Table 5 Summary of Reported Patients who Exhibited Isolated Adrenocorticotropin Deficiency (IAD) during Cancer Treatment with anti-PD-1
Case | Age/sex | Target cancer | Type of anti PD-1 | Regimen | Time to onset of IAD/course | Major symptom-s at IAD onset | MRI of pituitary gland | Hyponatr-emia | Eosinopgi-lia | Treatmen-t | Ref |
|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 79/M | Lung adenocarcinoma | Nivo | NA | 8.5 M/20 | AL, nausea, Difficult waking | NP | ( +) | (-) | HC | [16] |
2 | 71/M | Renal cell carcinoma (multiple lung metastases) | Nivo | 3 mg/kg/2w | 6 M/14 | AL,GM, Mild conscious-ness disturban-ce | NP | ( +) | ( +) | HC,PDN | [17] |
3 | 39/M | metastatic malignant melanoma | Nivo | 3 mg/kg/2w | 9 M/13 | GM | NP | (-) | ( +) | HC | [18] |
4 | 53/M | advanced melanoma | Nivo | 3 mg/kg/2w | 14 W/NA | GF, muscle pain, vomiting | NP | (-) | ( +) | HC | [19] |
5 | 72/M | advanced melanoma | Nivo | 3 mg/kg/2w | 30 W/NA | AL, GF, vomiting | NP | ( +) | NA | HC | [19] |
6 | 76/F | Metastatic melanoma | Nivo | 2 mg/kg/3w | NA/9 | AL, bradykine-sia | NA | ( +) | NA | cortisol | [20] |
7 | 75/M | Lung adenocarcinoma | Nivo | 3 mg/kg/2w | 23 W/9 | AL, Progressi-ve fatigue | NP | ( +) | (-) | HC | [21] |
8 | 61/M | Squamous cell carcinoma | Nivo | 3 mg/kg/2w | 15 W/8 | AL, GM | NP | ( +) | (-) | HC | [22] |
9 | 63/F | Lung adenocarcinoma | Nivo | 3 mg/kg/2w | 8 M/17 | Anorexia,fatigue, myalgia, Difficult walking | slightly thickened | ( +) | NA | HC | [23] |
10 | 73/M | Squamous cell carcinoma | Nivo | 3Â mg/kg/2w | 5Â M/NA | GF, arthralgia | NP | NA | NA | HC | [24] |
11 | 74/F | Renal Cell Carcinoma( pulmonary metastasis) | Nivo | 3 mg/kg/2w | NA/5 | AL, GF, nausea | NP | ( +) | ( +) | HC | [25] |
12 | 58/M | Malignant Melanoma( liver metastasis) | Nivo | 3Â mg/kg/2w | 8Â M/NA | AL, fatigue, weakness | NP | (-) | NA | HC | [26] |
13 | 52/F | Breast cancer(lung and liver metastasis) | Nivo | 0.36Â mg/kg/2w | 6Â M/NA | GF | NP | NA | NA | HC | [27] |
14 | 70/M | advanced urothelial carcinomar (of the left kidney) | Nivo | 3 mg/kg/2w | NA/9 | anorexia,general weakness, nausea | NP | ( +) | NA | HC | [28] |
15 | 65/F | metastatic cecal cancer | Keytruda | NA(200Â mg/NA) | 7Â W/2 | severe fatigue | NP | NA | NA | HC | [29] |
16 | 85/F | Advanced squamous cell lung carcinoma | Keytruda | 200 mg/3w | NA/8 | AL,GF | higher intensity on T2-weighted imaging | ( +) | (-) | HC | [30] |
17 | 59/M | Non-small-cell Lung Cancer(adrenal metastasis) | Keytruda | 200 mg/3w | 7 M/5 | anorexia, fatigue, slight fever | NP | ( +) | NA | HC | [31] |
Our case | 66/M | Lung adenocarcinoma | Sintilimab | 200 mg/3w | 3 M/3 | GF, nausea, vomiting | NP | ( +) | (-) | PDN | / |