Table 3 Association of MC4R variant rs17782313 with macronutrient intakes and energy intake in general linear models

Energy (kcal/d)

Overweight

CT/TT

CC/TT

24.47 (-47.79,96.75(

-46.71 (-167.8, 74.40)

0.50

0.44

6.80 (-72.31, 85.92)

-32.47 (-162.8, 97.89)

0.86^†

0.62^†

75.36 (-5.73, 156.4)

60.60 (-70.4, 191.6)

0.06^†

0.36^†

Obese

CT/TT

CC/TT

-70.09 (-183.8,43.64)

382.91 (215.2, 547.1)

0.22

<0.001

-34.50 (-184.7, 115.7)

379.2 (217.4, 540.1)

0.65^†

<0.001^†

-29.53(-190.7, 131.6)

311.5 (211.9, 539.8)

0.71^†

0.002^†

Total

CT/TT

CC/TT

54.88 (-35.97, 145.7)

127.56 (-4.35, 259.48)

0.23

0.058

138.1 (34.76, 241.4)

218.6 (68.49, 368.8)

0.009^†

0.004^†

146.8 (35.15, 258.6)

242.9 (83.31, 402.5)

0.01^†

0.003^†

Carbohydrate (g/d)

Overweight

CT/TT

CC/TT

-1.19 (-10.42, 8.02)

-12.94 (-28.31, 2.42)

0.79

0.09

-5.69 (-15.83, 4.44)

-16.19 (-32.91, 0.52)

0.27

0.05

-7.28 (-18.4, 3.83)

-18.69 (-36.55, -0.83)

0.19

0.04

Obese

CT/TT

CC/TT

-2.12 (-16.39, 12.14)

-14.05 (-31.95, 3.84)

0.76

0.12

-16 (-34.66, 2.65)

-26.88 (-50.86, -2.90)

0.09

0.02

-17.20 (-37.30, 2.88)

-27.30 (-52.67, -1.94)

0.09

0.03

Total

CT/TT

CC/TT

-1.71 (-9.74, 6.32)

-13.78 (-25.4, -2.16)

0.67

0.02

-8.47 (-17.7, 0.82)

-19.98 (-33.5, -6.44)

0.07

0.004

-9.54 (-19.6, -1.57)

-21.13 (-35.64, -6.63)

0.04

0.004

Protein (g/d)

Overweight

CT/TT

CC/TT

-2.68 (-6.09, 0.72)

3.25 (-2.48, 8.99)

0.12

0.26

-3.18 (-6.65, 0.28)

3.63 (-2.11, 9.37)

0.07

0.21

-2.99 (-6.95, 0.96)

2.11 (-4.24, 8.47)

0.13

0.51

Obese

CT/TT

CC/TT

1.21 (-5.37, 7.81)

-9.36 (-17.57, -1.14)

0.71

0.02

1.73 (-4.82, 8.31)

-9.51 (-17.85, -1.17)

0.60

0.03

3.41 (-3.16, 10)

-8.17 (-16.42, -0.03)

0.30

0.05

Total

CT/TT

CC/TT

-1.37 (-4.83, 2.08)

-4.20 (-9.22, 0.82)

0.43

0.10

-4.03 (-8.04, -0.02)

-7.14 (-12.98, -1.30)

0.04

0.01

-4.83 (-8.84, -0.82)

-7.65 (-13.51, -1.79)

0.05

0.01

Fat (g/d)

Overweight

CT/TT

CC/TT

2.33 (-1.76, 6.43)

9.96 (3.20, 16.72)

0.26

0.004

5.65 (1.31, 9.98)

14.16 (7.01, 21.32)

0.01

<0.001

5.02 (0.30, 9.74)

14.25 (6.66, 21.84)

0.03

<0.001

Obese

CT/TT

CC/TT

2.07 (-3.52, 7.67)

8.75 (1.79, 15.72)

0.46

0.01

10.56 (3.57, 17.55)

15.41 (6.43, 24.40)

0.003

0.001

11.36 (3.83, 18.88)

16.18 (6.68, 25.68)

0.003

0.001

Total

CT/TT

CC/TT

2.41 (-0.92, 5.75)

9.26 (4.48, 14.05)

0.15

<0.001

6.63 (2.92, 10.35)

13.12 (7.70, 18.53)

0.001

<0.001

7.05 (3.02,11.08)

13.92 (8.15, 19.69)

0.001

<0.001