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Table 3 The relationship between endocannabinoids (AEA and 2-AG) with FBS, HbA1c, insulin, HOMA-IR, CRP, SBP, and DBP (dependent variables) in the control group

From: Circulating endocannabinoid levels in pregnant women with gestational diabetes mellitus: a case–control study

Variable in the model (AEA)

Ba

R square

(95% CI)

P-value*

Variable in model (2-AG)

Ba

R square

(95% CI)

P-value*

Model 1

    

Model 1

    

FBS (mg/dL)

0.09

0.006

(-0.26- 0.46)

0.59

FBG (mg/dL)

0.02

0.001

(-0.21–0.26)

0.84

HbA1c (%)

0.03

0.01

(-0.05- 0.12)

0.41

HbA1c (%)

-0.01

0.004

(-0.06- 0.04)

0.68

Insulin (μIU/mL)

0.25

0.5

(-0.05- 0.55)

0.10

Insulin (μIU/mL)

0.34

0.25

(0.17- 0.52)

 < 0.001

HOMA-IR (mmol/L × μIU/mL)

0.05

0.05

(-0.01- 0.11)

0.09

HOMA-IR (mmol/L × μIU/mL)

0.06

0.25

(0.03- 0.10)

 < 0.001

CRP (mg/L)

-0.07

0.01

(-0.26- 0.10)

0.39

CRP (mg/L)

0.07

0.03

(-0.04–0.19)

0.20

SBP (mmHg)

0.29

0.01

(-0.44- 1.02)

0.42

SBP (mmHg)

0.40

0.06

(-0.06–0.86)

0.08

DBP (mmHg)

0.11

0.006

(-0.31- 0.53)

0.59

DBP (mmHg)

0.11

0.01

(-0.15- 0.38)

0.38

Model 2

    

Model 2

    

FBS (mg/dL)

0.08

0.06

(-0.29–0.46)

0.64

FBG (mg/dL)

0.005

0.06

(-0.24- 0.25)

0.96

HbA1c (%)

0.04

0.05

(-0.04–0.13)

0.34

HbA1c (%)

-0.004

0.03

(-0.06- 0.05)

0.90

Insulin (μIU/mL)

0.16

0.24

(-0.12–0.46)

0.25

Insulin (μIU/mL)

0.28

0.37

(0.10- 0.46)

0.002

HOMA-IR (mmol/L × μIU/mL)

0.03

0.24

(-0.02- 0.09)

0.24

HOMA-IR (mmol/L × μIU/mL)

0.05

0.37

(0.02–0.09)

0.002

CRP (mg/L)

-0.08

0.06

(-0.28- 0.10)

0.37

CRP (mg/L)

0.08

0.08

(-0.03- 0.21)

0.16

SBP (mmHg)

0.25

0.16

(-0.46- 0.98)

0.47

SBP (mmHg)

0.37

0.20

(-0.09–0.83)

0.11

DBP (mmHg)

0.15

0.09

(-0.27- 0.58)

0.47

DBP (mmHg)

0.19

0.12

(-0.09- 0.47)

0.17

Model 3

    

Model 3

    

FBS (mg/dL)

0.04

0.14

(-0.32–0.42)

0.79

FBG (mg/dL)

-0.001

0.14

(-0.24- 0.24)

0.99

HbA1c (%)

0.03

0.09

(-0.05–0.13)

0.42

HbA1c (%)

-0.002

0.07

(-0.06- 0.06)

0.95

Insulin (μIU/mL)

0.17

0.28

(-0.12- 0.46)

0.24

Insulin (μIU/mL)

0.27

0.40

(0.09- 0.45)

0.003

HOMA-IR (mmol/L × μIU/mL)

-0.03

0.28

(-0.02- 0.09)

0.27

HOMA-IR (mmol/L × μIU/mL)

0.05

0.39

(0.01- 0.09)

0.004

CRP (mg/L)

-0.06

0.18

(-0.24- 0.12)

0.52

CRP (mg/L)

0.08

0.21

(-0.03- 0.20)

0.17

SBP (mmHg)

0.19

0.23

(-0.51- 0.91)

0.57

SBP (mmHg)

0.35

0.27

(-0.10- 0.81)

 

DBP (mmHg)

0.13

0.21

(-0.28- 0.54)

0.53

DBP (mmHg)

0.22

0.25

(-0.04- 0.49)

0.10

Model 4

    

Model 4

    

FBS (mg/dL)

0.04

0.42

(-0.35- 0.43)

0.83

FBG (mg/dL)

-0.10

0.43

(-0.35- 0.14)

0.39

HbA1c (%)

0.009

0.33

(-0.09- 0.11)

0.86

HbA1c (%)

-0.005

0.33

(-0.07- 0.05)

0.86

Insulin (μIU/mL)

0.19

0.50

(-0.12- 0.50)

0.22

Insulin (μIU/mL)

0.26

0.59

(0.08- 0.44)

0.006

HOMA-IR (mmol/L × μIU/mL)

0.03

0.51

(-0.02- 0.09)

0.22

HOMO-IR (mmol/L × μIU/mL)

0.05

0.60

(0.01- 0.08)

0.006

CRP (mg/L)

0.01

0.36

(-0.19- 0.23)

0.86

CRP (mg/L)

0.08

0.39

(-0.04- 0.21)

0.21

SBP (mmHg)

0.49

0.47

(-0.26- 1.24)

0.19

SBP (mmHg)

0.33

0.47

(-0.14- 0.81)

0.16

DBP (mmHg)

0.19

0.36

(-0.27–0.67)

0.40

DBP (mmHg)

0.24

0.40

(-0.04–0.54)

0.09

  1. Abbreviation: GDM Gestational Diabetes Mellitus, FBG Fasting blood sugar, HbA1C Glycosylated hemoglobin, HOMA-IR Hemostatic model assessment-insulin resistance, CRP C-reactive protein, SBP Systolic blood pressure, DBP Diastolic blood pressure, AEA Anandamide, 2-AG 2-Arachidonoylglycerol
  2. a B coefficient; regression slope
  3. * P < 0.05 statistically significant by linear regression. Model 1: unadjusted, model 2: adjusted for energy, carbohydrate, protein, and fat, model 3: adjusted for energy, carbohydrate, protein, and fat, weight gain, and BMI, model 4: adjusted for energy, carbohydrate, protein, and fat, weight gain, BMI, age, education, job, level of physical activity, sex of infant, family history of type 2 diabetes and gestational diabetes, number of pregnancies and weeks of pregnancy
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BMC Endocrine Disorders

ISSN: 1472-6823

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