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Table 4 The relationship between endocannabinoids (AEA and 2-AG) with FBG, HbA1c, insulin, HOMO-IR, CRP, SBP, and DBP (dependent variables) in the GDM group

From: Circulating endocannabinoid levels in pregnant women with gestational diabetes mellitus: a case–control study

Variable in model (AEA)

Ba

R square

(95% CI)

P-value*

Variable in model (2-AG)

Ba

R square

(95% CI)

P-value*

Model 1

    

Model 1

    

FBS (mg/dL)

1.27

0.15

(0.4- 2.15)

0.005

FBS (mg/dL)

1.59

0.23

(0.72- 2.46)

0.001

HbA1c (%)

0.04

0.12

(0.01- 0.08)

0.01

HbA1c (%)

0.06

0.18

(0.02- 0.10)

0.003

Insulin (μIU/mL)

0.22

0.08

(0.003- 0.45)

0.04

Insulin (μIU/mL)

0.46

0.31

(0.25- 0.66)

 < 0.001

HOMA-IR (mmol/L × μIU/mL)

0.09

0.12

(0.01- 0.16)

0.01

HOMA-IR (mmol/L × μIU/mL)

0.16

0.36

(0.10- 0.23)

 < 0.001

CRP (mg/L)

0.03

0.02

(-0.03- 0.11)

0.30

CRP (mg/L)

0.03

0.01

(-0.04- 0.10)

0.41

SBP (mmHg)

0.04

0.002

(-0.24- 0.33)

0.76

SBP (mmHg)

0.10

0.009

(-0.20- 0.40)

0.51

DBP (mmHg)

0.11

0.03

(-0.06- 0.29)

0.20

DBP (mmHg)

0.12

0.04

(-0.05- 0.31)

0.17

Model 2

    

Model 2

    

FBS (mg/dL)

1.17

0.25

(0.30–2.04)

0.009

FBS (mg/dL)

1.54

0.33

(0.68- 2.40)

0.001

HbA1c (%)

0.04

0.44

(0.01- 0.07)

0.008

HbA1c (%)

0.05

0.48

(0.02- 0.08)

0.002

Insulin (μIU/mL)

0.24

0.25

(0.02- 0.45)

0.02

Insulin (μIU/mL)

0.45

0.45

(0.26- 0.64)

 < 0.001

HOMA-IR (mmol/L × μIU/mL)

0.09

0.27

(0.02- 0.16)

0.01

HOMA-IR (mmol/L × μIU/mL)

0.16

0.49

(0.10- 0.22)

 < 0.001

CRP (mg/L)

0.04

0.25

(-0.02- 0.11)

0.18

CRP (mg/L)

0.04

0.24

(-0.03- 0.11)

0.26

SBP (mmHg)

0.09

0.15

(-0.19–0.37)

0.51

SBP (mmHg)

0.12

0.15

(-0.17- 0.41)

0.41

DBP (mmHg)

0.11

0.28

(-0.05- 0.27)

0.17

DBP (mmHg)

0.15

0.30

(-0.01- 0.32)

0.06

Model 3

    

Model 3

    

FBS (mg/dL)

-0.03

0.44

(-1.05- 0.98)

0. 49

FBS (mg/dL)

0.44

0.45

(-0.64- 1.54)

0.41

HbA1c (%)

0.01

0.49

(-0.02- 0.06)

0.40

HbA1c (%)

0.03

0.51

(-0.01- 0.07)

0.19

Insulin (μIU/mL)

-.02

0.40

(-0.28- 0.23)

0.87

Insulin (μIU/mL)

0.32

0.48

(0.06–0.58)

0.01

HOMA-IR (mmol/L × μIU/mL)

-0.01

0.48

(-0.09- 0.06)

0.76

HOMA-IR (mmol/L × μIU/mL)

0.10

0.55

(0.01- 0.18)

0.01

CRP (mg/L)

0.02

0.26

(-0.06- 0.11)

0.56

CRP (mg/L)

0.01

0.26

(-0.08- 0.11)

0.78

SBP (mmHg)

0.13

0.15

(-0.24, 0.52)

0.47

SBP (mmHg)

0.20

0.16

(-0.21–0.61)

0.33

DBP (mmHg)

0.10

0.34

(-0.1,0.31)

0.32

DBP (mmHg)

0.18

0.37

(-0.04- 0.40)

0.11

Model 4

    

Model 4

    

FBS (mg/dL)

-0.39

0.60

(-1.46- 0.67)

0.45

FBS (mg/dL)

0.45

0.60

(-0.75- 1.66)

0.45

HbA1c (%)

0.01

0.57

(-0.03–0.06)

0.53

HbA1c (%)

0.01

0.57

(-0.03- 0.07)

0.51

Insulin (μIU/mL)

-0.08

0.61

(-0.34–0.17)

0.50

Insulin (μIU/mL)

0.24

0.64

(-0.03–0.53)

0.08

HOMA-IR (mmol/L × μIU/mL)

-0.03

0.64

(-0.12- 0.04)

0.34

HOMA-IR (mmol/L × μIU/mL)

0.08

0.66

(-0.01- 0.17)

0.08

CRP (mg/L)

0.01

0.42

(-0.08- 0.11)

0.74

CRP (mg/L)

0.04

0.43

(-0.06–0.15)

0.41

SBP (mmHg)

0.04

0.47

(-0.33–0.42)

0.80

SBP (mmHg)

0.24

0.49

(-0.17- 0.66)

0.24

DBP (mmHg)

0.04

0.58

(-0.16–0.25)

0.63

DBP (mmHg)

0.25

0.65

(0.03- 0.47)

0.02

  1. Abbreviation: GDM Gestational Diabetes Mellitus, FBS Fasting blood sugar, HbA1C Glycosylated hemoglobin, HOMA-IR Hemostatic model assessment-insulin resistance, CRP C-reactive protein, SBP Systolic blood pressure, DBP Diastolic blood pressure, AEA Anandamide, 2-AG 2-Arachidonoylglycerol
  2. a B coefficient; regression slope
  3. * P < 0.05 statistically significant by linear regression. Model 1: unadjusted, model 2: adjusted for energy, carbohydrate, protein, and fat, model 3: adjusted for energy, carbohydrate, protein, and fat, weight gain, and BMI, model 4: adjusted for energy, carbohydrate, protein, and fat, weight gain, BMI, age, education, job, level of physical activity, sex of infant, family history of type 2 diabetes and gestational diabetes, number of pregnancies and weeks of pregnancy
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BMC Endocrine Disorders

ISSN: 1472-6823

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