Table 3 Association of CD8, CXCR4, SDF-1 expression with clinicopathological features in PTC (TCGA-cohort, n = 456)
Characteristic | CD8 high/low (n = 218/238) | p-value* | CXCR4 high/low (n = 227/229) | p-value* | SDF-1 high/low (n = 226/230) | p-value* |
|---|---|---|---|---|---|---|
Age at diagnosis | ||||||
< 55 | 160/149 | 0.014 | 170/139 | 0.001 | 144/165 | 0.067 |
≥ 55 | 58/89 | 57/90 | 82/65 | |||
Sex (N, %) | ||||||
Male | 51/70 | 0.146 | 58/63 | 0.635 | 62/59 | 0.667 |
Female | 167/168 | 169/166 | 164/171 | |||
Histologic subtype | ||||||
PTC, classic | 177/178 | 0.101 | 188/167 | 0.011 | 190/165 | 0.002 |
PTC, follicular variant | 41/60 | 39/62 | 36/65 | |||
pT-Classification | ||||||
T1–2 | 138/156 | 0.620 | 142/152 | 0.392 | 0.032 | |
T3–4 | 79/81 | 84/76 | 68/92 | |||
pN-Classification | ||||||
N0 | 101/112 | 0.009 | 97/116 | 0.001 | 115/98 | 0.204 |
N1 | 103/91 | 116/78 | 88/106 | |||
Nx | 14/35 | 14/35 | 23/26 | |||
UICC stage | ||||||
I/II | 153/163 | 0.157 | 160/156 | 0.655 | 157/159 | 0.25 |
III | 47/43 | 46/44 | 49/41 | |||
IV | 17/31 | 21/27 | 19/29 | |||