Table 1 The correlation between TMPRSS4 and immune cells-related gene markers in THCA from the TIMER2.0 database

B cell

CD19

0.219

6.05E-07***

0.204

5.44E-06***

CD79A

0.289

2.85E-11***

0.275

6.34E-10***

CD8⁺ T cell

CD8A

0.099

2.49E-02*

0.096

3.38E-02*

CD8B

0.327

3.81E-14***

0.335

3.14E-14***

Dendritic cell

ITGAX

0.468

4.50E-29***

0.453

4.33E-26***

NRP1

0.007

0.8825

-0.003

0.945

CD1C

0.585

3.85E-48***

0.567

7.43E-43***

HLA-DPA1

0.428

4.54E-24***

0.411

2.46E-21***

HLA-DRA

0.443

7.18E-26***

0.424

1.01E-22***

HLA-DQB1

0.378

9.13E-19***

0.37

2.59E-17***

HLA-DPB1

0.395

1.71E-20***

0.38

3.65E-18***

M1 Macrophage

PTGS2

0.665

3.28E-66***

0.663

4.21E-63***

IRF5

0.590

4.52E-49***

0.586

2.99E-46***

NOS2

0.034

0.4385

0.041

0.372

M2 Macrophage

MS4A4A

0.400

5.15E-21***

0.385

1.12E-18***

VSIG4

0.399

7.22E-21***

0.388

5.68E-19***

CD163

0.382

4.39E-19***

0.368

4.59E-17***

Monocyte

CSF1R

0.299

5.61E-12***

0.287

9.83E-11***

CD86

0.438

3.20E-25***

0.421

2.03E-22***

Natural killer cell

KIR2DS4

-0.096

3.02E-02*

-0.094

3.72E-02*

KIR3DL3

0.009

0.844

0.011

0.815

KIR3DL2

0.018

0.684

0.006

0.903

KIR3DL1

-0.098

0.027*

-0.101

2.57E-02*

KIR2DL4

-0.107

0.016*

-0.112

0.013*

KIR2DL3

-0.033

0.462

-0.037

0.416

KIR2DL1

-0.156

4.01E-04***

-0.144

1.44E-03**

Neutrophils

CCR7

0.404

2.07E-21***

0.384

1.38E-18***

ITGAM

0.496

6.84E-33***

0.48

1.7E-29***

CEACAM8

0.408

7.23E-22***

0.405

1.23E-20***

T cell(general)

CD3D

0.344

1.33E-15***

0.334

3.24E-14***

CD3E

0.355

1.49E-16***

0.344

5.21E-15***

CD2

0.381

4.53E-19***

0.367

5.72E-17***

T cell exhaustion

CTLA4

0.459

7.40E-28***

0.445

4.7E-25***

LAG3

0.253

6.94E-09***

0.252

1.58E-08***

HAVCR2

0.424

1.19E-23***

0.408

5.25E-21***

GZMB

0.151

6.39E-04***

0.149

9.6E-04***

PDCD1

0.074

0.093

0.083

6.85E-02

TAM

CCL2

0.336

6.91E-15***

0.322

2.9E-13***

IL10

0.307

1.55E-12***

0.284

1.69E-10***

CD68

0.484

3.13E-31***

0.465

1.42E-27***

Tfh

BCL6

0.350

4.31E-16***

0.333

4.01E-14***

IL21

0.056

0.205

0.058

0.2

Th1

TBX21

0.111

0.012*

0.104

2.19E-02*

STAT4

0.490

4.01E-32***

0.486

3.11E-30***

STAT1

0.578

1.14E-46***

0.563

3.94E-42***

IFNG

0.210

1.72E-06***

0.201

7.77E-06***

IL13

0.145

1.07E-03***

0.143

1.57E-03**

Th2

GATA3

0.450

8.55E-27***

0.445

4.69E-25***

STAT6

0.350

4.35E-16***

0.338

1.81E-14***

STAT5A

0.374

2.18E-18***

0.375

8.75E-18***

Th17

STAT3

0.353

2.41E-16***

0.336

2.4E-14***

IL17A

0.185

2.70E-05***

0.177

8.36E-05***

Treg

FOXP3

0.537

2.07E-39***

0.521

2.6E-35***

CCR8

0.488

8.16E-32***

0.472

1.8E-28***

STAT5B

0.058

0.189

0.055

0.227

TGFB1

0.316

2.92E-13***

0.316

9.64E-13***