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Table 1 The odds ratios/hazard ratios (95% CIs) of prior antibiotic exposure (from 1993 to baseline) for subsequent incident type 2 diabetes and obesity/overweight prevalence

From: Use of antibiotics and risk of type 2 diabetes, overweight and obesity: the Cardiovascular Risk in Young Finns Study and the national FINRISK study

  

Type 2 Diabetes

Overweight/obesity (BMI > 25)

  

Age- and sex-adjusteda

Adjusted with risk factors b

Age- and sex-adjusteda

Adjusted with risk factors b

  

OR / HR c

95% CI

OR / HRc

95% CI

OR

95% CI

OR

95% CI

Antibiotics

YFS

1.043

1.013

1.074

1.034

1.002

1.066

1.043

1.019

1.068

1.040

1.009

1.072

FINRISK

1.022

1.016

1.029

1.018

1.010

1.027

1.023

1.018

1.029

1.027

1.021

1.032

Antifungals

YFS

1.044

0.963

1.133

1.048

0.960

1.144

1.028

0.963

1.097

1.003

0.921

1.091

Antivirals

YFS

1.174

0.958

1.439

1.180

0.958

1.453

1.000

0.847

1.181

1.003

0.921

1.091

  1. Overweight/obesity status defined at baseline (1997, 2002, 2007 or 2012) in FINRISK and at the most recent clinical follow-up (2011) in YFS. OR / HR (95% CI) per one prescribed course of systemic antimicrobial agents
  2. CI Confidence interval, OR Odds ratio, HR Hazard ratio, YFS The Cardiovascular Risk in Young Finns Study, FINRISK The national FINRISK study
  3. aFINRISK analyses adjusted additionally for study cohort
  4. bAdjusted for 1) age, sex, childhood family income, parental smoking and early life (age 6 to 24 years) body mass index, insulin, systolic blood pressure and physical activity in YFS. 2) age, sex, study cohort, income, smoking, systolic blood pressure, physical activity, body mass index (not included in the overweight/obesity model) at baseline in FINRISK
  5. cLogistic regression (odds ratios) was used in the YFS analyses and Cox’s proportional-hazards model in FINRISK analyses (hazard ratios)
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BMC Endocrine Disorders

ISSN: 1472-6823

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