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Table 1 Association of MC4R variant rs17782313 with baseline demographic characteristics

From: Association and interaction of the MC4R rs17782313 polymorphism with plasma ghrelin, GLP-1, cortisol, food intake and eating behaviors in overweight/obese Iranian adults

Variables

Overweight (n = 221)

Obese (n = 182)

Total (n = 403)

Genotype

P-value*

Genotype

P-value*

Genotype

P-value*

TT(n = 71)

CT(n = 127)

CC(n = 23)

 

TT(n = 29)

CT(n = 123)

CC(n = 30)

 

TT(n = 100)

CT(n = 250)

CC(n = 53)

 

Age(year)

37.4 ± 8.5

35.1 ± 9.4

35.2 ± 11

0.23

34.7 ± 8.6

37.2 ± 7.6

39.9 ± 7.2

0.04

36.9 ± 8.6

36.2 ± 8.6

38 ± 9.2

0.42

Weight(kg)

79.2 ± 7.3

81 ± 8.2

78.9 ± 6.8

0.20

89.9 ± 11a

91.7 ± 8

96.9 ± 9a

0.008

82.3 ± 10ab

86.4 ± 10a

89.5 ± 12b

<0.001

Males(%)

47.9(34)

63.8(81)

47.6(10)

0.06

34.5(10)

47.6(59)

63.3(19)

0.08

44(44)

55.6(140)

56.9(29)

0.12

Waist circumference(cm)

93.6 ± 7.6

95.4 ± 7

92 ± 5

0.05

102.7 ± 8a

103.8 ± 7

107.4 ± 8a

0.03

96.2 ± 8.8a

99.6 ± 8.3

101 ± 10a

0.001

Hip circumference(cm)

100.5 ± 9

101.7 ± 9

97.3 ± 7

0.11

108.6 ± 14

107.1 ± 7

107.4 ± 8

0.73

102.9 ± 11

104.4 ± 9

103.2 ± 9

0.34

Waist/Hip Ratio

0.92 ± 0.1

0.93 ± 0.1

0.94 ± 0.0

0.50

0.95 ± 0.1

0.96 ± 0.0

0.99 ± 0.0

0.19

0.93 ± 0.1a

0.95 ± 0.0

0.97 ± 0.0a

0.02

Married(%)

80.3(57)

73.2(93)

61.9(13)

0.22

75.9(22)

85.5(106)

83.3(25)

0.45

79(79)

79.4(200)

74.5(38)

0.44

Physical activity (MET-h/week)

32.4 ± 14a

23.7 ± 13

20.1 ± 9a

<0.001†

28 ± 15ab

18.5 ± 11a

17.7 ± 14b

<0.001†

31.2 ± 14ab

21.1 ± 12a

18.7 ± 12b

<0.001†

Current smoker (%)

5.6(4)

0

0

0.06

6.9(2)

5.6(7)

6.7(2)

0.94

7(7)

3.2(8)

3.9(2)

0.50

University graduate (%)

63.4(45)

72.4(92)

61.9(13)

0.33

69(20)

54.8(68)

60(18)

0.37

65(65)

63.5(160)

60.8(31)

0.87

Occupation unemployed

38(27)

37(47)

61.9(13)

0.08

44.8(13)

50(62)

46.7(14)

0.98

40(40)

43.7(110)

52.9(27)

0.48

GE

23.9(17)

37(47)

28.6(6)

27.6(8)

22.6(28)

26.7(8)

25(25)

29.8(75)

27.5(14)

worker

11.3(8)

6.3(8)

0

3.4(1)

4.8(6)

6.7(2)

9(9)

5.6(14)

3.9(2)

Self-employment

26.8(19)

19.7(25)

9.5(2)

24.1(7)

22.6(28)

20(6)

26(26)

21(53)

15.7(8)

  1. GE Government employee, MET Metabolic equivalents
  2. Values are presented as mean ± standard deviation or numbers (%)
  3. * P values were obtained from ANOVA or χ2 tests, where appropriate. † P values were obtained from kruskal–wallis test. a & b Significant difference between genotype by ANOVA with Tukey’s post hoc tests