Table 4 Overall Quality of Evidence for Thyroid function tests in preeclampsia women with healthy pregnant women
Outcome № of participants (studies) | Risk of bias | Inconsistency | Indirectness | Imprecision | Publication biasa | Overall certainty of evidence | Relative effect (95% CI) | What happens |
|---|---|---|---|---|---|---|---|---|
Thyroid Stimulating Hormone (TSH) № of participants: 4765 cases 16,763 controls 4765/ exposed 16,763/ unexposed (56 observational studies) | Not serious | Not serious | Not serious | Not serious | Publication bias strongly suspected | ⨁◯◯◯ Very low | 1.7 (1.39 to 2.02) | The evidence is very uncertain about the effect of preeclampsia on thyroid |
Total Thyroxine (TT4) № of participants: 4765 cases 16,763 controls / exposed / unexposed (38 observational studies) | Not serious | Not serious | Not serious | Not serious | None | ⨁⨁⨁◯ Moderate | -0.82 (-1.16 to -0.49) | Preeclamptic women may result in a large reduction in total Thyroxine |
Total Triiodothyronine (TT3) № of participants: 4765 cases 16,763 controls / exposed / unexposed (38 observational studies) | Not serious | Not serious | Not serious | Not serious | None | ⨁⨁◯◯ Low | -0.88 (-1.36 to -0.41) | The evidence suggests preeclamptic women reduces free T4 slightly |
Free T4 (FT4) № of participants: 4765 cases 16,763 controls / exposed / unexposed (22 observational studies) | Not serious | Not serious | Not serious | Not serious | None | ⨁⨁⨁◯ Moderate | 0.002 (-0.27 to 0.27) | The evidence suggests preeclamptic women reduces free T4 slightly |
Free T3 (FT3) № of participants: 4765 cases 16,763 controls / exposed / unexposed (28 observational studies) | Not serious | Not serious | Not serious | Not serious | None | ⨁⨁⨁◯ Moderate | -0.59 (-0.91 to -0.27 | The evidence suggests preeclamptic women reduces free T3 slightly |