Table 2 Association of CD8, CXCR4, pCXCR4, SDF-1 expression with clinicopathological features in DTC (TMA-cohort, n = 37)
Characteristic | CD8 cells/TMA punch median (IQR) (n = 37) | p-value* | CXCR4 histoscore median (IQR) (n = 37) | p-value* | pCXCR4 histoscore median (IQR) (n = 37) | p-value* | SDF-1 histoscore median (IQR) (n = 37) | p-value |
|---|---|---|---|---|---|---|---|---|
Age at diagnosis | ||||||||
< 55 | 10 (3, 14.5) | 0.97 | 15 (0, 120) | 0.21 | 5 (0, 50) | 0.18 | 100 (25, 200) | 0.08 |
≥ 55 | 7 (5, 19) | 95 (25, 140) | 20 (5, 180) | 200 (185, 250) | ||||
Sex (N) | ||||||||
Male | 6 (3, 12) | 0.28 | 10 (0, 50) | 0.16 | 5 (0, 30) | 0.56 | 180 (100, 200) | 0.68 |
Female | 10 (5, 15) | 90 (0, 90) | 10 (0,70) | 100 (30, 300) | ||||
Histologic subtype (N) | ||||||||
PTC, classic | 13.5 (4.5, 22.5) | 0.61 | 20 (0, 140) | 0.61 | 20 (0, 95) | 0.87 | 100 (15, 185) | 0.06 |
PTC, follicular variant | 9 (4, 13) | 50 (12.5, 130) | 5 (0, 50) | 140, 10, 200) | ||||
PTC, other variants | 8 (5, 15) | 0 (0, 140) | 10 (5, 180) | 200 (100, 300) | ||||
FTC | 6 (5, 10) | 90 (10, 270) | 10 (0, 30) | 180 (100, 200) | ||||
Oncocytic carcinoma | 6 (1.5, 13) | 17.5 (2.5, 60) | 50 (0, 140) | 300 (250, 300) | ||||
pT-Classification (N) | ||||||||
T1–2 | 12.5 (6.5, 15.5) | 0.05 | 40 (0, 150) | 0.65 | 5 (0, 50) | 0.42 | 180 (90, 250) | 0.71 |
T3–4 | 5 (3, 8) | 20 (0, 100) | 10 (0, 140) | 145 (15, 200) | ||||
pN-Classification (N) | ||||||||
N0 | 11 (7, 15) | 0.55 | 70 (2.5, 130) | 0.33 | 5 (0, 70) | 0.33 | 180 (15, 250) | 0.62 |
N1 | 5 (3, 20) | 0 (0, 160) | 0 (0, 10) | 100 (90, 180) | ||||
Nx | 8 (3, 13) | 30 (10, 140) | 10 (0, 140) | 190 (100, 200) | ||||