Table 3 Mixed effects regression analysis of proneurotensin. Associations are presented as β as well as well as standardized β coefficients with 95% confidence intervals CI’s, studying group*time interaction, adjusting for group status, follow-up time, age, sex, education, baseline BMI, fasting glucose and baseline insulin sensitivity index (ISI).

Follow-up time, months

-1.41 ( -6.04, 3.20)

-0.60

0.549

-1.57 (-6.19, 3.03)

-0.67

0.505

-2.54 (-7.44, 2.46)

-0.98

0.328

Group status (Intervention group)

3.55 (-13.34, 20.47)

0.41

0.681

0.07 (-17.09, 17.31)

0.01

0.994

-2.47 (-20.41, 15.34)

-0.27

0.787

Group status*time^a

11.24 (5.02, 17.48)^***

3.54^***

< 0.001

11.35 (5.13, 17.57)^***

3.58^***

< 0.001

11.44 (4.82, 18.02)^***

3.40^***

< 0.001

Age, years

0.37 (-0.43, 1.18)

0.89

0.372

0.55 (-0.27, 1.37)

1.27

0.205

Male sex

14.75 (-0.84, 30.33)

1.82

0.069

15.51 (-0.60, 31.60)

1.82

0.068

Education (high vs. low)

9.08 (-9.73, 27.87)

0.93

0.354

11.00 (-8.52, 30.53)

1.07

0.287

Baseline BMI

kg/m²

1.44 (-0.49, 3.37)

1.44

0.151

1.98 (-0.0002, 3.96)

1.90

0.058

Baseline fasting blood glucose mmol/l

-0.76 (-13.94, 12.38)

-0.11

0.912

Baseline ISI

0.07 (-0.04, 0.18)

1.21

0.228