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Table 2 Comparison of perioperative outcomes (excluding patients with severe chronic kidney disease)

From: The effect of preoperative sodium-glucose cotransporter 2 inhibitors on the incidence of perioperative metabolic acidosis: A retrospective cohort study

Outcomes

SGLT2-i (n = 27)

Matched Controls (n = 95)

p-value

Metabolic acidosis with euglycemia, n (%)

6 (22.2)

6 (6.3)

0.024

Metabolic acidosis, n (%)

6 (22.2)

7 (7.4)

0.038

ICU stay, hours, median [IQR]

23.00 [21.00, 47.50]

22.00 [18.00, 54.50]

0.15

Blood gas analysis of the lowest pH at ICU admission

Lowest pH, median [IQR]

7.33 [7.30, 7.36]

7.35 [7.32, 7.38]

0.11

PaCO2, mmHg, median [IQR]

40.20 [36.00, 44.35]

44.00 [40.05, 46.90]

0.002

Glucose, mg/dL, median [IQR]

144.00 [119.50, 171.00]

164.00 [133.50, 203.00]

0.027

Lactate, mmol/L, median [IQR]

1.41 [1.10, 1.81]

1.31 [1.08, 1.86]

0.94

Sodium, mEq/L, median [IQR]

137.20 [135.10, 138.35]

136.20 [134.45, 137.90]

0.20

Potassium, mEq/L, median [IQR]

4.14 [3.76, 4.52]

4.05 [3.88, 4.24]

0.31

Chloride, mEq/L, mean (SD)

106.59 (4.02)

105.23 (3.29)

0.074

Bicarbonate, mEq/L, median [IQR]

22.00 [18.55, 23.20]

23.70 [22.60, 25.10]

 < 0.001

Base excess, mmol/L. median [IQR]

-3.70 [-6.90, -2.05]

-2.20 [-3.45, -0.55]

 < 0.001

Anion gap, mEq/L, median [IQR]

13.30 [11.45, 16.55]

10.70 [9.10, 12.50]

0.002

  1. Abbreviation: ICU Intensive care unit, IQR Interquartile range, PaCO2 Partial pressure of arterial carbon dioxide, SD Standard deviation. Significant p-values (p < 0.05) are given in bold