and Toshitsugu Sugimoto

    BMC Endocrine Disorders 2016 16:66

    Published on: 24 November 2016

  11. Case report

    Case report of whole genome sequencing in the XY female: identification of a novel SRY mutation and revision of a misdiagnosis of androgen insensitivity syndrome

    The 46,XY female is characterised by a male karyotype and female phenotype arising due to any interruption in the sexual development pathways in utero. The cause is usually genetic and various genes are implicate...

    Sunita M. C. De Sousa, Karin S. Kassahn, Liam C. McIntyre, Chan-Eng Chong, Hamish S. Scott and David J. Torpy

    BMC Endocrine Disorders 2016 16:58

    Published on: 8 November 2016

  12. Research article

    Using Hashimoto thyroiditis as gold standard to determine the upper limit value of thyroid stimulating hormone in a Chinese cohort

    Subclinical hypothyroidism, commonly caused by Hashimoto thyroiditis (HT), is a risk factor for cardiovascular diseases. This disorder is defined as merely having elevated serum thyroid stimulating hormone (TS...

    Yu Li, Dong-Ning Chen, Jing Cui, Zhong Xin, Guang-Ran Yang, Ming-Jia Niu and Jin-Kui Yang

    BMC Endocrine Disorders 2016 16:57

    Published on: 6 November 2016

  13. Research article

    Familial early puberty: presentation and inheritance pattern in 139 families

    The mechanism that initiates the onset of puberty is largely unknown but the age of onset is mainly under genetic control and influenced by environmental factors including nutrition. The coexistence in the sam...

    Adélaïde Durand, Anu Bashamboo, Ken McElreavey and Raja Brauner

    BMC Endocrine Disorders 2016 16:50

    Published on: 13 September 2016

  14. Research article

    Adrenal fatigue does not exist: a systematic review

    The term “adrenal fatigue” (“AF”) has been used by some doctors, healthcare providers, and the general media to describe an alleged condition caused by chronic exposure to stressful situations. Despite this, “...

    Flavio A. Cadegiani and Claudio E. Kater

    BMC Endocrine Disorders 2016 16:48

    Published on: 24 August 2016

    The Erratum to this article has been published in BMC Endocrine Disorders 2016 16:63

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