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Table 3 Association of comorbidities with all-cause mortality in Type 1 DM patients

From: Epidemiology of type 1 and type 2 diabetes mellitus in Kazakhstan: data from unified National Electronic Health System 2014–2019

Variables

Crude HR and 95% CI

p-value

Model 1a

Adjusted HR and 95% CI

p-value

Model 2b

Adjusted HR and 95% CI

p-value

Diabetic neuropathy, yes

0.6

(0.53–0.67)

< 0.001

0.79

(0.7–0.89)

< 0.001

0.79

(0.68–0.92)

0.002

Coronary artery disease, yes

1.95

(1.82–2.09)

< 0.001

1.06

(0.99–1.14)

0.096

1.41

(1.27–1.55)

< 0.001

Hypertensionyes

1.39

(1.3–1.49)

< 0.001

0.68

(0.64–0.73)

< 0.001

0.51

(0.46–0.56)

< 0.001

Diabetic nephropathy, yes

1.92

(1.73–2.12)

< 0.001

1.71

(1.54–1.89)

< 0.001

2.13

(1.9–2.39)

< 0.001

Retinopathy, yes

0.53

(0.46–0.6)

< 0.001

0.75

(0.66–0.86)

< 0.001

0.68

(0.57–0.8)

< 0.001

Stroke, yes

3.0

(2.66–3.41)

< 0.001

1.67

(1.47–1.89)

< 0.001

1.7

(1.49–1.94)

< 0.001

Diabetic foot, yes

2.31

(2.13–2.5)

< 0.001

1.13

(1.04–1.23)

0.004

0.98

(0.88–1.09)

0.689

Amputations, yes

3.44

(3.12–3.81)

< 0.001

1.33

(1.2–1.48)

< 0.001

1.23

(1.07–1.4)

0.002

Neoplasms, yes

1.27

(1.12–1.44)

< 0.001

1.32

(1.17–1.5)

< 0.001

1.28

(1.13–1.45)

< 0.001

  1. aModel 1 adjusted for sex, age categories and ethnicity
  2. bModel 2 adjusted for sex, age categories, ethnicity, diabetic neuropathy, coronary artery disease, hypertension, diabetic nephropathy, retinopathy, stroke, diabetic foot, amputations and neoplasms