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Table 2 Baseline clinical characteristics, comorbidities, and the clinical outcomes in patients with known diabetes and newly diagnosed diabetes

From: Reduced antibody response to SARS-CoV-2 in COVID-19 patients with newly diagnosed diabetes: a retrospective observational study

 

Known diabetes

Newly diagnosed diabetes

p value

n = 31

n = 9

Age, yr

71.8 ± 14.4

61.0 ± 16.6

0.056

Female sex

9 (30)

2 (22)

0.667

Body mass index, kg/m2

24.4 ± 3.7

25.0 ± 4.3

0.642

Current Smoker

12 (38)

4 (44)

0.693

Symptom onset to admission, d

6.7 ± 3.7

7.5 ± 3.8

0.598

Comorbidities

  Hypertension

23 (74)

1 (11)

0.003

  COPD

2 (7)

1 (11)

0.728

  Cardiovascular disease

10 (32)

0 (0)

0.086

  Cancer history

2 (7)

2 (22)

0.540

Laboratory parameters at admission

  HbA1c, %

7.4 (7.0–8.0)

7.4 (6.8–8.8)

0.795

  White blood cells, 109/L

5.9 (4.2–6.7)

5.0 (4.3–5.1)

0.136

  Neutrophils, 109/L

3.9 (2.4–4.9)

3.2 (2.9–3.3)

0.566

  Lymphocyte, 109/L

1.1 (0.7–1.3)

1.1 (0.8–1.3)

0.769

  Albumin, g/dL

3.6 (2.9–3.9)

3.8 (3.5–4.0)

0.183

  BUN, mg/dL

17.0 (12.9–28.5)

12.5(10.7–15.4)

0.068

  Serum creatinine, mg/dL

0.81 (0.76–0.99)

0.74 (0.60–0.83)

0.095

  eGFR, mL/min per 1.73 m2

62.6 (53.1–73.8)

80.7 (70.6–88.5)

0.056

  C-reactive protein, mg/dL

4.5 (1.3–7.0)

5.9 (3.3–12.4)

0.388

  Ferritin, ng/mL

385 (274–874)

883 (733–1509)

0.130

  D-dimer, µg/mL

1.06 (0.84–1.91)

0.76 (0.67–0.96)

0.126

  The 4C mortality score

11 (7–14)

10 (8–10)

0.269

Adjuvant COVID-19 therapy

  Steroids

17 (55)

6 (67)

0.527

  Remdesivir

8 (26)

3 (33)

0.656

  Favipiravir

24 (77)

7 (78)

0.827

Severity

  Mild or Moderate

22 (71)

5 (56)

0.499

  Severe

6 (19)

1 (11)

0.496

  Critical

3 (10)

3 (33)

0.156

Clinical outcomes

  days of hospitalization, d

16.7 ± 11.4

10.7 ± 7.3

0.248

  Death

4 (13)

0 (23)

0.557

  1. Data are expressed as mean ± standard deviation (SD), median [interquartile range (IQR)], or as number [proportion (%)]
  2. Abbreviations: COPD Chronic obstructive pulmonary disease, BUN Blood urea nitrogen, eGFR Estimated glomerular filtration ratio, COVID-19 Coronavirus disease 2019
  3. P value for difference between groups in percent (Chi-square test or Fisher’s exact test), means (t test), or medians (Mann–Whitney U test)