Fig. 5From: Novel sedentary cage induced sedentariness in rats: evidence from relevant biomarkersSchematic illustrations of effect of sedentariness on cardiometabolic health. Effects of sedentariness on metabolic syndrome of obesity and insulin resistance on endothelial dysfunction and increased hypertension and atherosclerosis risk. Insulin resistance and adaptive hyperinsulinemia are apparent to be the basis of endothelial dysfunction by promoting endothelial activation and a proatherogenic environment. The adipokines enhance the detrimental effectsBack to article page